Article ; Online: Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids
Phytochemistry reviews. 2021 Aug., v. 20, no. 4 p.845-868
2021
Abstract: Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an ... ...
| Abstract | Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an unsaturated N-heterocycle (indolizidine/quinolizidine moieties). Natural PIAs and PQAs only could be obtained from finite plant families (such as Asclepiadaceae, Lauraceae and Urticaceae families, etc.). Up to date, more than one hundred natural PIAs, while only nine natural PQAs had been described. PIA and PQA analogues have been applied to the development of potent anticancer agents all along because of their excellent cytotoxic activity. However, in the last two decades, other great biological properties, such as anti-inflammatory and antiviral activities were revealed successively by different pharmacological assays. Especially because of their potent antiviral activity against coronavirus (TGEV, SARS CoV and MHV) and tobacco mosaic virus, PIA and PQA analogues have attracted much pharmaceutical attention again, some of them have been used to present interesting targets for total or semi synthesis, and structure–activity relationship (SAR) study for the development of antiviral agents. In this review, natural PIA and PQA analogues obtained in the last two decades with their herbal origins, key spectroscopic characteristics for structural identification, biological activity with possible SARs and application prospects were systematically summarized. We hope this paper can stimulate further investigations on PIA and PQA analogues as an important source for potential drug discovery. |
|---|---|
| Keywords | Apocynaceae ; Lauraceae ; Tobacco mosaic virus ; Urticaceae ; antiviral properties ; cytotoxicity ; indolizidines ; metabolites ; moieties ; phenanthrenes ; plant biochemistry ; spectroscopy ; structure-activity relationships |
| Language | English |
| Dates of publication | 2021-08 |
| Size | p. 845-868. |
| Publishing place | Springer Netherlands |
| Document type | Article ; Online |
| Note | Review |
| ZDB-ID | 2065661-0 |
| ISSN | 1572-980X ; 1568-7767 |
| ISSN (online) | 1572-980X |
| ISSN | 1568-7767 |
| DOI | 10.1007/s11101-020-09723-3 |
| Database | NAL-Catalogue (AGRICOLA) |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.