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  1. Article: Exogenous glutathione reverses meropenem resistance in carbapenem-resistant

    Yi, Juan / Liu, Chao / Yang, Ping / Wu, Zhen-Chao / Du, Chun-Jing / Shen, Ning

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1327230

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1327230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.

    Du, Chun-Jing / Liu, Jing-Yuan / Chen, Hui / Yan, Shuo / Pu, Lin / Xiong, Hao-Feng / Xiang, Pan / Li, Chuan-Sheng / Zhang, Ming / Xie, Ru-Ming / Chen, Bu-Dong / Li, Ang

    Infectious diseases of poverty

    2020  Volume 9, Issue 1, Page(s) 149

    Abstract: Background: Accurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis ... ...

    Abstract Background: Accurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.
    Methods: A total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P < 0.05.
    Results: The presence of consolidation, halo signs, and nodules (all P < 0.05) were significantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia. Small nodules (32.5% in cytomegalovirus pneumonia, 6.41% in pneumocystis pneumonia, P < 0.001) without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia. Large nodules were not found in any of patients with cytomegalovirus pneumonia. The presence of ground-glass opacity, reticulation, and bronchial wall thickening (all P > 0.05) were common in both groups.
    Conclusions: Analysis of consolidation, nodules, and halo signs may contribute to the differential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia. However, some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients. CT features are potentially useful for the differential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Adult ; Cytomegalovirus ; Female ; HIV-1 ; Humans ; Male ; Middle Aged ; Pneumonia, Pneumocystis/complications ; Pneumonia, Pneumocystis/diagnostic imaging ; Pneumonia, Pneumocystis/pathology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; Viral Load
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2689396-4
    ISSN 2049-9957 ; 2049-9957
    ISSN (online) 2049-9957
    ISSN 2049-9957
    DOI 10.1186/s40249-020-00768-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: GLRB variants regulate nearby gene expression in human brain tissues.

    Wu, Qing-Jian / Yang, Ming-Feng / Hao, Pi-da / Yan, Cheng-Jun / Du, Chun-Jing / Li, Han-Xia / Hou, Ya-Jun / Sun, Bao-Liang / Sun, Shu-Yin

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 13326

    Abstract: A recent genome-wide association study (GWAS) identified four genetic variants rs78726293, rs191260602, rs17035816 and rs7688285 in GLRB gene to be associated with panic disorder (PD) risk. In fact, GWAS is an important first step to investigate the ... ...

    Abstract A recent genome-wide association study (GWAS) identified four genetic variants rs78726293, rs191260602, rs17035816 and rs7688285 in GLRB gene to be associated with panic disorder (PD) risk. In fact, GWAS is an important first step to investigate the genetics of human complex diseases. In order to translate into opportunities for new diagnostics and therapies, we must identify the genes perturbed by these four variants, and understand how these variant functionally contributes to the underlying disease pathogenesis. Here, we investigated the effect of these four genetic variants and the expression of three nearby genes including PDGFC, GLRB and GRIA2 in human brain tissues using the GTEx (version 6) and Braineac eQTLs datasets. In GTEx (version 6) dataset, the results showed that both rs17035816 and rs7688285 variants could significantly regulate PDGFC and GLRB gene expression. In Braineac dataset, the results showed that rs17035816 variant could significantly regulate GLRB and GRIA2 gene expression. We believe that these findings further provide important supplementary information about the regulating mechanisms of rs17035816 and rs7688285 variants in PD risk.
    MeSH term(s) Brain/metabolism ; Databases, Genetic ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Panic Disorder/genetics ; Quantitative Trait Loci ; Receptors, Glycine/genetics ; Receptors, Glycine/metabolism
    Chemical Substances GLRB protein, human ; Receptors, Glycine
    Language English
    Publishing date 2017-10-17
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-13702-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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