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  1. Article ; Online: [Development the agricultural synthesis biology course for postgraduates].

    DU, Hao

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2024  Volume 40, Issue 4, Page(s) 1251–1260

    Abstract: To attain the aims of high-quality agricultural development, the Ministry of Education is in the process of establishing master's and doctoral programs in biological breeding engineering at universities with a strong agricultural focus. These programs ... ...

    Abstract To attain the aims of high-quality agricultural development, the Ministry of Education is in the process of establishing master's and doctoral programs in biological breeding engineering at universities with a strong agricultural focus. These programs will incorporate a dedicated course on agricultural synthetic biology, aiming to equip graduate students with the ability to tackle critical scientific and technological challenges in biological breeding while fostering innovations in agriculture. The course places emphasis on interdisciplinary collaboration, innovation, and the practical application of new advancement, ensuring compatibility with both domestic and international agricultural standards in the future.
    MeSH term(s) Agriculture ; Synthetic Biology/education ; Education, Graduate ; Crops, Agricultural/growth & development
    Language Chinese
    Publishing date 2024-04-24
    Publishing country China
    Document type Journal Article ; English Abstract ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.230539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Fungal luminescence pathways: research and applications].

    Wu, Yujie / Xu, Jiarui / Chen, Hongyu / DU, Hao

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2024  Volume 40, Issue 1, Page(s) 1–14

    Abstract: The fungal bioluminescence pathway (FBP) is a metabolic pathway responsible for the generation of bioluminescence derived from fungi. This pathway utilizes caffeic acid as the substrate, generating a high-energy intermediate, and the decomposition of ... ...

    Abstract The fungal bioluminescence pathway (FBP) is a metabolic pathway responsible for the generation of bioluminescence derived from fungi. This pathway utilizes caffeic acid as the substrate, generating a high-energy intermediate, and the decomposition of which yields green fluorescence with a wavelength of approximately 520 nm. The FBP is evolutionally conserved in luminescent fungal groups. Unlike other bioluminescent systems, the FBP is particularly suitable for engineering applications in eukaryotic organisms, especially in plants. Currently, metabolically engineered luminescent plants are able to emit visible light to illuminate its surroundings, which can be visualized clearly in the dark. The fungal bioluminescent system could be explored in various applications in molecular biology, biosensors and glowing ornamental plants, and even green lighting along city streets.
    MeSH term(s) Luminescence ; Light ; Fluorescence ; Eukaryota ; Green Light
    Language Chinese
    Publishing date 2024-01-23
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.230385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Primary Bladder Non-Hodgkin Lymphoma: A Case Report.

    Zheng, Haobo / Du, Hao / Liu, Junjiang

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52688

    Abstract: Primary bladder lymphoma, a rare form of non-Hodgkin's lymphoma, is diagnosed through histopathology and immunostaining. Most bladder lymphomas are of the B-cell type, with a higher incidence in women and often presenting with hematuria. This report ... ...

    Abstract Primary bladder lymphoma, a rare form of non-Hodgkin's lymphoma, is diagnosed through histopathology and immunostaining. Most bladder lymphomas are of the B-cell type, with a higher incidence in women and often presenting with hematuria. This report details an exceptionally rare case of primary bladder T-cell lymphoma. A 50-year-old male, without hematuria or other symptoms, was diagnosed during a routine ultrasound. A computed tomography scan showed a tumor located in the anterior, right, and posterior walls. The patient underwent transurethral resection of the bladder lesion. Pathological examination of the tumor showed that it was composed of lymphoid tissue, in accordance with peripheral T-cell lymphoma of non-Hodgkin subtype.
    Language English
    Publishing date 2024-01-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Theoretical Prediction of the Reaction Probabilities of H, O, and OH Radicals on the Polypropylene Surface.

    Du, Hao / Sato, Masahiro / Komuro, Atsushi / Ono, Ryo

    The journal of physical chemistry. A

    2024  Volume 128, Issue 6, Page(s) 1041–1048

    Abstract: To determine the H-abstraction reaction probabilities of H/O/OH radicals with a polypropylene (PP) surface, a first-principles calculation was performed based on the DLPNO-CCSD(T)/CBS//M06-2X-D3/def-TZVP theory level. The PP chain model used in this ... ...

    Abstract To determine the H-abstraction reaction probabilities of H/O/OH radicals with a polypropylene (PP) surface, a first-principles calculation was performed based on the DLPNO-CCSD(T)/CBS//M06-2X-D3/def-TZVP theory level. The PP chain model used in this study was 2,4,6-trimethylheptane. The rate constants of the H/O/OH radicals with the isolated PP chain model were calculated based on the conventional transition-state theory. By comparing the experimental values and considering the error factors and their compensation, it was concluded that the orders of magnitude of the predicted rate constants were accurate. The resulting rate constants were converted to reaction probabilities between the H/O/OH radicals and the PP surface. The method used in this study is applicable for obtaining theoretical values of surface reaction probabilities based on first-principles calculations. The calculation at the DLPNO-CCSD(T)/CBS theory level has high accuracy but consumes a large amount of computational resources. The study also demonstrated that the double-hybrid functionals, wB97x-2-D3(BJ) and rev-DSD-PBEP86-D3(BJ), with a 3-ζ or 4-ζ basis set, could reproduce the electronic energy values obtained from DLPNO-CCSD(T)/CBS while using only approximately 1/100 of the computational resources required by the latter under our computer configuration.
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c07531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The toxic effects of petroleum pollutants to microalgae in marine environment.

    Yu, Lili / Xia, Wei / Du, Hao

    Marine pollution bulletin

    2024  Volume 201, Page(s) 116235

    Abstract: Marine oil pollution is one of the major global environmental pollution problems. Marine microalgae are the foundation of the marine food chain, providing the main primary productivity of the ocean. They not only maintain the energy flow and material ... ...

    Abstract Marine oil pollution is one of the major global environmental pollution problems. Marine microalgae are the foundation of the marine food chain, providing the main primary productivity of the ocean. They not only maintain the energy flow and material cycle of the entire marine ecosystem, but also play an important role in regulating global climate change. Exploring the impact of petroleum pollutants on marine microalgae is extremely important for studying marine environmental pollution. This review first introduced the sources, compositions, and forms of petroleum pollutants and their migration and transformation processes in the ocean. Then, the toxic effects of petroleum pollutants on marine microalgae were summarized. The growth of marine microalgae showed low-concentration promotion and high-concentration inhibition. The population growth and interspecific relationships of marine microalga was changed and the photosynthesis of marine microalgae was influenced. Finally, potential research directions and suggestions for marine microalgae in the future were proposed.
    MeSH term(s) Petroleum/toxicity ; Microalgae ; Ecosystem ; Environmental Pollutants ; Water Pollutants, Chemical/toxicity
    Chemical Substances Petroleum ; Environmental Pollutants ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2024.116235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Educational neurotechnology: Where do we go from here?

    Privitera, Adam John / Du, Hao

    Trends in neuroscience and education

    2022  Volume 29, Page(s) 100195

    Abstract: Recent educational trends point to an interest in educational neurotechnology. While these tools have the potential to change education, little is known about whether their use improves educational outcomes. Additionally, their adoption may be negatively ...

    Abstract Recent educational trends point to an interest in educational neurotechnology. While these tools have the potential to change education, little is known about whether their use improves educational outcomes. Additionally, their adoption may be negatively impacted by teachers' lack of knowledge about the brain. In this paper we outline the potential of educational neurotechnology including what we know, what we do not yet know, and additional considerations for the ethical, successful adoption of these tools in classrooms around the world. Special consideration is given to the training needs of pre- and in-service educators whose support will be essential to the successful adoption of educational neurotechnology.
    Language English
    Publishing date 2022-10-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2694503-4
    ISSN 2211-9493 ; 2452-0837
    ISSN (online) 2211-9493
    ISSN 2452-0837
    DOI 10.1016/j.tine.2022.100195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Na

    Lei, Xinyu / Du, Hao / Lu, Pengxian / Zhang, Hanlu / Zhang, Meng

    ACS applied materials & interfaces

    2024  Volume 16, Issue 5, Page(s) 6048–6056

    Abstract: Batteries can be activated by external mechanical force and generate current, enabling a smart class of electrochemical-mechanical strain energy harvesters therefrom. Here, we have developed a ... ...

    Abstract Batteries can be activated by external mechanical force and generate current, enabling a smart class of electrochemical-mechanical strain energy harvesters therefrom. Here, we have developed a Na
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c14118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SwinPA-Net: Swin Transformer-Based Multiscale Feature Pyramid Aggregation Network for Medical Image Segmentation.

    Du, Hao / Wang, Jiazheng / Liu, Min / Wang, Yaonan / Meijering, Erik

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 4, Page(s) 5355–5366

    Abstract: The precise segmentation of medical images is one of the key challenges in pathology research and clinical practice. However, many medical image segmentation tasks have problems such as large differences between different types of lesions and similar ... ...

    Abstract The precise segmentation of medical images is one of the key challenges in pathology research and clinical practice. However, many medical image segmentation tasks have problems such as large differences between different types of lesions and similar shapes as well as colors between lesions and surrounding tissues, which seriously affects the improvement of segmentation accuracy. In this article, a novel method called Swin Pyramid Aggregation network (SwinPA-Net) is proposed by combining two designed modules with Swin Transformer to learn more powerful and robust features. The two modules, named dense multiplicative connection (DMC) module and local pyramid attention (LPA) module, are proposed to aggregate the multiscale context information of medical images. The DMC module cascades the multiscale semantic feature information through dense multiplicative feature fusion, which minimizes the interference of shallow background noise to improve the feature expression and solves the problem of excessive variation in lesion size and type. Moreover, the LPA module guides the network to focus on the region of interest by merging the global attention and the local attention, which helps to solve similar problems. The proposed network is evaluated on two public benchmark datasets for polyp segmentation task and skin lesion segmentation task as well as a clinical private dataset for laparoscopic image segmentation task. Compared with existing state-of-the-art (SOTA) methods, the SwinPA-Net achieves the most advanced performance and can outperform the second-best method on the mean Dice score by 1.68%, 0.8%, and 1.2% on the three tasks, respectively.
    MeSH term(s) Neural Networks, Computer ; Benchmarking ; Learning ; Semantics ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3204090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Biomechanical Consequences of Walking With the Suspended Backpacks.

    Lin, Xin / Yin, Shucong / Du, Hao / Leng, Yuquan / Fu, Chenglong

    IEEE transactions on bio-medical engineering

    2024  Volume 71, Issue 6, Page(s) 2001–2011

    Abstract: Objective: This article aimed to investigate the biomechanical mechanisms underlying the energetic advantages of the suspended backpacks during load carriage.: Methods: In this study, we examined eight adults walking with a 15 kg load at 5 km/h with ... ...

    Abstract Objective: This article aimed to investigate the biomechanical mechanisms underlying the energetic advantages of the suspended backpacks during load carriage.
    Methods: In this study, we examined eight adults walking with a 15 kg load at 5 km/h with a designed suspended backpack, in which the load could be switched to locked and suspended with four combinations of stiffness. Mechanical work and metabolic cost were measured during load carriage.
    Results: The results showed that the suspended backpacks led to an average reduction of 23.35% in positive work, 24.77% in negative work, and a 12.51% decrease in metabolic cost across all suspended load conditions. Notably, the decreased mechanical work predominantly occurred during single support (averaging 84.19% and 71.16% for positive and negative work, respectively), rather than during double support.
    Conclusion: Walking with the suspended backpack induced a phase shift between body movement and load movement, altering the human-load interaction. This adjustment caused the body and load to move against each other, resulting in flatter trajectories of the human-load system center of mass (COM) velocities and corresponding profiles in ground reaction forces (GRFs), along with reduced vertical excursions of the trunk. Consequently, this interplay led to flatter trajectories in mechanical work rate and reduced mechanical work, ultimately contributing to the observed reduction in energetic expenditure.
    Significance: Understanding these mechanisms is essential for the development of more effective load-carrying devices and strategies in various applications, particularly for enhancing walking abilities during load carriage.
    MeSH term(s) Humans ; Walking/physiology ; Biomechanical Phenomena/physiology ; Male ; Adult ; Weight-Bearing/physiology ; Female ; Energy Metabolism/physiology ; Young Adult ; Gait/physiology
    Language English
    Publishing date 2024-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2024.3359614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Weakly-Supervised 3D Medical Image Segmentation Using Geometric Prior and Contrastive Similarity.

    Du, Hao / Dong, Qihua / Xu, Yan / Liao, Jing

    IEEE transactions on medical imaging

    2023  Volume 42, Issue 10, Page(s) 2936–2947

    Abstract: Medical image segmentation is almost the most important pre-processing procedure in computer-aided diagnosis but is also a very challenging task due to the complex shapes of segments and various artifacts caused by medical imaging, (i.e., low-contrast ... ...

    Abstract Medical image segmentation is almost the most important pre-processing procedure in computer-aided diagnosis but is also a very challenging task due to the complex shapes of segments and various artifacts caused by medical imaging, (i.e., low-contrast tissues, and non-homogenous textures). In this paper, we propose a simple yet effective segmentation framework that incorporates the geometric prior and contrastive similarity into the weakly-supervised segmentation framework in a loss-based fashion. The proposed geometric prior built on point cloud provides meticulous geometry to the weakly-supervised segmentation proposal, which serves as better supervision than the inherent property of the bounding-box annotation (i.e., height and width). Furthermore, we propose the contrastive similarity to encourage organ pixels to gather around in the contrastive embedding space, which helps better distinguish low-contrast tissues. The proposed contrastive embedding space can make up for the poor representation of the conventionally-used gray space. Extensive experiments are conducted to verify the effectiveness and the robustness of the proposed weakly-supervised segmentation framework. The proposed framework are superior to state-of-the-art weakly-supervised methods on the following publicly accessible datasets: LiTS 2017 Challenge, KiTS 2021 Challenge and LPBA40. We also dissect our method and evaluate the performance of each component.
    MeSH term(s) Artifacts ; Diagnosis, Computer-Assisted ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2023.3269523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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