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  1. Article ; Online: Three new C-geranylated flavonoids from Paulownia catalpifolia T. Gong ex D.Y. Hong seeds with their inhibitory effects on xanthine oxidase

    Xiao, Cheng-mei / Jia, Xian-hui / Du, Hong-fang / Zhao, Huan-xin / Du, Cheng-lin / Tang, Wen-zhao / Wang, Xiao-Jing

    Phytochemical Society of Europe Phytochemistry letters. 2020 Apr., v. 36 p.162-165

    2020  

    Abstract: Three new C-geranylated flavonoids named as paucatalinones L (1), M (2), and N (3) were isolated from the seeds of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, NMR and CD techniques. Among them, ... ...

    Abstract Three new C-geranylated flavonoids named as paucatalinones L (1), M (2), and N (3) were isolated from the seeds of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, NMR and CD techniques. Among them, paucatalinone N (3) was the fifth C-geranylflavone derivative obtained from Paulownia genus, and its geranyl variation was firstly displayed in Paulownia C-geranylated flavonoids. Moreover, Compounds 1 and 3 showed good inhibitory effects on xanthine oxidase.
    Keywords Paulownia ; flavonoids ; nuclear magnetic resonance spectroscopy ; seeds ; xanthine oxidase ; Paulownia catalpifolia T. Gong ex D.Y. Hong ; C-geranylated flavonoids ; Paucatalinones L, M and N
    Language English
    Dates of publication 2020-04
    Size p. 162-165.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2020.02.002
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: [Regulatory effect of compound Coptidis Rhizoma capsule on unbalanced expression of renal tissue TGF-β1/BMP-7 and Smad signaling pathway in rats with early diabetic nephropathy].

    Liu, Sheng / Chen, Xiang-qing / Tang, Li-qin / Yu, Na / Zhang, Xiao-li / Du, Hong-fang

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2015  Volume 40, Issue 5, Page(s) 938–945

    Abstract: Objective: To investigate the effect of compound Coptidis Rhizoma capsule (CCRC) on unbalanced expression of renal tissue TGF-β1/BMP-7 and Smad signaling pathway in rats with early diabetic nephropathy (DN), and discuss CCRC's effect on DN rats with ... ...

    Abstract Objective: To investigate the effect of compound Coptidis Rhizoma capsule (CCRC) on unbalanced expression of renal tissue TGF-β1/BMP-7 and Smad signaling pathway in rats with early diabetic nephropathy (DN), and discuss CCRC's effect on DN rats with early diabetic nephropathy and its possible mechanism.
    Method: DN model rats were established by injecting streptozotocin (STZ). The rats were randomly divided into seven groups: the normal group, the model group, the enalapril treatment group, the xiaoke pill treatment group and three CRCC treatment groups. They were orally administered once a day for five weeks. The fasting blood glucose (FBG), blood urea nitrogen (BUN), serum creatinine (Scr), insulin (Ins), 24 h urinary protein (24 h Upro) and 24 h urinary microalbumin (24 h UmAlb) were tested. The pathological changes in renal tissues were examined by optical microscopy. Immuno- histochemical measures were used to detect the expressions of TGF-β1, BMP-7, Smad2/3, Smad1/5, and Smad7 protein, and RT-PCR was used to detect TGF-β1 mRNA and BMP-7 mRNA in renal tissues.
    Result: Compared with model group, BUN, Scr, Ins, 24 h Upro and 24 h UmAlb levels decreased at different degrees in CCRC treatment groups; the abnormal pathomorphology in renal tissue was improved; immunohistochemistry results showed that the expression of TGF-β1 and Smad2/3 were reduced, while the expression of BMP-7, Smad1/5 and Smad7 increased in CRCC treatment groups; the expression of TGF-β1 mRNA were reduced, but the expression of BMP-7 mRNA had no obvious change in CRCC treatment groups.
    Conclusion: CRCC can improve the early renal function, delay the progression of chronic renal pathology and maintain the dynamic balance of TGF-β1/BMP-7 expression in renal tissues of DN rats. The mechanism may be related to down-regulation of renal TGF-β1 and up-regulation of BMP-7 through Smad signaling pathway.
    MeSH term(s) Animals ; Bone Morphogenetic Protein 7/genetics ; Bone Morphogenetic Protein 7/metabolism ; Coptis/chemistry ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Rhizome/chemistry ; Signal Transduction/drug effects ; Smad Proteins/genetics ; Smad Proteins/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Bone Morphogenetic Protein 7 ; Smad Proteins ; Transforming Growth Factor beta1
    Language Chinese
    Publishing date 2015-03
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Undescribed C-geranylflavonoids isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong with their protection on human umbilical vein endothelial cells injury induced by hydrogen peroxide.

    Wang, Ying-Ai / Guo, Xing / Jia, Xian-Hui / Xue, Jing / Du, Hong-Fang / Du, Cheng-Lin / Tang, Wen-Zhao / Wang, Xiao-Jing / Zhao, Yun-Xue

    Phytochemistry

    2018  Volume 158, Page(s) 126–134

    Abstract: Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia ... ...

    Abstract Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were elucidated distinctly according to their UV, IR, MS, NMR, and CD data. Among them, two compounds were substituted with unusual modified geranyl groups, namely paucatalinone F with an oxygenated cyclogeranyl substituent and paucatalinone H with a terminal pyranoid geranyl substituent. Furthermore, the protective effects on human umbilical vein endothelial cells (HUVECs) injury induced by H
    MeSH term(s) Apoptosis/drug effects ; Circular Dichroism ; Drug Evaluation, Preclinical/methods ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Fruit/chemistry ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Hydrogen Peroxide/toxicity ; Lamiales/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Ultraviolet
    Chemical Substances Flavonoids ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2018-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2018.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
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