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  1. Article: Food Processing and Nutrition Strategies for Improving the Health of Elderly People with Dysphagia: A Review of Recent Developments.

    Liu, Ting / Zheng, Jianheng / Du, Jun / He, Gengsheng

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Dysphagia, or swallowing difficulty, is a common morbidity affecting 10% to 33% of the elderly population. Individuals with dysphagia can experience appetite, reduction, weight loss, and malnutrition as well as even aspiration, dehydration, and long-term ...

    Abstract Dysphagia, or swallowing difficulty, is a common morbidity affecting 10% to 33% of the elderly population. Individuals with dysphagia can experience appetite, reduction, weight loss, and malnutrition as well as even aspiration, dehydration, and long-term healthcare issues. However, current therapies to treat dysphagia can routinely cause discomfort and pain to patients. To prevent these risks, a non-traumatic and effective treatment of diet modification for safe chewing and swallowing is urgently needed for the elderly. This review mainly summarizes the chewing and swallowing changes in the elderly, as well as important risk factors and potential consequences of dysphagia. In addition, three texture-modified food processing strategies to prepare special foods for the aged, as well as the current statuses and future trends of such foods, are discussed. Nonthermal food technologies, gelation, and 3D printing techniques have been developed to prepare soft, moist, and palatable texture-modified foods for chewing and swallowing safety in elderly individuals. In addition, flavor enhancement and nutrition enrichment are also considered to compensate for the loss of sensory experience and nutrients. Given the trend of population aging, multidisciplinary cooperation for dysphagia management should be a top priority.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13020215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The relationship between theory of mind and moral sensitivity among Chinese preschool children: the mediating role of empathy.

    Du, Jun / Liang, Yuan / Guo, Di / Xiao, Ying

    BMC psychology

    2024  Volume 12, Issue 1, Page(s) 112

    Abstract: Background: Identifying moral behavior in complex situations is the key ability for children to develop prosocial behavior. The theory of mind (ToM) and empathy provide the cognition and emotional motivation required for the development of moral ... ...

    Abstract Background: Identifying moral behavior in complex situations is the key ability for children to develop prosocial behavior. The theory of mind (ToM) and empathy provide the cognition and emotional motivation required for the development of moral sensitivity. In this study, we investigated the associations among ToM, empathy, and moral sensitivity and explored the possible differences between Chinese preschool children aged 4 and 5 years.
    Methods: One hundred and thirty children completed the unexpected-content and change-of-location tasks as well as questionnaires about empathy and moral sensitivity individually. A one-way analysis of variance and the multi-group mediation SEM were used to examine the associations of the three variables and age differences.
    Results: The scores of 5-year-old children in the dimensions of care, fairness, authority, and sanctity and the total score were higher than those of 4-year-old children. Moral sensitivity was positively correlated with both ToM and empathy after we controlled for verbal IQ and gender. Multigroup mediation analyses showed age-based differences in the associations among moral sensitivity, ToM, and empathy. Empathy's mediation effect was partial among 4-year-old children and complete among 5-year-old children.
    Conclusions: These findings contribute to understanding the cognitive and emotional factors in the formation of children's moral sensitivity. They also point to a promising approach to promoting the development of moral sensitivity and evidence for educators to understand the process of children's socialization.
    MeSH term(s) Humans ; Child, Preschool ; Empathy ; Theory of Mind ; Morals ; Emotions ; China
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-024-01600-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Insights into postural orthostatic tachycardia syndrome after COVID-19 in pediatric patients.

    Cui, Ya-Xi / Du, Jun-Bao / Jin, Hong-Fang

    World journal of pediatrics : WJP

    2024  Volume 20, Issue 3, Page(s) 201–207

    MeSH term(s) Humans ; Child ; Postural Orthostatic Tachycardia Syndrome/diagnosis ; Postural Orthostatic Tachycardia Syndrome/epidemiology ; Postural Orthostatic Tachycardia Syndrome/etiology ; COVID-19
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-024-00796-0
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    Zs.A 6309: Show issues Location:
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  4. Article ; Online: Hierarchical graph contrastive learning of local and global presentation for multimodal sentiment analysis.

    Du, Jun / Jin, Jianhang / Zhuang, Jian / Zhang, Cheng

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5335

    Abstract: Multi-modal sentiment analysis (MSA) aims to regress or classify the overall sentiment of utterances through acoustic, visual, and textual cues. However, most of the existing efforts have focused on developing the expressive ability of neural networks to ...

    Abstract Multi-modal sentiment analysis (MSA) aims to regress or classify the overall sentiment of utterances through acoustic, visual, and textual cues. However, most of the existing efforts have focused on developing the expressive ability of neural networks to learn the representation of multi-modal information within a single utterance, without considering the global co-occurrence characteristics of the dataset. To alleviate the above issue, in this paper, we propose a novel hierarchical graph contrastive learning framework for MSA, aiming to explore the local and global representations of a single utterance for multimodal sentiment extraction and the intricate relations between them. Specifically, regarding to each modality, we extract the discrete embedding representation of each modality, which includes the global co-occurrence features of each modality. Based on it, for each utterance, we build two graphs: local level graph and global level graph to account for the level-specific sentiment implications. Then, two graph contrastive learning strategies is adopted to explore the different potential presentations based on graph augmentations respectively. Furthermore, we design a cross-level comparative learning for learning local and global potential representations of complex relationships.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54872-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Strategies of strengthening the supporting role of science and technology in public health emergency: A case study on the COVID-19

    DU, Jun

    Chinese Journal of Medical Science Research Management

    Abstract: Objective The research was aimed to discuss the role of science and technology research in the public health emergency response, and to provide theoretical support for building Healthy China, implementing the National Strategy of Innovation-Driven ... ...

    Abstract Objective The research was aimed to discuss the role of science and technology research in the public health emergency response, and to provide theoretical support for building Healthy China, implementing the National Strategy of Innovation-Driven Development. Methods Take COVID-19 as an example, to sum up the characteristics and the function of science and technology research in the public health emergency prevention and control system. Results In order to make the scientific and technological research as the supporting system in public health emergency, we need to strengthen the basic research, to improve the research and development for controlling product with the independent intellectual property, to optimize the training system and evaluating system in public health technology, to deepen the international collaboration and to popularize the basic scientific knowledge. Conclusions Through systematically arrangement for disease controlling and prevention, for the industrial supporting, for the health improvement, for the talent training system and for the cooperation and the communication, we need to fasten the technological innovation for better preparation and responding to public health emergencies.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #6338
    Database COVID19

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  6. Article ; Online: A Brand New BRCA-CRisk Model Precisely Predicts the Prognosis of Patients With Breast Cancer and

    Zhao, Yu-Fei / Du, Jun-Xian / Zhu, Wei

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 16, Page(s) 3076

    MeSH term(s) Humans ; Female ; Breast Neoplasms/genetics ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation ; Prognosis ; Germ-Line Mutation
    Chemical Substances BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02893
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 650: Show issues

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  7. Article ; Online: Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy.

    He, Zongyan / Du, Jun / Miao, Yuqing / Li, Yuhao

    Advanced healthcare materials

    2023  Volume 12, Issue 22, Page(s) e2300234

    Abstract: As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because of its ability to penetrate deep tissue with few side effects. As the key factor of SDT, it is meaningful to design and synthesize efficient ... ...

    Abstract As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because of its ability to penetrate deep tissue with few side effects. As the key factor of SDT, it is meaningful to design and synthesize efficient sonosensitizers. Compared with organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, inorganic sonosensitizers with stable properties, good dispersion, and long blood circulation time, have great development potential in SDT. This review summarizes possible mechanisms of SDT (sonoexcitation and ultrasonic cavitation) in detail. Based on these mechanisms, the design and synthesis of inorganic nanosonosensitizers can be divided into three categories: traditional inorganic semiconductor sonosensitizers, enhanced inorganic semiconductor sonosensitizers, and cavitation-enhanced sonosensitizers. Subsequently, the current efficient construction methods of sonosensitizers are summarized including accelerated semiconductor charge separation and enhanced production of reactive oxygen species through ultrasonic cavitation. Furthermore, the advantages and disadvantages of different inorganic sonosensitizers and detailed strategies are systematically discussed on how to enhance SDT. Hopefully, this review could provide new insights into the design and synthesis of efficient inorganic nano-sonosensitizers for SDT.
    MeSH term(s) Humans ; Ultrasonic Therapy/methods ; Neoplasms/therapy ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-05-01
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202300234
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    Zs.A 6966: Show issues Location:
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  8. Article ; Online: Prognostic impact of MICALL1 and associates with immune infiltration in liver hepatocellular carcinoma patients.

    Yang, Yixing / Zhao, Weizhen / Du, Jun / Wang, Yueyuan

    Cancer biomarkers : section A of Disease markers

    2023  Volume 37, Issue 3, Page(s) 147–160

    Abstract: Background: Liver hepatocellular carcinoma (LIHC) is one of the most malignancy over the world. Previous studies have proven that Molecules Interacting with CasL-Like 1 (MICALL1) participated in cellular trafficking cascades, while there has no study to ...

    Abstract Background: Liver hepatocellular carcinoma (LIHC) is one of the most malignancy over the world. Previous studies have proven that Molecules Interacting with CasL-Like 1 (MICALL1) participated in cellular trafficking cascades, while there has no study to explore the function and carcinogenic mechanism MICALL1 in LIHC.
    Methods: We aimed to investigate the relationship between MICALL1 mRNA expression and LIHC using TCGA database. The expression of MICALL1 protein in clinic samples were examined by UALCAN database. Kaplan-Meier method was used for survival analysis. Logistic regression and Cox regression were performed to evaluate the prognostic significance of MICALL1. The MICALL1-binding protein were built by the STRING tool. Enrichment analysis by GO, KEGG and GSEA was used to explore possible function of MICALL1. The ssGSEA method was used to investigate the association between MICALL1 expression and the immune infiltration level in LIHC.
    Results: The expression and prognostic value of different MICAL family members in LIHC were evaluated. The expression of MICALL1 was significantly increased at both the transcript and protein levels in LIHC tissues. Further, the LIHC patients with high MICALL1 levels showed a worse OS, DSS and PFI. Some clinicopathologic features were identified to be related to MICALL1 expression in LIHC included clinical T stage, pathologic stage, histologic grade and AFP concentration. Univariate and multivariate survival analysis showed that MICALL1 was an independent prognostic marker for OS and DSS. Further enrichment analysis revealed that the K-RAS, TNFα/NF-κB and inflammatory response were significantly enriched in the high MICALL1 expression group. Immune infiltration analysis showed that high MICALL1 expression was correlated with infiltration level of macrophage cells, Th2 cells and some other immune cell types, including TFH.
    Conclusions: MICALL1 expression was significantly associated with immune cell infiltration and may regarded as a promising prognostic biomarker for LIHC patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Prognosis ; Liver Neoplasms/genetics ; Databases, Factual
    Language English
    Publishing date 2023-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-220370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6127: Show issues Location:
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  9. Article ; Online: Baroreflex sensitivity and its implication in neurally mediated syncope in children.

    Cui, Ya-Xi / Du, Jun-Bao / Jin, Hong-Fang

    World journal of pediatrics : WJP

    2023  Volume 19, Issue 11, Page(s) 1023–1029

    MeSH term(s) Humans ; Child ; Baroreflex ; Syncope, Vasovagal/diagnosis ; Syncope/etiology ; Tilt-Table Test
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-023-00693-y
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  10. Article ; Online: UK trade in the time of COVID-19: A review.

    Du, Jun / Shepotylo, Oleksandr

    The World economy

    2021  Volume 45, Issue 5, Page(s) 1409–1446

    Abstract: This paper offers a detailed review of the UK's trade performance during the COVID-19 crisis and reflects on how this may be revived. During 2020, UK goods exports contracted more sharply than those of its international peers. Statistics suggest that UK ... ...

    Abstract This paper offers a detailed review of the UK's trade performance during the COVID-19 crisis and reflects on how this may be revived. During 2020, UK goods exports contracted more sharply than those of its international peers. Statistics suggest that UK had a deeper decline and slower recovery than Germany, Italy, Spain and the US. Further, the trends from 2017 to 2019 show a weakening in the UK's global competitiveness, suggesting a more persistent development against the backdrop of productivity slowdown and Brexit uncertainty. We analyse the confluence of internal and external factors that impact on UK trade and emphasise the importance of boosting productivity in the recovery from the COVID crisis and Brexit.
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1473825-9
    ISSN 1467-9701 ; 0378-5920
    ISSN (online) 1467-9701
    ISSN 0378-5920
    DOI 10.1111/twec.13220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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