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Article: [Acidophil stem cell pituitary neuroendocrine tumors/adenoma: a clinicopathological analysis of five cases].

Lou, L / Du, S X / Fu, Y T / Shao, Q Q / Guo, W L / Zong, Y P / Qin, M M / Tian, X X / Li, Y H

Zhonghua bing li xue za zhi = Chinese journal of pathology

2024 Volume 53, Issue 5, Page(s) 446–451

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/metabolism ; Female ; Male ; Middle Aged ; Adult ; Aged ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/metabolism ; Neuroendocrine Tumors/surgery ; Young Adult ; Adenoma/pathology ; Adenoma/metabolism ; Prolactin/metabolism ; Immunohistochemistry
Chemical Substances	Prolactin (9002-62-4)
Language	Chinese
Publishing date	2024-04-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
DOI	10.3760/cma.j.cn112151-20231019-00275
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Zs.MO 360: Show issues

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Article ; Online: Meta-analysis comparing denosumab and zoledronic acid for treatment of bone metastases in patients with advanced solid tumours.

Zheng, G Z / Chang, B / Lin, F X / Xie, D / Hu, Q X / Yu, G Y / Du, S X / Li, X D

European journal of cancer care

2017 Volume 26, Issue 6

Abstract: The purpose of this meta-analysis was to evaluate the efficacy of denosumab, compared with zoledronic acid (ZA), in delaying skeletal-related events (SREs) and enhancing overall survival in patients with advanced solid tumours and bone metastases. A ... ...

Abstract	The purpose of this meta-analysis was to evaluate the efficacy of denosumab, compared with zoledronic acid (ZA), in delaying skeletal-related events (SREs) and enhancing overall survival in patients with advanced solid tumours and bone metastases. A systematic literature search of several electronic databases, including PubMed, Medline, Embase, the Cochrane Library, CKNI and Web of Science with Conference Proceedings, was performed. Only randomised controlled trials assessing denosumab in comparison with ZA, in patients with advanced solid tumours and metastatic-stage disease, were included. The primary outcome was the time to first SRE. The risk of developing subsequent on-study SREs and overall survival were also evaluated. Three randomised controlled trials with a total of 5,544 patients with advanced solid tumours and bone metastases were included in the meta-analysis. There were 2,776 patients treated with denosumab and 2,768 treated with ZA. The pooled analysis showed that denosumab was superior to ZA in delaying time to first on-study SRE (odds ratio [OR]: 0.82; 95% CI: 0.75-0.89, p < 0.0001) and multiple SREs (risk ratio: 0.81; 95% CI: 0.74-0.88, p < 0.0001). However, no significant difference was found in overall survival improvement between denosumab and ZA (OR: 1.02; 95% CI: 0.91-1.15, p = 0.71). This meta-analysis indicates that denosumab is superior to ZA in delaying SREs for patients with bone metastases. No significant difference was observed between denosumab and ZA, regarding overall survival. We support denosumab as a potential novel treatment option for the management of bone metastases in advanced solid tumours.
MeSH term(s)	Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/complications ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Denosumab/therapeutic use ; Diphosphonates/therapeutic use ; Female ; Fractures, Spontaneous/etiology ; Fractures, Spontaneous/prevention & control ; Humans ; Hypercalcemia/etiology ; Hypercalcemia/prevention & control ; Imidazoles/therapeutic use ; Male ; Orthopedic Procedures ; Prostatic Neoplasms/pathology ; Radiotherapy ; Spinal Cord Compression/etiology ; Spinal Cord Compression/prevention & control
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; Imidazoles ; Denosumab (4EQZ6YO2HI) ; zoledronic acid (6XC1PAD3KF)
Language	English
Publishing date	2017-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis
ZDB-ID	1303114-4
ISSN	1365-2354 ; 0961-5423 ; 1360-5801
ISSN (online)	1365-2354
ISSN	0961-5423 ; 1360-5801
DOI	10.1111/ecc.12541
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Article ; Online: Osteomyelitis as the only manifestation of late latent syphilis: case report and literature review.

Liu, Z-Y / Zhang, Y / Qiu, K-F / Du, S-X

International journal of STD & AIDS

2011 Volume 22, Issue 6, Page(s) 353–355

Abstract: Bone infection, particularly of the skull and the long bones of the legs and arms, despite being a common characteristic of tertiary stage syphilis and congenital syphilis in the past, is seldom encountered clinically due to effective antibiotic therapy. ...

Abstract	Bone infection, particularly of the skull and the long bones of the legs and arms, despite being a common characteristic of tertiary stage syphilis and congenital syphilis in the past, is seldom encountered clinically due to effective antibiotic therapy. We report a case of a 62-year-old man who presented with one-month acute pain in the left leg. Treponema pallidum particle agglutination test was positive, and radiography showed a pathological fracture of the left tibiofibula. Surgical debridement and biopsy of the bone marrow were performed and a pathological diagnosis of syphilis osteomyelitis was entertained. The patient's symptoms resolved completely after a six-week course of penicillin. We identified 17 previously published cases of bone lesions of syphilis, eight of which had syphilitic osteomyelitis, seven were syphilitic osteitis and two had syphilitic periostitis. We suggest that bone lesions such as osteomyelitis caused by syphilis can be the only manifestation of late latent syphilis.
MeSH term(s)	Humans ; Male ; Middle Aged ; Osteomyelitis/microbiology ; Radiography ; Syphilis, Latent/physiopathology ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/microbiology ; Treponema pallidum/isolation & purification
Language	English
Publishing date	2011-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1258/ijsa.2011.010387
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Article ; Online: Intrinsic Two-Dimensional Organic Topological Insulators in Metal-Dicyanoanthracene Lattices.

Zhang, L Z / Wang, Z F / Huang, B / Cui, B / Wang, Zhiming / Du, S X / Gao, H-J / Liu, Feng

Nano letters

2016 Volume 16, Issue 3, Page(s) 2072–2075

Abstract: We predict theoretical existence of intrinsic two-dimensional organic topological insulator (OTI) states in Cu-dicyanoanthracene (DCA) lattice, a system that has also been grown experimentally on Cu substrate, based on first-principle density functional ... ...

Abstract	We predict theoretical existence of intrinsic two-dimensional organic topological insulator (OTI) states in Cu-dicyanoanthracene (DCA) lattice, a system that has also been grown experimentally on Cu substrate, based on first-principle density functional theory calculations. The pz-orbital Kagome bands having a Dirac point lying exactly at the Fermi level are found in the freestanding Cu-DCA lattice. The tight-binding model analysis, the calculated Chern numbers, and the semi-infinite Dirac edge states within the spin-orbit coupling gaps all confirm its intrinsic topological properties. The intrinsic TI states are found to originate from a proper number of electrons filling of the hybridized bands from Cu atomic and DCA molecular orbitals based on which similar lattices containing noble metal atoms (Au and Cu) and those molecules with two CN groups (DCA and cyanogens) are all predicted to be intrinsic OTIs.
Language	English
Publishing date	2016-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.6b00110
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Article ; Online: Highly Anisotropic Dirac Fermions in Square Graphynes.

Zhang, L Z / Wang, Z F / Wang, Zhiming M / Du, S X / Gao, H-J / Liu, Feng

The journal of physical chemistry letters

2015 Volume 6, Issue 15, Page(s) 2959–2962

Abstract: We predict a family of 2D carbon (C) allotropes, square graphynes (S-graphynes) that exhibit highly anisotropic Dirac fermions, using first-principle calculations within density functional theory. They have a square unit-cell containing two sizes of ... ...

Abstract	We predict a family of 2D carbon (C) allotropes, square graphynes (S-graphynes) that exhibit highly anisotropic Dirac fermions, using first-principle calculations within density functional theory. They have a square unit-cell containing two sizes of square C rings. The equal-energy contour of their 3D band structure shows a crescent shape, and the Dirac crescent has varying Fermi velocities from 0.6 × 10(5) to 7.2 × 10(5) m/s along different k directions. Near the Fermi level, the Dirac crescent can be nicely expressed by an extended 2D Dirac model Hamiltonian. Furthermore, tight-binding band fitting reveals that the Dirac crescent originates from the next-nearest-neighbor interactions between C atoms. S-graphynes may be used to build new 2D electronic devices taking advantages of their highly directional charge transport.
Language	English
Publishing date	2015-08-06
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.5b01337
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Article ; Online: Impact of heterocirculene molecular symmetry upon two-dimensional crystallization.

Xiao, W D / Zhang, Y Y / Tao, L / Aït-Mansour, K / Chernichenko, K Y / Nenajdenko, V G / Ruffieux, P / Du, S X / Gao, H-J / Fasel, R

Scientific reports

2014 Volume 4, Page(s) 5415

Abstract: Despite the development of crystal engineering, it remains a great challenge to predict the crystal structure even for the simplest molecules, and a clear link between molecular and crystal symmetry is missing in general. Here we demonstrate that the two- ...

Abstract	Despite the development of crystal engineering, it remains a great challenge to predict the crystal structure even for the simplest molecules, and a clear link between molecular and crystal symmetry is missing in general. Here we demonstrate that the two-dimensional (2D) crystallization of heterocirculenes on a Au(111) surface is greatly affected by the molecular symmetry. By means of ultrahigh vacuum scanning tunneling microscopy, we observe a variety of 2D crystalline structures in the coverage range from submonolayer to monolayer for D(8h)-symmetric sulflower (C16S8), whereas D(4h)-symmetric selenosulflower (C16S4Se4) forms square and rectangular lattices at submonolayer and monolayer coverages, respectively. No long-range ordered structure is observed for C(1h)-symmetric selenosulflower (C16S5Se3) self-assembling at submonolayer coverage. Such different self-assembly behaviors for the heterocirculenes with reduced molecular symmetries derive from the tendency toward close packing and the molecular symmetry retention in 2D crystallization due to van der Waals interactions.
Language	English
Publishing date	2014-06-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep05415
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Article ; Online: Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers.

Luke, J M / Vincent, J M / Du, S X / Gerdemann, U / Leen, A M / Whalen, R G / Hodgson, C P / Williams, J A

Gene therapy

2010 Volume 18, Issue 4, Page(s) 334–343

Abstract: Methods to improve plasmid-mediated transgene expression are needed for gene medicine and gene vaccination applications. To maintain a low risk of insertional mutagenesis-mediated gene activation, expression-augmenting sequences would ideally function to ...

Abstract	Methods to improve plasmid-mediated transgene expression are needed for gene medicine and gene vaccination applications. To maintain a low risk of insertional mutagenesis-mediated gene activation, expression-augmenting sequences would ideally function to improve transgene expression from transiently transfected intact plasmid, but not from spurious genomically integrated vectors. We report herein the development of potent minimal, antibiotic-free, high-manufacturing-yield mammalian expression vectors incorporating rationally designed additive combinations of expression enhancers. The SV40 72 bp enhancer incorporated upstream of the cytomegalovirus (CMV) enhancer selectively improved extrachromosomal transgene expression. The human T-lymphotropic virus type I (HTLV-I) R region, incorporated downstream of the CMV promoter, dramatically increased mRNA translation efficiency, but not overall mRNA levels, after transient transfection. A similar mRNA translation efficiency increase was observed with plasmid vectors incorporating and expressing the protein kinase R-inhibiting adenoviral viral associated (VA)1 RNA. Strikingly, HTLV-I R and VA1 did not increase transgene expression or mRNA translation efficiency from plasmid DNA after genomic integration. The vector platform, when combined with electroporation delivery, further increased transgene expression and improved HIV-1 gp120 DNA vaccine-induced neutralizing antibody titers in rabbits. These antibiotic-free vectors incorporating transient expression enhancers are safer, more potent alternatives to improve transgene expression for DNA therapy or vaccination.
MeSH term(s)	Animals ; Cell Line ; Gene Expression ; Gene Transfer Techniques ; Genetic Vectors ; Humans ; Plasmids ; RNA, Messenger/metabolism ; Transgenes ; eIF-2 Kinase/antagonists & inhibitors
Chemical Substances	RNA, Messenger ; eIF-2 Kinase (EC 2.7.11.1)
Keywords	covid19
Language	English
Publishing date	2010-11-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1191036-7
ISSN	1476-5462 ; 0969-7128
ISSN (online)	1476-5462
ISSN	0969-7128
DOI	10.1038/gt.2010.149
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Article ; Online: Identifying multiple configurations of complex molecules in dynamical processes: time resolved tunneling spectroscopy and density functional theory calculation.

Liu, Q / Zhang, Y Y / Jiang, N / Zhang, H G / Gao, L / Du, S X / Gao, H-J

Physical review letters

2010 Volume 104, Issue 16, Page(s) 166101

Abstract: We report for the first time a new methodology to determine molecular configurations of a large molecular complex in a dynamical process on a metal surface by combining time-resolved tunneling spectroscopy (I-t) and density functional theory calculation ( ...

Abstract	We report for the first time a new methodology to determine molecular configurations of a large molecular complex in a dynamical process on a metal surface by combining time-resolved tunneling spectroscopy (I-t) and density functional theory calculation (DFT). Two examples, (t-Bu)4-ZnPc and FePc, representing molecular rotation and lateral diffusion on Au(111) surfaces, respectively, were applied to demonstrate our method. Through analysis of statistical occupation time for each configuration, the molecular configuration numbers and energy differences between different configurations of these molecular systems could be unambiguously determined. These experimental results are further compared with DFT calculation to determine corresponding molecular configurations. Importantly, through the spatial I-t mapping, valuable insights of molecular surface diffusion paths are obtained.
Language	English
Publishing date	2010-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.104.166101
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Article ; Online: Graphene based quantum dots.

Zhang, H G / Hu, H / Pan, Y / Mao, J H / Gao, M / Guo, H M / Du, S X / Greber, T / Gao, H-J

Journal of physics. Condensed matter : an Institute of Physics journal

2010 Volume 22, Issue 30, Page(s) 302001

Abstract: Laterally localized electronic states are identified on a single layer of graphene on ruthenium by low temperature scanning tunneling spectroscopy (STS). The individual states are separated by 3 nm and comprise regions of about 90 carbon atoms. This ... ...

Abstract	Laterally localized electronic states are identified on a single layer of graphene on ruthenium by low temperature scanning tunneling spectroscopy (STS). The individual states are separated by 3 nm and comprise regions of about 90 carbon atoms. This constitutes a highly regular quantum dot-array with molecular precision. It is evidenced by quantum well resonances (QWRs) with energies that relate to the corrugation of the graphene layer. The dI/dV conductance spectra are modeled by a layer height dependent potential-well with a delta-function potential that describes the barrier for electron penetration into graphene. The resulting QWRs are strongest and lowest in energy on the isolated 'hill' regions with a diameter of 2 nm, where the graphene is decoupled from the surface.
Language	English
Publishing date	2010-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/0953-8984/22/30/302001
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Article ; Online: Diffusivity control in molecule-on-metal systems using electric fields.

Jiang, N / Zhang, Y Y / Liu, Q / Cheng, Z H / Deng, Z T / Du, S X / Gao, H-J / Beck, M J / Pantelides, S T

Nano letters

2010 Volume 10, Issue 4, Page(s) 1184–1188

Abstract: The development of methods for controlling the motion and arrangement of molecules adsorbed on a metal surface would provide a powerful tool for the design of molecular electronic devices. Recently, metal phthalocyanines (MPc) have been extensively ... ...

Abstract	The development of methods for controlling the motion and arrangement of molecules adsorbed on a metal surface would provide a powerful tool for the design of molecular electronic devices. Recently, metal phthalocyanines (MPc) have been extensively considered for use in such devices. Here we show that applied electric fields can be used to turn off the diffusivity of iron phthalocyanine (FePc) on Au(111) at fixed temperature, demonstrating a practical and direct method for controlling and potentially patterning FePc layers. Using scanning tunneling microscopy, we show that the diffusivity of FePc on Au(111) is a strong function of temperature and that applied electric fields can be used to retard or enhance molecular diffusion at fixed temperature. Using spin-dependent density-functional calculations, we then explore the origin of this effect, showing that applied fields modify both the molecule-surface binding energies and the molecular diffusion barriers through an interaction with the dipolar Fe-Au adsorption bond. On the basis of these results FePc on Au(111) is a promising candidate system for the development of adaptive molecular device structures.
Language	English
Publishing date	2010-02-23
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/nl903473p
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