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  1. Article ; Online: Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis.

    Wu, Lin / Du, Yuxin / Wang, Litao / Zhang, Yingmei / Ren, Jun

    Redox biology

    2024  Volume 72, Page(s) 103157

    Abstract: Background: Doxorubicin (DOX) is a chemotherapeutic drug, while its clinical use is greatly limited by the life-threatening cardiotoxicity. N: Methods: Mice were administrated with DOX (accumulative dosage of 20 mg/kg) repeatedly to establish a ... ...

    Abstract Background: Doxorubicin (DOX) is a chemotherapeutic drug, while its clinical use is greatly limited by the life-threatening cardiotoxicity. N
    Methods: Mice were administrated with DOX (accumulative dosage of 20 mg/kg) repeatedly to establish a chronic DIC model. Cardiomyocyte-specific conditional METTL3 knockout mice were employed to evaluate the effects of altered m
    Results: DOX led to increased levels in m
    Conclusion: METTL3 plays a cardinal role in the etiology of DIC by regulating cardiac iron metabolism and ferroptosis through TFRC m
    MeSH term(s) Animals ; Mice ; Doxorubicin/adverse effects ; Cardiotoxicity/etiology ; Cardiotoxicity/metabolism ; Methyltransferases/metabolism ; Methyltransferases/genetics ; Ferroptosis/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/drug effects ; Mice, Knockout ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Male ; Humans
    Chemical Substances Doxorubicin (80168379AG) ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-) ; Adenosine (K72T3FS567) ; N-methyladenosine (CLE6G00625)
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Trace element zinc and skin disorders.

    Zou, Pan / Du, Yuxin / Yang, Chunguang / Cao, Yuchun

    Frontiers in medicine

    2023  Volume 9, Page(s) 1093868

    Abstract: Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and ...

    Abstract Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1093868
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  3. Article: The green tide causative-species

    Liu, Qing / Cui, Ruifei / Du, Yuxin / Shen, Junjie / Jin, Cuili / Zhou, Xiaojian

    Heliyon

    2024  Volume 10, Issue 9, Page(s) e29641

    Abstract: In order to study the role of oil spills in the occurrence of green tide in the Yellow Sea, the physiological characteristics and photosynthetic activities of green tide causative- ... ...

    Abstract In order to study the role of oil spills in the occurrence of green tide in the Yellow Sea, the physiological characteristics and photosynthetic activities of green tide causative-species
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29641
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  4. Article ; Online: Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice.

    Liu, Bingjie / Du, Yuxin / Xu, Chang / Liu, Qingzhen / Zhang, Lidong

    Brain research

    2023  Volume 1811, Page(s) 148375

    Abstract: With the approval of s-ketamine nasal spray as a novel antidepressant, its robust antidepressant effects have been intensively examined in clinical trials. However, the therapeutic efficacy and mechanisms of repeated intermittent drug administration ... ...

    Abstract With the approval of s-ketamine nasal spray as a novel antidepressant, its robust antidepressant effects have been intensively examined in clinical trials. However, the therapeutic efficacy and mechanisms of repeated intermittent drug administration remain unclear. In the present study, we applied a classic chronic unpredictable mild stress (CUMS) model to induce depressive-like behaviors of mice and evaluated the role of repeated s-ketamine administration (10 mg/kg, 7 consecutive days) in ameliorating depressive-like behaviors and modulating related molecular pathways. A battery of behavioral tests were performed to assess CUMS-induced depression. The protein expressions of GluN1, GluN2A, GluN2B, GluR1, CaMKIIα, phosphorylated CaMKIIα (p-CaMKIIα), BDNF, TrkB, phosphorylated TrkB (p-TrkB), mTOR, and phosphorylated mTOR (p-mTOR) as well as modification of synaptic ultrastructure was identified in hippocampal tissues. It turned out that s-ketamine manifested evident antidepressant effects with improved synaptic plasticity. Meanwhile, the results suggested that s-ketamine could differentially modulate glutamate receptors with upregulated GluN1 and GluR1 levels and downregulated GluN2B levels. CUMS-induced elevation of CaMKIIα phosphorylation and decline of BDNF, TrkB phosphorylation and mTOR could also be reversed through s-ketamine treatment. Together, our study provided evidence that selectively modulated glutamate receptors as well as CaMKIIα and mTOR signaling were involved in repeated s-ketamine administration.
    MeSH term(s) Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Antidepressive Agents/therapeutic use ; Hippocampus/metabolism ; Depression/drug therapy ; Depression/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Receptors, Glutamate/metabolism ; Stress, Psychological/metabolism ; Disease Models, Animal
    Chemical Substances Esketamine (50LFG02TXD) ; Brain-Derived Neurotrophic Factor ; Antidepressive Agents ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Receptors, Glutamate
    Language English
    Publishing date 2023-05-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2023.148375
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Prognostic relevance of genetic variations in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma.

    Yu, Hui / Du, Yuxin / Xu, Ji / Zhang, Mingzhi

    Translational cancer research

    2022  Volume 8, Issue 6, Page(s) 2485–2495

    Abstract: T-cell acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are highly aggressive malignant tumors. With the current intensive treatment regimens, event-free survival (EFS) rates of up to 60-90% can be achieved, but the survival rate of ... ...

    Abstract T-cell acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are highly aggressive malignant tumors. With the current intensive treatment regimens, event-free survival (EFS) rates of up to 60-90% can be achieved, but the survival rate of relapsed patients remains poor-only approximately 3-12%. Therefore, precise and effective prognostic parameters are highly needed to further improve survival rates along with reduced acute and long-term toxicities, including the rate of secondary malignancies. In addition, gene mutations can be used as therapeutic targets. This review highlights several gene mutations with a high frequency or a strong influence associated with favorable or unfavorable aspects of prognosis-
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.10.04
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  6. Article ; Online: Sarcoplasmic Reticulum Ca

    Du, Yuxin / Demillard, Laurie J / Ren, Jun

    Biochemical pharmacology

    2022  Volume 200, Page(s) 115059

    Abstract: Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death (SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), ... ...

    Abstract Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death (SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), idiopathic ventricular fibrillation (IVF) and arrhythmogenic right ventricular cardiomyopathy (ARVC/D) may also be instigated by genetic mutations of sarcoplasmic reticulum (SR) proteins, including ryanodine receptor type-2 (RyR2), calsequestrin 2, SR Ca
    MeSH term(s) Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Calcium/metabolism ; Humans ; Mutation ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism ; Tachycardia, Ventricular/genetics ; Tachycardia, Ventricular/metabolism
    Chemical Substances Ryanodine Receptor Calcium Release Channel ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.115059
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Colonial morphology weakens the response of different inorganic carbon uptake systems to CO

    Zheng, Baohai / Du, Yuxin / Deng, Yuting / Zhao, Teng / Dong, Peichang / Shi, Junqiong / Wu, Zhongxing

    Harmful algae

    2023  Volume 128, Page(s) 102491

    Abstract: Rising atmospheric ... ...

    Abstract Rising atmospheric CO
    MeSH term(s) Microcystis ; Carbon Dioxide ; Ecosystem ; Carbon ; Lakes
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-08-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091119-1
    ISSN 1878-1470 ; 1568-9883
    ISSN (online) 1878-1470
    ISSN 1568-9883
    DOI 10.1016/j.hal.2023.102491
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    In stock of ZB MED Bonn / Germany

    Z 7473: Show issues

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  8. Article ; Online: A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9).

    Lv, Yan / Ma, Xiao / Ma, Yuxin / Du, Yuxin / Feng, Jifeng

    Genes & diseases

    2022  Volume 10, Issue 6, Page(s) 2366–2382

    Abstract: Over the past few decades, advances in immunological knowledge have led to the identification of novel immune checkpoints, reinvigorating cancer immunotherapy. Immunotherapy, represented by immune checkpoint inhibitors, has become the leader in the ... ...

    Abstract Over the past few decades, advances in immunological knowledge have led to the identification of novel immune checkpoints, reinvigorating cancer immunotherapy. Immunotherapy, represented by immune checkpoint inhibitors, has become the leader in the precision treatment of cancer, bringing a new dawn to the treatment of most cancer patients. Galectin-9 (LGALS9), a member of the galectin family, is a widely expressed protein involved in immune regulation and tumor pathogenesis, and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor cell survival through its interaction with its receptor Tim-3. In the review, based on a brief description of the signaling mechanisms and immunomodulatory activities of galectin-9 and Tim-3, we summarize the targeted expression patterns of galectin-9 in a variety of malignancies and the promising mechanisms of anti-galectin-9 therapy in stimulating anti-tumor immune responses.
    Language English
    Publishing date 2022-06-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2022.05.020
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  9. Article ; Online: Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity.

    Wu, Lin / Wang, Litao / Du, Yuxin / Zhang, Yingmei / Ren, Jun

    Trends in pharmacological sciences

    2022  Volume 44, Issue 1, Page(s) 34–49

    Abstract: Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and hematologic malignancies, but its clinical application is hampered by life-threatening cardiotoxicity including cardiac dilation and heart failure. Mitochondrial quality ... ...

    Abstract Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and hematologic malignancies, but its clinical application is hampered by life-threatening cardiotoxicity including cardiac dilation and heart failure. Mitochondrial quality control processes, including mitochondrial proteostasis, mitophagy, and mitochondrial dynamics and biogenesis, serve to maintain mitochondrial homeostasis in the cardiovascular system. Importantly, recent advances have unveiled a major role for defective mitochondrial quality control in the etiology of DOX cardiomyopathy. Moreover, specific interventions targeting these quality control mechanisms to preserve mitochondrial function have emerged as potential therapeutic strategies to attenuate DOX cardiotoxicity. However, clinical translation is challenging because of obscure mechanisms of action and potential adverse effects. The purpose of this review is to provide new insights regarding the role of mitochondrial quality control in the pathogenesis of DOX cardiotoxicity, and to explore promising therapeutic approaches targeting these mechanisms to aid clinical management.
    MeSH term(s) Humans ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Cardiotoxicity/metabolism ; Doxorubicin/adverse effects ; Doxorubicin/metabolism ; Mitochondria ; Mitophagy ; Heart Failure ; Myocytes, Cardiac/metabolism ; Apoptosis
    Chemical Substances Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2022.10.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 6: Show issues

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  10. Article ; Online: Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy.

    Du, Yuxin / Wu, Lin / Wang, Litao / Reiter, Russel J / Lip, Gregory Y H / Ren, Jun

    Cytokine & growth factor reviews

    2023  Volume 74, Page(s) 40–55

    Abstract: Extracellular vesicles (EVs), encompassing exosomes, microvesicles (MVs), and apoptotic bodies (ABs), are cell-derived heterogeneous nanoparticles with a pivotal role in intercellular communication. EVs are enclosed by a lipid-bilayer membrane to escape ... ...

    Abstract Extracellular vesicles (EVs), encompassing exosomes, microvesicles (MVs), and apoptotic bodies (ABs), are cell-derived heterogeneous nanoparticles with a pivotal role in intercellular communication. EVs are enclosed by a lipid-bilayer membrane to escape enzymatic degradation. EVs contain various functional molecules (e.g., nucleic acids, proteins, lipids and metabolites) which can be transferred from donor cells to recipient cells. EVs provide many advantages including accessibility, modifiability and easy storage, stability, biocompatibility, heterogeneity and they readily penetrate through biological barriers, making EVs ideal and promising candidates for diagnosis/prognosis biomarkers and therapeutic tools. Recently, EVs were implicated in both physiological and pathophysiological settings of cardiovascular system through regulation of cell-cell communication. Numerous studies have reported a role for EVs in the pathophysiological progression of cardiovascular diseases (CVDs) and have evaluated the utility of EVs for the diagnosis/prognosis and therapeutics of CVDs. In this review, we summarize the biology of EVs, evaluate the perceived biological function of EVs in different CVDs along with a consideration of recent progress for the application of EVs in diagnosis/prognosis and therapies of CVDs.
    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/metabolism ; Extracellular Vesicles/physiology ; Exosomes/metabolism ; Cell Communication
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2023.09.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2653: Show issues Location:
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