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  1. Article ; Online: The Causal Associations between Adipokines and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

    Cai, Xiaoying / Wang, Yaqing / Li, Ying / Du, Zhanxin / Wang, Zhongxing

    Journal of Alzheimer's disease reports

    2024  Volume 8, Issue 1, Page(s) 75–83

    Abstract: Background: Observational studies have indicated the association of alteration of adipokines with Alzheimer's disease (AD). However, it remains unclear whether the associations are causal.: Objective: To determine the causal associations between ... ...

    Abstract Background: Observational studies have indicated the association of alteration of adipokines with Alzheimer's disease (AD). However, it remains unclear whether the associations are causal.
    Objective: To determine the causal associations between adipokines and AD.
    Methods: A Mendelian randomization (MR) method was applied to investigate the causal relationships of adipokines, including adiponectin and resistin, with risk of AD. Genetic proxies from genome-wide association studies (GWAS) of adiponectin and resistin were selected as instrumental variables. GWAS summary statistics for AD were extracted as outcome.
    Results: In this study, we found evidence of the causal effects of adiponectin on AD (OR: 0.850, 95% CI: 0.731-0.990,
    Conclusions: This study provides evidence of causality between adiponectin and risk of AD. However, no genetic susceptibility of resistin was discovered for AD.
    Language English
    Publishing date 2024-01-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-230110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Central venous pressure monitoring and mortality: What was neglected?

    Gao, Shaowei / Du, Zhanxin / Yang, Lu / Wang, Zhongxing

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 624

    MeSH term(s) Central Venous Pressure ; Data Management ; Databases, Factual ; Monitoring, Physiologic
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03350-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Association of glioma CD44 expression with glial dynamics in the tumour microenvironment and patient prognosis.

    Du, Zhanxin / Wang, Yaqing / Liang, Jiaqi / Gao, Shaowei / Cai, Xiaoying / Yu, Yu / Qi, Zhihui / Li, Jing / Xie, Yubin / Wang, Zhongxing

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 5203–5217

    Abstract: Because of the heterogeneity of lower-grade gliomas (LGGs), patients show various survival outcomes that are not reliably predicted by histological classification. The tumour microenvironment (TME) contributes to the initiation and progression of brain ... ...

    Abstract Because of the heterogeneity of lower-grade gliomas (LGGs), patients show various survival outcomes that are not reliably predicted by histological classification. The tumour microenvironment (TME) contributes to the initiation and progression of brain LGGs. Identifying potential prognostic markers based on the immune and stromal components in the TME will provide new insights into the dynamic modulation of these two components of the TME in LGGs. We applied ESTIMATE to calculate the ratio of immune and stromal components from The Cancer Genome Atlas database. After combined differential gene expression analysis, protein-protein interaction network construction and survival analysis, CD44 was screened as an independent prognostic factor and subsequently validated utilizing data from the Chinese Glioma Genome Atlas database. To decipher the association of glioma cell CD44 expression with stromal cells in the TME and tumour progression, RT-qPCR, cell viability and wound healing assays were employed to determine whether astrocytes enhance glioma cell viability and migration by upregulating CD44 expression. Surprisingly, M1 macrophages were identified as positively correlated with CD44 expression by CIBERSORT analysis. CD44
    Language English
    Publishing date 2022-09-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Association of glioma CD44 expression with glial dynamics in the tumour microenvironment and patient prognosis

    Du, Zhanxin / Wang, Yaqing / Liang, Jiaqi / Gao, Shaowei / Cai, Xiaoying / Yu, Yu / Qi, Zhihui / Li, Jing / Xie, Yubin / Wang, Zhongxing

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: Because of the heterogeneity of lower-grade gliomas (LGGs), patients show various survival outcomes that are not reliably predicted by histological classification. The tumour microenvironment (TME) contributes to the initiation and progression of brain ... ...

    Abstract Because of the heterogeneity of lower-grade gliomas (LGGs), patients show various survival outcomes that are not reliably predicted by histological classification. The tumour microenvironment (TME) contributes to the initiation and progression of brain LGGs. Identifying potential prognostic markers based on the immune and stromal components in the TME will provide new insights into the dynamic modulation of these two components of the TME in LGGs. We applied ESTIMATE to calculate the ratio of immune and stromal components from The Cancer Genome Atlas database. After combined differential gene expression analysis, protein–protein interaction network construction and survival analysis, CD44 was screened as an independent prognostic factor and subsequently validated utilizing data from the Chinese Glioma Genome Atlas database. To decipher the association of glioma cell CD44 expression with stromal cells in the TME and tumour progression, RT–qPCR, cell viability and wound healing assays were employed to determine whether astrocytes enhance glioma cell viability and migration by upregulating CD44 expression. Surprisingly, M1 macrophages were identified as positively correlated with CD44 expression by CIBERSORT analysis. CD44⁺ glioma cells were further suggested to interact with microglia-derived macrophages (M1 phenotype) via osteopontin signalling on the basis of single-cell sequencing data. Overall, we found that astrocytes could elevate the CD44 expression level of glioma cells, enhancing the recruitment of M1 macrophages that may promote glioma stemness via osteopontin-CD44 signalling. Thus, glioma CD44 expression might coordinate with glial activities in the TME and serve as a potential therapeutic target and prognostic marker for LGGs.
    Keywords astrocytes ; biotechnology ; brain ; cell viability ; databases ; gene expression regulation ; genome ; glioma ; histology ; macrophages ; neoplasm progression ; osteopontin ; patients ; phenotype ; prognosis ; protein-protein interactions ; therapeutics
    Language English
    Size p. 5203-5217.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.09.003
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Biodegradable packaging films with ε-polylysine/ZIF-L composites

    Zhang, Lei / Wang, Ziyuan / Jiao, Yi / Wang, Zichen / Tang, Xiuming / Du, Zhanxin / Zhang, Zeyang / Lu, Shihai / Qiao, Changsheng / Cui, Jiandong

    Lebensmittel-Wissenschaft + Technologie. 2022 Aug. 15, v. 166

    2022  

    Abstract: Recent years, biobased polymer packaging film in food packaging has witnessed great developments. However, it is still a challenge to develop biodegradable packaging films with antimicrobial property and mechanical strength. Herein, agar and polyvinyl ... ...

    Abstract Recent years, biobased polymer packaging film in food packaging has witnessed great developments. However, it is still a challenge to develop biodegradable packaging films with antimicrobial property and mechanical strength. Herein, agar and polyvinyl alcohol (PVA)/Chitosan (CS) packaging films with ε-polylysine/ZIF-L nanocomposites (ε-PL@ZIF-L) were developed for the first time. Due to the incorporation of the nanocomposite, UV/visible light barrier properties (the transmittance decreased by 10.9%) of the films were improved, and the elongation at break of the composite agar films were increased by 43.0%. In the antimicrobial assays, with 4% ε-PL@ZIF-L, the inhibition zone diameters against Bacillus subtilis were 10 times as compared with the pure PVA/CS film. Furthermore, compared with commercial PE film, agar films and PVA/CS films with 4% ε-PL@ZIF-L nanocomposites could provide long-term protection for strawberry to avoid the microbial infection and prolong the shelf life of the fruit at 25 °C. The results suggested that the agar and PVA/CS packaging films with ε-PL@ZIF-L nanocomposites could significantly behave as potent antibacterial material in food packaging and preservation systems.
    Keywords Bacillus subtilis ; agar ; antibiotics ; antimicrobial properties ; biodegradability ; biopolymers ; fruits ; light ; nanocomposites ; polyvinyl alcohol ; shelf life ; strawberries ; strength (mechanics) ; transmittance
    Language English
    Dates of publication 2022-0815
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 241369-3
    ISSN 0460-1173 ; 0023-6438
    ISSN 0460-1173 ; 0023-6438
    DOI 10.1016/j.lwt.2022.113776
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2634: Show issues

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  6. Article: Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization Study.

    Gao, Shaowei / Zhou, Huaqiang / Luo, Siyu / Cai, Xiaoying / Ye, Fang / He, Qiulan / Huang, Chanyan / Zheng, Xiaoyang / Li, Ying / Du, Zhanxin / Wang, Yaqing / Qi, Zhihui / Wang, Zhongxing

    Frontiers in genetics

    2021  Volume 12, Page(s) 758639

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.758639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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