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Article ; Online: Application of CRISPR-cas-based technology for the identification of tuberculosis, drug discovery and vaccine development.

Shi, Liqin / Gu, Ruiqi / Long, Jinzhao / Duan, Guangcai / Yang, Haiyan

2024 Volume 51, Issue 1, Page(s) 466

Abstract: Tuberculosis (TB), which caused by Mycobacterium tuberculosis, is the leading cause of death from a single infectious agent and continues to be a major public health burden for the global community. Despite being the only globally licenced prophylactic ... ...

Abstract	Tuberculosis (TB), which caused by Mycobacterium tuberculosis, is the leading cause of death from a single infectious agent and continues to be a major public health burden for the global community. Despite being the only globally licenced prophylactic vaccine, Bacillus Calmette-Guérin (BCG) has multiple deficiencies, and effective diagnostic and therapeutic options are limited. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is an adaptive immune system that is found in bacteria and has great potential for the development of novel antituberculosis drugs and vaccines. In addition, CRISPR-Cas is currently recognized as a prospective tool for the development of therapies for TB infection with potential diagnostic and therapeutic value, and CRISPR-Cas may become a viable tool for eliminating TB in the future. Herein, we systematically summarize the current applications of CRISPR-Cas-based technology for TB detection and its potential roles in drug discovery and vaccine development.
MeSH term(s)	Humans ; CRISPR-Cas Systems/genetics ; Tuberculosis/prevention & control ; Tuberculosis/microbiology ; Mycobacterium tuberculosis/genetics ; Drug Discovery ; Vaccine Development
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09424-6
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Article ; Online: Recent advances in exploiting carrageenans as a versatile functional material for promising biomedical applications.

Liu, Fang / Duan, Guangcai / Yang, Haiyan

International journal of biological macromolecules

2023 Volume 235, Page(s) 123787

Abstract: Carrageenans are a group of biopolymers widely found in red seaweeds. Commercial carrageenans have been traditionally used as emulsifiers, stabilizers, and thickening and gelling agents in food products. Carrageenans are regarded as bioactive ... ...

Abstract	Carrageenans are a group of biopolymers widely found in red seaweeds. Commercial carrageenans have been traditionally used as emulsifiers, stabilizers, and thickening and gelling agents in food products. Carrageenans are regarded as bioactive polysaccharides with disease-modifying and microbiota-modulating activities. Novel biomedical applications of carrageenans as biocompatible functional materials for fabricating hydrogels and nanostructures, including carbon dots, nanoparticles, and nanofibers, have been increasingly exploited. In this review, we describe the unique structural characteristics of carrageenans and their functional relevance. We summarize salient physicochemical features, including thixotropic and shear-thinning properties, of carrageenans. Recent results from clinical trials in which carrageenans were applied as both antiviral and antitumor agents and functional materials are discussed. We also highlight the most recent advances in the development of carrageenan-based targeted drug delivery systems with various pharmaceutical formulations. Promising applications of carrageenans as a bioink material for 3D printing in tissue engineering and regenerative medicine are systematically evaluated. We envisage some key hurdles and challenges in the commercialization of carrageenans as a versatile material for clinical practice. This comprehensive review of the intimate relationships among the structural features, unique rheological properties, and biofunctionality of carrageenans will provide novel insights into their biomedicine application potential.
MeSH term(s)	Carrageenan/chemistry ; Seaweed ; Hydrogels ; Biopolymers ; Biocompatible Materials/chemistry
Chemical Substances	Carrageenan (9000-07-1) ; Hydrogels ; Biopolymers ; Biocompatible Materials
Language	English
Publishing date	2023-02-27
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123787
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Article ; Online: Recent advances in exploiting carrageenans as a versatile functional material for promising biomedical applications

Liu, Fang / Duan, Guangcai / Yang, Haiyan

International Journal of Biological Macromolecules. 2023 Apr., v. 235 p.123787-

2023

Abstract	Carrageenans are a group of biopolymers widely found in red seaweeds. Commercial carrageenans have been traditionally used as emulsifiers, stabilizers, and thickening and gelling agents in food products. Carrageenans are regarded as bioactive polysaccharides with disease-modifying and microbiota-modulating activities. Novel biomedical applications of carrageenans as biocompatible functional materials for fabricating hydrogels and nanostructures, including carbon dots, nanoparticles, and nanofibers, have been increasingly exploited. In this review, we describe the unique structural characteristics of carrageenans and their functional relevance. We summarize salient physicochemical features, including thixotropic and shear-thinning properties, of carrageenans. Recent results from clinical trials in which carrageenans were applied as both antiviral and antitumor agents and functional materials are discussed. We also highlight the most recent advances in the development of carrageenan-based targeted drug delivery systems with various pharmaceutical formulations. Promising applications of carrageenans as a bioink material for 3D printing in tissue engineering and regenerative medicine are systematically evaluated. We envisage some key hurdles and challenges in the commercialization of carrageenans as a versatile material for clinical practice. This comprehensive review of the intimate relationships among the structural features, unique rheological properties, and biofunctionality of carrageenans will provide novel insights into their biomedicine application potential.
Keywords	biopolymers ; carbon ; carrageenan ; commercialization ; drugs ; hydrogels ; medicine ; nanofibers ; nanoparticles ; Bioink ; Biosensor ; Drug delivery ; Nanoparticle
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123787
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Emerging concerns of blood-brain barrier dysfunction caused by neurotropic enteroviral infections.

Han, Shujie / Ji, Wangquan / Duan, Guangcai / Chen, Shuaiyin / Yang, Haiyan / Jin, Yuefei

Virology

2024 Volume 591, Page(s) 109989

Abstract: Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain ... ...

Abstract	Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain barrier (BBB) is a protective barrier that prevents dangerous substances from entering the central nervous system (CNS). Recently, numerous EVs have been demonstrated to have the ability to disrupt BBB, and further lead to severe neurological damage. However, the precise mechanisms of BBB disruption associated with these EVs remain largely unknown. In this Review, we focus on the molecular mechanisms of BBB dysfunction caused by EVs, emphasizing the invasiveness of enterovirus A71 (EVA71), which will provide a research direction for further treatment and prevention of CNS disorders.
MeSH term(s)	Humans ; Blood-Brain Barrier ; Enterovirus Infections ; Enterovirus/physiology ; Central Nervous System ; Biological Transport
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2024.109989
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Article: Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics.

Li, Zijie / Ji, Wangquan / Chen, Shuaiyin / Duan, Guangcai / Jin, Yuefei

Vaccines

2023 Volume 11, Issue 3

Abstract: Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [ ... ]. ...

Abstract	Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [...].
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11030571
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genome mining reveals the prevalence and extensive diversity of toxin-antitoxin systems in

Xu, Jie / Wang, Ying / Liu, Fang / Duan, Guangcai / Yang, Haiyan

Frontiers in microbiology

2023 Volume 14, Page(s) 1165981

Abstract: Introduction: Staphylococcus aureus (S. aureus): Methods: We conducted a comprehensive : Results: Our analysis revealed a median of seven TA systems per genome, with three type II TA groups (HD, HD_3, and YoeB) being present in over 80% of the ... ...

Abstract	Introduction: Staphylococcus aureus (S. aureus) Methods: We conducted a comprehensive Results: Our analysis revealed a median of seven TA systems per genome, with three type II TA groups (HD, HD_3, and YoeB) being present in over 80% of the strains. Additionally, we observed that TA genes were predominantly encoded in the chromosomal DNA, with some TA systems also found within the Staphylococcal Cassette Chromosomal mec (SCCmec) genomic islands. Discussion: This study provides a comprehensive overview of the diversity and prevalence of TA systems in
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1165981
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Article ; Online: A review on circular RNAs and bacterial infections.

Yuan, Haitao / Liu, Fang / Long, Jinzhao / Duan, Guangcai / Yang, Haiyan

International journal of biological macromolecules

2023 Volume 244, Page(s) 125391

Abstract: Bacterial infections and related diseases have been a major burden on social public health and economic stability around the world. However, the effective diagnostic methods and therapeutic approaches to treat bacterial infections are still limited. As a ...

Abstract	Bacterial infections and related diseases have been a major burden on social public health and economic stability around the world. However, the effective diagnostic methods and therapeutic approaches to treat bacterial infections are still limited. As a group of non-coding RNA, circular RNAs (circRNAs) that were expressed specifically in host cells and played a key regulatory role have the potential to be of diagnostic and therapeutic values. In this review, we systematically summarize the role of circRNAs in common bacterial infections and their potential roles as diagnostic markers and therapeutic targets.
MeSH term(s)	Humans ; RNA, Circular/genetics ; Bacterial Infections/genetics
Chemical Substances	RNA, Circular
Language	English
Publishing date	2023-06-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125391
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Article ; Online: The association of sickle cell disorder with adverse outcomes in COVID-19 patients: A meta-analysis.

Liang, Tianyi / Guo, Kaixin / Ni, Peng / Duan, Guangcai / Zhang, Rongguang

Journal of medical virology

2023 Volume 95, Issue 10, Page(s) e29120

Abstract: The aim is to elucidate the relationship between sickle cell disorder and severe COVID-19. We systematically searched the required articles in three electronic databases, extracting and pooling effect sizes (ES) and 95% confidence interval (CI) from each ...

Abstract	The aim is to elucidate the relationship between sickle cell disorder and severe COVID-19. We systematically searched the required articles in three electronic databases, extracting and pooling effect sizes (ES) and 95% confidence interval (CI) from each eligible study to evaluate the effect of combined sickle cell disorder on adverse consequences in patients with COVID-19. This meta-analysis included 21 studies. Sickle cell disease (SCD) was a risk factor for mortality (pooled ES = 1.70, 95% CI: 1.00-2.92, p = 0.001), hospitalization (pooled ES = 6.21, 95% CI: 3.60-10.70, p = 0.000) and intensive care unit (ICU) admission (pooled ES = 2.29, 95% CI: 1.61-3.24, p = 0.099) in COVID-19 patients. Patients with SCD had an increased risk of respiratory failure/mechanical ventilation, but a statistical association was not found (pooled ES = 1.21, 95%CI: 0.74-1.98, p = 0.036). There was significant heterogeneity between SCD and death, hospitalization, and respiratory failure/mechanical ventilation. The results of meta-regression of SCD and hospitalization suggested that the tested variables including Area (p = 0.642), study design (p = 0.739), sample size (p = 0.397), proportion of males (p = 0.708), effect type (p = 0.723), whether confounding factors are adjusted (p = 0.606) might not be the source of heterogeneity. In addition, sickle cell trait (SCT) was significantly associated with the mortality (pooled ES = 1.54, 95% CI: 1.28-1.85, p = 0.771) and hospitalization (pooled ES = 1.20, 95% CI: 1.07-1.35，p = 0.519) in patients with COVID-19. But any increased risk of ICU admission/severe (pooled ES = 1.24, 95% CI: 0.95-1.62, p = 0.520) and mechanical ventilation (OR = 1.00, 95%CI:0.59-1.69) in COVID-19 patients with SCT was not observed. Sensitivity analysis demonstrated that the results were robust. The results of the funnel plot and Egger's test did not support the existence of publication bias. Current meta-analysis indicated that sickle cell disorder has a meaningful impact on COVID-19 progression to severe cases and associated deaths. However, further investigations and research to validate the current findings is indispensable.
MeSH term(s)	Humans ; Male ; Anemia, Sickle Cell/complications ; COVID-19/complications ; Hospitalization ; Respiratory Insufficiency/complications ; Risk Factors
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29120
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Article ; Online: Impact of non-pharmaceutical interventions during COVID-19 pandemic on measles and mumps in Mainland China.

Xu, Jie / Wang, Yujia / Duan, Guangcai / Liu, Fang / Yang, Haiyan

The Journal of infection

2023 Volume 86, Issue 3, Page(s) 256–308

MeSH term(s)	Humans ; Infant ; COVID-19 ; Mumps/epidemiology ; Mumps/prevention & control ; Pandemics/prevention & control ; Measles/epidemiology ; Measles/prevention & control ; Rubella ; China/epidemiology ; Measles-Mumps-Rubella Vaccine ; Antibodies, Viral
Chemical Substances	Measles-Mumps-Rubella Vaccine ; Antibodies, Viral
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.01.009
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Article ; Online: Recommendations of Controlling and Preventing Acute Health Risks of Fine Particulate Matter Pollution - China, 2021.

Expert Consensus Task Force / Shi, Xiaoming / Duan, Guangcai

China CDC weekly

2022 Volume 4, Issue 16, Page(s) 329–341

Abstract: The task force has comprehensively reviewed efforts for air pollution prevention and control, the acute health effects of fine particles ( ... ...

Abstract	The task force has comprehensively reviewed efforts for air pollution prevention and control, the acute health effects of fine particles (PM
Language	English
Publishing date	2022-04-25
Publishing country	China
Document type	Journal Article
ISSN	2096-7071
ISSN (online)	2096-7071
DOI	10.46234/ccdcw2022.078
Database	MEDical Literature Analysis and Retrieval System OnLINE

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