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Artikel ; Online: Distinctive trajectories of the COVID-19 epidemic by age and gender: A retrospective modeling of the epidemic in South Korea.

Yu, Xinhua / Duan, Jiasong / Jiang, Yu / Zhang, Hongmei

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Band 98, Seite(n) 200–205

Abstract: Objectives: Elderly people had suffered a disproportionate burden of COVID-19. We hypothesized that males and females in different age groups might have different epidemic trajectories.: Methods: Using publicly available data from South Korea, daily ... ...

Abstract	Objectives: Elderly people had suffered a disproportionate burden of COVID-19. We hypothesized that males and females in different age groups might have different epidemic trajectories. Methods: Using publicly available data from South Korea, daily new COVID-19 cases were assessed using generalized additive models, assuming Poisson and negative binomial distributions. Epidemic dynamics by age and gender groups were explored using interactions between smoothed time terms and age and gender. Results: A negative binomial distribution fitted the daily case counts best. The relationship between the dynamic patterns of daily new cases and age groups was statistically significant (p<0.001), but this was not the case with gender groups. People aged 20-39 years led the epidemic processes in South Korean society with two peaks - one major peak around March 1 and a smaller peak around April 7, 2020. The epidemic process among people aged 60 or above trailed behind that of the younger age group, and with smaller magnitude. After March 15, there was a consistent decline of daily new cases among elderly people, despite large fluctuations in case counts among young adults. Conclusions: Although young people drove the COVID-19 epidemic throughout society, with multiple rebounds, elderly people could still be protected from infection after the peak of the epidemic.
Mesh-Begriff(e)	Adolescent ; Adult ; Age Distribution ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/epidemiology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Republic of Korea/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Sex Characteristics ; Young Adult
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-07-02
Erscheinungsland	Canada
Dokumenttyp	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.06.101
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Distinctive trajectories of the COVID-19 epidemic by age and gender

Yu, Xinhua / Duan, Jiasong / Jiang, Yu / Zhang, Hongmei

International Journal of Infectious Diseases

A retrospective modeling of the epidemic in South Korea

2020 Band 98, Seite(n) 200–205

Schlagwörter	Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
Sprache	Englisch
Verlag	Elsevier BV
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.06.101
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Distinctive trajectories of the COVID-19 epidemic by age and gender: A retrospective modeling of the epidemic in South Korea

Yu, Xinhua / Duan, Jiasong / Jiang, Yu / Zhang, Hongmei

Int J Infect Dis

Abstract: OBJECTIVES: Elderly people had suffered a disproportionate burden of COVID-19. We hypothesized that males and females in different age groups might have different epidemic trajectories. METHODS: Using publicly available data from South Korea, daily new ... ...

Abstract	OBJECTIVES: Elderly people had suffered a disproportionate burden of COVID-19. We hypothesized that males and females in different age groups might have different epidemic trajectories. METHODS: Using publicly available data from South Korea, daily new COVID-19 cases were assessed using generalized additive models, assuming Poisson and negative binomial distributions. Epidemic dynamics by age and gender groups were explored using interactions between smoothed time terms and age and gender. RESULTS: A negative binomial distribution fitted the daily case counts best. The relationship between the dynamic patterns of daily new cases and age groups was statistically significant (p<0.001), but this was not the case with gender groups. People aged 20-39 years led the epidemic processes in South Korean society with two peaks - one major peak around March 1 and a smaller peak around April 7, 2020. The epidemic process among people aged 60 or above trailed behind that of the younger age group, and with smaller magnitude. After March 15, there was a consistent decline of daily new cases among elderly people, despite large fluctuations in case counts among young adults. CONCLUSIONS: Although young people drove the COVID-19 epidemic throughout society, with multiple rebounds, elderly people could still be protected from infection after the peak of the epidemic.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #624019
Datenquelle	COVID19

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Artikel: Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years

Rathod, Rutu / Rathod, Aniruddha / Rahimabad, Parnian Kheirkhah / Duan, Jiasong / Zhang, Hongmei / Arshad, S. Hasan / Karmaus, Wilfried

Genes. 2021 July 31, v. 12, no. 8

2021

Abstract: DNA methylation (DNAm) patterns over time at 1146 CpGs on coronavirus-related genes were assessed to understand whether the varying differences in susceptibility, symptoms, and the outcomes of the SARS-CoV-2 infection in children and young adults could ... ...

Abstract	DNA methylation (DNAm) patterns over time at 1146 CpGs on coronavirus-related genes were assessed to understand whether the varying differences in susceptibility, symptoms, and the outcomes of the SARS-CoV-2 infection in children and young adults could be explained through epigenetic alterations in a host cell’s transcriptional apparatus to coronaviruses. DNAm data from the Isle of Wight birth cohort (IOWBC) at birth, 10, 18, and 26 years of age were included. Linear mixed models with repeated measurements stratified by sex were used to examine temporal patterns, and cluster analysis was performed to identify CpGs following similar patterns. CpGs on autosomes and sex chromosomes were analyzed separately. The association of identified CpGs and expression of their genes were evaluated. Pathway enrichment analyses of the genes was conducted at FDR = 0.05. DNAm at 635 of the 1146 CpGs on autosomes showed statistically significant time effects (FDR = 0.05). The 635 CpGs were classified into five clusters with each representing a unique temporal pattern of DNAm. Of the 29 CpGs on sex chromosomes, DNAm at seven CpGs in males and eight CpGs in females showed time effects (FDR = 0.05). Sex-specific and non-specific associations of DNAm with gene expression were found at 24 and 93 CpGs, respectively. Genes which mapped the 643 CpGs represent 460 biological processes. We suggest that the observed variability in DNAm with advancing age may partially explain differing susceptibility, disease severity, and mortality of coronavirus infections among different age groups.
Schlagwörter	Coronavirus infections ; DNA methylation ; Severe acute respiratory syndrome coronavirus 2 ; autosomes ; cluster analysis ; disease severity ; epigenetics ; gene expression ; mortality ; transcription (genetics)
Sprache	Englisch
Erscheinungsverlauf	2021-0731
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12081198
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years.

Rathod, Rutu / Rathod, Aniruddha / Rahimabad, Parnian Kheirkhah / Duan, Jiasong / Zhang, Hongmei / Arshad, S Hasan / Karmaus, Wilfried

Genes

2021 Band 12, Heft 8

Abstract	DNA methylation (DNAm) patterns over time at 1146 CpGs on coronavirus-related genes were assessed to understand whether the varying differences in susceptibility, symptoms, and the outcomes of the SARS-CoV-2 infection in children and young adults could be explained through epigenetic alterations in a host cell's transcriptional apparatus to coronaviruses. DNAm data from the Isle of Wight birth cohort (IOWBC) at birth, 10, 18, and 26 years of age were included. Linear mixed models with repeated measurements stratified by sex were used to examine temporal patterns, and cluster analysis was performed to identify CpGs following similar patterns. CpGs on autosomes and sex chromosomes were analyzed separately. The association of identified CpGs and expression of their genes were evaluated. Pathway enrichment analyses of the genes was conducted at FDR = 0.05. DNAm at 635 of the 1146 CpGs on autosomes showed statistically significant time effects (FDR = 0.05). The 635 CpGs were classified into five clusters with each representing a unique temporal pattern of DNAm. Of the 29 CpGs on sex chromosomes, DNAm at seven CpGs in males and eight CpGs in females showed time effects (FDR = 0.05). Sex-specific and non-specific associations of DNAm with gene expression were found at 24 and 93 CpGs, respectively. Genes which mapped the 643 CpGs represent 460 biological processes. We suggest that the observed variability in DNAm with advancing age may partially explain differing susceptibility, disease severity, and mortality of coronavirus infections among different age groups.
Mesh-Begriff(e)	Adolescent ; Adult ; COVID-19/genetics ; Child ; CpG Islands ; DNA Methylation ; Epigenome ; Female ; Humans ; Male
Sprache	Englisch
Erscheinungsdatum	2021-07-31
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12081198
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma.

Rathod, Aniruddha / Duan, Jiasong / Zhang, Hongmei / Holloway, John W / Ewart, Susan / Arshad, S Hasan / Karmaus, Wilfried

Epigenetics insights

2020 Band 13, Seite(n) 2516865720923395

Abstract: The cause and underlying mechanisms that contribute to asthma pathogenesis are not well known. Both genome- and epigenome-wide association studies have identified genes associated with asthma risk. It is unknown to what extent genes identified in these ... ...

Abstract	The cause and underlying mechanisms that contribute to asthma pathogenesis are not well known. Both genome- and epigenome-wide association studies have identified genes associated with asthma risk. It is unknown to what extent genes identified in these two types of studies overlap. Based on existing literature and the DisGeNET database, we extracted overlapping genes identified in genetic and epigenetic studies of childhood asthma. Through analyses of variance, we assessed whether DNA methylation (DNAm) at 5'-C-phosphate-G-3' (CpGs) on the overlapping genes was associated with neighboring single-nucleotide polymorphisms (SNPs) within 1M base pairs (bps) and with low linkage disequilibrium (
Sprache	Englisch
Erscheinungsdatum	2020-07-22
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2516-8657
ISSN (online)	2516-8657
DOI	10.1177/2516865720923395
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels.

Han, Luhang / Kaushal, Akhilesh / Zhang, Hongmei / Kadalayil, Latha / Duan, Jiasong / Holloway, John W / Karmaus, Wilfried / Banerjee, Pratik / Tsai, Shih-Fen / Wen, Hui-Ju / Arshad, Syed Hasan / Wang, Shu-Li

Epigenetics insights

2021 Band 14, Seite(n) 25168657211008108

Abstract: Immunoglobulin E (IgE) is known to play an important role in allergic diseases. Epigenetic traits acquired due to modification of deoxyribonucleic acid (DNA) methylation (DNAm) in early life may have phenotypic consequences through their role in ... ...

Abstract	Immunoglobulin E (IgE) is known to play an important role in allergic diseases. Epigenetic traits acquired due to modification of deoxyribonucleic acid (DNA) methylation (DNAm) in early life may have phenotypic consequences through their role in transcriptional regulation with relevance to the developmental origins of diseases including allergy. However, epigenome-scale studies on the longitudinal association of cord blood DNAm with IgE over time are lacking. Our study aimed to examine the association of DNAm at birth with childhood serum IgE levels during early life. Genome-scale DNAm and total serum IgE measured at birth, 5, 8, and 11 years of children in the Taiwan Maternal and Infant Cohort Study were included in the study in the discovery stage. Linear mixed models were implemented to assess the association between cord blood DNAm at ~310K 5'-cytosine-phosphate-guanine-3' (CpG) sites with repeated IgE measurements, adjusting for cord blood IgE. Identified statistically significant CpGs (at a false discovery rate, FDR, of 0.05) were further tested in an independent replication cohort, the Isle of Wight (IoW) birth cohort. We mapped replicated CpGs to genes and conducted gene ontology analysis using ToppFun to identify significantly enriched pathways and biological processes of the genes. Cord blood DNAm of 273 CpG sites were significantly (FDR = 0.05) associated with IgE levels longitudinally. Among the identified CpGs available in both cohorts (184 CpGs), 92 CpGs (50%) were replicated in the IoW in terms of consistency in direction of associations between DNA methylation and IgE levels later in life, and 16 of the 92 CpGs showed statistically significant associations (
Sprache	Englisch
Erscheinungsdatum	2021-04-05
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2516-8657
ISSN (online)	2516-8657
DOI	10.1177/25168657211008108
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

Budu-Aggrey, Ashley / Kilanowski, Anna / Sobczyk, Maria K / Shringarpure, Suyash S / Mitchell, Ruth / Reis, Kadri / Reigo, Anu / Mägi, Reedik / Nelis, Mari / Tanaka, Nao / Brumpton, Ben M / Thomas, Laurent F / Sole-Navais, Pol / Flatley, Christopher / Espuela-Ortiz, Antonio / Herrera-Luis, Esther / Lominchar, Jesus V T / Bork-Jensen, Jette / Marenholz, Ingo /

Arnau-Soler, Aleix / Jeong, Ayoung / Fawcett, Katherine A / Baurecht, Hansjorg / Rodriguez, Elke / Alves, Alexessander Couto / Kumar, Ashish / Sleiman, Patrick M / Chang, Xiao / Medina-Gomez, Carolina / Hu, Chen / Xu, Cheng-Jian / Qi, Cancan / El-Heis, Sarah / Titcombe, Philip / Antoun, Elie / Fadista, João / Wang, Carol A / Thiering, Elisabeth / Wu, Baojun / Kress, Sara / Kothalawala, Dilini M / Kadalayil, Latha / Duan, Jiasong / Zhang, Hongmei / Hadebe, Sabelo / Hoffmann, Thomas / Jorgenson, Eric / Choquet, Hélène / Risch, Neil / Njølstad, Pål / Andreassen, Ole A / Johansson, Stefan / Almqvist, Catarina / Gong, Tong / Ullemar, Vilhelmina / Karlsson, Robert / Magnusson, Patrik K E / Szwajda, Agnieszka / Burchard, Esteban G / Thyssen, Jacob P / Hansen, Torben / Kårhus, Line L / Dantoft, Thomas M / Jeanrenaud, Alexander C S N / Ghauri, Ahla / Arnold, Andreas / Homuth, Georg / Lau, Susanne / Nöthen, Markus M / Hübner, Norbert / Imboden, Medea / Visconti, Alessia / Falchi, Mario / Bataille, Veronique / Hysi, Pirro / Ballardini, Natalia / Boomsma, Dorret I / Hottenga, Jouke J / Müller-Nurasyid, Martina / Ahluwalia, Tarunveer S / Stokholm, Jakob / Chawes, Bo / Schoos, Ann-Marie M / Esplugues, Ana / Bustamante, Mariona / Raby, Benjamin / Arshad, Syed / German, Chris / Esko, Tõnu / Milani, Lili A / Metspalu, Andres / Terao, Chikashi / Abuabara, Katrina / Løset, Mari / Hveem, Kristian / Jacobsson, Bo / Pino-Yanes, Maria / Strachan, David P / Grarup, Niels / Linneberg, Allan / Lee, Young-Ae / Probst-Hensch, Nicole / Weidinger, Stephan / Jarvelin, Marjo-Riitta / Melén, Erik / Hakonarson, Hakon / Irvine, Alan D / Jarvis, Deborah / Nijsten, Tamar / Duijts, Liesbeth / Vonk, Judith M / Koppelmann, Gerard H / Godfrey, Keith M / Barton, Sheila J / Feenstra, Bjarke / Pennell, Craig E / Sly, Peter D / Holt, Patrick G / Williams, L Keoki / Bisgaard, Hans / Bønnelykke, Klaus / Curtin, John / Simpson, Angela / Murray, Clare / Schikowski, Tamara / Bunyavanich, Supinda / Weiss, Scott T / Holloway, John W / Min, Josine L / Brown, Sara J / Standl, Marie / Paternoster, Lavinia

Nature communications

2023 Band 14, Heft 1, Seite(n) 6172

Abstract: Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3, ... ...

Abstract	Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.
Mesh-Begriff(e)	Humans ; Genome-Wide Association Study ; Dermatitis, Atopic/genetics ; Genetic Predisposition to Disease/genetics ; Hispanic or Latino/genetics ; Black People ; Polymorphism, Single Nucleotide
Sprache	Englisch
Erscheinungsdatum	2023-10-04
Erscheinungsland	England
Dokumenttyp	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41180-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Distinctive trajectories of the COVID-19 epidemic by age and gender: A retrospective modeling of the epidemic in South Korea.

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Artikel ; Online: Distinctive trajectories of the COVID-19 epidemic by age and gender

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Artikel: Distinctive trajectories of the COVID-19 epidemic by age and gender: A retrospective modeling of the epidemic in South Korea

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Artikel: Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years

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Artikel ; Online: Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years.

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Artikel ; Online: Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma.

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Artikel ; Online: DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels.

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Artikel ; Online: European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

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