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  1. Article ; Online: Antibiotic Exposure and Risk of New-Onset Inflammatory Bowel Disease: A Systematic Review and Dose-Response Meta-Analysis.

    Duan, Ruqiao / Zhang, Cunzheng / Li, Gaonan / Li, Jun / Duan, Liping

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Abstract: Background & aims: The association between antibiotic exposure and inflammatory bowel disease (IBD) remains controversial, especially whether there is a dose-response relationship. We aimed to conduct a systematic review and meta-analysis to thoroughly ... ...

    Abstract Background & aims: The association between antibiotic exposure and inflammatory bowel disease (IBD) remains controversial, especially whether there is a dose-response relationship. We aimed to conduct a systematic review and meta-analysis to thoroughly evaluate the risk of new-onset IBD associated with antibiotic exposure.
    Methods: Four databases were searched from their inception to September 30, 2023 for all relevant studies. The risk estimates were pooled together using random-effects models, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, stratified by IBD subtype, age, exposure period, study type, and antibiotic classes. Dose-response relationship between the number of antibiotic prescriptions and IBD risk was assessed using generalized least squares regression analysis.
    Results: Twenty-eight studies involving 153,027 patients with IBD were included. Antibiotic exposure was significantly associated with an increased risk of new-onset IBD for prescription-based studies (pooled OR, 1.41; 95% CI, 1.29-1.53) and for questionnaire-based studies (pooled OR, 1.35; 95% CI, 1.08-1.68). This association existed for both Crohn's disease and ulcerative colitis, as well as in children and adults for prescription-based studies. The majority of antibiotic classes were associated with an increased IBD risk, with metronidazole (OR, 1.70; 95% CI, 1.38-2.10) and quinolones (OR, 1.56; 95% CI, 1.37-1.77) having relatively higher risk estimates. A positive nonlinear dose-response association was observed between the number of antibiotic prescriptions and IBD risk.
    Conclusions: Antibiotic exposure was significantly associated with an increased risk of new-onset IBD, and a positive nonlinear dose-response relationship was observed. Antibiotic stewardship may be important for reducing IBD risk.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Helicobacter pylori infection is associated with reduced risk of Barrett's esophagus: a meta-analysis and systematic review.

    Du, Yan-Lin / Duan, Ru-Qiao / Duan, Li-Ping

    BMC gastroenterology

    2021  Volume 21, Issue 1, Page(s) 459

    Abstract: Background: Helicobacter pylori (Hp) is a class I carcinogen in gastric carcinogenesis, but its role in Barrett's esophagus (BE) is unknown. Therefore, we aimed to explore the possible relationship.: Methods: We reviewed observational studies ... ...

    Abstract Background: Helicobacter pylori (Hp) is a class I carcinogen in gastric carcinogenesis, but its role in Barrett's esophagus (BE) is unknown. Therefore, we aimed to explore the possible relationship.
    Methods: We reviewed observational studies published in English until October 2019. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for included studies.
    Results: 46 studies from 1505 potential citations were eligible for inclusion. A significant inverse relationship with considerable heterogeneity was found between Hp (OR = 0.70; 95% CI, 0.51-0.96; P = 0.03) and BE, especially the CagA-positive Hp strain (OR = 0.28; 95% CI, 0.15-0.54; P = 0.0002). However, Hp infection prevalence was not significantly different between patients with BE and the gastroesophageal reflux disease (GERD) control (OR = 0.99; 95% CI, 0.82-1.19; P = 0.92). Hp was negatively correlated with long-segment BE (OR = 0.47; 95% CI, 0.25-0.90; P = 0.02) and associated with a reduced risk of dysplasia. However, Hp had no correlated with short-segment BE (OR = 1.11; 95% CI, 0.78-1.56; P = 0.57). In the present infected subgroup, Hp infection prevalence in BE was significantly lower than that in controls (OR = 0.69; 95% CI, 0.54-0.89; P = 0.005); however, this disappeared in the infection history subgroup (OR = 0.88; 95% CI, 0.43-1.78; P = 0.73).
    Conclusions: Hp, especially the CagA-positive Hp strain, and BE are inversely related with considerable heterogeneity, which is likely mediated by a decrease in GERD prevalence, although this is not observed in the absence of current Hp infection.
    MeSH term(s) Barrett Esophagus/epidemiology ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/epidemiology ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Observational Studies as Topic
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-021-02036-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The efficacy and safety of acid suppressants for gastrointestinal bleeding prophylaxis in cardiac care unit patients.

    Chen, Chen / Liu, Hui / Duan, Ruqiao / Wang, Fangfang / Duan, Liping

    Journal of gastroenterology and hepatology

    2021  Volume 36, Issue 8, Page(s) 2131–2140

    Abstract: Background and aim: Concerns regarding adverse events associated with proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) for gastrointestinal bleeding (GIB) prophylaxis in the intensive care unit have increased in recent years. ... ...

    Abstract Background and aim: Concerns regarding adverse events associated with proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) for gastrointestinal bleeding (GIB) prophylaxis in the intensive care unit have increased in recent years. Few studies have focused on acid suppressant use in the cardiac care unit (CCU) setting exclusively. We performed a cohort study to determine the efficacy and safety of acid suppressants for GIB prophylaxis in CCU patients.
    Methods: This retrospective cohort study included adults who were admitted directly to the CCU for more than 2 days from January 1, 2014, to April 30, 2019. The Crusade score was calculated to evaluate the risk of GIB. The primary outcomes were clinically important gastrointestinal bleeding (CIGIB), hospital-acquired pneumonia (HAP), and in-hospital mortality.
    Results: Of the 3318 patients enrolled, 2284 (68.8%) patients received PPIs, 515 (15.5%) received H2RAs, and 519 (15.7%) received no acid suppressants. After adjusting for potential confounders, utilization of PPIs (2.69, 95% confidence interval [0.62-11.73]) and H2RAs (1.41, 95% confidence interval [0.19-10.36]) were not associated with a lower risk of CIGIB than the control. Sensitivity analyses revealed that PPI use was an independent risk factor for in-hospital mortality in patients over 75 years old, with an adjusted odds ratio of 4.08 (1.14-14.63). PPIs increased the risk of HAP in patients over 75 years old and in those with heart failure, with adjusted odds ratios of 2.38 (1.06-5.34) and 2.88 (1.34-7.28), respectively.
    Conclusions: Proton pump inhibitors and H2RAs for GIB prophylaxis in CCU patients were not associated with a lower risk of CIGIB than the controls. PPI therapy is associated with increased risks of HAP and in-hospital mortality in patients over 75 years old. PPIs may increase the risk of HAP in patients with heart failure.
    MeSH term(s) Aged ; Critical Care ; Female ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/prevention & control ; Healthcare-Associated Pneumonia/etiology ; Heart Failure/complications ; Heart Failure/mortality ; Heart Failure/therapy ; Histamine H2 Antagonists/adverse effects ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Proton Pump Inhibitors/adverse effects ; Retrospective Studies ; Risk Factors ; Treatment Outcome
    Chemical Substances Histamine H2 Antagonists ; Proton Pump Inhibitors
    Language English
    Publishing date 2021-02-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 299: Show issues

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  4. Article ; Online: Alterations of Gut Microbiota in Patients With Irritable Bowel Syndrome Based on 16S rRNA-Targeted Sequencing: A Systematic Review.

    Duan, Ruqiao / Zhu, Shiwei / Wang, Ben / Duan, Liping

    Clinical and translational gastroenterology

    2019  Volume 10, Issue 2, Page(s) e00012

    Abstract: Introduction: Alterations of gut microbiota have been thought to be associated with irritable bowel syndrome (IBS). Many studies have reported significant alterations of gut microbiota in patients with IBS based on 16S ribosomal RNA-targeted sequencing. ...

    Abstract Introduction: Alterations of gut microbiota have been thought to be associated with irritable bowel syndrome (IBS). Many studies have reported significant alterations of gut microbiota in patients with IBS based on 16S ribosomal RNA-targeted sequencing. However, results from these studies are inconsistent or even contradictory. We performed a systematic review to explore the alterations of gut microbiota in patients with IBS compared with healthy controls (HCs).
    Methods: The databases PubMed, Cochrane Library, Web of Science, and Embase were searched for studies published until February 28, 2018, for case-control studies detecting gut microbiota in patients with IBS. Methodological quality was assessed using the Newcastle-Ottawa Scale. The α-diversity and alterations of gut microbiota in patients with IBS compared with HCs were analyzed.
    Results: Sixteen articles involving 777 patients with IBS and 461 HCs were included. Quality assessment scores of the studies ranged from 5 to 7. For most studies, patients with IBS had a lower α-diversity than HCs in both fecal and mucosal samples. Relatively consistent changes in fecal microbiota for patients with IBS included increased Firmicutes, decreased Bacteroidetes, and increased Firmicutes:Bacteroidetes ratio at the phylum level, as well as increased Clostridia and Clostridiales, decreased Bacteroidia and Bacteroidales at lower taxonomic levels. Results for mucosal microbiota were inconsistent.
    Conclusions: Alterations of gut microbiota exist in patients with IBS and have significant association with the development of IBS. Further studies are needed to draw conclusions about gut microbiota changes in patients with IBS.
    Translational impact: This knowledge might improve the understanding of microbial signatures in patients with IBS and would guide future therapeutic strategies.
    MeSH term(s) Bacteria/genetics ; Bacteria/isolation & purification ; DNA, Bacterial/isolation & purification ; Feces/microbiology ; Gastrointestinal Microbiome/genetics ; Humans ; Irritable Bowel Syndrome/microbiology ; RNA, Ribosomal, 16S/genetics
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Exploring the association between short-term exposure to ambient fine particulate matter pollution and emergency admissions for peptic ulcer bleeding in Beijing, China

    Duan, Ruqiao / Tian, Yaohua / Hu, Yonghua / Duan, Liping

    Atmospheric environment. 2019 Sept. 15, v. 213

    2019  

    Abstract: Air pollution affects the pathophysiology of gastrointestinal tract and has been linked to several gastrointestinal diseases in recent years. However, little is known about the association of air pollution with peptic ulcer bleeding (PUB). We aimed to ... ...

    Abstract Air pollution affects the pathophysiology of gastrointestinal tract and has been linked to several gastrointestinal diseases in recent years. However, little is known about the association of air pollution with peptic ulcer bleeding (PUB). We aimed to conduct a time-series study to examine the association between short-term exposure to fine particulate matter (PM2.5) and emergency admissions for PUB in Beijing, China.Data on emergency admissions for PUB between January 1, 2010, and June 30, 2012 were obtained from the Beijing Medical Claim Data for Employees. Measurements of PM2.5 concentration were obtained from the United States Embassy air-monitoring station. A generalized additive Poisson model was applied to explore the association between PM2.5 concentrations and emergency admissions for PUB, with stratification by gender and age.A total of 5123 emergency admissions for PUB were identified. Short-term exposure to outdoor PM2.5 was significantly associated with increased emergency admissions for PUB at lag0 day. A 10 μg/m3 increase in PM2.5 concentration at lag0 day corresponded to a 0.56% (95% confidence interval (CI) 0.04%–1.08%; P = 0.035) increase in emergency admissions for PUB. There was a clear concentration-response association between PM2.5 concentrations and emergency admissions for PUB. The PM2.5 effect estimates were greater in elderly people (≥65 years old) with the difference approaching statistical significance (percentage change 0.78, 95% CI 0.03%–1.54% in patients ≥65 years old; percentage change 0.32, 95% CI -0.38%–1.03% in patients <65 years old; P = 0.073), but the difference between men and women was not significant (percentage change 0.75, 95% CI 0.08%–1.43% in man; percentage change 0.27, 95% CI -0.51%–1.07% in woman; P = 0.368).Short-term elevation in outdoor PM2.5 concentrations was associated with increased emergency admissions for PUB, particularly in elderly people. Future studies are warranted to confirm the findings and elucidate the mechanisms underlying the association.
    Keywords acute exposure ; air pollution ; atmospheric chemistry ; confidence interval ; elderly ; gastrointestinal system ; gender ; hemorrhage ; human resources ; men ; models ; particulates ; pathophysiology ; patients ; peptic ulcers ; time series analysis ; women ; China ; United States
    Language English
    Dates of publication 2019-0915
    Size p. 485-490.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 216368-8
    ISSN 0004-6981 ; 1352-2310
    ISSN 0004-6981 ; 1352-2310
    DOI 10.1016/j.atmosenv.2019.06.037
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis.

    Wang, Ben / Duan, Ruqiao / Duan, Liping

    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

    2018  Volume 24, Issue 3, Page(s) 141–150

    Abstract: Background/aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder.: Materials and methods: A systematic search was ... ...

    Abstract Background/aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder.
    Materials and methods: A systematic search was conducted by searching PubMed, Embase, and Cochrane library databases using the following search terms: "functional gastrointestinal disorders," "Sleep disturbance," "Sleep disorder," "insomnia," "Dysomnias," "irritable bowel syndrome," and "IBS." Studies evaluating the association between IBS and sleep disorder were identified. Data analysis was conducted using meta-analysis software Comprehensive Meta-Analysis (CMA) 2.0. Heterogeneity across studies was evaluated by χ
    Results: The bibliographical search yielded a total of 2866 studies. Finally, 36 studies including 63620 participants were identified. The prevalence of sleep disorder in IBS was 37.6% (95% CI: 31.4% to 44.3%) based on this meta-analysis. The pooled odds ratio was 2.618 (95% CI: 2.052% to 3.341). Publication bias was not determined. Regarding the sensitivity analysis, the outcome was stable regardless of which study was removed.
    Conclusions: The prevalence of sleep disorder was higher in IBS compared to healthy controls and may be associated with the pathogenesis of IBS. The prevalence of sleep disorder in IBS may differ according to different areas, age, gender, occupation, and IBS diagnostic criteria. Further studies are needed to investigate any possible causal relationship between sleep disorder and IBS.
    MeSH term(s) Female ; Humans ; Irritable Bowel Syndrome/complications ; Male ; Odds Ratio ; Prevalence ; Sleep Wake Disorders/epidemiology
    Language English
    Publishing date 2018-04-13
    Publishing country India
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2299174-8
    ISSN 1998-4049 ; 1319-3767
    ISSN (online) 1998-4049
    ISSN 1319-3767
    DOI 10.4103/sjg.SJG_603_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6710: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Association between short-term exposure to fine particulate pollution and outpatient visits for ulcerative colitis in Beijing, China: A time-series study.

    Duan, Ruqiao / Wu, Yao / Wang, Mengying / Wu, Junhui / Wang, Xiaowen / Wang, Zijing / Hu, Yonghua / Duan, Liping

    Ecotoxicology and environmental safety

    2021  Volume 214, Page(s) 112116

    Abstract: Environmental factors play an important role in the development of ulcerative colitis (UC). However, only few studies have examined the effects of air pollution on UC occurrence. We conducted a time-series analysis to explore the association between ... ...

    Abstract Environmental factors play an important role in the development of ulcerative colitis (UC). However, only few studies have examined the effects of air pollution on UC occurrence. We conducted a time-series analysis to explore the association between short-term exposure to fine particulate matter (PM
    MeSH term(s) Aged ; Air Pollutants/analysis ; Air Pollution/analysis ; Beijing/epidemiology ; Colitis, Ulcerative/epidemiology ; Environmental Exposure/analysis ; Female ; Humans ; Male ; Outpatients ; Particulate Matter/analysis ; Seasons
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2021-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2021.112116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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