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Article ; Online: The role of post-translational modifications in synaptic AMPA receptor activity.

Corti, Elisa / Duarte, Carlos B

2023 Volume 51, Issue 1, Page(s) 315–330

Abstract: AMPA-type receptors for the neurotransmitter glutamate are very dynamic entities, and changes in their synaptic abundance underlie different forms of synaptic plasticity, including long-term synaptic potentiation (LTP), long-term depression (LTD) and ... ...

Abstract	AMPA-type receptors for the neurotransmitter glutamate are very dynamic entities, and changes in their synaptic abundance underlie different forms of synaptic plasticity, including long-term synaptic potentiation (LTP), long-term depression (LTD) and homeostatic scaling. The different AMPA receptor subunits (GluA1-GluA4) share a common modular structure and membrane topology, and their intracellular C-terminus tail is responsible for the interaction with intracellular proteins important in receptor trafficking. The latter sequence differs between subunits and contains most sites for post-translational modifications of the receptors, including phosphorylation, O-GlcNAcylation, ubiquitination, acetylation, palmitoylation and nitrosylation, which affect differentially the various subunits. Considering that each single subunit may undergo modifications in multiple sites, and that AMPA receptors may be formed by the assembly of different subunits, this creates multiple layers of regulation of the receptors with impact in synaptic function and plasticity. This review discusses the diversity of mechanisms involved in the post-translational modification of AMPA receptor subunits, and their impact on the subcellular distribution and synaptic activity of the receptors.
MeSH term(s)	Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Synapses/metabolism ; Neuronal Plasticity/physiology ; Long-Term Potentiation/physiology ; Protein Processing, Post-Translational
Chemical Substances	Receptors, AMPA
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST20220827
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Article ; Online: Systematic review of the uncertainty of coral reef futures under climate change.

Klein, Shannon G / Roch, Cassandra / Duarte, Carlos M

Nature communications

2024 Volume 15, Issue 1, Page(s) 2224

Abstract: Climate change impact syntheses, such as those by the Intergovernmental Panel on Climate Change, consistently assert that limiting global warming to 1.5 °C is unlikely to safeguard most of the world's coral reefs. This prognosis is primarily based on a ... ...

Abstract	Climate change impact syntheses, such as those by the Intergovernmental Panel on Climate Change, consistently assert that limiting global warming to 1.5 °C is unlikely to safeguard most of the world's coral reefs. This prognosis is primarily based on a small subset of available models that apply similar 'excess heat' threshold methodologies. Our systematic review of 79 articles projecting coral reef responses to climate change revealed five main methods. 'Excess heat' models constituted one third (32%) of all studies but attracted a disproportionate share (68%) of citations in the field. Most methods relied on deterministic cause-and-effect rules rather than probabilistic relationships, impeding the field's ability to estimate uncertainty. To synthesize the available projections, we aimed to identify models with comparable outputs. However, divergent choices in model outputs and scenarios limited the analysis to a fraction of available studies. We found substantial discrepancies in the projected impacts, indicating that the subset of articles serving as a basis for climate change syntheses may project more severe consequences than other studies and methodologies. Drawing on insights from other fields, we propose methods to incorporate uncertainty into deterministic modeling approaches and propose a multi-model ensemble approach to generating probabilistic projections for coral reef futures.
MeSH term(s)	Animals ; Coral Reefs ; Climate Change ; Anthozoa/physiology ; Uncertainty ; Global Warming ; Ecosystem
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46255-2
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Article: Energy efficiency in large office buildings post-COVID-19 in Europe's top five economies.

Cortiços, Nuno D / Duarte, Carlos C

Energy for sustainable development : the journal of the International Energy Initiative

2022 Volume 68, Page(s) 410–424

Abstract: Since the World Health Organization announced the COVID-19 pandemic, indoor airflows became a synonym for virus super-spreaders and the focus point for the scientific community and professional associations across the globe, disrupting all daily life ... ...

Abstract	Since the World Health Organization announced the COVID-19 pandemic, indoor airflows became a synonym for virus super-spreaders and the focus point for the scientific community and professional associations across the globe, disrupting all daily life dimensions. Europe's quick response to control the disease led the REHVA board to address mitigation guidelines, reassessed by each member association's following national specifics. The present study aims to quantify the energy consumption and CO
Language	English
Publishing date	2022-04-26
Publishing country	India
Document type	Journal Article
ISSN	0973-0826
ISSN	0973-0826
DOI	10.1016/j.esd.2022.04.006
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Article ; Online: Discernible decline in macroplastic litter inputs to the central eastern Red Sea shoreline during the COVID-19 lockdown.

Martynova, Anastasiia / Valluzzi, Letizia / Omar, Mohamed S / Duarte, Carlos M

Marine pollution bulletin

2024 Volume 201, Page(s) 116264

Abstract: Plastic debris accumulating on beaches pose a major threat to marine ecosystems. Unexpected events affecting human operations, such as the COVID-19 pandemic, which prompted governments to implement safety measures and restrictions, can serve as an ... ...

Abstract	Plastic debris accumulating on beaches pose a major threat to marine ecosystems. Unexpected events affecting human operations, such as the COVID-19 pandemic, which prompted governments to implement safety measures and restrictions, can serve as an unplanned investigation of anthropogenic pressure on the marine environment. This study aimed to explore deviations in macroplastic delivery rates to the central eastern Red Sea shoreline during three distinct population mobility periods: before, during, and after COVID-19 restrictions, spanning from January 2019 to June 2022. We observed a 50 % reduction in the estimated macroplastic delivery rates during the lockdown, followed by a 25 % increase after restrictions were eased. Seasonal variations in delivery rates were also observed, with higher values during the winter monsoon. Reduced shoreline litter delivery during the pandemic highlights human operations as a cause of macroplastic litter and suggests the potential of temporary measures to reduce plastic pollution in the coastal environment.
MeSH term(s)	Humans ; Waste Products/analysis ; Ecosystem ; Indian Ocean ; Pandemics ; Environmental Monitoring ; Plastics ; Bathing Beaches ; COVID-19 ; Communicable Disease Control
Chemical Substances	Waste Products ; Plastics
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2024.116264
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Article ; Online: Mitochondria as central hubs in synaptic modulation.

Duarte, Filipe V / Ciampi, Daniele / Duarte, Carlos B

Cellular and molecular life sciences : CMLS

2023 Volume 80, Issue 6, Page(s) 173

Abstract: Mitochondria are present in the pre- and post-synaptic regions, providing the energy required for the activity of these very specialized neuronal compartments. Biogenesis of synaptic mitochondria takes place in the cell body, and these organelles are ... ...

Abstract	Mitochondria are present in the pre- and post-synaptic regions, providing the energy required for the activity of these very specialized neuronal compartments. Biogenesis of synaptic mitochondria takes place in the cell body, and these organelles are then transported to the synapse by motor proteins that carry their cargo along microtubule tracks. The transport of mitochondria along neurites is a highly regulated process, being modulated by the pattern of neuronal activity and by extracellular cues that interact with surface receptors. These signals act by controlling the distribution of mitochondria and by regulating their activity. Therefore, mitochondria activity at the synapse allows the integration of different signals and the organelles are important players in the response to synaptic stimulation. Herein we review the available evidence regarding the regulation of mitochondrial dynamics by neuronal activity and by neuromodulators, and how these changes in the activity of mitochondria affect synaptic communication.
MeSH term(s)	Mitochondria/metabolism ; Neurons/metabolism ; Organelles/metabolism ; Kinesins/metabolism ; Microtubules/metabolism
Chemical Substances	Kinesins (EC 3.6.4.4)
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-04814-8
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Article: COVID-19: The impact in US high-rise office buildings energy efficiency.

Cortiços, Nuno D / Duarte, Carlos C

Energy and buildings

2021 Volume 249, Page(s) 111180

Abstract: The COVID-19 pandemic, through stay-at-home orders, forced rapid changes to social human behavior and interrelations, targeting the work environments to protect workers and users. Rapidly, global organizations, US associations, and professionals stepped ... ...

Abstract	The COVID-19 pandemic, through stay-at-home orders, forced rapid changes to social human behavior and interrelations, targeting the work environments to protect workers and users. Rapidly, global organizations, US associations, and professionals stepped in to mitigate the virus's spread in buildings' living and work environments. The institutions proposed new HVAC settings without efficiency concerns, as improved flow rates and filtering for irradiation, humidity, and temperature. Current literature consensually predicted an increase in energy consumption due to new measures to control the SARS-CoV-2 spread. The research team assumed the effort of validating the prior published outcomes, applied to US standardized high-rise office buildings, as defined and set by the key entities in the field, by resorting to a methodology based on software energy analysis. The study compares a standard high-rise office building energy consumption, CO
Language	English
Publishing date	2021-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1502295-x
ISSN	0378-7788
ISSN	0378-7788
DOI	10.1016/j.enbuild.2021.111180
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Article ; Online: How Long After Compliance Do You Benefit From Regulation? An Empirical Study on Diagnostic Imaging Equipment Requirements

Duarte, Carlos Henrique C

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2019 Volume 2019, Page(s) 4141–4147

Abstract: Few economic sectors are more regulated than healthcare. While excessive healthcare regulation is a bad thing, regulation compliance brings with it the benefits of market entry, product quality and availability, as well as access to tax rebates and ... ...

Abstract	Few economic sectors are more regulated than healthcare. While excessive healthcare regulation is a bad thing, regulation compliance brings with it the benefits of market entry, product quality and availability, as well as access to tax rebates and credit benefits. In this paper, we investigate some connections between regulatory compliance and normative technical requirements. We present a multi-company exploratory case study on the variability of mean times-to-benefit after compliance. We focus here on the diagnostic imaging equipment segment and the normative context in Brazil. We show that, in what regards current tax benefit regulations, time-to-benefit depends on the normative technical requirements that different categories of diagnostic imaging equipment comply with. This suggests that product-engineering practices should be concerned not only with analyzing and ensuring compliance, but also with regulation diversity and dynamics.
MeSH term(s)	Brazil ; Commerce ; Diagnostic Imaging/standards ; Government Regulation ; Industry
Language	English
Publishing date	2019-12-30
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2019.8856338
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Article ; Online: Influence of global warming and industrialization on coral reefs: A 600-year record of elemental changes in the Eastern Red Sea.

Cai, Chunzhi / Hammerman, Nicholas Matthew / Pandolfi, John M / Duarte, Carlos M / Agusti, Susana

The Science of the total environment

2024 Volume 914, Page(s) 169984

Abstract: The Red Sea has been recognized as a coral reef refugia, but it is vulnerable to warming and pollution. Here we investigated the spatial and temporal trends of 15 element concentrations in 9 coral reef sediment cores (aged from the 1460s to the 1980s AD) ...

Abstract	The Red Sea has been recognized as a coral reef refugia, but it is vulnerable to warming and pollution. Here we investigated the spatial and temporal trends of 15 element concentrations in 9 coral reef sediment cores (aged from the 1460s to the 1980s AD) to study the influence of global warming and industrialization on the Eastern Red Sea coral reefs. We found Na, Ca, Cr, Fe, Co, Ni, and Sr concentrations were higher in the northern Red Sea (i.e., Yanbu), whereas Mg, P, S, Mn, and Cd concentrations were higher in the southern Red Sea (i.e., Thuwal & Al Lith) reef sediments. In the central (i.e., Thuwal) to southern (i.e., Al Lith) Red Sea, the study revealed diverse temporal trends in element concentrations. However, both reef sedimentation rates (-36.4 % and -80.5 %, respectively) and elemental accumulation rates (-49.4 % for Cd to -12.2 % for Zn in Thuwal, and -86.2 % for Co to -61.4 % for Cu in Al Lith) exhibited a declining pattern over time, possibly attributed to warming-induced thermal bleaching. In the central to northern Red Sea (i.e., Yanbu), the severity of thermal bleaching is low, while the reef sedimentation rates (187 %), element concentrations (6.7 % for S to 764 % for Co; except Na, Mg, Ca, Sr, and Cd), and all elemental accumulation rates (190 % for Mg to 2697 % for Co) exponentially increased from the 1970s, probably due the rapid industrialization in Yanbu. Our study also observed increased trace metal concentrations (e.g., Cu, Zn, and Ni) in the Thuwal and Al Lith coral reefs with severe bleaching histories, consistent with previous reports that trace metals might result in decreased resistance of corals to thermal stress under warming scenarios. Our study points to the urgent need to reduce the local discharge of trace metal pollutants to protect this biodiversity hotspot.
MeSH term(s)	Animals ; Coral Reefs ; Global Warming ; Indian Ocean ; Cadmium ; Industrial Development ; Anthozoa
Chemical Substances	Cadmium (00BH33GNGH)
Language	English
Publishing date	2024-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.169984
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Article: Energy efficiency in large office buildings post-COVID-19 in Europe's top five economies

Cortiços, Nuno D. / Duarte, Carlos C.

International Energy Initiative Energy for sustainable development. 2022 June, v. 68

2022

Abstract	Since the World Health Organization announced the COVID-19 pandemic, indoor airflows became a synonym for virus super-spreaders and the focus point for the scientific community and professional associations across the globe, disrupting all daily life dimensions. Europe's quick response to control the disease led the REHVA board to address mitigation guidelines, reassessed by each member association's following national specifics. The present study aims to quantify the energy consumption and CO₂ emissions of “large office” buildings in top-five European economies under the COVID-19 guidelines under the post-pandemic telework forecast. Methodology resorted to a standard model under Building Energy Simulation assessment to compare prior and posterior scenarios. The latter displays a tendency to increase energy and CO₂ emissions in all locations, in the first form 10.18% (Rome) to 69.48% (Paris); and second 5.80% (Rome) and 120.61% (Paris), which will affect national energy production and imports, urban pollution and business competitiveness. On a different scope, future HVAC guidelines need to address the incoming figures, particularly in highly dense urban areas. Also, to comply with the goals set by the Paris Accord.
Keywords	COVID-19 infection ; World Health Organization ; carbon dioxide ; energy efficiency ; models ; pollution ; sustainable development ; telecommuting ; viruses ; Europe
Language	English
Dates of publication	2022-06
Size	p. 410-424.
Publishing place	Elsevier Inc.
Document type	Article
ISSN	0973-0826
DOI	10.1016/j.esd.2022.04.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intergovernmental Panel on Blue Foods in Support of Sustainable Development and Nutritional Security.

Bank, Michael S / Duarte, Carlos M / Sonne, Christian

Environmental science & technology

2022 Volume 56, Issue 9, Page(s) 5302–5305

MeSH term(s)	Food ; Food Supply ; Sustainable Development
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.2c00119
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