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  1. Article ; Online: Nontyphoidal Salmonellosis Leading to Fatal Outcome in an Allogeneic Hematopoietic Stem Cell Transplant Recipient From Northeastern Brazil.

    Costa, Bruno Almeida / Duarte, Fernando Barroso / Duarte, João Vitor Araújo / Duarte, Isabella Araújo / Barroso, Karine Sampaio Nunes / Gonçalves, Alexia Triandopolis

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2023  Volume 21, Issue 5, Page(s) 477–480

    MeSH term(s) Humans ; Brazil/epidemiology ; Salmonella Infections/diagnosis ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/adverse effects
    Language English
    Publishing date 2023-04-19
    Publishing country Turkey
    Document type Letter
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2022.0317
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    Zs.A 6632: Show issues Location:
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  2. Article ; Online: Myelopathy associated with intrathecal methotrexate.

    Rodrigues, Pedro Gustavo Barros / Lima, Talles Tavares de / Duarte, Fernando Barroso / Nóbrega, Paulo Ribeiro

    Practical neurology

    2021  Volume 22, Issue 2, Page(s) 141–144

    Abstract: A 21-year-old man developed progressive and bilateral lower limb numbness, gait impairment and urinary incontinence over 10 days. He had received intrathecal methotrexate 20 days previously for acute lymphoblastic B-cell leukaemia, following 7 months of ... ...

    Abstract A 21-year-old man developed progressive and bilateral lower limb numbness, gait impairment and urinary incontinence over 10 days. He had received intrathecal methotrexate 20 days previously for acute lymphoblastic B-cell leukaemia, following 7 months of systemic chemotherapy. MR scan of the spinal cord showed bilateral symmetric and extensive T2/fluid attenuated inversion recovery (FLAIR) increased signal involving the dorsal columns in the thoracic cord. His serum folate concentration was at the lower end of the normal range. We stopped the intrathecal chemotherapy and gave folate; after a few days, he progressively improved. Myelopathy is an important adverse effect of intrathecal methotrexate, which may cause clinical and imaging features resembling subacute combined degeneration of the spinal cord. CNS infiltration must be excluded, intrathecal chemotherapy stopped and deficiency of folate or vitamin B12 treated as appropriate.
    MeSH term(s) Adult ; Humans ; Magnetic Resonance Imaging ; Male ; Methotrexate/adverse effects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/chemically induced ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Spinal Cord Diseases/chemically induced ; Spinal Cord Diseases/diagnostic imaging ; Subacute Combined Degeneration/chemically induced ; Subacute Combined Degeneration/diagnostic imaging ; Young Adult
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/practneurol-2021-003154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6001: Show issues Location:
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  3. Article ; Online: Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature.

    Costa, Bruno Almeida / da Luz, Kaiza Vilarinho / Campos, Sarah Emanuelle Viana / Lopes, Germison Silva / Leitão, João Paulo de Vasconcelos / Duarte, Fernando Barroso

    Hematology, transfusion and cell therapy

    2022  Volume 44, Issue 1, Page(s) 26–31

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin- ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases of previously healthy young adults diagnosed with a hematologic malignancy after experiencing COVID-19, we raise the hypothesis that the SARS-Cov-2 infection could act as a trigger for leukemogenesis in predisposed individuals.
    Methods: This was a case series performed through extraction of relevant clinical information from the medical records of three patients admitted to our Hematology unit between August 2020 and September 2020.
    Main results: Considering the relatively rapid development of cytopenias following recovery from COVID-19, it cannot be ruled out that SARS-Cov-2 played a role in leukemogenesis in those patients. Based on previous
    Conclusion: Despite the advances in pathophysiological and clinical characterization of COVID-19, the consequences of the pandemic to the incidence of hematologic diseases are still to be elucidated. In this context, future dissection of the status of the local bone marrow renin-angiotensin system in leukemogenesis is a clinically relevant basic research area.
    Language English
    Publishing date 2022-01-19
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2021.11.015
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  4. Article ; Online: Hematological changes in Covid-19 infections.

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 2, Page(s) 99

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Hematologic Diseases/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.2.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: American Society of Transplantation and Cellular Therapy International Affair Committee: Report of the Third Workshop on Global Perspective to Access to Transplantation at the 2022 Tandem Meeting.

    Okamoto, Shinichiro / Iida, Minako / Hamad, Nada / Duarte, Fernando Barroso / Sureda, Anna / Srivastava, Alok / Galeano, Sebastian / Chao, Nelson / Rondelli, Damiano / Flowers, Mary E

    Transplantation and cellular therapy

    2023  Volume 29, Issue 7, Page(s) 410–417

    MeSH term(s) Transplantation, Homologous ; Societies
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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  6. Article ; Online: Epidemiology of immune thrombocytopenia: study of adult patients at a referral hematology service in Northeastern Brazil.

    Kubrusly, Bruna Sobreira / Kubrusly, Elsie Sobreira / Rocha, Hermano Alexandre Lima / Júnior, Antonio Brazil Viana / Kubrusly, Marcela Sobreira / Ribeiro, Lucas Loiola Ponte Albuquerque / Ribeiro, Rosângela de Albuquerque / Duarte, Fernando Barroso

    Hematology, transfusion and cell therapy

    2023  

    Abstract: Immune thrombocytopenia (ITP) is an acquired bleeding disorder observed in the clinical practice. Little is known about its epidemiology in Brazil. The present study was conducted at a hematology referral center which covers a population of over 8 ... ...

    Abstract Immune thrombocytopenia (ITP) is an acquired bleeding disorder observed in the clinical practice. Little is known about its epidemiology in Brazil. The present study was conducted at a hematology referral center which covers a population of over 8 million in 184 municipalities in the state of Ceará. The purpose of this study was to draw a demographic profile of adult ITP patients with regard to sex, age, geographical origin and distribution across the state, and the proportion of secondary ITP. Following ethics committee approval, information was collected with an ad hoc instrument. The sample consisted of 187 adult ITP patients attending the Walter Cantídio University Hospital in 2015. The median follow-up time was 67 months (range: 1 month to 29 years). Female sex (n = 154; 82.35 %) was strongly prevalent in all age brackets, with an overall female/male ratio of 4.7:1. The median age was 41 ± 16.1 with an interquartile range of 29-55.5 years; there was no difference between the genders. Secondary ITP (18/187; 9.6 %) displayed a bimodal distribution and a linear increase between 38 and >68 years of age. The results of this survey on the epidemiology of ITP in Brazil suggest that ethnic and geographical factors may have a great impact on age and sex distribution and on the distribution of secondary ITP.
    Language English
    Publishing date 2023-11-17
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.09.2363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Hematological changes in Covid-19 infections

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associação Médica Brasileira v.66 n.2 2020

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-02-01
    Publisher Associação Médica Brasileira
    Publishing country br
    Document type Book ; Online
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  8. Article ; Online: Risk factors for renal impairment in patients with hematological cancer receiving antineoplastic treatment.

    Travassos, Priscila Nunes Costa / de Barros Silva, Paulo Goberlânio / Freitas, Milena Oliveira / Braga, Marcus Davis Machado / Duarte, Fernando Barroso / de Oliveira Maia, Jéssica Karen / Pitombeira, Helena / de Sousa, Jacqueline Holanda / Alves, Ana Paula Negreiros Nunes

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 9, Page(s) 7271–7280

    Abstract: Purpose: Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders in patients with oncohematological neoplasms ... ...

    Abstract Purpose: Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders in patients with oncohematological neoplasms receiving antineoplastic treatment.
    Methods: This retrospective cohort study included 75 patients with hematological cancer who underwent chemotherapy between 2012 and 2018 in the Hematology Sector of the Walter Cantídeo University Hospital of the Federal University of Ceará. Sociodemographic and clinical data, blood biochemical assessment findings, and glomerular filtration rate (GFR) were analyzed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The data were tabulated; transferred to the Statistical Package for the Social Sciences software, version 20.0; and analyzed using Pearson's chi-square test or Fisher's exact test for categorical variables followed by a multinomial logistic regression model (p < 0.05).
    Results: The prevalence of renal disorders was 52.4% according to the CKD-EPI equation for GFR events. There was a significant association between the decrease in GFRs and the following variables: female sex (p = 0.002), diagnosis of multiple myeloma (p = 0.008), start of treatment within 40 days (p = 0.005), and the following antineoplastic treatments: cyclophosphamide, vincristine, and prednisone (p = 0.026); irarubicin (p = 0.032); azacytidine, dexamethasone, and cyclophosphamide (p < 0.001); zoledronic acid (p < 0.001); and pamidronate (p = 0.012). CALGB 8811 (p < 0.001) was inversely associated with a reduction in the GFR.
    Conclusions: The prevalence of renal disorders was high in patients with oncohematological neoplasms receiving antineoplastic treatment. This requires periodic monitoring of the evaluation of renal function since reductions in GFRs were significantly associated with different treatment protocols used.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Creatinine ; Cyclophosphamide ; Female ; Glomerular Filtration Rate ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/epidemiology ; Humans ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies ; Risk Factors
    Chemical Substances Antineoplastic Agents ; Cyclophosphamide (8N3DW7272P) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-05-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-07159-3
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    Zs.A 3697: Show issues Location:
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  9. Article: Histopathological evaluation of the bone marrow in refractory anemia with ring sideroblasts and thrombocytosis associated to the JAK2-V617F mutation.

    Duarte, Fernando Barroso / Rocha, Francisco Dário / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 1, Page(s) 69–70

    Language English
    Publishing date 2014-02-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140017
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  10. Article: Histopathological evaluation of the bone marrow in refractory anemia with ring sideroblasts and thrombocytosis associated to the JAK2-V617F mutation.

    Duarte, Fernando Barroso / Filho, Francisco Dário Rocha / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 1, Page(s) 69–70

    Language Portuguese
    Publishing date 2014-03-12
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140017
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