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  1. Article: Neuroendocrine carcinoma of cervix and review literature.

    Verma, Saransh / Dubey, Harshita / Gupta, Swati / Ranjan, Amar / Goel, Harsh / Sharma, Anil

    International journal of surgery case reports

    2023  Volume 105, Page(s) 107982

    Abstract: Introduction: Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer with poor prognosis and high mortality. Recurrence is seen with multi-organ metastasis including liver.: Case presentation: A 65 year old female ... ...

    Abstract Introduction: Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer with poor prognosis and high mortality. Recurrence is seen with multi-organ metastasis including liver.
    Case presentation: A 65 year old female presented with vaginal bleeding for the past one year. Cervical cancer screening and biopsy demonstrated poorly differentiated squamous carcinoma. Immunohistochemistry showed positive expression of chromogranin, synaptophysin, pancytokeratin, TTP1, and CEA and negative expression of p40 and estrogen receptors. An adenocarcinoma with neuroendocrine tumor was suggested. Hysterectomy with bilateral salpingo-oophrectomy was performed. This was followed by carboplatin and etoposide therapy to have clinical remission for a year. Then recurrence was observed to start same drugs again resulting in to partial improvement. It was followed by radiotherapy. The patient succumbed to death approximately after three months.
    Conclusion: A metastatic lesion in liver may be a case of Neuroendocrine tumor of cervix, a rare condition that can be easily missed on histopathological examination. More studies are required to establish a standard therapeutic protocol.
    Language English
    Publishing date 2023-03-20
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2023.107982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Therapy related complications in plasmablastic lymphoma in immunocompetent individual.

    Dubey, Harshita / Gupta, Swati / Jha, Tanvi / Tanwar, Khushi / Verma, Saransh / Ranjan, Amar / Tanwar, Pranay

    American journal of blood research

    2022  Volume 12, Issue 5, Page(s) 168–171

    Abstract: Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma seen in immunocompromised individuals. It has a diffuse growth pattern, with no standard therapy and a poor survival rate. Due to overlap in ... ...

    Abstract Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma seen in immunocompromised individuals. It has a diffuse growth pattern, with no standard therapy and a poor survival rate. Due to overlap in presenting features with lymphoma and myeloma, PBL is often a diagnostic dilemma. We present a case of PBL in a young immunocompetent female who developed treatment associated complications.
    Case report: A 36-year-old presented with a lesion extending from the oral cavity to the pharynx and involving the angle of the mandible. Radiology and laryngoscopy described a growth pattern that was diagnosed to be PBL on histopathology. The patient underwent chemotherapy using level II DA-EPOCH (dose-adjusted-etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) and prophylactic granulocyte-colony stimulating factor along with radiotherapy and ultimately, achieved metabolic response. However, she developed several episodes of paralytic ileus, cytopenia, oral ulcers, dermatitis and long-standing hypothyroidism as therapy-related complications and has been on treatment for the same ever since.
    Conclusions: Thus, a high index of suspicion is necessary for early diagnosis and rapid initiation of therapy. Further, there is a need to detect and address therapy related complications early to prevent long-standing, therapy-related side effects from developing and deteriorating the patient's quality of life.
    Language English
    Publishing date 2022-10-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2620435-6
    ISSN 2160-1992
    ISSN 2160-1992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bone marrow metastasis of testicular germ cell tumour: A rare case

    Dubey, Harshita / Ranjan, Amar / Jain, Garima / Kumar, Chandan / Batra, Atul / Chellapuram, Santosh Kumar / Gupta, Swati / Goel, Harsh / Sharma, Anil / Tanwar, Pranay

    Heliyon. 2023 May 29, p.e16703-

    2023  

    Abstract: Germ cell tumour (GCT) is the most common testicular tumour that commonly presents as a painless mass. Bone marrow metastasis in cases of testicular GCT is rare; only few case reports are available till date in the literature. Here an adult male ... ...

    Abstract Germ cell tumour (GCT) is the most common testicular tumour that commonly presents as a painless mass. Bone marrow metastasis in cases of testicular GCT is rare; only few case reports are available till date in the literature. Here an adult male presented with an intra-abdominal mass in right iliac fossa with inguinal lymphadenopathy with a deranged kidney function test. Bone marrow (BM) aspirate smear revealed metastatic tumour cells, but BM-biopsy was unremarkable. High serum Beta - HCG (38286 mIU/L) pointed towards germ cell lesion. Lymph node biopsy along with immunomarkers confirmed metastatic foci from germ cell tumor and managed as per standard protocol. Rarely BM aspirate is seen positive for malignancy, while biopsy turns out to be negative. Secondly, BM metastasis of GCT should be considered while dealing with cases like this. This is certified that the informed consent has been obtained from the patient.
    Keywords adults ; biopsy ; blood serum ; bone marrow ; germ cells ; ilium ; kidney function tests ; lymph nodes ; lymphatic diseases ; males ; metastasis ; neoplasms ; patients ; testes ; Germ cell tumour ; Bone marrow aspirate ; Testis
    Language English
    Dates of publication 2023-0529
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16703
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Bone marrow metastasis of testicular germ cell tumour: A rare case.

    Dubey, Harshita / Jain, Garima / Kumar, Chandan / Ranjan, Amar / Batra, Atul / Chellapuram, Santosh Kumar / Gupta, Swati / Goel, Harsh / Sharma, Anil / Tanwar, Pranay

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16703

    Abstract: Germ cell tumour (GCT) is the most common testicular tumour that commonly presents as a painless mass. Bone marrow metastasis in cases of testicular GCT is rare; only few case reports are available till date in the literature. Here an adult male ... ...

    Abstract Germ cell tumour (GCT) is the most common testicular tumour that commonly presents as a painless mass. Bone marrow metastasis in cases of testicular GCT is rare; only few case reports are available till date in the literature. Here an adult male presented with an intra-abdominal mass in right iliac fossa with inguinal lymphadenopathy with a deranged kidney function test. Bone marrow (BM) aspirate smear revealed metastatic tumour cells, but BM-biopsy was unremarkable. High serum Beta - HCG (38286 mIU/L) pointed towards germ cell lesion. Lymph node biopsy along with immunomarkers confirmed metastatic foci from germ cell tumor and managed as per standard protocol. Rarely BM aspirate is seen positive for malignancy, while biopsy turns out to be negative. Secondly, BM metastasis of GCT should be considered while dealing with cases like this.
    Informed consent: This is certified that the informed consent has been obtained from the patient.
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of HE4 as a prognostic biomarker in uterine cervical cancer

    Dubey, Harshita / Ranjan, Amar / Durai, Julieana / Khan, M A / Lakshmy, R / Khurana, Sachin / Gupta, Swati / Meena, Jyoti / Ray, M D / Tanwar, Pranay / Chopra, Anita / Tiwari, Sanat

    Cancer treatment and research communications

    2022  Volume 34, Page(s) 100672

    Abstract: Introduction: Uterine cervical cancer (UCC) is the fourth most common health problem worldwide among women. Currently available biomarkers CA125, CA199, and CEA for diagnosis or prognostic evaluation of UCC have not got widespread acceptance.: Method!# ...

    Abstract Introduction: Uterine cervical cancer (UCC) is the fourth most common health problem worldwide among women. Currently available biomarkers CA125, CA199, and CEA for diagnosis or prognostic evaluation of UCC have not got widespread acceptance.
    Method: Whole blood samples of 64 patients with UCC were collected along with 63 healthy females and tested for serum levels of HE4 (sHE4). A cut-off value for positive result 64.0 pmol/L was set. Statistical analysis of different clinical variables was done.
    Result: Serum level of HE4 has a significant role in the diagnosis of uterine cervical cancer. Its level increases with age, higher parity (P < 0.05), stage (P < 0.16), tumor size, and parametrial invasion. Negative result was seen with vaginal invasion, lymph node involvement & cases which had recurrence. Various histological types showed variable results. So the serum level of HE4 (sHE) level may play a role in the diagnosis & therapeutic monitoring of UCC. But the prognostic evaluation needs further studies.
    Conclusion: sHE4 is useful in the diagnosis of cervical cancer, but its prognostic significance is under the question marks. It may be associated with higher values in higher stages. Higher parity of the patient is associated with higher level of HE4 in UCC.
    MeSH term(s) Female ; Humans ; Prognosis ; Proteins/analysis ; Uterine Cervical Neoplasms/diagnosis ; WAP Four-Disulfide Core Domain Protein 2
    Chemical Substances Proteins ; WAP Four-Disulfide Core Domain Protein 2 ; WFDC2 protein, human
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2022.100672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinicopathological and laboratory parameters of plasma cell leukemia among Indian population.

    Dubey, Harshita / Goel, Harsh / Verma, Saransh / Gupta, Swati / Tanwar, Khushi / Rahul, Ekta / Kapoor, Gautam / Vasantharaman, Jayashimman / Ranjan, Amar / Tanwar, Pranay / Chopra, Anita

    American journal of blood research

    2022  Volume 12, Issue 6, Page(s) 190–195

    Abstract: Background: Plasma cell leukemia (PCL) is a rare and aggressive plasma cell neoplasm distinguished by extensive clonal expansion of plasma cells in the bone marrow (BM) and peripheral blood (PB). PCL is divided into two subtypes: primary (pPCL) ... ...

    Abstract Background: Plasma cell leukemia (PCL) is a rare and aggressive plasma cell neoplasm distinguished by extensive clonal expansion of plasma cells in the bone marrow (BM) and peripheral blood (PB). PCL is divided into two subtypes: primary (pPCL) originates
    Methods: In this study, we retrospectively reviewed and evaluated the clinicopathological features, laboratory parameters, immunophenotypic profile, and patient outcomes of 17 PCL cases diagnosed among 180 plasma cell dyscrasia patients during the study period to establish a correlation between pPCL & sPCL for diagnosis and management of PCL.
    Results: A total of 17 PCL patients were diagnosed among 180 plasma cell dyscrasia patients during the study period. Among PCL patients, 9 cases had pPCL (52.94% of all PCL patients), and 8 cases had sPCL (47.06% of all PCL patients). Peculiar differences were seen between the two PCL types. Both types of PCL had a younger age at the time of diagnosis, having elevated BM plasma cell infiltration percentage, frequent anemia, thrombocytopenia, elevated beta-2-microglobulin (B2M) levels, raised LDH levels, and positive M-protein in both serum and urine. In addition, SFLC assay and Immunofixation assay showed higher κ and lower λ in pPCL compared with sPCL (P<0.05). Higher Renal insufficiency was also observed in pPCL compared to sPCL (P=0.335). The survival and response to treatment of PCL patients remain considerably poor, sPCL exhibit shorter overall survival (OS) than pPCL with (median 1.75 months vs. 7 months respectively,
    Conclusion: Our study characterizes the clinical and laboratory features of pPCL and sPCL and may aid physicians in prognosticating the course of disease of their patients. However, future multicentre studies are the need of the hour to develop accurate diagnostic criteria and establish the efficacy of therapeutic regimens.
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2620435-6
    ISSN 2160-1992
    ISSN 2160-1992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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