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  1. Book: Acid base and electrolyte disorders

    Dubose, Thomas D. / Hamm, L. Lee

    a companion to Brenner & Rector's The kidney

    2002  

    Title variant Acid-base and electrolyte disorders
    Author's details Thomas D. DuBose ; L. Lee Hamm
    Keywords Kidney Diseases ; Kidney / physiopathology ; Acid-Base Imbalance ; Water-Electrolyte Imbalance
    Language English
    Size XVI, 547 S. : zahlr. Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013463236
    ISBN 0-7216-8956-6 ; 978-0-7216-8956-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 4360 order for loan Magazin

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  2. Article ; Online: Missense mutations and proximal RTA. Have we reached a new threshold? Focus on "missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis".

    Petrovic, Snezana / Dubose, Thomas D

    American journal of physiology. Cell physiology

    2013  Volume 305, Issue 4, Page(s) C373–4

    MeSH term(s) Acidosis, Renal Tubular/metabolism ; Humans ; Kidney Tubules, Proximal/metabolism ; Mutation, Missense ; Sodium-Bicarbonate Symporters/metabolism
    Chemical Substances SLC4A4 protein, human ; Sodium-Bicarbonate Symporters
    Language English
    Publishing date 2013-05-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00152.2013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chronic kidney disease: cause and consequence of cardiovascular disease.

    Freedman, Barry I / Dubose, Thomas D

    Archives of internal medicine

    2007  Volume 167, Issue 11, Page(s) 1113–1115

    MeSH term(s) Albuminuria/epidemiology ; Atherosclerosis/epidemiology ; Cardiovascular Diseases/epidemiology ; Continental Population Groups ; Glomerular Filtration Rate ; Humans ; Kidney Failure, Chronic/epidemiology ; Risk Factors
    Language English
    Publishing date 2007-06-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 211575-x
    ISSN 1538-3679 ; 0003-9926 ; 0888-2479 ; 0730-188X
    ISSN (online) 1538-3679
    ISSN 0003-9926 ; 0888-2479 ; 0730-188X
    DOI 10.1001/archinte.167.11.1113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incessant ventricular tachycardia and cardiogenic shock: a common presentation of an uncommon diagnosis.

    Drafts, Brandon C / Sutton, Brian J / Dubose, Thomas D / Thohan, Vinay

    The American journal of the medical sciences

    2011  Volume 342, Issue 6, Page(s) 527–529

    Abstract: Giant cell myocarditis is a rare and highly lethal disease that is characterized by a rapidly progressive course of biventricular dysfunction. The authors present a case of giant cell myocarditis that presented with incessant ventricular tachycardia and ... ...

    Abstract Giant cell myocarditis is a rare and highly lethal disease that is characterized by a rapidly progressive course of biventricular dysfunction. The authors present a case of giant cell myocarditis that presented with incessant ventricular tachycardia and cardiogenic shock in which clinical improvement was achieved with immunosuppressive therapy.
    MeSH term(s) Adult ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Biopsy ; Blood Chemical Analysis ; Cardiac Catheterization ; Coronary Angiography ; Cyclosporine/therapeutic use ; Diagnosis, Differential ; Electrocardiography ; Giant Cells/pathology ; Heart/diagnostic imaging ; Heart/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Magnetic Resonance Imaging ; Male ; Myocarditis/diagnosis ; Myocarditis/drug therapy ; Myocarditis/physiopathology ; Myocardium/pathology ; North Carolina ; Prednisone/therapeutic use ; Shock, Cardiogenic/diagnostic imaging ; Shock, Cardiogenic/drug therapy ; Shock, Cardiogenic/physiopathology ; Tachycardia, Ventricular/diagnostic imaging ; Tachycardia, Ventricular/drug therapy ; Tachycardia, Ventricular/pathology ; Tachycardia, Ventricular/physiopathology ; Treatment Outcome ; Ventricular Dysfunction, Left/physiopathology
    Chemical Substances Anti-Arrhythmia Agents ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Amiodarone (N3RQ532IUT) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1097/MAJ.0b013e31822a6bdd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hepatitis C virus and cocaine-induced rhabdomyolysis.

    Moossavi, Shahab / Wallace, Eric L / Martin, Thomas J / Dubose, Thomas D

    The American journal of medicine

    2010  Volume 123, Issue 12, Page(s) e5–6

    MeSH term(s) Acute Disease ; Biomarkers/blood ; Chronic Disease ; Cocaine-Related Disorders/complications ; Creatine Kinase/blood ; Hepatitis C/complications ; Hospitalization ; Humans ; Male ; Middle Aged ; Muscle, Skeletal/virology ; Recurrence ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/enzymology ; Rhabdomyolysis/virology ; Transaminases/blood
    Chemical Substances Biomarkers ; Transaminases (EC 2.6.1.-) ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Case Reports ; Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2010.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake.

    Codina, Juan / Li, Jian / Dubose, Thomas D

    American journal of physiology. Cell physiology

    2005  Volume 288, Issue 6, Page(s) C1279–86

    Abstract: The carboxy terminus (CT) of the colonic H(+)-K(+)-ATPase is required for stable assembly with the beta-subunit, translocation to the plasma membrane, and efficient function of the transporter. To identify protein-protein interactions involved in the ... ...

    Abstract The carboxy terminus (CT) of the colonic H(+)-K(+)-ATPase is required for stable assembly with the beta-subunit, translocation to the plasma membrane, and efficient function of the transporter. To identify protein-protein interactions involved in the localization and function of HKalpha(2), we selected 84 amino acids in the CT of the alpha-subunit of mouse colonic H(+)-K(+)-ATPase (CT-HKalpha(2)) as the bait in a yeast two-hybrid screen of a mouse kidney cDNA library. The longest identified clone was CD63. To characterize the interaction of CT-HKalpha(2) with CD63, recombinant CT-HKalpha(2) and CD63 were synthesized in vitro and incubated, and complexes were immunoprecipitated. CT-HKalpha(2) protein (but not CT-HKalpha(1)) coprecipitated with CD63, confirming stable assembly of HKalpha(2) with CD63. In HEK-293 transfected with HKalpha(2) plus beta(1)-Na(+)-K(+)-ATPase, suppression of CD63 by RNA interference increased cell surface expression of HKalpha(2)/NKbeta(1) and (86)Rb(+) uptake. These studies demonstrate that CD63 participates in the regulation of the abundance of the HKalpha(2)-NKbeta(1) complex in the cell membrane.
    MeSH term(s) Animals ; Antigens, CD/metabolism ; Antigens, CD/physiology ; Cell Line ; Cell Membrane/enzymology ; Colon/enzymology ; Gene Expression/physiology ; H(+)-K(+)-Exchanging ATPase/metabolism ; Humans ; Kidney/enzymology ; Mice ; Platelet Membrane Glycoproteins/metabolism ; Platelet Membrane Glycoproteins/physiology ; Rats ; Rubidium Radioisotopes ; Saccharomyces cerevisiae ; Tetraspanin 30
    Chemical Substances Antigens, CD ; CD63 protein, human ; Cd63 protein, mouse ; Platelet Membrane Glycoproteins ; Rubidium Radioisotopes ; Tetraspanin 30 ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10)
    Language English
    Publishing date 2005-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00463.2004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A carboxy-terminus motif of HKalpha2 is necessary for assembly and function.

    Codina, Juan / Li, Jian / Dubose, Thomas D

    Kidney international

    2004  Volume 66, Issue 6, Page(s) 2283–2292

    Abstract: Background: The present experiments were designed to study the importance of the carboxy-terminus of HKalpha2, for both function and integrity of assembly with beta1-Na+,K+-ATPase.: Methods: For this purpose, stop codons were created, by polymerase ... ...

    Abstract Background: The present experiments were designed to study the importance of the carboxy-terminus of HKalpha2, for both function and integrity of assembly with beta1-Na+,K+-ATPase.
    Methods: For this purpose, stop codons were created, by polymerase chain reaction (PCR), at different positions in the carboxy-terminus of HKalpha2. Subsequently, chimeras between HKalpha2 and the carboxy-terminus of alpha1-Na+,K+-ATPase or with the carboxy-terminus of the gastric H+,K+-ATPase were created. Human embryonic kidney HEK-293 cells were used as expression systems for functional studies using 86Rb+ uptake and alpha/beta assembly using specific antibodies.
    Results: The results demonstrate that the entire carboxy-terminus of HKalpha2 is required for optimal protection of the alpha/beta complex from degradation and for functionality as evidenced by 86Rb+ uptake. The results also demonstrate that there was flexibility in the sequence of the carboxy-terminus. The last two tyrosines (Y1035Y1036) of HKalpha2 could be mutated to alanines and the carboxy-terminus of HKalpha2 could be replaced by the carboxy-terminus of alpha1-Na+,K+-ATPase while preserving transport activity.
    Conclusion: The entire carboxy-terminus of HKalpha2 is required for stable assembly with beta1-Na+,K+-ATPase and functionality.
    MeSH term(s) Amino Acid Sequence ; Cell Line ; Cloning, Molecular ; Epitopes/genetics ; H(+)-K(+)-Exchanging ATPase/chemistry ; H(+)-K(+)-Exchanging ATPase/genetics ; H(+)-K(+)-Exchanging ATPase/metabolism ; Humans ; Kidney/cytology ; Molecular Sequence Data ; Mutagenesis ; Protein Structure, Tertiary ; Protein Subunits/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Rubidium Radioisotopes ; Sodium-Potassium-Exchanging ATPase/metabolism ; Structure-Activity Relationship ; Transfection
    Chemical Substances ATP1B1 protein, human ; Epitopes ; Protein Subunits ; Proto-Oncogene Proteins c-myc ; Rubidium Radioisotopes ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9)
    Language English
    Publishing date 2004-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1111/j.1523-1755.2004.66014.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A comprehensive 3-year internal medicine residency research curriculum.

    Ruiz, Jimmy / Wallace, Eric L / Miller, David P / Loeser, Richard F / Miles, Matthew / Dubose, Thomas D / Lichstein, Peter R

    The American journal of medicine

    2011  Volume 124, Issue 5, Page(s) 469–473

    MeSH term(s) Curriculum ; Humans ; Internal Medicine/education ; Internship and Residency/organization & administration ; Internship and Residency/standards ; Internship and Residency/trends ; Mentors ; North Carolina ; Program Development ; Program Evaluation ; Research/education
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2011.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Achieving diversity in academic internal medicine: recommendations for leaders.

    Wesson, Donald E / King, Talmadge E / Todd, Robert F / Torres, Esther A / Hellmann, David B / Flack, John M / Dubose, Thomas D / Schuster, Victor L

    The American journal of medicine

    2006  Volume 119, Issue 1, Page(s) 76–81

    MeSH term(s) Academic Medical Centers ; Cultural Diversity ; Faculty, Medical ; Humans ; Internal Medicine/education ; Minority Groups ; School Admission Criteria ; Students, Medical
    Language English
    Publishing date 2006-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2005.10.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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