LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Publisher Correction

    Chunyan Wang / Wentao Li / Dubravka Drabek / Nisreen M. A. Okba / Rien van Haperen / Albert D. M. E. Osterhaus / Frank J. M. van Kuppeveld / Bart L. Haagmans / Frank Grosveld / Berend-Jan Bosch

    Nature Communications, Vol 11, Iss 1, Pp 1-

    A human monoclonal antibody blocking SARS-CoV-2 infection

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: A human monoclonal antibody blocking SARS-CoV-2 infection

    Chunyan Wang / Wentao Li / Dubravka Drabek / Nisreen M. A. Okba / Rien van Haperen / Albert D. M. E. Osterhaus / Frank J. M. van Kuppeveld / Bart L. Haagmans / Frank Grosveld / Berend-Jan Bosch

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 6

    Abstract: Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a ... ...

    Abstract Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
    Keywords Science ; Q ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Publisher Correction

    Chunyan Wang / Wentao Li / Dubravka Drabek / Nisreen M. A. Okba / Rien van Haperen / Albert D. M. E. Osterhaus / Frank J. M. van Kuppeveld / Bart L. Haagmans / Frank Grosveld / Berend-Jan Bosch

    Nature Communications, Vol 11, Iss 1, Pp 1-

    A human monoclonal antibody blocking SARS-CoV-2 infection

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: A human monoclonal antibody blocking SARS-CoV-2 infection

    Chunyan Wang / Wentao Li / Dubravka Drabek / Nisreen M. A. Okba / Rien van Haperen / Albert D. M. E. Osterhaus / Frank J. M. van Kuppeveld / Bart L. Haagmans / Frank Grosveld / Berend-Jan Bosch

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 6

    Abstract: Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a ... ...

    Abstract Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

    Chunyan Wang / Emma L. Hesketh / Tatiana M. Shamorkina / Wentao Li / Peter J. Franken / Dubravka Drabek / Rien van Haperen / Sarah Townend / Frank J. M. van Kuppeveld / Frank Grosveld / Neil A. Ranson / Joost Snijder / Raoul J. de Groot / Daniel L. Hurdiss / Berend-Jan Bosch

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies ... ...

    Abstract Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies against this endemic coronavirus.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

    Chunyan Wang / Rien van Haperen / Javier Gutiérrez-Álvarez / Wentao Li / Nisreen M. A. Okba / Irina Albulescu / Ivy Widjaja / Brenda van Dieren / Raul Fernandez-Delgado / Isabel Sola / Daniel L. Hurdiss / Olalekan Daramola / Frank Grosveld / Frank J. M. van Kuppeveld / Bart L. Haagmans / Luis Enjuanes / Dubravka Drabek / Berend-Jan Bosch

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: Here, the authors report the isolation and characterization of two human monoclonal antibodies (mAbs) from immunized mice with trimeric spike ectodomains of three human betacoronaviruses HCoV-OC43, SARS-CoV and MERSCoV, and show that while exhibiting ... ...

    Abstract Here, the authors report the isolation and characterization of two human monoclonal antibodies (mAbs) from immunized mice with trimeric spike ectodomains of three human betacoronaviruses HCoV-OC43, SARS-CoV and MERSCoV, and show that while exhibiting cross-reactivity, the mAbs only neutralize MERS-CoV but not SARS-CoV nor SARS-CoV-2, likely due to the subtle epitope differences in the spike S2 fusion subunit.
    Keywords Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Multimeric single-domain antibody complexes protect against bunyavirus infections

    Paul J Wichgers Schreur / Sandra van de Water / Michiel Harmsen / Erick Bermúdez-Méndez / Dubravka Drabek / Frank Grosveld / Kerstin Wernike / Martin Beer / Andrea Aebischer / Olalekan Daramola / Sara Rodriguez Conde / Karen Brennan / Dorota Kozub / Maiken Søndergaard Kristiansen / Kieran K Mistry / Ziyan Deng / Jan Hellert / Pablo Guardado-Calvo / Félix A Rey /
    Lucien van Keulen / Jeroen Kortekaas

    eLife, Vol

    2020  Volume 9

    Abstract: The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a ... ...

    Abstract The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a broadly applicable strategy, based on llama-derived single-domain antibodies (VHHs), for the development of bunyavirus biotherapeutics. The method was validated using the zoonotic Rift Valley fever virus (RVFV) and Schmallenberg virus (SBV), an emerging pathogen of ruminants, as model pathogens. VHH building blocks were assembled into highly potent neutralizing complexes using bacterial superglue technology. The multimeric complexes were shown to reduce and prevent virus-induced morbidity and mortality in mice upon prophylactic administration. Bispecific molecules engineered to present two different VHHs fused to an Fc domain were further shown to be effective upon therapeutic administration. The presented VHH-based technology holds great promise for the development of bunyavirus antiviral therapies.
    Keywords bunyavirus ; therapy ; single-domain antibody ; vhh ; rift valley fever virus ; schmallenberg virus ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: A dual reporter mouse model of the human β-globin locus

    Petros Papadopoulos / Laura Gutiérrez / Reinier van der Linden / John Kong-A-San / Alex Maas / Dubravka Drabek / George P Patrinos / Sjaak Philipsen / Frank Grosveld

    PLoS ONE, Vol 7, Iss 12, p e

    applications and limitations.

    2012  Volume 51272

    Abstract: The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disorders in the world, ... ...

    Abstract The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disorders in the world, which results in quantitative defects of the globins, based on a number of genome variations found in the globin gene clusters. Hereditary persistence of fetal hemoglobin (HPFH) also caused by similar types of genomic alterations can compensate for the loss of adult hemoglobin. Understanding the regulation of the human γ-globin gene expression is a challenge for the treatment of thalassemia. A mouse model that facilitates high-throughput assays would simplify such studies. We have generated a transgenic dual reporter mouse model by tagging the γ- and β-globin genes with GFP and DsRed fluorescent proteins respectively in the endogenous human β-globin locus. Erythroid cell lines derived from this mouse model were tested for their capacity to reactivate the γ-globin gene. Here, we discuss the applications and limitations of this fluorescent reporter model to study the genetic basis of red blood cell disorders and the potential use of such model systems in high-throughput screens for hemoglobinopathies therapeutics.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

    Ksenija Drabek / Laura Gutiérrez / Marcel Vermeij / Thomas Clapes / Sunita R. Patel / Jean-Charles Boisset / Jeffrey van Haren / Ana L. Pereira / Zhe Liu / Umut Akinci / Tatjana Nikolic / Wilfred van IJcken / Mirjam van den Hout / Marjolein Meinders / Clara Melo / Clara Sambade / Dubravka Drabek / Rudi W. Hendriks / Sjaak Philipsen /
    Mieke Mommaas / Frank Grosveld / Helder Maiato / Joseph E. Italiano, Jr. / Catherine Robin / Niels Galjart

    Cell Reports, Vol 2, Iss 4, Pp 781-

    2012  Volume 788

    Abstract: Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells. We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, ... ...

    Abstract Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells. We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, progressive anemia, and pancytopenia, due to defects in megakaryopoiesis, in erythropoiesis, and in the maintenance of hematopoietic stem cell activity. Furthermore, microtubule stability and organization are affected upon attachment of Clasp2 knockout hematopoietic stem-cell-enriched populations, and these cells do not home efficiently toward their bone marrow niche. Strikingly, CLASP2-deficient hematopoietic stem cells contain severely reduced mRNA levels of c-Mpl, which encodes the thrombopoietin receptor, an essential factor for megakaryopoiesis and hematopoietic stem cell maintenance. Our data suggest that thrombopoietin signaling is impaired in Clasp2 knockout mice. We propose that the CLASP2-mediated stabilization of microtubules is required for proper attachment, homing, and maintenance of hematopoietic stem cells and that this is necessary to sustain c-Mpl transcription.
    Keywords Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2012-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top