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  1. Book ; Thesis: Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma (HNSCC) by regulating the homologous recombination factors PSMC3IP and RAD54L

    Nathansen, Jacqueline / Dubrovska, Anna / Rothkamm, Kai

    2022  

    Institution Zentrum für Innovationskompetenz OncoRay
    Author's details von Jacqueline Nathansen, M.Sc. geboren in Großenhain, Deutschland ; Zentrum für Innovationskompetenz OncoRay [Dresden]
    Language English
    Size xi, 179 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030077916
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1002 order for loan Magazin

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  2. Book ; Thesis: Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

    Schniewind, Iñaki / Dubrovska, Anna / Falkenburger, Björn

    2023  

    Institution Zentrum für Innovationskompetenz OncoRay
    Author's details von Iñaki Schniewind aus Gießen ; Zentrum für Innovationskompetenz OncoRay [Dresden]
    Language English
    Size XXVI, 55 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030654160
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
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  3. Book ; Thesis: Cellular plasticity affects the radiosensitivity of the aldehyde dehydrogenase positive population in prostate cancer

    Schwarz, Franziska Maria / Dubrovska, Anna / Erdmann, Kati

    2022  

    Institution Zentrum für Innovationskompetenz OncoRay
    Author's details von Franziska Maria Schwarz, M.Sc. geboren in Leonberg, Deutschland ; Zentrum für Innovationskompetenz OncoRay [Dresden]
    Language English
    Size xiv, 167, F Seiten, Illustrationen, Diagramme (farbig)
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021745284
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 481 order for loan Magazin

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  4. Article: CD98 heavy chain as a prognostic biomarker and target for cancer treatment.

    Xia, Pu / Dubrovska, Anna

    Frontiers in oncology

    2023  Volume 13, Page(s) 1251100

    Abstract: The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), ... ...

    Abstract The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1251100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cancer Stem Cells as a Therapeutic Target: Current Clinical Development and Future Prospective.

    Philchenkov, Alex / Dubrovska, Anna

    Stem cells (Dayton, Ohio)

    2023  Volume 42, Issue 3, Page(s) 173–199

    Abstract: The key role of cancer stem cells (CSCs) in tumor development and therapy resistance makes them essential biomarkers and therapeutic targets. Numerous agents targeting CSCs, either as monotherapy or as part of combination therapy, are currently being ... ...

    Abstract The key role of cancer stem cells (CSCs) in tumor development and therapy resistance makes them essential biomarkers and therapeutic targets. Numerous agents targeting CSCs, either as monotherapy or as part of combination therapy, are currently being tested in clinical trials to treat solid tumors and hematologic malignancies. Data from ongoing and future clinical trials testing novel approaches to target tumor stemness-related biomarkers and pathways may pave the way for further clinical development of CSC-targeted treatments and CSC-guided selection of therapeutic regimens. In this concise review, we discuss recent progress in developing CSC-directed treatment approaches, focusing on clinical trials testing CSC-directed therapies. We also consider the further development of CSC-assay-guided patient stratification and treatment personalization.
    MeSH term(s) Humans ; Antineoplastic Agents/therapeutic use ; Neoplasms/therapy ; Biomarkers, Tumor/metabolism ; Neoplastic Stem Cells/metabolism
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1093/stmcls/sxad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1894: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Metabolic Targeting of Cancer Stem Cells.

    Mukha, Anna / Dubrovska, Anna

    Frontiers in oncology

    2020  Volume 10, Page(s) 537930

    Abstract: Most human tumors possess a high heterogeneity resulting from both clonal evolution and cell differentiation program. The process of cell differentiation is initiated from a population of cancer stem cells (CSCs), which are enriched in tumor-regenerating ...

    Abstract Most human tumors possess a high heterogeneity resulting from both clonal evolution and cell differentiation program. The process of cell differentiation is initiated from a population of cancer stem cells (CSCs), which are enriched in tumor-regenerating and tumor-propagating activities and responsible for tumor maintenance and regrowth after treatment. Intrinsic resistance to conventional therapies, as well as a high degree of phenotypic plasticity, makes CSCs hard-to-target tumor cell population. Reprogramming of CSC metabolic pathways plays an essential role in tumor progression and metastatic spread. Many of these pathways confer cell adaptation to the microenvironmental stresses, including a shortage of nutrients and anti-cancer therapies. A better understanding of CSC metabolic dependences as well as metabolic communication between CSCs and the tumor microenvironment are of utmost importance for efficient cancer treatment. In this mini-review, we discuss the general characteristics of CSC metabolism and potential metabolic targeting of CSC populations as a potent strategy to enhance the efficacy of conventional treatment approaches.
    Language English
    Publishing date 2020-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.537930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tumor markers as an entry for SARS-CoV-2 infection?

    Xia, Pu / Dubrovska, Anna

    The FEBS journal

    2020  Volume 287, Issue 17, Page(s) 3677–3680

    Abstract: Coronavirus disease 2019 (COVID-19), the highly contagious illness caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe, becoming one of the most challenging public health crisis of our times. SARS- ... ...

    Abstract Coronavirus disease 2019 (COVID-19), the highly contagious illness caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe, becoming one of the most challenging public health crisis of our times. SARS-CoV-2 can cause severe disease associated with multiple organ damage. Cancer patients have a higher risk of SARS-CoV-2 infection and death. While the virus uses angiotensin-converting enzyme 2 (ACE2) as the primary entry receptor, the recent experimental and clinical findings suggest that some tumor markers, including CD147 (basigin), can provide an additional entry for SARS-CoV-2 infection through binding to the viral spike (S) protein. In the absence of specific viral drugs, blocking of CD147 might be a way to prevent virus invasion. Identifying other target proteins is of high importance as targeting the alternative receptors for SARS-CoV-2 might open up a promising avenue for the treatment of COVID-19 patients, including those who have cancer.
    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Basigin/antagonists & inhibitors ; Basigin/genetics ; Basigin/immunology ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; COVID-19/drug therapy ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Clinical Trials as Topic ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/virology ; Protein Binding ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; BSG protein, human ; Biomarkers, Tumor ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; metuximab ; spike protein, SARS-CoV-2 ; meplazumab (0EL07E29VQ) ; Basigin (136894-56-9) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online ; Conference proceedings: Report on the International Workshop 'Cancer stem cells: the mechanisms of radioresistance and biomarker discovery'.

    Dubrovska, Anna

    International journal of radiation biology

    2014  Volume 90, Issue 8, Page(s) 607–614

    Abstract: The aim of the Workshop "Cancer stem cells: The mechanisms of radioresistance and biomarker discovery", which was held on 23-24 September 2013 at OncoRay - National Center for Radiation Research in Oncology in Dresden, Germany, was to bring together the ... ...

    Abstract The aim of the Workshop "Cancer stem cells: The mechanisms of radioresistance and biomarker discovery", which was held on 23-24 September 2013 at OncoRay - National Center for Radiation Research in Oncology in Dresden, Germany, was to bring together the most recent viewpoints and insights about: (i) the molecular characterization and regulation of CSC, (ii) the mechanisms of CSC radioresistance, and (iii) the discovery of new CSC targeting therapeutics and biomarkers. In this report some research aspects presented in these three topics are highlighted.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/radiation effects ; Radiation Tolerance
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Congresses
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.3109/09553002.2014.920968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.280: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Tumor markers as an entry for SARS‐CoV‐2 infection?

    Xia, Pu / Dubrovska, Anna

    FEBS journal. 2020 Sept., v. 287, no. 17

    2020  

    Abstract: Coronavirus disease 2019 (COVID‐19), the highly contagious illness caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has spread across the globe, becoming one of the most challenging public health crisis of our times. SARS‐ ... ...

    Abstract Coronavirus disease 2019 (COVID‐19), the highly contagious illness caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has spread across the globe, becoming one of the most challenging public health crisis of our times. SARS‐CoV‐2 can cause severe disease associated with multiple organ damage. Cancer patients have a higher risk of SARS‐CoV‐2 infection and death. While the virus uses angiotensin‐converting enzyme 2 (ACE2) as the primary entry receptor, the recent experimental and clinical findings suggest that some tumor markers, including CD147 (basigin), can provide an additional entry for SARS‐CoV‐2 infection through binding to the viral spike (S) protein. In the absence of specific viral drugs, blocking of CD147 might be a way to prevent virus invasion. Identifying other target proteins is of high importance as targeting the alternative receptors for SARS‐CoV‐2 might open up a promising avenue for the treatment of COVID‐19 patients, including those who have cancer.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; death ; disease severity ; neoplasms ; peptidyl-dipeptidase A ; public health ; risk ; viruses
    Language English
    Dates of publication 2020-09
    Size p. 3677-3680.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15499
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2006/704: Show issues

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  10. Article: Immunotargeting of Cancer Stem Cells.

    Köseer, Ayse Sedef / Di Gaetano, Simona / Arndt, Claudia / Bachmann, Michael / Dubrovska, Anna

    Cancers

    2023  Volume 15, Issue 5

    Abstract: The generally accepted view is that CSCs hijack the signaling pathways attributed to normal stem cells that regulate the self-renewal and differentiation processes. Therefore, the development of selective targeting strategies for CSC, although clinically ...

    Abstract The generally accepted view is that CSCs hijack the signaling pathways attributed to normal stem cells that regulate the self-renewal and differentiation processes. Therefore, the development of selective targeting strategies for CSC, although clinically meaningful, is associated with significant challenges because CSC and normal stem cells share many important signaling mechanisms for their maintenance and survival. Furthermore, the efficacy of this therapy is opposed by tumor heterogeneity and CSC plasticity. While there have been considerable efforts to target CSC populations by the chemical inhibition of the developmental pathways such as Notch, Hedgehog (Hh), and Wnt/β-catenin, noticeably fewer attempts were focused on the stimulation of the immune response by CSC-specific antigens, including cell-surface targets. Cancer immunotherapies are based on triggering the anti-tumor immune response by specific activation and targeted redirecting of immune cells toward tumor cells. This review is focused on CSC-directed immunotherapeutic approaches such as bispecific antibodies and antibody-drug candidates, CSC-targeted cellular immunotherapies, and immune-based vaccines. We discuss the strategies to improve the safety and efficacy of the different immunotherapeutic approaches and describe the current state of their clinical development.
    Language English
    Publishing date 2023-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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