Article ; Online: Capability of processed EEG parameters to monitor conscious sedation in endoscopy is similar to general anaesthesia.
United European gastroenterology journal
2021 Volume 9, Issue 3, Page(s) 354–361
Abstract: Background: Reliable and safe sedation is a prerequisite for endoscopic interventions. The current standard is rather safe, yet, an objective device to measure sedation depth is missing. To date, anaesthesia monitors based on processed ... ...
| Abstract | Background: Reliable and safe sedation is a prerequisite for endoscopic interventions. The current standard is rather safe, yet, an objective device to measure sedation depth is missing. To date, anaesthesia monitors based on processed electroencephalogram (EEG) have not been utilised in conscious sedation. Objective: To investigate EEG parameters to differentiate consciousness in endoscopic propofol sedation. Methods: In total, 171 patients aged 21-83 years (ASA I-III) undergoing gastrointestinal and bronchial endoscopy were enrolled. Standard monitoring and a frontotemporal two-channel EEG were recorded. The state of consciousness was identified by repeated requests to squeeze the investigator's hand. Results: In total, 1132 state-of-consciousness (SOC) transitions were recorded in procedures ranging from 5 to 69 min. Thirty-four EEG parameters from the frequency domain, time-frequency domain and complexity measures were calculated. Area under the curve ranged from 0.51 to 0.82 with complexity and optimised frequency domain parameters yielding the best results. Conclusion: Prediction of the SOC with processed EEG parameters is feasible, and the results for sedation in endoscopic procedures are similar to those reported from general anaesthesia. These results are insufficient for a clinical application, but prediction capability may be increased with optimisation and modelling. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Anesthesia, General ; Area Under Curve ; Bronchoscopy ; Conscious Sedation ; Consciousness ; Electroencephalography/methods ; Endoscopy, Gastrointestinal ; Female ; Humans ; Hypnotics and Sedatives ; Intraoperative Neurophysiological Monitoring/methods ; Male ; Middle Aged ; Propofol ; Time Factors ; Young Adult |
| Chemical Substances | Hypnotics and Sedatives ; Propofol (YI7VU623SF) |
| Language | English |
| Publishing date | 2021-02-11 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2728585-6 |
| ISSN | 2050-6414 ; 2050-6406 |
| ISSN (online) | 2050-6414 |
| ISSN | 2050-6406 |
| DOI | 10.1177/2050640620959153 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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