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  1. Book: Football's secret trade

    Duff, Alex / Panja, Tariq

    how the player transfer market was infiltrated

    2017  

    Abstract: A no-holds-barred exposé on the financial transactions of the world's favourite sport The transfer fees clubs pay to sign top players now top €4 billion a year but much of the money has been flowing out of the game. A small group of wealthy ... ...

    Author's details Alex Duff, Tariq Panja
    Abstract "A no-holds-barred exposé on the financial transactions of the world's favourite sport The transfer fees clubs pay to sign top players now top €4 billion a year but much of the money has been flowing out of the game. A small group of wealthy investors including Russian oligarchs, English racehorse owners and a former billionaire gold miner have seized the opportunity to enter this booming market. Some have moved in on the territory of banks and lent money to clubs in exchange for a share in fees generated by Cristiano Ronaldo, Neymar and dozens more of today's stars. Others have acquired obscure teams to get a piece of the pie. Even as the global financial crisis sent fortunes tumbling this select group found a profitable place to park their money. The size of the transfer market has continued to rise –- it increased seven-fold in value the last two decades, more than the FTSE share index. Between them, these wealthy investors have amassed hundreds of millions of euros in profits. At the same time, they have managed to stay out of the spotlight the world’s most popular sport brings. Football’s Secret Trade follows the money along a trail very few know about, from nondescript offices in the U.K. and ramshackle stadiums of South American clubs you have probably never heard of to offshore bank accounts in the Caribbean. Warning – you won’t see a major transfer deal in the same light again."

    "The book will appeal to a global audience: to anyone with an interest in soccer, sports and business. They will be shocked to learn what goes on behind the scenes of the world's most popular sport."

    Machine generated contents note: Prologue 1 1 The Son of Jesús 9 2 The Chess Champion 23 3 The British Tax Exile 41 4 An East End Scandal 53 5 The Prime Minister's Men 67 6 The 100-to-1 Shot 79 7 The Switzerland of South America 93 8 "Todo Pasa" 107 9 Buenos Aires to Manchester 121 10 "I Want 40% for the Boy" 137 11 The Pharmacist's Medicine 151 12 Working on a Dream 161 13 The Baur au Lac 175 14 The End Game? 187 Epilogue 199 Bibliography 207 Acknowledgments 209 About the Authors 211 Index 213
    Keywords Soccer/Economic aspects ; Soccer players/Trading of ; Sportler ; Fußball ; Profisport ; Sportbranche ; Vermittlungstätigkeit ; Welt
    Language English
    Size vi, 223 Seiten
    Publisher Wiley
    Publishing place Chichester, West Sussex, United Kingdom
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9781119145424 ; 9781119145448 ; 9781119145455 ; 1119145422 ; 1119145449 ; 1119145457
    Database ECONomics Information System

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  2. Article ; Online: Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase.

    Leahy, Darren / Grant, Cameron / Jackson, Alex / Duff, Alex / Tardiota, Nicholas / Van Haeften, Jessica / Chen, Xingchen / Peake, Jonathan M / Kruppa, Michael D / Smith, Eliot T / Johnson, David A / Lott, William B / Harris, Jonathan M

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 17

    Abstract: Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune ... ...

    Abstract Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune response to invading pathogens, it is responsible for the collateral host tissue damage observed in chronic conditions such as chronic obstructive pulmonary disease (COPD), and in more acute disorders such as the lung injuries associated with COVID-19 infection. Previously, a combinatorially selected activity-based probe revealed an unexpected substrate preference for oxidised methionine, which suggests a link to oxidative pathogen clearance by neutrophils. Here we use oxidised model substrates and inhibitors to confirm this observation and to show that neutrophil elastase is specifically selective for the di-oxygenated methionine sulfone rather than the mono-oxygenated methionine sulfoxide. We also posit a critical role for ordered solvent in the mechanism of HNE discrimination between the two oxidised forms methionine residue. Preference for the sulfone form of oxidised methionine is especially significant. While both host and pathogens have the ability to reduce methionine sulfoxide back to methionine, a biological pathway to reduce methionine sulfone is not known. Taken together, these data suggest that the oxidative activity of neutrophils may create rapidly cleaved elastase "super substrates" that directly damage tissue, while initiating a cycle of neutrophil oxidation that increases elastase tissue damage and further neutrophil recruitment.
    MeSH term(s) Biocatalysis ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain/genetics ; Enzyme Assays ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Leukocyte Elastase/antagonists & inhibitors ; Leukocyte Elastase/genetics ; Leukocyte Elastase/metabolism ; Lung/immunology ; Lung/pathology ; Lung/virology ; Methionine/analogs & derivatives ; Methionine/metabolism ; Molecular Dynamics Simulation ; Neutrophil Infiltration ; Neutrophils/enzymology ; Neutrophils/immunology ; Oxidation-Reduction/drug effects ; Proteolysis/drug effects ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/pathology ; SARS-CoV-2/immunology ; Substrate Specificity/immunology
    Chemical Substances methionine sulfone (1118-85-0) ; Methionine (AE28F7PNPL) ; ELANE protein, human (EC 3.4.21.37) ; Leukocyte Elastase (EC 3.4.21.37) ; methionine sulfoxide (XN1XVI4B2C)
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26175344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer.

    Suraweera, Amila / Duff, Alex / Adams, Mark N / Jekimovs, Christian / Duijf, Pascal H G / Liu, Cheng / McTaggart, Matthew / Beard, Sam / O'Byrne, Kenneth J / Richard, Derek J

    British journal of cancer

    2021  Volume 124, Issue 9, Page(s) 1612

    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01242-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer.

    Suraweera, Amila / Duff, Alex / Adams, Mark N / Jekimovs, Christian / Duijf, Pascal H G / Liu, Cheng / McTaggart, Matthew / Beard, Sam / O'Byrne, Kenneth J / Richard, Derek J

    British journal of cancer

    2020  Volume 123, Issue 4, Page(s) 591–603

    Abstract: Background: Non-small cell lung cancers (NSCLC) account for 85-90% of all lung cancers. As drug resistance critically impairs chemotherapy effectiveness, there is great need to identify new therapeutic targets. The aims of this study were to investigate ...

    Abstract Background: Non-small cell lung cancers (NSCLC) account for 85-90% of all lung cancers. As drug resistance critically impairs chemotherapy effectiveness, there is great need to identify new therapeutic targets. The aims of this study were to investigate the prognostic and therapeutic potential of the copper-metabolism-domain-protein, COMMD4, in NSCLC.
    Methods: The expression of COMMD4 in NSCLC was investigated using bioinformatic analysis, immunoblotting of immortalised human bronchial epithelial (HBEC) and NSCLC cell lines, qRT-PCR and immunohistochemistry of tissue microarrays. COMMD4 function was additionally investigated in HBEC and NSCLC cells depleted of COMMD4, using small interfering RNA sequences.
    Results: Bioinformatic analysis and in vitro analysis of COMMD4 transcripts showed that COMMD4 levels were upregulated in NSCLC and elevated COMMD4 was associated with poor prognosis in adenocarcinoma (ADC). Immunoblotting demonstrated that COMMD4 expression was upregulated in NSCLC cells and siRNA-depletion of COMMD4, decreased cell proliferation and reduced cell viability. Cell death was further enhanced after exposure to DNA damaging agents. COMMD4 depletion caused NSCLC cells to undergo mitotic catastrophe and apoptosis.
    Conclusions: Our data indicate that COMMD4 may function as a prognostic factor in ADC NSCLC. Additionally, COMMD4 is a potential therapeutic target for NSCLC, as its depletion induces cancer cell death.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Computational Biology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Tissue Array Analysis ; Up-Regulation
    Chemical Substances Adaptor Proteins, Signal Transducing ; Biomarkers, Tumor
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-0899-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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