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Article ; Online: Role of TKI for Metastatic Osteogenic Sarcoma.

Duffaud, Florence

2020 Volume 21, Issue 8, Page(s) 65

Abstract: Opinion statement: Osteosarcomas (OS) belong to a large family of mesenchymal tumor entities which exhibit heterogenous histological, genetic, and molecular features. Current OS treatment regimen consists of the combination of surgery and intensive ... ...

Abstract	Opinion statement: Osteosarcomas (OS) belong to a large family of mesenchymal tumor entities which exhibit heterogenous histological, genetic, and molecular features. Current OS treatment regimen consists of the combination of surgery and intensive multi-agent chemotherapy. Ever since the introduction of chemotherapy, 5-year survival rate among OS patients has improved to 60-75%. However, 30-35% of OS patients are associated with pulmonary metastasis and relapse, which have significantly poor prognosis, with an overall 5-year survival rate of about 20%. The fact that OS are both rare forms of cancer and highly heterogeneous may explain why patients' survival has not improved in the past three decades, especially for metastatic/relapsed and unresectable osteosarcomas. Patients who experience relapse with metastatic disease have limited therapeutic options, often receiving additional cytotoxic therapy such as ifosfamide and etoposide and/or carboplatin or gemcitabine plus docetaxel. Novel precise OS-targeted thrapies are being developed with the hope of improving metastatic/relapsed OS prognosis. This review provides an overview of the most updated targeted therapies in relapsed/metastatic osteosarcoma and dicusses some clinical options in order to improve progression-free survival.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Bone Neoplasms/drug therapy ; Bone Neoplasms/etiology ; Bone Neoplasms/pathology ; Clinical Trials as Topic ; Disease Management ; Drug Evaluation, Preclinical ; Humans ; Molecular Targeted Therapy ; Osteosarcoma/drug therapy ; Osteosarcoma/etiology ; Osteosarcoma/pathology ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; Protein Kinase Inhibitors ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2020-06-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-020-00760-w
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Zs.A 5523: Show issues

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Article ; Online: Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review.

Krouma, Manel / Farah, Kaissar / Choucha, Anis / Appay, Romain / Duffaud, Florence / Fuentes, Stephane / Dufour, Henry

Neuro-Chirurgie

2024 , Page(s) 101562

Abstract: Intradural Extraosseous Ewing sarcoma (IEES) is an infrequent occurrence. We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed ... ...

Abstract	Intradural Extraosseous Ewing sarcoma (IEES) is an infrequent occurrence. We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patients with intradural spinal tumors with careful consideration of this diagnosis. To further investigate this condition, we conducted a thorough review of the literature on IEES involving the lumbar spine and cauda equina. Our analysis revealed that patients with this condition frequently exhibit rapidly progressive neurological symptoms likely attributed to hemorrhagic transformation. This characteristic may serve as a distinguishing factor from other lesion types, particularly benign ones. Our study provides a comprehensive summary that can offer direction for clinical management in comparable uncommon and novel cases.
Language	English
Publishing date	2024-04-13
Publishing country	France
Document type	Journal Article
ZDB-ID	207146-0
ISSN	1773-0619 ; 0028-3770 ; 0150-9586
ISSN (online)	1773-0619
ISSN	0028-3770 ; 0150-9586
DOI	10.1016/j.neuchi.2024.101562
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Article ; Online: Diffusion weighted imaging changes in extra-abdominal desmoid tumor after cryotherapy.

Cadour, Farah / Tradi, Farouk / Bartoli, Axel / Duffaud, Florence / Gaubert, Jean-Yves

Annals of medicine

2023 Volume 55, Issue 1, Page(s) 521–525

Abstract: Desmoid tumors (DT) are rare benign tumors with a local invasion potential and recurrence. It is characterized on histology by an abnormal fibroblastic proliferation in a collagenous stroma, in variable proportions leading to heterogeneity of the lesion ... ...

Abstract	Desmoid tumors (DT) are rare benign tumors with a local invasion potential and recurrence. It is characterized on histology by an abnormal fibroblastic proliferation in a collagenous stroma, in variable proportions leading to heterogeneity of the lesion signal on magnetic resonance imaging (MRI). Current guidelines propose watchful waiting but in case of progression or symptoms, cryotherapy may be a therapeutic option in its extra-abdominal form. Tumor recurrence is mostly detected based on post-contrast magnetic resonance imaging (MRI). Although DWI sequence is the key-sequence for tumor detection in oncologic imaging, there are very few data in literature on diffusion weighted imaging (DWI) in DT generally and even fewer on DT after cryotherapy. DWI changes after cryotherapy may be confusing and suspicious of residual tumor or tumor recurrence when displaying low ADC values; thus knowledge of possible DWI patterns after cryotherapy of DT seem paramount. We found that the early changes of DT after cryotherapy are hyperintensity on DWI sequence with low ADC values (<1.00 × 10
MeSH term(s)	Male ; Humans ; Fibromatosis, Aggressive/diagnostic imaging ; Fibromatosis, Aggressive/therapy ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/therapy ; Diffusion Magnetic Resonance Imaging/methods ; Necrosis ; Cryotherapy
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2174589
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Zs.A 680: Show issues

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Article ; Online: Pembrolizumab monotherapy for advanced chordoma - Authors' reply.

Blay, Jean-Yves / Penel, Nicolas / Duffaud, Florence / Bompas, Emmanuelle / Massard, Christophe / Chevret, Sylvie

The Lancet. Oncology

2023 Volume 24, Issue 10, Page(s) e400

MeSH term(s)	Humans ; Chordoma/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Agents, Immunological/adverse effects
Chemical Substances	pembrolizumab (DPT0O3T46P) ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00454-0
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

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Article ; Online: "Fortunately I felt pain, or I would have thought I was on my way out": experiencing pain and negotiating analgesic treatment in the context of cancer.

Restivo, Léa / Dudoit, Éric / Duffaud, Florence / Salas, Sébastien / Dany, Lionel

Journal of psychosocial oncology

2022 Volume 41, Issue 2, Page(s) 150–165

Abstract: Objectives: To explore cancer patients' experience of pain and coping strategies as well as beliefs and representations associated with pain, pain management and treatments.: Method and participants: A qualitative study based on semi-structured ... ...

Abstract	Objectives: To explore cancer patients' experience of pain and coping strategies as well as beliefs and representations associated with pain, pain management and treatments. Method and participants: A qualitative study based on semi-structured interviews was conducted among 16 patients with cancer. The inductive research strategy adopted derived from the Grounded Theory approach and the data transcribed verbatim were gradually analyzed involving researcher triangulation. Findings: The experience of pain and the coping strategies developed by patients to deal with it are shaped by the experience and representations of cancer associated with death and suffering. Pain acts both as an indication to the patients that they are still alive and as an indicator of the progression of the disease. Cancer also models patients' relationships to analgesic treatments and health care providers, since pain is an area in which patients can take back control of what is happening to them. Patients' expression of reluctance to accept analgesic treatments is also influenced by the significance of opioid treatments in this context, which are perceived as an indication that the end of life is close. Conclusions: The contextualization of pain through the particularities of cancer is critical in order to understand cancer patients' experience of pain. Implications for psychosocial providers: Not only patients' knowledge but also the meaning-making of pain should be incorporated in interventions targeting pain management.
MeSH term(s)	Humans ; Negotiating ; Pain/psychology ; Neoplasms/psychology ; Adaptation, Psychological ; Qualitative Research ; Analgesics
Chemical Substances	Analgesics
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	605892-9
ISSN	1540-7586 ; 0734-7332
ISSN (online)	1540-7586
ISSN	0734-7332
DOI	10.1080/07347332.2022.2074337
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Zs.A 2006: Show issues

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Article ; Online: Response to letter entitled: Re: Efficacy and safety of regorafenib in patients with metastatic or locally-advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.

Duffaud, Florence / Schiffler, Camille / Chabaud, Sylvie / Blay, Jean-Yves

European journal of cancer (Oxford, England : 1990)

2021 Volume 157, Page(s) 527–528

MeSH term(s)	Chondrosarcoma ; Double-Blind Method ; Humans ; Phenylurea Compounds/adverse effects ; Pyridines/adverse effects
Chemical Substances	Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2021.08.009
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Regorafenib for the Treatment of Sarcoma.

Blay, Jean-Yves / Duffaud, Florence / George, Suzanne / Maki, Robert G / Penel, Nicolas

Current treatment options in oncology

2022 Volume 23, Issue 11, Page(s) 1477–1502

Abstract: Opinion statement: Sarcomas are a rare group of tumors with many subtypes, conventionally classified into soft-tissue sarcomas and bone sarcomas. Chemotherapeutic regimens form the mainstay of systemic therapy but are not well defined beyond the first- ... ...

Abstract	Opinion statement: Sarcomas are a rare group of tumors with many subtypes, conventionally classified into soft-tissue sarcomas and bone sarcomas. Chemotherapeutic regimens form the mainstay of systemic therapy but are not well defined beyond the first-line setting and clinical outcomes are variable. Tyrosine kinase inhibitors (TKIs), with a broad inhibition profile which have been shown to target tumor angiogenesis, have an established role in the treatment of sarcomas without characteristic driver alterations. One such TKI, regorafenib, has been evaluated in sarcomas and clinical data are discussed in this review. An overview of regorafenib data from five phase 2 and one phase 1b clinical trials in over 10 sarcoma subtypes (both soft-tissue and bone) in adult and pediatric patients is reviewed. Regorafenib demonstrated clinical benefit in patients with non-adipocytic soft-tissue sarcomas, osteosarcoma and Ewing sarcoma who had progressed on prior therapy. Patients with otherwise limited treatment options may therefore benefit from regorafenib therapy.
MeSH term(s)	Adult ; Humans ; Child ; Phenylurea Compounds/adverse effects ; Sarcoma/drug therapy ; Soft Tissue Neoplasms/drug therapy ; Osteosarcoma/drug therapy ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Protein Kinase Inhibitors/adverse effects
Chemical Substances	regorafenib (24T2A1DOYB) ; Phenylurea Compounds ; Protein Kinase Inhibitors
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-022-00990-0
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Article: Recent advances in managing gastrointestinal stromal tumor.

Duffaud, Florence / Le Cesne, Axel

F1000Research

2017 Volume 6, Page(s) 1689

Abstract: Constitutive activating mutations ... ...

Abstract	Constitutive activating mutations in
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699932-8
ISSN	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.11118.1
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Article ; Online: From rare to well-done: importance of rare tumors in cancer therapeutic advances.

Duffaud, Florence / Piperno-Neumann, Sophie / Penel, Nicolas / Blay, Jean-Yves

Oncotarget

2019 Volume 10, Issue 40, Page(s) 3998–3999

Language	English
Publishing date	2019-06-18
Publishing country	United States
Document type	Editorial
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.27020
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Article ; Online: Sarcomes utérins du stroma de haut grade et sarcomes indifférenciés – Référentiels de prise en charge du Groupe Sarcome Français et du Groupe des Tumeurs Rares Gynécologiques.

Roussel-Simonin, Cyril / Croce, Sabrina / Guyon, Frédéric / Llacer, Carmen / Ray-Coquard, Isabelle / Meeus, Pierre / Genestie, Catherine / Taieb, Sophie / Malhaire, Caroline / Duffaud, Florence / Pautier, Patricia

Bulletin du cancer

2023 Volume 110, Issue 7-8, Page(s) 855–864

Abstract: High-grade endometrial stromal sarcoma (HGESS) and uterine undifferentiated sarcoma (UUS) are rare uterine malignancies arising from mesenchymal endometrial cells. They are characterized by aggressive behavior and poor prognosis. Median age of diagnostic ...

Title translation	Uterin sarcoma, high-grade stroma, indifferenciated, referential.
Abstract	High-grade endometrial stromal sarcoma (HGESS) and uterine undifferentiated sarcoma (UUS) are rare uterine malignancies arising from mesenchymal endometrial cells. They are characterized by aggressive behavior and poor prognosis. Median age of diagnostic is 55years. The most common symptoms are vaginal bleeding, abdominal pain, and pelvic mass. Approximately 65 % are diagnosed witch advance disease stage III or IV according to the International Federation of Gynecology and Obstetrics classification. Median overall survival is around 20months. The management of the disease must be discussed in multidisciplinary staff meetings. The standard management of HGESS and UUS is total hysterectomy with bilateral oophorectomy. Systematic lymphadenectomy is not recommended. Adjuvant therapies, such as chemotherapy and radiotherapy must be discussed. In case of oligo-metastasic disease, surgery of the primary tumor and metastasis must be discussed and if not operable the standard management is doxorubine-based chemotherapy.
MeSH term(s)	Female ; Humans ; Middle Aged ; Uterine Neoplasms/surgery ; Sarcoma/surgery ; Combined Modality Therapy ; Hysterectomy ; Ovariectomy ; Endometrial Neoplasms/therapy ; Endometrial Neoplasms/pathology ; Neoplasm Staging
Language	French
Publishing date	2023-04-14
Publishing country	France
Document type	English Abstract ; Practice Guideline
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2023.03.017
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