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  1. AU="Dufresne, Philippe J"
  2. AU="Dickey, Erin M"
  3. AU="Alessia Nava"
  4. AU="Yamoah, Peter"
  5. AU="Solit, David"
  6. AU="Raymond, Benjamin"
  7. AU="Maddi, Abhiram"
  8. AU="Rodríguez, Johanna G"
  9. AU="Frans, J"
  10. AU="Elisa Palazzari"

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  1. Artikel: Corrigendum to 'Rhinitis due to

    Langlois, Isabelle / Barrs, Vanessa R / Dufresne, Philippe J

    Medical mycology case reports

    2021  Band 33, Seite(n) 38

    Abstract: This corrects the article DOI: 10.1016/j.mmcr.2020.11.001.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.mmcr.2020.11.001.].
    Sprache Englisch
    Erscheinungsdatum 2021-07-08
    Erscheinungsland Netherlands
    Dokumenttyp Published Erratum
    ZDB-ID 2670415-8
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2021.06.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Microbiological characterization of

    Lieu, Anthony / Lee, Todd C / Lawandi, Alexander / Tellier, Raymond / Cheng, Matthew P / Dufresne, Philippe J

    Journal of clinical microbiology

    2023  Band 61, Heft 11, Seite(n) e0091323

    Abstract: Bronchoalveolar lavage is usually employed for molecular diagnosis ... ...

    Abstract Bronchoalveolar lavage is usually employed for molecular diagnosis of
    Mesh-Begriff(e) Humans ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/microbiology ; Retrospective Studies ; Bronchoalveolar Lavage Fluid/microbiology ; Sensitivity and Specificity ; Canada ; Polymerase Chain Reaction/methods ; Pneumocystis carinii/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-10-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00913-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Quick versus Quantitative: Evaluation of Two Commercial Real-Time PCR Assays for the Detection of Pneumocystis jirovecii from Bronchoalveolar Lavage Fluids.

    Belanger, Corrie R / Locher, Kerstin / Velapatino, Billie / Dufresne, Philippe J / Eckbo, Eric / Charles, Marthe

    Microbiology spectrum

    2023  Band 11, Heft 4, Seite(n) e0102123

    Abstract: Two commercial real-time PCR assays for the detection of Pneumocystis jirovecii were compared, the quantitative RealStar P. jirovecii assay and the qualitative DiaSorin P. jirovecii assay, the latter of which can be used without nucleic acid extraction. ... ...

    Abstract Two commercial real-time PCR assays for the detection of Pneumocystis jirovecii were compared, the quantitative RealStar P. jirovecii assay and the qualitative DiaSorin P. jirovecii assay, the latter of which can be used without nucleic acid extraction. Archived bronchoalveolar lavage (BAL) specimens (
    Mesh-Begriff(e) Humans ; Pneumocystis carinii/genetics ; Bronchoalveolar Lavage Fluid ; Real-Time Polymerase Chain Reaction/methods ; Pneumonia, Pneumocystis/diagnosis ; Sensitivity and Specificity
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01021-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Keratitis from an entomopathogenic fungus: second case of Metarhizium anisopliae infection in Canada.

    Antaki, Fares / Bouhadana, David / Toma, Emil / Dufresne, Philippe J / Robert, Marie-Claude

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Band 56, Heft 6, Seite(n) e189–e191

    Mesh-Begriff(e) Canada ; Humans ; Keratitis/microbiology ; Male ; Metarhizium ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2021-05-06
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.04.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Changing Patterns of Disease Severity in Blastomyces dermatitidis Infection, Quebec, Canada.

    Carignan, Alex / Boudhrioua, Chiheb / Moreira, Sandrine / Pelletier, Andrée Ann / Dufour, Kevin / Pépin, Jacques / Allard, Catherine / Marcoux, Dominique / Dufresne, Philippe J

    Emerging infectious diseases

    2021  Band 27, Heft 11, Seite(n) 2810–2817

    Abstract: This retrospective multicenter cohort study assessed temporal changes in the severity and mortality rate of blastomycosis in Quebec, Canada, and identified risk factors for death in patients with blastomycosis in 1988-2016. The primary outcome was 90-day ...

    Abstract This retrospective multicenter cohort study assessed temporal changes in the severity and mortality rate of blastomycosis in Quebec, Canada, and identified risk factors for death in patients with blastomycosis in 1988-2016. The primary outcome was 90-day all-cause deaths. Among 185 patients, 122 (66%) needed hospitalization and 30 (16%) died. We noted increases in the proportion of severe cases, in age at diagnosis and in the proportion of diabetic and immunocompromised patients over time. Independent risk factors for death were age (adjusted odds ratio [aOR] 1.04, 95% CI 1.00-1.07), immunosuppression (aOR 4.2, 95% CI 1.5-11.6), and involvement of >2 lung lobes (aOR 5.3, 95% CI 1.9-14.3). There was no association between the Blastomyces genotype group and all-cause mortality. The proportion of severe cases of blastomycosis has increased in Quebec over the past 30 years, partially explained by the higher number of immunosuppressed patients.
    Mesh-Begriff(e) Blastomyces ; Blastomycosis/epidemiology ; Cohort Studies ; Humans ; Quebec/epidemiology ; Retrospective Studies ; Severity of Illness Index
    Sprache Englisch
    Erscheinungsdatum 2021-10-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2711.210552
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Reagent-Free Identification of Clinical Yeasts by Use of Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy.

    Lam, Lisa M T / Dufresne, Philippe J / Longtin, Jean / Sedman, Jacqueline / Ismail, Ashraf A

    Journal of clinical microbiology

    2019  Band 57, Heft 5

    Abstract: Invasive fungal infections by opportunistic yeasts have increased concomitantly with the growth of an immunocompromised patient population. Misidentification of yeasts can lead to inappropriate antifungal treatment and complications. Attenuated total ... ...

    Abstract Invasive fungal infections by opportunistic yeasts have increased concomitantly with the growth of an immunocompromised patient population. Misidentification of yeasts can lead to inappropriate antifungal treatment and complications. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is a promising method for rapid and accurate identification of microorganisms. ATR-FTIR spectroscopy is a standalone, inexpensive, reagent-free technique that provides results within minutes after initial culture. In this study, a comprehensive spectral reference database of 65 clinically relevant yeast species was constructed and tested prospectively on spectra recorded (from colonies taken from culture plates) for 318 routine yeasts isolated from various body fluids and specimens received from 38 microbiology laboratories over a 4-month period in our clinical laboratory. ATR-FTIR spectroscopy attained comparable identification performance with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). In a preliminary validation of the ATR-FTIR method, correct identification rates of 100% and 95.6% at the genus and species levels, respectively, were achieved, with 3.5% unidentified and 0.9% misidentified. By expanding the number of spectra in the spectral reference database for species for which isolates could not be identified or had been misidentified, we were able to improve identification at the species level to 99.7%. Thus, ATR-FTIR spectroscopy provides a new standalone method that can rival MALDI-TOF MS for the accurate identification of a broad range of medically important yeasts. The simplicity of the ATR-FTIR spectroscopy workflow favors its use in clinical laboratories for timely and low-cost identification of life-threatening yeast strains for appropriate treatment.
    Mesh-Begriff(e) Body Fluids/microbiology ; Databases, Factual ; Humans ; Indicators and Reagents ; Mycoses/diagnosis ; Mycoses/microbiology ; Prospective Studies ; Spectroscopy, Fourier Transform Infrared ; Yeasts/classification ; Yeasts/isolation & purification
    Chemische Substanzen Indicators and Reagents
    Sprache Englisch
    Erscheinungsdatum 2019-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01739-18
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Four genomic clades of Candida auris identified in Canada, 2012-2019.

    De Luca, Domenica G / Alexander, David C / Dingle, Tanis C / Dufresne, Philippe J / Hoang, Linda M / Kus, Julianne V / Schwartz, Ilan S / Mulvey, Michael R / Bharat, Amrita

    Medical mycology

    2021  Band 60, Heft 1

    Abstract: Candida auris is an emerging yeast that is associated with antifungal resistance and healthcare-associated outbreaks. From 2012 to 2019, there were 24 known cases of C. auris colonization or infection in Canada. Isolates were from axilla/groin (n = 6), ... ...

    Abstract Candida auris is an emerging yeast that is associated with antifungal resistance and healthcare-associated outbreaks. From 2012 to 2019, there were 24 known cases of C. auris colonization or infection in Canada. Isolates were from axilla/groin (n = 6), ear (n = 5), blood (n = 4), toe (n = 2), and a variety of other sites (n = 7). Canadian isolates belonged to the four main genomic clades: Clade I (formerly called South Asian clade, n = 12), Clade II (East Asian, n = 3), Clade III (African, n = 4), and Clade IV (South American, n = 5). Isolates within each clade were clonal; however, whole genome sequencing may be helpful in identifying clusters within healthcare facilities.
    Lay summary: The fungal pathogen Candida auris has caused many hospital outbreaks and is often multidrug resistant. All four major strains of C. auris were identified in Canada from 2012 to 2019. Genomic epidemiology may be useful for identifying and reducing transmission of C. auris within hospitals.
    Mesh-Begriff(e) Animals ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Canada/epidemiology ; Candida/genetics ; Candida auris ; Genomics ; Microbial Sensitivity Tests/veterinary
    Chemische Substanzen Antifungal Agents
    Sprache Englisch
    Erscheinungsdatum 2021-12-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myab079
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Draft Genome Sequences of Azole-Resistant and Azole-Susceptible Aspergillus turcosus Clinical Isolates Recovered from Bronchoalveolar Lavage Fluid Samples.

    Parent-Michaud, Maxime / Dufresne, Philippe J / Fournier, Éric / Martineau, Christine / Moreira, Sandrine / Perkins, Vincent / de Repentigny, Louis / Dufresne, Simon F

    Microbiology resource announcements

    2019  Band 8, Heft 1

    Abstract: We present the draft genome sequences of two clinical strains of Aspergillus turcosus, one azole-susceptible (strain HMR-AF-23/LSPQ-01275) and the other azole-resistant (strain HMR-AF-1038/LSPQ-01280), isolated from bronchoalveolar lavage fluid of two ... ...

    Abstract We present the draft genome sequences of two clinical strains of Aspergillus turcosus, one azole-susceptible (strain HMR-AF-23/LSPQ-01275) and the other azole-resistant (strain HMR-AF-1038/LSPQ-01280), isolated from bronchoalveolar lavage fluid of two adult patients. These two strains are the first reported clinical isolates of A. turcosus.
    Sprache Englisch
    Erscheinungsdatum 2019-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01446-18
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Draft Genome Sequence of Azole-Resistant Aspergillus thermomutatus (Neosartorya pseudofischeri) Strain HMR-AF-39, Isolated from a Human Nasal Septum Abscess Aspirate.

    Parent-Michaud, Maxime / Dufresne, Philippe J / Fournier, Éric / Martineau, Christine / Moreira, Sandrine / Perkins, Vincent / de Repentigny, Louis / Dufresne, Simon F

    Microbiology resource announcements

    2019  Band 8, Heft 1

    Abstract: Here, we present the draft genome sequence of Aspergillus thermomutatus (formerly known as Neosartorya pseudofischeri; strain HMR-AF-39/LSPQ-01276), a cryptic species of Aspergillus section Fumigati. This species is intrinsically resistant to antifungal ... ...

    Abstract Here, we present the draft genome sequence of Aspergillus thermomutatus (formerly known as Neosartorya pseudofischeri; strain HMR-AF-39/LSPQ-01276), a cryptic species of Aspergillus section Fumigati. This species is intrinsically resistant to antifungal azoles and is recognized as an agent of invasive aspergillosis among immunocompromised hosts.
    Sprache Englisch
    Erscheinungsdatum 2019-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01444-18
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Triazole Antifungal Susceptibility Patterns among

    Cheng, Matthew P / Lawandi, Alexander / Lee, Todd C / Dufresne, Philippe J / Seidel, Danila / Verweij, Paul E / Cornely, Oliver A / Sheppard, Donald C

    Journal of clinical microbiology

    2019  Band 57, Heft 6

    Mesh-Begriff(e) Antifungal Agents/pharmacology ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Aspergillosis/microbiology ; Aspergillus/drug effects ; Drug Resistance, Fungal ; Humans ; Microbial Sensitivity Tests ; Quebec/epidemiology ; Triazoles/pharmacology
    Chemische Substanzen Antifungal Agents ; Triazoles
    Sprache Englisch
    Erscheinungsdatum 2019-05-24
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00404-19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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