Article ; Online: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis.
Molecular therapy : the journal of the American Society of Gene Therapy
2024 Volume 32, Issue 4, Page(s) 1125–1143
Abstract: The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we aim to decipher how sustained β-catenin ... ...
Abstract | The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we aim to decipher how sustained β-catenin activation regulates DLK1/DIO3 locus expression and the role this locus plays in HB and HCC development in mouse models deleted for Apc (Apc |
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MeSH term(s) | Animals ; Humans ; Mice ; beta Catenin/genetics ; beta Catenin/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Catenins/genetics ; Catenins/metabolism ; Cell Proliferation/genetics ; Liver Neoplasms/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Up-Regulation |
Chemical Substances | beta Catenin ; Calcium-Binding Proteins ; Catenins ; DLK1 protein, human ; Membrane Proteins ; iodothyronine deiodinase type III (EC 1.11.1.-) ; CTNNB1 protein, human |
Language | English |
Publishing date | 2024-02-03 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2010592-7 |
ISSN | 1525-0024 ; 1525-0016 |
ISSN (online) | 1525-0024 |
ISSN | 1525-0016 |
DOI | 10.1016/j.ymthe.2024.01.036 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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