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  1. AU="Dumolard, Anne"
  2. AU="Cheng-Zhong Zhang"
  3. AU="Song, Jiwu"
  4. AU="Terwilliger, Gordon"
  5. AU="Elhamzaoui, Hamza"
  6. AU="Béganton, Benoît"
  7. AU=Smith Zachary D.
  8. AU="Dotta, Federico"
  9. AU="Palmer, Andre"
  10. AU="Cai, Biao"
  11. AU="Leroux, Michel R"
  12. AU="Thomson, Jaidyn"
  13. AU="Novillo-Del Álamo, Blanca"
  14. AU="Deps, Patrícia D"

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  1. Artikel ; Online: Central Sensitization and Small-fiber Neuropathy Are Associated in Patients With Fibromyalgia.

    Dumolard, Anne / Lefaucheur, Jean-Pascal / Hodaj, Enkelejda / Liateni, Zaki / Payen, Jean-François / Hodaj, Hasan

    The Clinical journal of pain

    2023  Band 39, Heft 1, Seite(n) 8–14

    Abstract: Objective: To study the prevalence of small-fiber neuropathy (SFN) in a large cohort of patients with fibromyalgia (FM) and to better characterize the subset of patients with both FM and SFN.: Methods: This 1-year, retrospective, observational cohort ...

    Abstract Objective: To study the prevalence of small-fiber neuropathy (SFN) in a large cohort of patients with fibromyalgia (FM) and to better characterize the subset of patients with both FM and SFN.
    Methods: This 1-year, retrospective, observational cohort study included 265 patients with FM. They all performed electrochemical skin conductance (ESC) using the Sudoscan device, 1 of the simplest and most reliable technique to assess the distal autonomic nerve fibers. They completed 4 self-assessment questionnaires: (1) the Central Sensitization Inventory (CSI), (2) the Neuropathic Pain Symptom Inventory (NPSI), and (3) the Hospital Anxiety and Depression Scale (HADS), the Fibromyalgia Impact Questionnaire (FIQ).
    Results: Fifty-three patients (20%) had reduced ESC values. These patients had higher CSI and HADS scores, and a larger intake of analgesic drugs compared with patients with no ESC abnormalities. Central sensitization, which was extreme in 69% of the patients (CSI score ≥60), was 1 of the main determinants of ESC abnormalities and was associated with a higher NPSI score, even though these 2 factors were not correlated.
    Conclusion: Over the past 10 years, studies have shown that a significant proportion of patients with FM have signs of small nerve fiber impairment. The possible involvement of SFN, in the occurrence and presentation of clinical symptoms in FM patients, remains however unclear. This is the first study that showed an association between central sensitization and both small nerve fiber impairment and neuropathic pain features in FM patients, rather than a direct association between SFN and neuropathic pain.
    Mesh-Begriff(e) Humans ; Fibromyalgia/complications ; Fibromyalgia/diagnosis ; Central Nervous System Sensitization ; Retrospective Studies ; Neuralgia/epidemiology ; Neuralgia/complications ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2023-01-01
    Erscheinungsland United States
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 632582-8
    ISSN 1536-5409 ; 0749-8047
    ISSN (online) 1536-5409
    ISSN 0749-8047
    DOI 10.1097/AJP.0000000000001085
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  2. Artikel ; Online: Long-term analgesic effect of trans-spinal direct current stimulation compared to non-invasive motor cortex stimulation in complex regional pain syndrome.

    Hodaj, Hasan / Payen, Jean-Francois / Hodaj, Enkelejda / Sorel, Marc / Dumolard, Anne / Vercueil, Laurent / Delon-Martin, Chantal / Lefaucheur, Jean-Pascal

    Brain communications

    2023  Band 5, Heft 4, Seite(n) fcad191

    Abstract: The aim of the present study was to compare the analgesic effect of motor cortex stimulation using high-frequency repetitive transcranial magnetic stimulation or transcranial direct current stimulation and transcutaneous spinal direct current stimulation ...

    Abstract The aim of the present study was to compare the analgesic effect of motor cortex stimulation using high-frequency repetitive transcranial magnetic stimulation or transcranial direct current stimulation and transcutaneous spinal direct current stimulation in patients with complex regional pain syndrome. Thirty-three patients with complex regional pain syndrome were randomized to one of the three treatment groups (repetitive transcranial magnetic stimulation,
    Sprache Englisch
    Erscheinungsdatum 2023-07-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcad191
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  3. Artikel ; Online: Neural Correlates of Pain-Autonomic Coupling in Patients With Complex Regional Pain Syndrome Treated by Repetitive Transcranial Magnetic Stimulation of the Motor Cortex.

    Delon-Martin, Chantal / Lefaucheur, Jean-Pascal / Hodaj, Enkeledja / Sorel, Marc / Dumolard, Anne / Payen, Jean-François / Hodaj, Hasan

    Neuromodulation : journal of the International Neuromodulation Society

    2023  Band 27, Heft 1, Seite(n) 188–199

    Abstract: Objectives: Complex regional pain syndrome (CRPS) is a chronic pain condition involving autonomic dysregulation. In this study, we report the results of an ancillary study to a larger clinical trial investigating the treatment of CRPS by neuromodulation. ...

    Abstract Objectives: Complex regional pain syndrome (CRPS) is a chronic pain condition involving autonomic dysregulation. In this study, we report the results of an ancillary study to a larger clinical trial investigating the treatment of CRPS by neuromodulation. This ancillary study, based on functional magnetic resonance imaging (fMRI), evaluated the neural correlates of pain in patients with CRPS in relation to the sympathetic nervous system and for its potential relief after repetitive transcranial magnetic stimulation of the motor cortex.
    Materials and methods: Eleven patients with CRPS at one limb (six women, five men, aged 52.0 ± 9.6 years) were assessed before and one month after the end of a five-month repetitive transcranial magnetic stimulation (rTMS) therapy targeting the motor cortex contralateral to the painful limb, by means of electrochemical skin conductance (ESC) measurement, daily pain intensity scores on a visual numerical scale (VNS), and fMRI with motor tasks (alternation of finger movements and rest). The fMRI scans were analyzed voxelwise using ESC and VNS pain score as regressors to derive their neural correlates. The criterion of response to rTMS therapy was defined as ≥30% reduction in VNS pain score one month after treatment compared with baseline.
    Results: At baseline, ESC values were reduced in the affected limb vs the nonaffected limb. There was a covariance of VNS with brain activation in a small region of the primary somatosensory cortex (S1) contralateral to the painful side on fMRI investigation. After rTMS therapy on motor cortex related to the painful limb, the VNS pain scores significantly decreased by 22% on average. The criterion of response was met in six of 11 patients (55%). In these responders, at one month after treatment, ESC value increased and returned to normal in the CRPS-affected limb, and overall, the increase in ESC correlated with the decrease in VNS after motor cortex rTMS therapy. At one month after treatment, there also was a covariance of both variables (ESC and VNS) with fMRI activation of the S1 region previously mentioned. The fMRI activation of other brain regions (middle frontal gyrus and temporo-parietal junction) showed correlation with ESC values before and after treatment. Finally, we found a positive correlation at one month after treatment (not at baseline) between VNS pain score and fMRI activation in the temporo-parietal junction contralateral to painful side.
    Conclusions: This study first shows a functional pain-autonomic coupling in patients with CRPS, which could involve a specific S1 region. However, the modulation of sympathetic sudomotor activities expressed by ESC changes was rather correlated with functional changes in other brain regions. Finally, the pain relief observed at one month after rTMS treatment was associated with a reduced activation of the temporo-parietal junction on the side in which rTMS was performed. These findings open perspectives to define new targets or biomarkers for using rTMS to treat CRPS-associated pain.
    Clinical trial registration: The Clinicaltrials.gov registration number for the study is NCT02817880.
    Mesh-Begriff(e) Male ; Humans ; Female ; Transcranial Magnetic Stimulation/methods ; Motor Cortex/diagnostic imaging ; Treatment Outcome ; Pain ; Complex Regional Pain Syndromes/diagnostic imaging ; Complex Regional Pain Syndromes/therapy ; Magnetic Resonance Imaging
    Sprache Englisch
    Erscheinungsdatum 2023-08-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1016/j.neurom.2023.05.005
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  4. Artikel ; Online: A drug free solution for improving the quality of life of fibromyalgia patients (Fibrepik): study protocol of a multicenter, randomized, controlled effectiveness trial.

    Chipon, Emilie / Bosson, Jean-Luc / Minier, Laure / Dumolard, Anne / Vilotitch, Antoine / Crouzier, David / Maindet, Caroline

    Trials

    2022  Band 23, Heft 1, Seite(n) 740

    Abstract: Background: Fibromyalgia is a form of chronic widespread pain that is defined as a syndrome of chronic symptoms of moderate to severe intensity, including diffuse pain, fatigue, sleep disturbance, cognitive impairment, and numerous somatic complaints. ... ...

    Abstract Background: Fibromyalgia is a form of chronic widespread pain that is defined as a syndrome of chronic symptoms of moderate to severe intensity, including diffuse pain, fatigue, sleep disturbance, cognitive impairment, and numerous somatic complaints. To date, there is no specific drug treatment for fibromyalgia but only symptomatic treatments. A drug free solution based on a wristband that emits millimeter waves associated with a therapeutic coaching program was developed. The application of millimeter waves on an innervated area has been described to have a neuromodulating effect, due to endorphin release stimulation and parasympathetic activation. Coaching is carried out to improve the patient's adherence and to increase compliance and effectiveness of the treatment. Regular use of this solution by fibromyalgia patients is expected to improve sleep quality, reduce anxiety and pain levels, and, at the end, increase the quality of life.
    Methods: This trial is performed over 8 French inclusion centers for a total of 170 patients. The effectiveness of the solution is evaluated according to the primary objective, the improvement of the quality of life measured through the dedicated Fibromyalgia Impact Questionnaire after 3 months. Patients are randomized in two groups, Immediate or Delayed. The Immediate group has access to the solution just after randomization in addition to standard care, while Delayed has access to the standard of care and waits for 3 months to have the solution. The purpose of this methodology is to limit deception bias and facilitate inclusion. The solution consists in using the device for three sessions of 30 min per day and four coaching sessions spread over the first 2 months of wristband usage.
    Discussion: The objective is to confirm the effect of the integrative approach based on endorphin stimulation and a therapeutic coaching program in nociplastic pain and specifically for the patient suffering from fibromyalgia. If the effectiveness of the solution is demonstrated, we will be able to respond to the demand of fibromyalgia patients for access to an effective non-medicinal treatment to improve their quality of life.
    Trial registration: ClinicalTrials.gov NCT05058092.
    Mesh-Begriff(e) Endorphins ; Fibromyalgia/diagnosis ; Fibromyalgia/therapy ; Humans ; Multicenter Studies as Topic ; Pain ; Pain Measurement ; Quality of Life ; Randomized Controlled Trials as Topic
    Chemische Substanzen Endorphins
    Sprache Englisch
    Erscheinungsdatum 2022-09-05
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06693-z
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  5. Artikel ; Online: Long-term prophylactic efficacy of transcranial direct current stimulation in chronic migraine. A randomised, patient-assessor blinded, sham-controlled trial.

    Hodaj, Hasan / Payen, Jean-François / Mick, Gerard / Vercueil, Laurent / Hodaj, Enkelejda / Dumolard, Anne / Noëlle, Bénédicte / Delon-Martin, Chantal / Lefaucheur, Jean-Pascal

    Brain stimulation

    2022  Band 15, Heft 2, Seite(n) 441–453

    Abstract: Objective: To assess the prophylactic effect of anodal tDCS of the left motor cortex in patients with resistant chronic migraine (CM) and its long-term maintenance.: Methods: In a patient-assessor blinded, sham-controlled trial, 36 patients were ... ...

    Abstract Objective: To assess the prophylactic effect of anodal tDCS of the left motor cortex in patients with resistant chronic migraine (CM) and its long-term maintenance.
    Methods: In a patient-assessor blinded, sham-controlled trial, 36 patients were randomized to receive anodal tDCS (active group, n = 18) or sham tDCS (sham group, n = 18). The studied population was characterized by a previous failure of at least 3 classes of preventive drugs and a mean duration of migraine history of 26 years. The tDCS procedure consisted of an induction phase of 5 consecutive daily sessions (week 1) followed by a maintenance phase of 1 weekly session during the next 4 weeks and two bimonthly sessions in the next month, for a total of 11 sessions during 2 months. Anodal tDCS was delivered at 2 mA intensity for 20 min over the left motor cortex. The primary endpoint was the reduction in the monthly number of migraine attacks from baseline to each period of follow-up (months 1, 2, 3, 5) between the active and sham groups.
    Results: The monthly number of migraine attacks expressed as the percentage of reduction from baseline was significantly reduced in the active versus the sham group, from the end of first month (-21% ± 22 vs. -2% ±25, p = 0.019) to the end of follow-up (3-month post-treatment) (-32% ± 33 vs. -6% ±39, p = 0.011). At this time, the rate of responders, defined as a reduction of the monthly number of migraine attacks ≥30% from baseline, was significantly higher in the active group than in the sham group (50% vs. 14%, p = 0.043).
    Conclusion: Our results show a marked prophylactic effect of anodal tDCS of the left motor cortex in resistant CM extending several months after the stimulation period, and suggest that this neuromodulatory approach may be part of the prophylactic alternatives available for CM.
    Mesh-Begriff(e) Double-Blind Method ; Electrodes ; Humans ; Migraine Disorders/prevention & control ; Motor Cortex/physiology ; Transcranial Direct Current Stimulation/methods
    Sprache Englisch
    Erscheinungsdatum 2022-02-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2022.02.012
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  6. Artikel ; Online: Treatment of pudendal neuralgia by high-frequency rTMS of the medial wall of motor cortex bilaterally using an angled figure-of-eight coil.

    Hodaj, Hasan / Payen, Jean-François / Dumolard, Anne / Delon-Martin, Chantal / Lefaucheur, Jean-Pascal

    Brain stimulation

    2020  Band 13, Heft 5, Seite(n) 1412–1413

    Sprache Englisch
    Erscheinungsdatum 2020-07-23
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2020.07.009
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  7. Artikel ; Online: Long-term treatment of chronic orofacial, pudendal, and central neuropathic limb pain with repetitive transcranial magnetic stimulation of the motor cortex.

    Hodaj, Hasan / Payen, Jean-François / Hodaj, Enkelejda / Dumolard, Anne / Maindet, Caroline / Cracowski, Jean-Luc / Delon-Martin, Chantal / Lefaucheur, Jean-Pascal

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2020  Band 131, Heft 7, Seite(n) 1423–1432

    Abstract: Objective: To assess the long-term analgesic effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex in patients with chronic pain syndrome.: Methods: The study included 57 patients (orofacial pain, n = 26, ... ...

    Abstract Objective: To assess the long-term analgesic effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex in patients with chronic pain syndrome.
    Methods: The study included 57 patients (orofacial pain, n = 26, pudendal neuralgia, n = 18, and neuropathic limb pain, n = 13) with an "induction phase" of 12 daily rTMS sessions for 3 weeks, followed by a "maintenance phase" of bi-monthly sessions for the next five months.
    Results: All pain measures significantly decreased from baseline to the end of the induction phase. Analgesic response, defined as pain intensity decrease ≥ 30% compared to baseline, was observed in 39 patients (68%), who could be differentiated from non-responders from the 7th rTMS session. At the end of the maintenance phase (D180), 27 patients (47%) were still responders. Anxio-depressive symptoms and quality of life also improved. The analgesic response at the end of the induction phase was associated with lower pain score at baseline, and the response at the end of the maintenance phase was associated with lower anxio-depressive score at baseline.
    Conclusion: The analgesic efficacy of motor cortex rTMS can be maintained in the long term in various chronic pain conditions. Patients with high pain level and severe anxio-depressive symptoms may have a less favorable profile to respond to the procedure.
    Significance: The overall impact of rTMS treatment on daily life requires a multidimensional evaluation that goes beyond the analgesic effect that can be achieved.
    Mesh-Begriff(e) Aged ; Chronic Pain/therapy ; Extremities/innervation ; Facial Pain/therapy ; Female ; Humans ; Male ; Middle Aged ; Mononeuropathies/therapy ; Motor Cortex/physiology ; Pudendal Neuralgia/therapy ; Quality of Life ; Transcranial Magnetic Stimulation/methods
    Sprache Englisch
    Erscheinungsdatum 2020-04-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2020.03.022
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  8. Artikel ; Online: The interest of gait markers in the identification of subgroups among fibromyalgia patients

    Auvinet Bernard / Chaleil Denis / Cabane Jean / Dumolard Anne / Hatron Pierre / Juvin Robert / Lanteri-Minet Michel / Mainguy Yves / Negre-Pages Laurence / Pillard Fabien / Riviere Daniel / Maugars Yves-Michel

    BMC Musculoskeletal Disorders, Vol 12, Iss 1, p

    2011  Band 258

    Abstract: Abstract Background Fibromyalgia (FM) is a heterogeneous syndrome and its classification into subgroups calls for broad-based discussion. FM subgrouping, which aims to adapt treatment according to different subgroups, relies in part, on psychological and ...

    Abstract Abstract Background Fibromyalgia (FM) is a heterogeneous syndrome and its classification into subgroups calls for broad-based discussion. FM subgrouping, which aims to adapt treatment according to different subgroups, relies in part, on psychological and cognitive dysfunctions. Since motor control of gait is closely related to cognitive function, we hypothesized that gait markers could be of interest in the identification of FM patients' subgroups. This controlled study aimed at characterizing gait disorders in FM, and subgrouping FM patients according to gait markers such as stride frequency (SF), stride regularity (SR), and cranio-caudal power (CCP) which measures kinesia. Methods A multicentre, observational open trial enrolled patients with primary FM (44.1 ± 8.1 y), and matched controls (44.1 ± 7.3 y). Outcome measurements and gait analyses were available for 52 pairs. A 3-step statistical analysis was carried out. A preliminary single blind analysis using k-means cluster was performed as an initial validation of gait markers. Then in order to quantify FM patients according to psychometric and gait variables an open descriptive analysis comparing patients and controls were made, and correlations between gait variables and main outcomes were calculated. Finally using cluster analysis, we described subgroups for each gait variable and looked for significant differences in self-reported assessments. Results SF was the most discriminating gait variable (73% of patients and controls). SF, SR, and CCP were different between patients and controls. There was a non-significant association between SF, FIQ and physical components from Short-Form 36 (p = 0.06). SR was correlated to FIQ (p = 0.01) and catastrophizing (p = 0.05) while CCP was correlated to pain (p = 0.01). The SF cluster identified 3 subgroups with a particular one characterized by normal SF, low pain, high activity and hyperkinesia. The SR cluster identified 2 distinct subgroups: the one with a reduced SR was distinguished by high FIQ, poor coping and altered affective status. Conclusion Gait analysis may provide additional information in the identification of subgroups among fibromyalgia patients. Gait analysis provided relevant information about physical and cognitive status, and pain behavior. Further studies are needed to better understand gait analysis implications in FM.
    Schlagwörter Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the musculoskeletal system ; RC925-935
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2011-11-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The interest of gait markers in the identification of subgroups among fibromyalgia patients.

    Auvinet, Bernard / Chaleil, Denis / Cabane, Jean / Dumolard, Anne / Hatron, Pierre / Juvin, Robert / Lanteri-Minet, Michel / Mainguy, Yves / Negre-Pages, Laurence / Pillard, Fabien / Riviere, Daniel / Maugars, Yves-Michel

    BMC musculoskeletal disorders

    2011  Band 12, Seite(n) 258

    Abstract: Background: Fibromyalgia (FM) is a heterogeneous syndrome and its classification into subgroups calls for broad-based discussion. FM subgrouping, which aims to adapt treatment according to different subgroups, relies in part, on psychological and ... ...

    Abstract Background: Fibromyalgia (FM) is a heterogeneous syndrome and its classification into subgroups calls for broad-based discussion. FM subgrouping, which aims to adapt treatment according to different subgroups, relies in part, on psychological and cognitive dysfunctions. Since motor control of gait is closely related to cognitive function, we hypothesized that gait markers could be of interest in the identification of FM patients' subgroups. This controlled study aimed at characterizing gait disorders in FM, and subgrouping FM patients according to gait markers such as stride frequency (SF), stride regularity (SR), and cranio-caudal power (CCP) which measures kinesia.
    Methods: A multicentre, observational open trial enrolled patients with primary FM (44.1 ± 8.1 y), and matched controls (44.1 ± 7.3 y). Outcome measurements and gait analyses were available for 52 pairs. A 3-step statistical analysis was carried out. A preliminary single blind analysis using k-means cluster was performed as an initial validation of gait markers. Then in order to quantify FM patients according to psychometric and gait variables an open descriptive analysis comparing patients and controls were made, and correlations between gait variables and main outcomes were calculated. Finally using cluster analysis, we described subgroups for each gait variable and looked for significant differences in self-reported assessments.
    Results: SF was the most discriminating gait variable (73% of patients and controls). SF, SR, and CCP were different between patients and controls. There was a non-significant association between SF, FIQ and physical components from Short-Form 36 (p = 0.06). SR was correlated to FIQ (p = 0.01) and catastrophizing (p = 0.05) while CCP was correlated to pain (p = 0.01). The SF cluster identified 3 subgroups with a particular one characterized by normal SF, low pain, high activity and hyperkinesia. The SR cluster identified 2 distinct subgroups: the one with a reduced SR was distinguished by high FIQ, poor coping and altered affective status.
    Conclusion: Gait analysis may provide additional information in the identification of subgroups among fibromyalgia patients. Gait analysis provided relevant information about physical and cognitive status, and pain behavior. Further studies are needed to better understand gait analysis implications in FM.
    Mesh-Begriff(e) Adult ; Biomarkers ; Catastrophization/diagnosis ; Catastrophization/psychology ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Comorbidity ; Disability Evaluation ; Female ; Fibromyalgia/classification ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Gait Disorders, Neurologic/diagnosis ; Gait Disorders, Neurologic/epidemiology ; Gait Disorders, Neurologic/psychology ; Humans ; Middle Aged ; Pain Measurement/methods ; Physical Examination/methods ; Surveys and Questionnaires/standards ; Young Adult
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2011-11-11
    Erscheinungsland England
    Dokumenttyp Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/1471-2474-12-258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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