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Article ; Online: Reconstruction of thermoacoustic emission sources induced by proton irradiation using numerical time reversal.

Mast, T Douglas / Johnstone, David A / Dumoulin, Charles L / Lamba, Michael A / Patch, Sarah K

2023 Volume 68, Issue 2

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Protons ; Proton Therapy/methods ; Acoustics ; Sound ; Radiation, Ionizing ; Phantoms, Imaging ; Monte Carlo Method
Chemical Substances	Protons
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acabfc
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Zs.A 199: Show issues

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Article ; Online: MR Angiography Series: Fundamentals of Contrast-enhanced MR Angiography.

Primrose, Colin W / Hecht, Elizabeth M / Roditi, Giles / François, Christopher J / Maki, Jeffrey H / Dumoulin, Charles L / DeMarco, J Kevin / Douglas, Peter

Radiographics : a review publication of the Radiological Society of North America, Inc

2021 Volume 41, Issue 4, Page(s) E138–E139

Abstract: The Society for Magnetic Resonance Angiography (SMRA) is a group of researchers and clinicians who are passionate about the benefits of MR angiography (MRA) but understand its challenges. Their mission is to study MRA, continually improve and innovate ... ...

Abstract	The Society for Magnetic Resonance Angiography (SMRA) is a group of researchers and clinicians who are passionate about the benefits of MR angiography (MRA) but understand its challenges. Their mission is to study MRA, continually improve and innovate for the benefit of patients, and most important, educate the medical community so they can take full advantage of the benefits of MRA and overcome its challenges. In support of that mission, the authors have created a series of self-learning modules on behalf of the SMRA to demystify MRA protocols and help the reader perform patient-friendly high-quality MRA on a routine basis in clinical practice.
MeSH term(s)	Angiography, Digital Subtraction ; Contrast Media ; Humans ; Magnetic Resonance Angiography ; Sensitivity and Specificity
Chemical Substances	Contrast Media
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.2021200215
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Zs.A 1751: Show issues

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Article ; Online: MR Imaging of Pediatric Musculoskeletal Tumors:: Recent Advances and Clinical Applications.

Lee, Mi-Jung / Chhabra, Avneesh / Pressey, Joseph G / Dumoulin, Charles L / Kim, Hee Kyung

Magnetic resonance imaging clinics of North America

2019 Volume 27, Issue 2, Page(s) 341–371

Abstract: Pediatric musculoskeletal tumors comprise approximately 10% of childhood neoplasms, and MR imaging has been used as the imaging evaluation standard for these tumors. The role of MR imaging in these cases includes identification of tumor origin, tissue ... ...

Abstract	Pediatric musculoskeletal tumors comprise approximately 10% of childhood neoplasms, and MR imaging has been used as the imaging evaluation standard for these tumors. The role of MR imaging in these cases includes identification of tumor origin, tissue characterization, and definition of tumor extent and relationship to adjacent structures as well as therapeutic response in posttreatment surveillance. Technical advances have enabled quantitative evaluation of biochemical changes in tumors. This article reviews recent updates to MR imaging of pediatric musculoskeletal tumors, focusing on advanced MR imaging techniques and providing information on the relevant physics of these techniques, clinical applications, and pitfalls.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Musculoskeletal Diseases/diagnostic imaging ; Musculoskeletal System/diagnostic imaging
Language	English
Publishing date	2019-02-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196851-5
ISSN	1557-9786 ; 1064-9689
ISSN (online)	1557-9786
ISSN	1064-9689
DOI	10.1016/j.mric.2019.01.010
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Article ; Online: Intracardiac MR imaging (ICMRI) guiding-sheath with amplified expandable-tip imaging and MR-tracking for navigation and arrythmia ablation monitoring: Swine testing at 1.5 and 3T.

Schmidt, Ehud J / Olson, Gregory / Tokuda, Junichi / Alipour, Akbar / Watkins, Ronald D / Meyer, Eric M / Elahi, Hassan / Stevenson, William G / Schweitzer, Jeffrey / Dumoulin, Charles L / Johnson, Thomas / Kolandaivelu, Aravindan / Loew, Wolfgang / Halperin, Henry R

Magnetic resonance in medicine

2022 Volume 87, Issue 6, Page(s) 2885–2900

Abstract: Purpose: Develop a deflectable intracardiac MR imaging (ICMRI) guiding-sheath to accelerate imaging during MR-guided electrophysiological (EP) interventions for radiofrequency (500 kHz) ablation (RFA) of arrythmia. Requirements include imaging at three ... ...

Abstract	Purpose: Develop a deflectable intracardiac MR imaging (ICMRI) guiding-sheath to accelerate imaging during MR-guided electrophysiological (EP) interventions for radiofrequency (500 kHz) ablation (RFA) of arrythmia. Requirements include imaging at three to five times surface-coil SNR in cardiac chambers, vascular insertion, steerable-active-navigation into cardiac chambers, operation with ablation catheters, and safe levels of MR-induced heating. Methods: ICMRI's 6 mm outer-diameter (OD) metallic-braided shaft had a 2.6 mm OD internal lumen for ablation-catheter insertion. Miniature-Baluns (MBaluns) on ICMRI's 1 m shaft reduced body-coil-induced heating. Distal section was a folded "star"-shaped imaging-coil mounted on an expandable frame, with an integrated miniature low-noise-amplifier overcoming cable losses. A handle-activated movable-shaft expanded imaging-coil to 35 mm OD for imaging within cardiac-chambers. Four MR-tracking micro-coils enabled navigation and motion-compensation, assuming a tetrahedron-shape when expanded. A second handle-lever enabled distal-tip deflection. ICMRI with a protruding deflectable EP catheter were used for MR-tracked navigation and RFA using a dedicated 3D-slicer user-interface. ICMRI was tested at 3T and 1.5T in swine to evaluate (a) heating, (b) cardiac-chamber access, (c) imaging field-of-view and SNR, and (d) intraprocedural RFA lesion monitoring. Results: The 3T and 1.5T imaging SNR demonstrated >400% SNR boost over a 4 × 4 × 4 cm Conclusion: ICMRI assisted EP-catheter navigation to difficult targets and accelerated RFA monitoring.
MeSH term(s)	Animals ; Arrhythmias, Cardiac ; Catheter Ablation/methods ; Equipment Design ; Heart Atria ; Magnetic Resonance Imaging/methods ; Swine
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29168
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Article ; Online: A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging.

Pratt, Ronald G / Lee, Greg / McAllister, Aaron S / Smith, Daniel R / Myer, Gregory D / Ireland, Christopher M / Loew, Wolfgang M / Lanier, Matt / Wang, Hui / Diekfuss, Jed A / Yuan, Weihong / Dumoulin, Charles L

Journal of neuroscience methods

2022 Volume 382, Page(s) 109728

Abstract: Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI ... ...

Abstract	Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles. New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images. Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors. Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify "brain slosh" in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI).
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain/physiology ; Head ; Acceleration ; Rheology
Language	English
Publishing date	2022-10-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2022.109728
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Zs.A 1486: Show issues

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Article ; Online: Fusing acceleration and saturation techniques with wave amplitude labeling of time-shifted zeniths MR elastography.

Wang, Hui / Pednekar, Amol / Tkach, Jean A / Bridgewater, Kaley R / Trout, Andrew T / Dillman, Jonathan R / Dumoulin, Charles L

Magnetic resonance in medicine

2020 Volume 85, Issue 3, Page(s) 1552–1560

Abstract: Purpose: To design a new 2D gradient recalled echo MR elastography (MRE) pulse sequence with inflow saturation for measuring liver stiffness in half the breath-hold time compared to standard of care (SC) 2D GRE MRE sequences.: Methods: FASTWALTZ ( ... ...

Abstract	Purpose: To design a new 2D gradient recalled echo MR elastography (MRE) pulse sequence with inflow saturation for measuring liver stiffness in half the breath-hold time compared to standard of care (SC) 2D GRE MRE sequences. Methods: FASTWALTZ (fusing acceleration and saturation techniques with wave amplitude labeling of time-shifted zeniths) MRE employs an interleaved dual TR strategy with wave amplitude labeling and compressed SENSE undersampling to reduce breath-hold time while incorporating inflow saturation to suppress flow artifacts. The sequence was implemented and compared with SC MRE both in phantoms and in vivo in 5 asymptomatic volunteers. Stiffness values, region of interest size, and breath-hold times were compared between sequences. Results: Stiffness values were comparable between FASTWALTZ and SC MRE for both phantoms and in-vivo data. In volunteers, the group mean stiffness values at 60 Hz and region of interest size were 1.96 ± 0.30 kilopascals and 2279 ± 516 mm Conclusion: FASTWALTZ provides comparable stiffness values in half the breath-hold time compared to SC MRE and may have clinical benefits in patients with limited breath-holding capacity.
MeSH term(s)	Acceleration ; Echo-Planar Imaging ; Elasticity Imaging Techniques ; Humans ; Magnetic Resonance Imaging ; Reproducibility of Results
Language	English
Publishing date	2020-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28488
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Article ; Online: Respiratory-triggered spin-echo echo-planar imaging-based mr elastography for evaluating liver stiffness.

Wang, Hui / Tkach, Jean A / Trout, Andrew T / Dumoulin, Charles L / Dillman, Jonathan R

Journal of magnetic resonance imaging : JMRI

2018 Volume 50, Issue 2, Page(s) 391–396

Abstract: Background: Magnetic resonance elastography (MRE) has proven to be useful for assessing chronic liver disease. However, MRE images are acquired with breath-holding (BH) to limit respiratory motion artifacts, which may be difficult in some patients.: ... ...

Abstract	Background: Magnetic resonance elastography (MRE) has proven to be useful for assessing chronic liver disease. However, MRE images are acquired with breath-holding (BH) to limit respiratory motion artifacts, which may be difficult in some patients. Purpose: To implement a respiratory-triggered (RT) spin-echo echo-planar imaging (SE-EPI) MRE technique and to validate its performance through comparison to a BH SE-EPI MRE technique. Study type: Prospective feasibility study. Subjects: Twenty-three adult volunteers (18 without and 5 with liver disease). Field strength/sequences: 1.5 T Philips Ingenia MR scanner; RT and BH SE-EPI MRE sequences. Assessment: Four axial images were obtained through the middle of the liver with each technique. Liver stiffness measurements (in kPa) were made from elastograms, with 95% confidence maps overlaid, for both MRE sequences. Statistical tests: Liver stiffness measurements were compared using the paired t-test (two-sided). Absolute agreement between the two techniques was evaluated using Lin's concordance coefficient (r Results: There was excellent agreement (r Data conclusion: RT SE-EPI MRE is feasible and yields comparable results to BH SE-EPI MRE. Level of evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:391-396.
MeSH term(s)	Adult ; Artifacts ; Echo-Planar Imaging/methods ; Elasticity Imaging Techniques/methods ; Feasibility Studies ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Liver/diagnostic imaging ; Liver Diseases/diagnostic imaging ; Male ; Middle Aged ; Motion ; Prospective Studies ; Reproducibility of Results ; Respiration ; Young Adult
Language	English
Publishing date	2018-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.26610
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Human upper-airway respiratory airflow: In vivo comparison of computational fluid dynamics simulations and hyperpolarized 129Xe phase contrast MRI velocimetry.

Xiao, Qiwei / Stewart, Neil J / Willmering, Matthew M / Gunatilaka, Chamindu C / Thomen, Robert P / Schuh, Andreas / Krishnamoorthy, Guruprasad / Wang, Hui / Amin, Raouf S / Dumoulin, Charles L / Woods, Jason C / Bates, Alister J

PloS one

2021 Volume 16, Issue 8, Page(s) e0256460

Abstract: Computational fluid dynamics (CFD) simulations of respiratory airflow have the potential to change the clinical assessment of regional airway function in health and disease, in pulmonary medicine and otolaryngology. For example, in diseases where ... ...

Abstract	Computational fluid dynamics (CFD) simulations of respiratory airflow have the potential to change the clinical assessment of regional airway function in health and disease, in pulmonary medicine and otolaryngology. For example, in diseases where multiple sites of airway obstruction occur, such as obstructive sleep apnea (OSA), CFD simulations can identify which sites of obstruction contribute most to airway resistance and may therefore be candidate sites for airway surgery. The main barrier to clinical uptake of respiratory CFD to date has been the difficulty in validating CFD results against a clinical gold standard. Invasive instrumentation of the upper airway to measure respiratory airflow velocity or pressure can disrupt the airflow and alter the subject's natural breathing patterns. Therefore, in this study, we instead propose phase contrast (PC) velocimetry magnetic resonance imaging (MRI) of inhaled hyperpolarized 129Xe gas as a non-invasive reference to which airflow velocities calculated via CFD can be compared. To that end, we performed subject-specific CFD simulations in airway models derived from 1H MRI, and using respiratory flowrate measurements acquired synchronously with MRI. Airflow velocity vectors calculated by CFD simulations were then qualitatively and quantitatively compared to velocity maps derived from PC velocimetry MRI of inhaled hyperpolarized 129Xe gas. The results show both techniques produce similar spatial distributions of high velocity regions in the anterior-posterior and foot-head directions, indicating good qualitative agreement. Statistically significant correlations and low Bland-Altman bias between the local velocity values produced by the two techniques indicates quantitative agreement. This preliminary in vivo comparison of respiratory airway CFD and PC MRI of hyperpolarized 129Xe gas demonstrates the feasibility of PC MRI as a technique to validate respiratory CFD and forms the basis for further comprehensive validation studies. This study is therefore a first step in the pathway towards clinical adoption of respiratory CFD.
MeSH term(s)	Humans ; Hydrodynamics ; Magnetic Resonance Imaging ; Trachea ; Xenon Isotopes
Chemical Substances	Xenon Isotopes ; Xenon-129
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0256460
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Article ; Online: MRI Conditional Actively Tracked Metallic Electrophysiology Catheters and Guidewires With Miniature Tethered Radio-Frequency Traps: Theory, Design, and Validation.

Alipour, Akbar / Meyer, Eric S / Dumoulin, Charles L / Watkins, Ronald D / Elahi, Hassan / Loew, Wolfgang / Schweitzer, Jeffrey / Olson, Gregory / Chen, Yue / Tao, Susumu / Guttman, Michael / Kolandaivelu, Aravindan / Halperin, Henry R / Schmidt, Ehud J

IEEE transactions on bio-medical engineering

2019 Volume 67, Issue 6, Page(s) 1616–1627

Abstract: Objective: Cardiovascular interventional devices typically have long metallic braids or backbones to aid in steerability and pushability. However, electromagnetic coupling of metallic-based cardiovascular interventional devices with the radiofrequency ( ... ...

Abstract	Objective: Cardiovascular interventional devices typically have long metallic braids or backbones to aid in steerability and pushability. However, electromagnetic coupling of metallic-based cardiovascular interventional devices with the radiofrequency (RF) fields present during Magnetic Resonance Imaging (MRI) can make a device unsafe for use in an MRI scanner. We aimed to develop MRI conditional actively-tracked cardiovascular interventional devices by sufficiently attenuating induced currents on the metallic braid/tube and internal-cabling using miniaturized resonant floating RF traps (MBaluns). Method: MBaluns were designed for placement at multiple locations along a conducting cardiovascular device to prevent the establishment of standing waves and to dissipate RF-induced energy. The MBaluns were constructed with loosely-wound solenoids to be sensitive to transverse magnetic fields created by both surface currents on the device's metallic backbone and common-mode currents on internal cables. Electromagnetic simulations were used to optimize MBalun parameters. Following optimization, two different MBalun designs were applied to MR-actively-tracked metallic guidewires and metallic-braided electrophysiology ablation catheters. Control-devices were constructed without MBaluns. MBalun performance was validated using network-analyzer quantification of current attenuation, electromagnetic Specific-Absorption-Rate (SAR) analysis, thermal tests during high SAR pulse sequences, and MRI-guided cardiovascular navigation in swine. Results: Electromagnetic SAR simulations resulted in ≈20 dB attenuation at the tip of the wire using six successive MBaluns. Network-analyzer tests confirmed ∼17 dB/MBalun surface-current attenuation. Thermal tests indicated temperature decreases of 5.9 °C in the MBalun-equipped guidewire tip. Both devices allowed rapid vascular navigation resulting from good torquability and MR-Tracking visibility. Conclusion: MBaluns increased device diameter by 20%, relative to conventional devices, providing a spatially-efficient means to prevent heating during MRI. Significance: MBaluns allow use of long metallic components, which improves mechanical performance in active MR-guided interventional devices.
MeSH term(s)	Animals ; Catheters ; Electrophysiology ; Equipment Design ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Radio Waves ; Swine
Language	English
Publishing date	2019-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2019.2941460
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Article ; Online: Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging.

Niedbalski, Peter J / Willmering, Matthew M / Robertson, Scott H / Freeman, Matthew S / Loew, Wolfgang / Giaquinto, Randy O / Ireland, Christopher / Pratt, Ronald G / Dumoulin, Charles L / Woods, Jason C / Cleveland, Zackary I

Magnetic resonance in medicine

2019 Volume 82, Issue 1, Page(s) 367–376

Abstract: Purpose: Hyperpolarized (HP) media enable biomedical imaging applications that cannot be achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is challenging, because relaxation and radio-frequency pulsing generate ... ...

Abstract	Purpose: Hyperpolarized (HP) media enable biomedical imaging applications that cannot be achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is challenging, because relaxation and radio-frequency pulsing generate spatially varying signal decay during acquisition. We demonstrate that, by combining center-out k-space sampling with postacquisition keyhole reconstruction, voxel-by-voxel maps of regional HP magnetization decay can be generated with no additional data collection. Theory and methods: Digital phantom, HP Results: Mean, keyhole-derived decay terms showed excellent agreement with the decay used in simulations (R Conclusions: We have demonstrated that center-out trajectories combined with keyhole reconstruction can be used to map regional HP signal decay and to quantitatively correct images. This approach may be used to improve the accuracy of quantitative measures obtained from hyperpolarized media. Although validated with gaseous HP
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Contrast Media ; Cystic Fibrosis/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Lung/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Phantoms, Imaging ; Signal Processing, Computer-Assisted ; Xenon Isotopes
Chemical Substances	Contrast Media ; Xenon Isotopes
Language	English
Publishing date	2019-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.27721
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