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  1. Book ; Thesis: Häufigkeit von Notfalloperationen nach kolorektaler Endoskopischer Mukosaresektion (EMR) versus Endoskopischer Submukosadissektion (ESD)

    Moeller, Karola / Dumoulin, Franz Ludwig

    Eine Metaanalyse

    2022  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Karola Moeller ; 1. Gutachter: Prof. Dr. med. Franz Ludwig Dumoulin
    Language German
    Size 65 Seiten, Illustrationen, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2022
    HBZ-ID HT021315901
    Database Catalogue ZB MED Medicine, Health

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    2022 D 330 order for loan Magazin

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  2. Book ; Thesis: Endoskopische Submukosadissektion in der Therapie von Frühkarzinomen des oberen Gastrointestinaltrakts

    Mocker, Lena Katharina / Dumoulin, Franz Ludwig

    2020  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Lena Katharina Mocker, geb. Liese ; 1. Gutachter: Prof. Dr. med. Franz Ludwig Dumoulin
    Language German ; English
    Size 39 Seiten, Illustrationen, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
    Note Enthält Veröffentlichung: "Implementation of endoscopic submucosal dissection for early upper gastrointestinal tract cancer after primary experience in colorectal endoscopic submucosal dissection", DOI:10.1055/a-0854-3610
    HBZ-ID HT020455430
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Massive Größenprogredienz und maligne Transformation einer muzinös-zystischen Neoplasie des Pankreas in der Schwangerschaft – ein Fallbericht.

    Scheyda-Yoo, Katharina / Hofer, Ulrich / Várnai-Händel, Alinda / Maus, Martin K-H / Dumoulin, Franz Ludwig

    Zeitschrift fur Gastroenterologie

    2024  

    Abstract: Background: Mucinous-cystic neoplasms (MCN) account for 10% of all pancreatic cystic lesions. They are found almost exclusively in females. MCN have an ovarian-like stroma and often estrogen and progesterone receptors. During pregnancy, they can ... ...

    Title translation Rapid growth and malignant transformation of a mucinous cystic neoplasm during pregnancy - a case report.
    Abstract Background: Mucinous-cystic neoplasms (MCN) account for 10% of all pancreatic cystic lesions. They are found almost exclusively in females. MCN have an ovarian-like stroma and often estrogen and progesterone receptors. During pregnancy, they can massively increase in size and transform into malignancy.
    Case report: We report on a 29-year-old woman in whom a 35mm cyst in the pancreatic tail had been diagnosed several years ago. After workup the lesions had been classified as a pseudocyst. During pregnancy, the cyst massively increased in size and finally was resected. Histology showed a mucinous-cystic neoplasia with focal malignant transformation.
    Conclusion: Cystic neoplasms of the pancreas require a differentiated management. While overtreatment should be avoided, malignant transformation always merits consideration - in particular if the cystic lesion is located in the pancreatic tail. Women with suspected MCN or cystic pancreatic lesions of uncertain etiology should be informed about the (rare) risk of a malignant transformation of an MCN and should be closely monitored during pregnancy.
    Language German
    Publishing date 2024-04-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2239-7898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Artificial Intelligence in the Management of Barrett's Esophagus and Early Esophageal Adenocarcinoma.

    Dumoulin, Franz Ludwig / Rodriguez-Monaco, Fabian Dario / Ebigbo, Alanna / Steinbrück, Ingo

    Cancers

    2022  Volume 14, Issue 8

    Abstract: Esophageal adenocarcinoma is increasing in incidence and is the most common subtype of esophageal cancer in Western societies. The stepwise progression of Barrett´s metaplasia to high-grade dysplasia and invasive adenocarcinoma provides an opportunity ... ...

    Abstract Esophageal adenocarcinoma is increasing in incidence and is the most common subtype of esophageal cancer in Western societies. The stepwise progression of Barrett´s metaplasia to high-grade dysplasia and invasive adenocarcinoma provides an opportunity for screening and surveillance. There are important unresolved issues, which include (i) refining the definition of the screening population in order to avoid unnecessary invasive diagnostics, (ii) a more precise prediction of the (very heterogeneous) individual progression risk from metaplasia to invasive cancer in order to better tailor surveillance recommendations, (iii) improvement of the quality of endoscopy in order to reduce the high miss rate for early neoplastic lesions, and (iv) support for the diagnosis of tumor infiltration depth in order to guide treatment decisions. Artificial intelligence (AI) systems might be useful as a support to better solve the above-mentioned issues.
    Language English
    Publishing date 2022-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14081918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endoscopic Treatment of T1 Colorectal Cancer.

    Metter, Klaus / Weißinger, Stephanie Ellen / Várnai-Händel, Alinda / Grund, Karl-Ernst / Dumoulin, Franz Ludwig

    Cancers

    2023  Volume 15, Issue 15

    Abstract: Commonly accepted criteria for curative resection of T1 colorectal cancer include R0 resection with horizontal and vertical clear margins (R0), absence of lympho-vascular or vessel infiltration (L0, V0), a low to moderate histological grading (G1/2), low ...

    Abstract Commonly accepted criteria for curative resection of T1 colorectal cancer include R0 resection with horizontal and vertical clear margins (R0), absence of lympho-vascular or vessel infiltration (L0, V0), a low to moderate histological grading (G1/2), low tumor cell budding, and limited (<1000 µm) infiltration into the submucosa. However, submucosal infiltration depth in the absence of other high-risk features has recently been questioned as a high-risk situation for lymph-node metastasis. Consequently, endoscopic resection techniques should focus on the acquisition of qualitatively and quantitively sufficient submucosal tissue. Here, we summarize the current literature on lymph-node metastasis risk after endoscopic resection of T1 colorectal cancer. Moreover, we discuss different endoscopic resection techniques with respect to the quality of the resected specimen.
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15153875
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  6. Article ; Online: Endoscopic resection techniques for colorectal neoplasia: Current developments.

    Dumoulin, Franz Ludwig / Hildenbrand, Ralf

    World journal of gastroenterology

    2019  Volume 25, Issue 3, Page(s) 300–307

    Abstract: Endoscopic polypectomy and endoscopic mucosal resection (EMR) are the established treatment standards for colorectal polyps. Current research aims at the reduction of both complication and recurrence rates as well as on shortening procedure times. Cold ... ...

    Abstract Endoscopic polypectomy and endoscopic mucosal resection (EMR) are the established treatment standards for colorectal polyps. Current research aims at the reduction of both complication and recurrence rates as well as on shortening procedure times. Cold snare resection is the emerging standard for the treatment of smaller (< 5mm) polyps and is possibly also suitable for the removal of non-cancerous polyps up to 9 mm. The method avoids thermal damage, has reduced procedure times and probably also a lower risk for delayed bleeding. On the other end of the treatment spectrum, endoscopic submucosal dissection (ESD) offers
    MeSH term(s) Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy/methods ; Colonoscopy/trends ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection/methods ; Endoscopic Mucosal Resection/trends ; Humans ; Intestinal Mucosa/pathology ; Intestinal Mucosa/surgery ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Treatment Outcome
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v25.i3.300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  7. Article: Massive Größenprogredienz und maligne Transformation einer muzinös-zystischen Neoplasie des Pankreas in der Schwangerschaft – ein Fallbericht

    Scheyda-Yoo, Katharina / Hofer, Ulrich / Várnai-Händel, Alinda / Maus, Martin K.-H. / Dumoulin, Franz Ludwig

    Zeitschrift für Gastroenterologie

    2024  

    Abstract: Hintergrund: Muzinös-zystische Neoplasien (MCN) machen 10% aller zystischen Pankreasläsionen aus. Sie kommen fast ausschließlich bei weiblichen Patienten vor und weisen ein ovar-ähnliches Stroma sowie häufig Östrogen- und Progesteronrezeptoren auf. ... ...

    Abstract Hintergrund: Muzinös-zystische Neoplasien (MCN) machen 10% aller zystischen Pankreasläsionen aus. Sie kommen fast ausschließlich bei weiblichen Patienten vor und weisen ein ovar-ähnliches Stroma sowie häufig Östrogen- und Progesteronrezeptoren auf. Während einer Schwangerschaft können sie massiv an Größe zunehmen und maligne entarten.
    Fallbericht: Wir berichten von einer 29-jährigen Patientin, bei der vor einigen Jahren eine 35mm große Zyste im Pankreasschwanz aufgefallen und als Pseudozyste eingestuft worden war. Im Rahmen einer Schwangerschaft kam es zu einer massiven Größenzunahme der Zyste, die sich letztendlich als muzinös-zystische Neoplasie mit fokaler maligner Transformation herausstellte.
    Schlussfolgerung: Zystische Neoplasien des Pankreas bedürfen eines differenzierten Managements, um einerseits eine Übertherapie, andererseits eine maligne Transformation im Intervall zu vermeiden. Patientinnen im gebärfähigen Alter mit V.a. MCN bzw. ätiologisch nicht sicher einzuordnenden zystischen Pankreasläsionen sollten über das (seltene) Phänomen des Progresses von MCN in der Schwangerschaft aufgeklärt und im Rahmen einer Schwangerschaft engmaschig überwacht werden.
    Keywords zystische Pankreasläsion ; pankreatische muzinös zystische Neoplasie ; maligne Transformation ; Schwangerschaft ; Cystic pancreatic lesion ; pancreatic mucinous cystic neoplasia ; malignant progression ; pregnancy
    Language German
    Publishing date 2024-04-24
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-2239-7898
    Database Thieme publisher's database

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  8. Article ; Online: An Unusual Encounter in the Rectum.

    Dumoulin, Franz Ludwig / Oeyen, Markus / Hildenbrand, Ralf

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 19, Issue 6, Page(s) e57–e58

    MeSH term(s) Foreign Bodies ; Humans ; Rectum/diagnostic imaging
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.03.070
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  9. Article: Current Trends in Endoscopic Diagnosis and Treatment of Early Esophageal Cancer.

    Dumoulin, Franz Ludwig / Hildenbrand, Ralf / Oyama, Tsuneo / Steinbrück, Ingo

    Cancers

    2021  Volume 13, Issue 4

    Abstract: Diagnosis of esophageal adenocarcinoma mostly occurs in the context of reflux disease or surveillance of Barrett's metaplasia. Optimal detection rates are obtained with high definition and virtual or dye chromoendoscopy. Smaller lesions can be treated ... ...

    Abstract Diagnosis of esophageal adenocarcinoma mostly occurs in the context of reflux disease or surveillance of Barrett's metaplasia. Optimal detection rates are obtained with high definition and virtual or dye chromoendoscopy. Smaller lesions can be treated with endoscopic mucosal resection. Endoscopic submucosal dissection (ESD) is an option for larger lesions. Endoscopic resection is considered curative (i.e., without significant risk of lymph node metastasis) if histopathology confirms en bloc and R0 resection of a well-differentiated (G1/2) tumor without infiltration of lymphatic or blood vessels and the maximal submucosal infiltration depth is 500µm. Ablation of remaining Barrett's metaplasia is important, to reduce the risk of metachronous cancer. Esophageal squamous cell cancer is associated with different risk factors, and most of the detected lesions are diagnosed during upper gastrointestinal endoscopy for other indications. Virtual high definition and dye chromoendoscopy with Lugol's solution are used for screening and evaluation. ESD is the preferred resection technique. The criteria for curative resection are similar to Barrett's cancer, but the maximum infiltration depth must not exceed lamina propria mucosae. Although a submucosal infiltration depth of up to 200 µm carries a substantial risk of lymph node metastasis, ESD combined with adjuvant chemo-radiotherapy gives excellent results. The complication rates of endoscopic resection are low, and the functional outcomes are favorable compared to surgery.
    Language English
    Publishing date 2021-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040752
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  10. Article ; Online: Topical oro-dispersible budesonide tablets for stricture prevention after near circumferential ESD for esophageal squamous cell cancer - a case report.

    Mathies, Daniel / Oyama, Tsuneo / Steinbrück, Ingo / Dumoulin, Franz Ludwig

    Zeitschrift fur Gastroenterologie

    2021  Volume 59, Issue 5, Page(s) 454–456

    Abstract: Background:  Endoscopic resection is the treatment of choice for early esophageal cancers. However, resections comprising more than 70-80 % of the circumference are associated with a high risk of stricture formation. Currently, repetitive local ... ...

    Title translation Topische orodispersible Budesonid-Tablette zur Strikturprävention nach subtotal zirkumferentieller ESD eines Plattenepithelfrühkarzinoms im Ösophagus – Ein Fallbericht.
    Abstract Background:  Endoscopic resection is the treatment of choice for early esophageal cancers. However, resections comprising more than 70-80 % of the circumference are associated with a high risk of stricture formation. Currently, repetitive local injections and/or systemic steroids are given for prevention.
    Case report:  We present here the case of a 78-year-old male patient who had a near circumferential endoscopic submucosal dissection for a pT1a mm, L0, V0, R0, G2 esophageal squamous cell cancer. At the end of endoscopic resection, 80 mg of triamcinolone was injected locally. The patient was then treated with oro-dispersible budesonide tablets (2 × 1 mg/day) and nystatin (4 × 100 000 I.E.) for 8 weeks. This treatment resulted in complete healing without any stricture formation and did not result in any complications.
    Discussion:  Treatment with orodispersible budesonide tablets could help prevent strictures after large endoscopic resections in the esophagus.
    MeSH term(s) Aged ; Budesonide/adverse effects ; Carcinoma, Squamous Cell/surgery ; Constriction, Pathologic ; Esophageal Neoplasms/surgery ; Esophageal Stenosis/chemically induced ; Esophageal Stenosis/prevention & control ; Esophagoscopy ; Humans ; Male ; Postoperative Complications ; Tablets
    Chemical Substances Tablets ; Budesonide (51333-22-3)
    Language English
    Publishing date 2021-03-18
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-1409-1076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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