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Article ; Online: Oncogene-induced senescence in meningiomas-an immunohistochemical study.

Mijajlović, Vladimir / Miler, Marko / Ilić, Rosanda / Rašić, Dejan / Dunđerović, Duško / Raičević, Savo / Soldatović, Ivan / De Luka, Silvio / Manojlović-Gačić, Emilija

Journal of neuro-oncology

2023 Volume 166, Issue 1, Page(s) 143–153

Abstract: Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to ... ...

Abstract	Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to the higher grades (grades 2 and 3) have not been elucidated yet. Senescence has been proposed as a potential mechanism constraining the malignant transformation of tumours. Senescence-associated beta-galactosidase (SA-β-GAL) and inhibitors of cyclin-dependent kinases p16 and p21 have been suggested as senescence markers. Methods: We analysed 318 meningiomas of total 343 (178 grade 1, 133 grade 2 and 7 grade 3). Tissue microarrays were constructed and stained immunohistochemically, using antibodies for SA-β-GAL, p16 and p21. Results: The positive correlation of the tumour grade with the expression of p16 (p = 0.016) and SA-β-GAL (p = 0.002) was observed. The expression of p16 and SA-β-GAL was significantly higher in meningiomas grade 2 compared to meningiomas grade 1 (p = 0.006 and p = 0.004, respectively). SA-β-GAL positivity positively correlated with p16 and p21 in the whole cohort. In grade 2 meningiomas, a positive correlation was only between SA-β-GAL and p16. Correlations of senescence markers in meningiomas grade 2 were not present. Conclusion: Our findings suggest the senescence activation in meningiomas grade 2 as a potential mechanism for the restraining of tumour growth and give hope for applying of promising senolytic therapy.
MeSH term(s)	Humans ; Meningioma ; Cellular Senescence/physiology ; Oncogenes ; beta-Galactosidase/metabolism ; Central Nervous System/chemistry ; Central Nervous System/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Meningeal Neoplasms
Chemical Substances	beta-Galactosidase (EC 3.2.1.23) ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-023-04532-y
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Article ; Online: Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature.

Ivaniš, S / Jovanović, M / Dunđerović, D / Zorić, G / Odalović, B / Slijepčević, N / Taušanović, K / Rovčanin, B / Buzejić, M / Vučen, D / Stepanović, B / Ilić, J / Parezanović, M / Marinković, M / Stojanović, M / Tošković, A / Mojsić, I / Živaljević, V

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 280, Issue 12, Page(s) 5637–5647

Abstract: Introduction: Non functional parathyroid carcinoma (PC) is one of the rarest malignant neoplasms. Due to the lack of symptoms and laboratory findings, it is mostly diagnosed in late AQ2 stages, when local invasion and dissemination are already present. ... ...

Abstract	Introduction: Non functional parathyroid carcinoma (PC) is one of the rarest malignant neoplasms. Due to the lack of symptoms and laboratory findings, it is mostly diagnosed in late AQ2 stages, when local invasion and dissemination are already present. However, our case is an exception, because it was detected in early stage, with no local invasion present. We present a case of the smallest non-functional PC yet reported and review of the literature. Case presentation: A 47-year-old woman was admitted to outpatient Clinic where fine-needle aspiration biopsy (FNAB) of bilateral thyroid nodules (slide 1) and central neck mass (slide 2), which was suspected to be an enlarged lymphatic nodule or parathyroid gland was performed. Results came back as Bethesda I-colloid (slide 1), and Bethesda IV (slide 2), stating that it is hard to distinguish thyroid gland oxyphil lesions from parathyroid cells. Total thyroidectomy was performed as well as excision of the left central neck mass, without any involvement of surrounding structures. Pathological examination revealed bilateral thyroid follicular nodular disease, papillary microcarcinoma, and parathyroid carcinoma with vascular and capsular invasion, measuring 10 × 8 × 7 mm. The immunohistochemical profile included positive PTH, Chromogranin A, and negative TTF1. Conclusion: Non-functional PC is usually diagnosed in advanced stages, already involving adjacent structures; however, this case presents a rare example. It is important not to exclude PC as a differential diagnosis in the absence of elevated Ca and PTH serum levels. Follow-up will be difficult, since there are no prognostic parameters to rely on.
MeSH term(s)	Female ; Humans ; Middle Aged ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/surgery ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Thyroid Nodule/pathology ; Thyroidectomy/methods
Language	English
Publishing date	2023-07-26
Publishing country	Germany
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-08137-z
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Article: Dual Role of

Jelača, Sanja / Jovanovic, Ivan / Bovan, Dijana / Jovanovic, Marina Z / Jurisevic, Milena M / Dunđerović, Duško / Dajic-Stevanovic, Zora / Arsenijevic, Nebojsa / Mijatović, Sanja / Maksimović-Ivanić, Danijela

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: Ethnomedicinal records have long mentioned the historical usage ... ...

Abstract	Ethnomedicinal records have long mentioned the historical usage of
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17030286
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Article ; Online: FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo.

Mihajlović, Ekatarina / Biancalana, Lorenzo / Jelača, Sanja / Chiaverini, Lorenzo / Dojčinović, Biljana / Dunđerović, Duško / Zacchini, Stefano / Mijatović, Sanja / Maksimović-Ivanić, Danijela / Marchetti, Fabio

Journal of medicinal chemistry

2024

Abstract: ... ...

Abstract	FETPY
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00377
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Article ; Online: Novel triphenyltin(IV) compounds with carboxylato

Kasalović, Marijana P / Jelača, Sanja / Milanović, Žiko / Maksimović-Ivanić, Danijela / Mijatović, Sanja / Lađarević, Jelena / Božić, Bojan / Marković, Zoran / Dunđerović, Duško / Rüffer, Tobias / Kretschmer, Robert / Kaluđerović, Goran N / Pantelić, Nebojša Đ

Dalton transactions (Cambridge, England : 2003)

2024

Abstract: Three newly synthesized triphenyltin(IV) compounds, Ph3SnL1 (L1- = 3-(4-methyl-2-oxoquinolin-1( ... ...

Abstract	Three newly synthesized triphenyltin(IV) compounds, Ph3SnL1 (L1- = 3-(4-methyl-2-oxoquinolin-1(2
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d4dt00182f
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Article ; Online: Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.

Drača, Dijana / Edeler, David / Saoud, Mohamad / Dojčinović, Biljana / Dunđerović, Duško / Đmura, Goran / Maksimović-Ivanić, Danijela / Mijatović, Sanja / Kaluđerović, Goran N

Journal of inorganic biochemistry

2021 Volume 217, Page(s) 111383

Abstract: CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP ...

Abstract	CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15\|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP and SBA-15\|CP revealed high cytotoxicity in lower μM range. The activity of SBA-15\|CP was found similar to the activity of CP alone. Both CP and SBA-15\|CP induced inhibition of cell proliferation (carboxyfluorescein succinimidyl ester - CFSE assay) along with G2/M arrest (4',6-diamidino-2-phenylindole - DAPI assay). Apoptosis (Annexin V/ propidium iodide - PI assay), through caspase activation (apostat assay) and nitric oxide (NO) production (diacetate(4-amino-5-methylamino-2',7'-difluorofluorescein-diacetat) - DAF FM assay), was identified as main mode of cell death. However, slight elevated autophagy (acridine orange - AO assay) was detected in treated B16F1 cells. CP and SBA-15\|CP did not affect production of ROS (reactive oxygen species) in B16F1 cells. Both SBA-15\|CP and CP induced in B16F1 G2 arrest and subsequent senescence. SBA-15\|CP, but not CP, blocked the growth of melanoma in C57BL/6 mice. Moreover, hepato- and nephrotoxicity in SBA-15\|CP treated animals were diminished in comparison to CP confirming multiply improved antitumor potential of immobilized CP. Outstandingly, SBA-15 boosted in vivo activity and diminished side effects of CP.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Carriers/chemistry ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology ; Mice, Inbred C57BL ; Nanoparticles/chemistry ; Nitric Oxide/metabolism ; Porosity ; Silicon Dioxide/chemistry ; Mice
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; SBA-15 ; Nitric Oxide (31C4KY9ESH) ; Silicon Dioxide (7631-86-9) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111383
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Article: Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy: A case report and review of literature.

Vujosevic, Snezana / Krnjevic, Djordjije / Bogojevic, Milan / Vuckovic, Ljiljana / Filipovic, Aleksandar / Dunđerović, Duško / Sopta, Jelena

World journal of clinical cases

2019 Volume 7, Issue 4, Page(s) 473–481

Abstract: Background: Leiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature (limited to English).: Case ... ...

Abstract	Background: Leiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature (limited to English). Case summary: Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed, followed by radiotherapy. Since metastases were also discovered in the lungs, sternum, and femur, chemotherapy was administered as well. Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus. Conclusion: Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.
Language	English
Publishing date	2019-01-26
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v7.i4.473
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Article: Mesoporous Silica Nanoparticles Enhance the Anticancer Efficacy of Platinum(IV)-Phenolate Conjugates in Breast Cancer Cell Lines.

Predarska, Ivana / Saoud, Mohamad / Drača, Dijana / Morgan, Ibrahim / Komazec, Teodora / Eichhorn, Thomas / Mihajlović, Ekatarina / Dunđerović, Duško / Mijatović, Sanja / Maksimović-Ivanić, Danijela / Hey-Hawkins, Evamarie / Kaluđerović, Goran N

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 21

Abstract: The main reasons for the limited clinical efficacy of the platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well as the possibility to introduce biologically active ligands in their ...

Abstract	The main reasons for the limited clinical efficacy of the platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well as the possibility to introduce biologically active ligands in their axial positions constructing multifunctional prodrugs, creating platinum(IV) complexes is a tempting strategy for addressing these limitations. Another strategy for developing chemotherapeutics with lower toxicity relies on the ability of nanoparticles to accumulate in greater quantities in tumor tissues through passive targeting. To combine the two approaches, three platinum(IV) conjugates based on a cisplatin scaffold containing in the axial positions derivatives of caffeic and ferulic acid were prepared and loaded into SBA-15 to produce the corresponding mesoporous silica nanoparticles (MSNs). The free platinum(IV) conjugates demonstrated higher or comparable activity with respect to cisplatin against different human breast cancer cell lines, while upon immobilization, superior antiproliferative activity with markedly increased cytotoxicity (more than 1000-fold lower IC
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12213767
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Article: Effects of Automation on Sustainability of Immunohistochemistry Laboratory.

Đorđević, Marija / Životić, Maja / Radojević Škodrić, Sanja / Nešović Ostojić, Jelena / Marković Lipkovski, Jasmina / Filipović, Jelena / Ćirović, Sanja / Kovačević, Sanjin / Dunđerović, Duško

Healthcare (Basel, Switzerland)

2021 Volume 9, Issue 7

Abstract: The COVID-19 pandemic that hit the world recently caused numerous changes affecting the health system in every department. Reduced staff numbers, mostly due to illness, led to an increase in automation at every stage of laboratory work. The ... ...

Abstract	The COVID-19 pandemic that hit the world recently caused numerous changes affecting the health system in every department. Reduced staff numbers, mostly due to illness, led to an increase in automation at every stage of laboratory work. The immunohistochemistry (IHC) laboratory conducts a high volume of slide staining every day. Therefore, we analyzed time and total costs required to obtain IHC slides in both the manual and automated way, comparing their efficiency by processing the same sample volume (48 microscope slides-the maximum capacity that an automated immunostainer-DAKO, Autostainer Link 48, Part No AS48030-can process over a single cycle). The total IHC procedure time to run 48 slides manually by one technician was 460 min, while the automated process finished a cycle within 390 min (15.22% less time). The final cost of a single manual IHC slide was 12.26 EUR and 7.69 EUR for slides labeled in the automated immunostainer, which reduced final costs by 37.27%. Thus, automation of the IHC procedure reduces the time and costs of the IHC process, contributing significantly to the sustainability of the healthcare system during the COVID-19 pandemic, overcoming insufficient human resources.
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare9070866
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Article ; Online: The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.

Krajnović, Tamara / Drača, Dijana / Kaluđerović, Goran N / Dunđerović, Duško / Mirkov, Ivana / Wessjohann, Ludger A / Maksimović-Ivanić, Danijela / Mijatović, Sanja

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2019 Volume 129, Page(s) 257–268

Abstract: Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo ... ...

Abstract	Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo in a murine metastatic model was investigated. Melanoma cell viability was diminished in a dose-dependent manner following the treatment with IXN. This decrease was a consequence of autophagy and caspase-dependent apoptosis. Additionally, the dividing potential of highly proliferative melanoma cells was dramatically affected by this isoflavanone, which was in correlation with an abrogated cell colony forming potential, indicating changes in their metastatic features. Concordantly, IXN promoted strong suppression of the processes that define metastasis- cell adhesion, invasion, and migration. Further investigation at the molecular level revealed that the abolished metastatic potential of a melanoma subclone was due to disrupted integrin signaling. Importantly, these results were reaffirmed in vivo where IXN inhibited the development of lung metastatic foci in tumor-challenged animals. The results of the present study may highlight the beneficial effects of IXN on melanoma as the most aggressive type of skin cancer and will hopefully shed a light on the possible use of this prenylflavonoid in the treatment of metastatic malignancies.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Adhesion/drug effects ; Cell Line, Tumor ; Humulus/chemistry ; Lung Neoplasms/prevention & control ; Lung Neoplasms/secondary ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Xanthones/pharmacology
Chemical Substances	Xanthones ; isoxanthohumol
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2019.04.046
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