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  1. Article ; Online: Response to Letter to the Editor 'Gestational cannabis use - Implications for neonatal size and maturity?'

    Ayonrinde, Oyekoya T / White, Scott W / Mehta, Shailender / Dunn, Mikaela L / Bradley, Clare / Fisher, Petrovia / Ayonrinde, Oyedeji A

    The Australian & New Zealand journal of obstetrics & gynaecology

    2023  Volume 63, Issue 6, Page(s) 831–832

    MeSH term(s) Infant, Newborn ; Humans ; Cannabis ; Gestational Age
    Language English
    Publishing date 2023-12-23
    Publishing country Australia
    Document type Letter
    ZDB-ID 390815-x
    ISSN 1479-828X ; 0004-8666
    ISSN (online) 1479-828X
    ISSN 0004-8666
    DOI 10.1111/ajo.13742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The prevalence and significance of gestational cannabis use at an Australian tertiary hospital.

    Dunn, Mikaela L / Bradley, Clare / Ayonrinde, Oyedeji A / Van Rooyen, Derrick M / Tait, Robert J / White, Scott W / Fisher, Petrovia / Sunanda, Gargeswari / Mehta, Shailender / Ayonrinde, Oyekoya T

    The Australian & New Zealand journal of obstetrics & gynaecology

    2022  Volume 63, Issue 1, Page(s) 6–12

    Abstract: Background: Cannabis is one of the most common non-prescribed psychoactive substances used in pregnancy. The prevalence of gestational cannabis use is increasing.: Aim: The aim was to examine the prevalence of gestational cannabis use and associated ... ...

    Abstract Background: Cannabis is one of the most common non-prescribed psychoactive substances used in pregnancy. The prevalence of gestational cannabis use is increasing.
    Aim: The aim was to examine the prevalence of gestational cannabis use and associated pregnancy and neonate outcomes.
    Materials and methods: A retrospective observational study involving pregnant women delivering in 2019 was conducted at a tertiary hospital in Perth, Western Australia. Gestational cannabis and other substance use records were based on maternal self-report. Pregnancy outcomes included neonatal gestational age, birthweight, birth length, head circumference, resuscitation measures, special care nursery admission, 5-min Apgar score and initial neonatal feeding method.
    Results: Among 3104 pregnant women (mean age: 31 years), gestational cannabis use was reported by 1.6% (n = 50). Cannabis users were younger, more likely to use other substances and experience mental illness or domestic violence compared with non-users. Neonates born to cannabis users had a lower mean gestational age, birthweight and birth length compared to those born to non-cannabis users. Gestational cannabis use (odds ratio (OR) 3.3, 95% confidence interval (CI) 1.6-6.7) and tobacco smoking (OR 2.2, 95% CI 1.5-3.6) were associated with increased odds of a low-birthweight neonate. Combined cannabis and tobacco use during pregnancy further increased the likelihood of low birthweight (LBW, adjusted OR 3.9, 95% CI 1.6-9.3). Multivariate logistic regression analysis adjusted for maternal sociodemographical characteristics, mental illness, alcohol, tobacco and other substance use demonstrated gestational cannabis use to be independently associated with LBW (OR 2.3, 95% CI 1.1-5.2).
    Conclusion: Gestational cannabis use was independently associated with low birthweight, synergistically affected by tobacco smoking.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Adult ; Birth Weight ; Cannabis/adverse effects ; Prevalence ; Tertiary Care Centers ; Australia/epidemiology ; Pregnancy Outcome/epidemiology ; Substance-Related Disorders
    Language English
    Publishing date 2022-07-18
    Publishing country Australia
    Document type Observational Study ; Journal Article
    ZDB-ID 390815-x
    ISSN 1479-828X ; 0004-8666
    ISSN (online) 1479-828X
    ISSN 0004-8666
    DOI 10.1111/ajo.13589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between gestational cannabis exposure and maternal, perinatal, placental, and childhood outcomes.

    Ayonrinde, Oyekoya T / Ayonrinde, Oyedeji A / Van Rooyen, Derrick / Tait, Robert / Dunn, Mikaela / Mehta, Shailender / White, Scott / Ayonrinde, Oyekunle K

    Journal of developmental origins of health and disease

    2020  Volume 12, Issue 5, Page(s) 694–703

    Abstract: Globally, the availability and formulations for the administration of cannabis are changing with decriminalization or legalization of recreational use in some jurisdictions, and the prescription of cannabis also occurring. These changes are likely to ... ...

    Abstract Globally, the availability and formulations for the administration of cannabis are changing with decriminalization or legalization of recreational use in some jurisdictions, and the prescription of cannabis also occurring. These changes are likely to affect the prevalence of use, including by women of childbearing age. The effects of in utero and infant alcohol and tobacco exposure are well-documented, but the outcomes of cannabis exposure are less certain. The content of delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis has progressively increased over several decades. This review explores the limited knowledge surrounding the epidemiology of gestational and postnatal cannabis exposure and implications for the mother-placenta-fetus/neonate triad. We examine cannabis' effects from antenatal and lactation exposure on (a) pregnancy and perinatal outcomes, (b) placental health, and (c) longer term cardiometabolic and neurodevelopmental risks and outcomes. Though definitive outcomes are lacking, gestational cannabis has been associated with increased risk of other substance use during pregnancy; impaired placental blood flow; increased risk of small for gestational age births; and associated complications. Childhood and adolescent outcomes are sparsely assessed, with suggested outcomes including increased risk of depression and attention-deficit hyperactivity disorder. Cardiometabolic implications of gestational cannabis use may include maternal fatty liver, obesity, insulin resistance, and increased risk of gestational diabetes mellitus (GDM), with potential consequences for the fetus. Clinical implications for pediatric practice were explored in a bid to understand any potential risk or impact on child health and development.
    MeSH term(s) Adult ; Cannabis/adverse effects ; Cannabis/metabolism ; Female ; Humans ; Infant, Newborn ; Maternal Exposure/adverse effects ; Maternal Exposure/statistics & numerical data ; Pregnancy ; Pregnancy Outcome/epidemiology
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2554780-X
    ISSN 2040-1752 ; 2040-1744
    ISSN (online) 2040-1752
    ISSN 2040-1744
    DOI 10.1017/S2040174420001166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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