Article ; Online: Spontaneous preterm birth as a function of normal cervical length in low-risk women.
2022 Volume 35, Issue 25, Page(s) 9978–9982
Abstract: Objectives: To identify if there is an increased risk for spontaneous preterm birth (sPTB) across the continuum of measured, normal cervical lengths (CL) in low-risk women.: Methods: Retrospective cohort study of women with singleton pregnancies and ... ...
Abstract | Objectives: To identify if there is an increased risk for spontaneous preterm birth (sPTB) across the continuum of measured, normal cervical lengths (CL) in low-risk women. Methods: Retrospective cohort study of women with singleton pregnancies and no history of prior sPTB. Women were included if they underwent mid-trimester transvaginal CL measurement between February 2016 and August 2018 and had a measured, normal CL ≥25mm. Women were excluded for progesterone exposure, fetal anomalies, or an unmeasurable CL due to a poorly developed lower uterine segment. The primary study outcome was sPTB <37 weeks. Secondary outcomes included: sPTB <35 weeks, birth gestational age (GA), and the number of hospital evaluations for suspected preterm labor (PTL). Cervical length was considered in interval groups 25-29mm, 30-34mm, 35-39mm, 40-44mm, and ≥45mm. Outcomes were analyzed with χ Results: 985 women were included. The incidence of sPTB <37 weeks was 3.7%, with a mean birth GA of 38.7 ± 2.4 weeks. The odds of sPTB <37 weeks decreased with increasing cervical length, considered in 5 mm intervals (odds ratio = 0.67; 95% confidence interval 0.49-0.90) and an increasing birth GA of 1 additional day for each CL increase of 3mm ( Conclusions: Among women without a history of sPTB, there was an association of decreased risk of sPTB <37 weeks and advanced delivery GA with increasing, but normal-range CL measurements. However, the association was poor and was not associated with spontaneous preterm birth <35 weeks, or the number of hospital evaluations for PTL. |
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MeSH term(s) | Infant, Newborn ; Pregnancy ; Female ; Humans ; Premature Birth/epidemiology ; Premature Birth/etiology ; Retrospective Studies ; Cervical Length Measurement ; Cervix Uteri/diagnostic imaging ; Obstetric Labor, Premature/epidemiology |
Language | English |
Publishing date | 2022-05-31 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2077261-0 |
ISSN | 1476-4954 ; 1057-0802 ; 1476-7058 |
ISSN (online) | 1476-4954 |
ISSN | 1057-0802 ; 1476-7058 |
DOI | 10.1080/14767058.2022.2081499 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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