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  1. Article: Combination of Extended Antivirals With Antiretrovirals for Severe Mpox in Advanced Human Immunodeficiency Virus Infection: Case Series of 4 Patients.

    Duong, Michael T / Tebas, Pablo / Ancha, Bhavya / Baron, Jillian / Chary, Pallavi / Isaacs, Stuart N / Szep, Zsofia

    Open forum infectious diseases

    2024  Volume 11, Issue 3, Page(s) ofae110

    Abstract: To gauge the safety and utility of extended tecovirimat/cidofovir for severe mpox, here we report our experience caring for 4 patients with mpox and advanced human immunodeficiency virus (HIV) at the Hospitals of the University of Pennsylvania during the ...

    Abstract To gauge the safety and utility of extended tecovirimat/cidofovir for severe mpox, here we report our experience caring for 4 patients with mpox and advanced human immunodeficiency virus (HIV) at the Hospitals of the University of Pennsylvania during the 2022 global outbreak. Three patients had recurrent courses complicated by superinfections, coinfections and insufficient nutrition/housing, requiring extended tecovirimat (5-16 weeks) and cidofovir (1-12 doses) with probenecid and fluids. At follow-up, patients had undetectable HIV RNA on antiretrovirals, improved ulcers and stable renal function on antivirals. Serology guided cessation for one 7-month cidofovir course. Overall findings support a comprehensive approach of prolonged tecovirimat/cidofovir with antiretrovirals for severe mpox, while addressing social factors.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment.

    Beagan, Jonathan A / Duong, Michael T / Titus, Katelyn R / Zhou, Linda / Cao, Zhendong / Ma, Jingjing / Lachanski, Caroline V / Gillis, Daniel R / Phillips-Cremins, Jennifer E

    Genome research

    2017  Volume 27, Issue 7, Page(s) 1139–1152

    Abstract: CTCF is an architectural protein with a critical role in connecting higher-order chromatin folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more dynamic during development than previously appreciated. Here, we set out ...

    Abstract CTCF is an architectural protein with a critical role in connecting higher-order chromatin folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more dynamic during development than previously appreciated. Here, we set out to understand the extent to which shifts in genome-wide CTCF occupancy contribute to the 3D reconfiguration of fine-scale chromatin folding during early neural lineage commitment. Unexpectedly, we observe a sharp decrease in CTCF occupancy during the transition from naïve/primed pluripotency to multipotent primary neural progenitor cells (NPCs). Many pluripotency gene-enhancer interactions are anchored by CTCF, and its occupancy is lost in parallel with loop decommissioning during differentiation. Conversely, CTCF binding sites in NPCs are largely preexisting in pluripotent stem cells. Only a small number of CTCF sites arise de novo in NPCs. We identify another zinc finger protein, Yin Yang 1 (YY1), at the base of looping interactions between NPC-specific genes and enhancers. Putative NPC-specific enhancers exhibit strong YY1 signal when engaged in 3D contacts and negligible YY1 signal when not in loops. Moreover, siRNA knockdown of
    MeSH term(s) CCCTC-Binding Factor/metabolism ; Cell Differentiation ; Cell Line ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Enhancer Elements, Genetic ; Genome-Wide Association Study ; Human Embryonic Stem Cells/cytology ; Human Embryonic Stem Cells/metabolism ; Humans ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; YY1 Transcription Factor/metabolism
    Chemical Substances CCCTC-Binding Factor ; CTCF protein, human ; Chromatin ; YY1 Transcription Factor ; YY1 protein, human
    Language English
    Publishing date 2017-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1284872-4
    ISSN 1549-5469 ; 1088-9051 ; 1054-9803
    ISSN (online) 1549-5469
    ISSN 1088-9051 ; 1054-9803
    DOI 10.1101/gr.215160.116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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