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Article: Data-driven kinematics-consistent model order reduction of fluid-structure interaction problems: application to deformable microcapsules in a Stokes flow.

Dupont, Claire / De Vuyst, Florian / Salsac, Anne-Virginie

2023 Volume 955

Abstract: In this paper, we present a generic approach of a dynamical data-driven model order reduction technique for three-dimensional fluid-structure interaction problems. A low-order continuous linear differential system is identified from snapshot solutions of ...

Abstract	In this paper, we present a generic approach of a dynamical data-driven model order reduction technique for three-dimensional fluid-structure interaction problems. A low-order continuous linear differential system is identified from snapshot solutions of a high-fidelity solver. The reduced order model (ROM) uses different ingredients like proper orthogonal decomposition (POD), dynamic mode decomposition (DMD) and Tikhonov-based robust identification techniques. An interpolation method is used to predict the capsule dynamics for any value of the governing non-dimensional parameters that are not in the training database. Then a dynamical system is built from the predicted solution. Numerical evidence shows the ability of the reduced model to predict the time-evolution of the capsule deformation from its initial state, whatever the parameter values. Accuracy and stability properties of the resulting low-order dynamical system are analysed numerically. The numerical experiments show a very good agreement, measured in terms of modified Hausdorff distance between capsule solutions of the full-order and low-order models both in the case of confined and unconfined flows. This work is a first milestone to move towards real time simulation of fluid-structure problems, which can be extended to non-linear low-order systems to account for strong material and flow non-linearities. It is a valuable innovation tool for rapid design and for the development of innovative devices.
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	218334-1
ISSN	1469-7645 ; 1750-6859 ; 0022-1120
ISSN (online)	1469-7645 ; 1750-6859
ISSN	0022-1120
DOI	10.1017/jfm.2022.1005
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Article: Emergency department CT examinations demonstrate no evidence of early viral circulation at the start of the COVID-19 pandemic-a multicentre epidemiological study.

Crombé, Amandine / Dupont, Claire / Casalonga, François / Seux, Mylène / Favard, Nicolas / Coulon, Agnès / Jurkovic, Thomas / Nivet, Hubert / Gorincour, Guillaume

Insights into imaging

2024 Volume 15, Issue 1, Page(s) 14

Abstract: Background: Biological studies suggested that the COVID-19 outbreak in France occurred before the first official diagnosis on January 24, 2020. We investigated this controversial topic using a large collection of chest CTs performed throughout French ... ...

Abstract	Background: Biological studies suggested that the COVID-19 outbreak in France occurred before the first official diagnosis on January 24, 2020. We investigated this controversial topic using a large collection of chest CTs performed throughout French emergency departments within 6 months before the 1st lockdown. Results: Overall, 49,311 consecutive patients (median age: 60 years, 23,636/49,311 [47.9%] women) with available chest CT images and reports from 61 emergency departments between September 1, 2020, and March 16, 2020 (day before the 1st French lockdown), were retrospectively included in this multicentre study. In the macroscopic analysis of reports automatically (labelled for presence of ground glass opacities [GGOs], reticulations, and bilateral and subpleural abnormalities), we found a significant breakpoint on February 17, 2020, for the weekly time series with 1, 2 and ≥ 3 of these 4 radiological features, with 146/49,311 (0.3%) patients showing bilateral abnormalities and ground glass opacities (GGOs) from that day. According to radiologists, 22/146 (15.1%) CT images showed typical characteristics of COVID-19, including 4/146 (2.7%) before February 2020. According to hospital records, one patient remained without microbial diagnosis, two patients had proven influenza A and one patient had concomitant influenza A and mycoplasma infection. Conclusion: These results suggest that SARS-CoV-2 was not circulating in the areas covered by the 61 emergency departments involved in our study before the official beginning of the COVID-19 outbreak in France. In emergency patients, the strong resemblance among mycoplasma, influenza A and SARS-CoV-2 lung infections on chest CT and the nonspecificity of CT patterns in low prevalence periods is stressed. Critical relevance statement: We proposed here an innovative approach to revisit a controversial 'real' start of the COVID-19 pandemic in France based on (1) a population-level approach combining text mining, time series analysis and an epidemiological dataset and (2) a patient-level approach with careful retrospective reading of chest CT scans complemented by analysis of samples performed contemporarily to the chest CT. We showed no evidence that SARS-CoV-2 was actively circulating in France before February 2020.
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-023-01590-8
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Book: Climate policy integration into EU energy policy

Dupont, Claire

progress and prospects

(Routledge studies in energy policy)

2016

Institution	Europäische Union
Author's details	Claire Dupont
Series title	Routledge studies in energy policy
Keywords	Climatic changes/Government policy ; Energy policy/Environmental aspects ; Environmental policy ; Energiepolitik ; Klimaschutz
Language	English
Size	xiii, 193 Seiten, Diagramme, 24 cm
Publisher	Routledge,Taylor & Francis Group
Publishing place	London ; New York, NY
Document type	Book
Note	Hier auch später erschienene, unveränderte Nachdrucke
ISBN	9781138065024 ; 9781138806467 ; 9781315751665 ; 1138065021 ; 1138806463 ; 1315751666
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Book ; Online: Data-driven kinematics-consistent model order reduction of fluid-structure interaction problems

Dupont, Claire / De Vuyst, Florian / Salsac, Anne-Virginie

application to deformable microcapsules in a Stokes flow

2022

Abstract	In this paper, we present a generic approach of a dynamical data-driven model order reduction technique for three-dimensional fluid-structure interaction problems. A low-order continuous linear differential system is identified from snapshot solutions of a high-fidelity solver. The reduced order model (ROM) uses different ingredients like proper orthogonal decomposition (POD), dynamic mode decomposition (DMD) and Tikhonov-based robust identification techniques. An interpolation method is used to predict the capsule dynamics for any value of the governing non-dimensional parameters that are not in the training database. Then a dynamical system is built from the predicted solution. Numerical evidence shows the ability of the reduced model to predict the time-evolution of the capsule deformation from its initial state, whatever the parameter values. Accuracy and stability properties of the resulting low-order dynamical system are analyzed numerically. The numerical experiments show a very good agreement, measured in terms of modified Hausdorff distance between capsule solutions of the full-order and low-order models both in the case of confined and unconfined flows. This work is a first milestone to move towards real time simulation of fluid-structure problems, which can be extended to non-linear low-order systems to account for strong material and flow non-linearities. It is a valuable innovation tool for rapid design and for the development of innovative devices.
Keywords	Computer Science - Computational Engineering ; Finance ; and Science ; Mathematics - Numerical Analysis ; 70-XX ; 92-XX ; 65-XX
Subject code	532
Publishing date	2022-03-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Climate Policy Integration into EU Energy Policy

Dupont, Claire

Progress and prospects

(Routledge Studies in Energy Policy)

2015

Series title	Routledge Studies in Energy Policy
Language	English
Size	1 Online-Ressource (209 pages)
Edition	1st ed
Document type	Book ; Online
ISBN	9781138065024 ; 9781317615835 ; 9781138065024 ; 1138065021 ; 1317615832 ; 1138065021
Database	ECONomics Information System

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Article ; Online: Evidence for low nanocompaction of heterochromatin in living embryonic stem cells.

Dupont, Claire / Chahar, Dhanvantri / Trullo, Antonio / Gostan, Thierry / Surcis, Caroline / Grimaud, Charlotte / Fisher, Daniel / Feil, Robert / Llères, David

The EMBO journal

2023 Volume 42, Issue 12, Page(s) e110286

Abstract: Despite advances in the identification of chromatin regulators and genome interactions, the principles of higher-order chromatin structure have remained elusive. Here, we applied FLIM-FRET microscopy to analyse, in living cells, the spatial organisation ... ...

Abstract	Despite advances in the identification of chromatin regulators and genome interactions, the principles of higher-order chromatin structure have remained elusive. Here, we applied FLIM-FRET microscopy to analyse, in living cells, the spatial organisation of nanometre range proximity between nucleosomes, which we called "nanocompaction." Both in naive embryonic stem cells (ESCs) and in ESC-derived epiblast-like cells (EpiLCs), we find that, contrary to expectations, constitutive heterochromatin is much less compacted than bulk chromatin. The opposite was observed in fixed cells. HP1α knockdown increased nanocompaction in living ESCs, but this was overridden by loss of HP1β, indicating the existence of a dynamic HP1-dependent low compaction state in pluripotent cells. Depletion of H4K20me2/3 abrogated nanocompaction, while increased H4K20me3 levels accompanied the nuclear reorganisation during EpiLCs induction. Finally, the knockout of the nuclear cellular-proliferation marker Ki-67 strongly reduced both interphase and mitotic heterochromatin nanocompaction in ESCs. Our data indicate that, contrary to prevailing models, heterochromatin is not highly compacted at the nanoscale but resides in a dynamic low nanocompaction state that depends on H4K20me2/3, the balance between HP1 isoforms, and Ki-67.
MeSH term(s)	Heterochromatin/genetics ; Ki-67 Antigen/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/chemistry ; Chromatin ; Embryonic Stem Cells
Chemical Substances	Heterochromatin ; Ki-67 Antigen ; Chromosomal Proteins, Non-Histone ; Chromatin
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2021110286
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Article ; Online: Patient-specific finite element simulation of peripheral artery percutaneous transluminal angioplasty to evaluate the procedure outcome without stent implantation.

Helou, Bernard / Bel-Brunon, Aline / Dupont, Claire / Ye, Wenfeng / Silvestro, Claudio / Rochette, Michel / Lucas, Antoine / Kaladji, Adrien / Haigron, Pascal

International journal for numerical methods in biomedical engineering

2023 Volume 39, Issue 3, Page(s) e3685

Abstract: The purpose of this work is to present a patient-specific (PS) modeling approach for simulating percutaneous transluminal angioplasty (PTA) endovascular treatment and assessing the balloon sizing influence on short-term outcomes in peripheral arteries, i. ...

Abstract	The purpose of this work is to present a patient-specific (PS) modeling approach for simulating percutaneous transluminal angioplasty (PTA) endovascular treatment and assessing the balloon sizing influence on short-term outcomes in peripheral arteries, i.e. without stent implantation. Two 3D PS stenosed femoral artery models, one with a dominant calcified atherosclerosis while the other with a lipidic plaque, were generated from pre-operative computed tomography angiography images. Elastoplastic constitutive laws were implemented within the plaque and artery models. Implicit finite element method (FEM) was used to simulate the balloon inflation and deflation for different sizings. Besides vessel strains, results were mainly evaluated in terms of the elastic recoil ratio (ERR) and lumen gain ratio (LGR) attained immediately after PTA. Higher LGR values were shown within the stenosed region of the lipidic patient. Simulated results also showed a direct and quantified correlation between balloon sizing and LGR and ERR for both patients after PTA, with a more significant influence on the lumen gain. The max principal strain values in the outer arterial wall increased at higher balloon sizes during inflation as well, with higher rates of increase when the plaque was calcified. Results show that our model could serve in finding a compromise for each stenosis type: maximizing the achieved lumen gain after PTA, but at the same time without damaging the arterial tissue. The proposed methodology can serve as a step toward a clinical decision support system to improve angioplasty balloon sizing selection prior to the surgery.
MeSH term(s)	Humans ; Finite Element Analysis ; Angioplasty/methods ; Angioplasty, Balloon ; Femoral Artery/surgery ; Constriction, Pathologic ; Stents ; Treatment Outcome
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540968-2
ISSN	2040-7947 ; 2040-7939
ISSN (online)	2040-7947
ISSN	2040-7939
DOI	10.1002/cnm.3685
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Article: Proton Pump Inhibitor Use and Associated Infectious Complications in the PICU: Propensity Score Matching Analysis.

Goyer, Isabelle / Lacotte, Edouard / Montreuil, Julien / Thibon, Pascal / Briant, Anaïs R / Dupont, Claire / Parienti, Jean-Jacques / Brossier, David

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2022 Volume 23, Issue 12, Page(s) e590–e594

Abstract: Objectives: We aimed to evaluate the association between proton pump inhibitor (PPI) exposure and nosocomial infection (NI) during PICU stay.: Design: Propensity score matched analysis of a single-center retrospective cohort from January 1, 2017, to ... ...

Abstract	Objectives: We aimed to evaluate the association between proton pump inhibitor (PPI) exposure and nosocomial infection (NI) during PICU stay. Design: Propensity score matched analysis of a single-center retrospective cohort from January 1, 2017, to December 31, 2018. Setting: Tertiary medical and surgical PICU in France. Patients: Patients younger than 18 years old, admitted to the PICU with a stay greater than 48 hours. Intervention: Patients were retrospectively allocated into two groups and compared depending on whether they received a PPI or not. Measurements and main results: Seven-hundred fifty-four patients were included of which 231 received a PPI (31%). PPIs were mostly used for stress ulcer prophylaxis (174/231; 75%), but upper gastrointestinal bleed risk factors were rarely present (18%). In the unadjusted analyses, the rate of NI was 8% in the PPI exposed group versus 2% in the nonexposed group. After propensity score matching ( n = 184 per group), we failed to identify an association between PPI exposure and greater odds of NI (adjusted odds ratio 2.9 [95% CI, 0.9-9.3]; p = 0.082). However, these data have not excluded the possibility that there is up to nine-fold greater odds of NI. Conclusions: This study highlights the prevalent use of PPIs in the PICU, and the potential association between PPIs and nine-fold greater odds of NI is not excluded.
MeSH term(s)	Humans ; Adolescent ; Child ; Proton Pump Inhibitors/adverse effects ; Histamine H2 Antagonists/therapeutic use ; Retrospective Studies ; Propensity Score ; Intensive Care Units, Pediatric
Chemical Substances	Proton Pump Inhibitors ; Histamine H2 Antagonists
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003063
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Article ; Online: Efficacy of infliximab after loss of response of/intolerance to adalimumab in pediatric Crohn's disease: A retrospective multicenter cohort study of the "GETAID pédiatrique".

Lecoutour, Anne / Dupont, Claire / Caldari, Dominique / Dumant, Clémentine / Vanrenterghem, Audrey / Ruiz, Mathias / Duclaux-Loras, Rémi / Berthet, Stéphanie / Dimitrov, Georges / Lacroix, Delphine / Duvant, Pauline / Roman, Céline / Wagner, Anne Claire / Bourmaud, Aurélie / Viala, Jérôme / Ruemmele, Frank M / Pigneur, Bénédicte

Journal of pediatric gastroenterology and nutrition

2024 Volume 78, Issue 5, Page(s) 1116–1125

Abstract: Background: Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can ... ...

Abstract	Background: Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can occur over time. The aim was to assess the efficacy of IFX as second line therapy after LOR or intolerance to ADA in pediatric CD patients at 1 year. Methods: We conducted a retrospective and multicenter study in France among the "GETAID pédiatrique" centers between April 2019 and April 2022. CD patients under 18 years old and treated with IFX after ADA failure or intolerance were included. We collected anthropometric, clinical, and biological data at baseline (start of IFX), at 6 and 12 months. Clinical remission was defined by a Weighted Pediatric CD Activity Index (wPCDAI) score less than 12.5 points. Results: Of the 32 patients included in our study, 27 (84.4%) were still on IFX at 12 months of the switch. Among them, 13 had discontinued ADA because of a LOR, 12 for insufficient response and 2 due to primary nonresponse. At M12, 22 patients were in corticosteroid free clinical remission (68.7%). Under IFX, the wPCDAI decreased over time (47.5 ± 24.1, 16.6 ± 21.2 and 9.7 ± 19.0 at M0, M6 and M12 respectively). The only factor associated with clinical remission at 12 months was absence of perianal disease at the end of the IFX induction. Conclusions: IFX is effective in maintaining remission at 1 year in pediatric CD patients experiencing a LOR or intolerance with ADA, and IFX could be an interesting therapeutic choice instead of other biologics in this situation.
MeSH term(s)	Humans ; Crohn Disease/drug therapy ; Adalimumab/therapeutic use ; Retrospective Studies ; Infliximab/therapeutic use ; Male ; Female ; Child ; Adolescent ; Gastrointestinal Agents/therapeutic use ; France ; Treatment Outcome ; Remission Induction/methods ; Treatment Failure
Chemical Substances	Adalimumab (FYS6T7F842) ; Infliximab (B72HH48FLU) ; Gastrointestinal Agents
Language	English
Publishing date	2024-01-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1002/jpn3.12044
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Article ; Online: Numerical simulation of fenestrated graft deployment: Anticipation of stent graft and vascular structure adequacy.

Dupont, Claire / Kaladji, Adrien / Rochette, Michel / Saudreau, Blandine / Lucas, Antoine / Haigron, Pascal

International journal for numerical methods in biomedical engineering

2020 Volume 37, Issue 1, Page(s) e03409

Abstract: Fenestrated endovascular aneurism repair (FEVAR) is a minimally invasive technique, and its success depends on the adequacy of the correspondence between the visceral arteries ostia and position of the fenestrations of the stent graft (SG) during its ... ...

Abstract	Fenestrated endovascular aneurism repair (FEVAR) is a minimally invasive technique, and its success depends on the adequacy of the correspondence between the visceral arteries ostia and position of the fenestrations of the stent graft (SG) during its deployment in juxtarenal aneurisms. However, the fenestration position is generally determined from a preoperative computerised tomography (CT) scan, without considering the vascular deformation induced by the insertion of the endovascular tools. Catheterisation difficulties may occur during clinical procedures. Accordingly, the objective of this work is to present an initial proof of concept aimed at anticipating and optimising the position of the fenestrations, while considering the vascular deformation induced by the insertion of the endovascular tools. The proposed method relies on the finite element method to simulate the SG deployment in a vascular structure (VS), and considers the vascular deformation induced by the tools. After determining the optimal simulation parameters for a patient-specific case, the robustness of the method is demonstrated on six other representative anatomies. The simulated SG is also compared with post-deployment CT observations, and demonstrates good adequacy. The results show that the numerically corrected fenestration positions, as determined from the simulated results following the insertion of the endovascular tools, deviate from those of the standard plan (as determined from the preoperative CT scan). This indicates that the SG-VS adequacy could be improved via simulation-based planning, to anticipate potential catheterisation difficulties.
MeSH term(s)	Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Humans ; Prosthesis Design ; Stents ; Treatment Outcome
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540968-2
ISSN	2040-7947 ; 2040-7939
ISSN (online)	2040-7947
ISSN	2040-7939
DOI	10.1002/cnm.3409
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