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  1. Article ; Online: The incidence of alpha-thalassemia in Iraqi Turks

    Duran Canatan

    Turkish Journal of Hematology, Vol 29, Iss 1, Pp 96-

    2012  Volume 96

    Keywords Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Language English
    Publishing date 2012-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

    Duran Canatan / Sevgi Kosaci Akdeniz

    Mediterranean Journal of Hematology and Infectious Diseases, Vol 4, Iss 1, Pp e2012051-e

    2012  Volume 2012051

    Abstract: Most of the techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at ... ...

    Abstract Most of the techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at different systemic diseases shows the quantity of the element at the body. The aim of this study was to compare the levels of iron and ferritin in saliva and serum in patients with thalassemia and iron deficiency anemia. For this purpose, 35 healthy children as control group and 71 thalassemia major, 10 thalassemia intermedia and 15 thalassemia trait patients were involved. Their saliva and serum iron and ferritin levels were measured. There was no statistically difference between age and gender in all groups and control group (p>0.05). In all groups saliva iron levels are higher than serum iron levels(p<0.05). Furthermore there was a positive correlation betwen serum and saliva iron levels in thalassemia major, intermedia and trait groups ( p=0.000, r=0.972, r=0.720, r=0.955) and also there was a positive correlation between serum and saliva iron levels in control and iron deficiency group (p= 0.000, r= 0.885, r= 0.368). In conclusion, Saliva iron and ferritin levels increase as well as serum in patients with thalassemia and decrease in patients with iron deficiency anemia. Saliva can be used for diagnosis routinely to shows the iron overload and deficiency of the body and its easy applicability and also a non-invasive procedure is important advantage.
    Keywords Anemia and thalassemia syndromes ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Subject code 610
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

    Duran Canatan / Sevgi Kosaci Akdeniz

    Mediterranean Journal of Hematology and Infectious Diseases, Vol 4, Iss 1, Pp e2012051-e

    2012  Volume 2012051

    Abstract: Most of the techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at ... ...

    Abstract Most of the techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at different systemic diseases shows the quantity of the element at the body. The aim of this study was to compare the levels of iron and ferritin in saliva and serum in patients with thalassemia and iron deficiency anemia. For this purpose, 35 healthy children as control group and 71 thalassemia major, 10 thalassemia intermedia and 15 thalassemia trait patients were involved. Their saliva and serum iron and ferritin levels were measured. There was no statistically difference between age and gender in all groups and control group (p>0.05). In all groups saliva iron levels are higher than serum iron levels(p<0.05). Furthermore there was a positive correlation betwen serum and saliva iron levels in thalassemia major, intermedia and trait groups ( p=0.000, r=0.972, r=0.720, r=0.955) and also there was a positive correlation between serum and saliva iron levels in control and iron deficiency group (p= 0.000, r= 0.885, r= 0.368). In conclusion, Saliva iron and ferritin levels increase as well as serum in patients with thalassemia and decrease in patients with iron deficiency anemia. Saliva can be used for diagnosis routinely to shows the iron overload and deficiency of the body and its easy applicability and also a non-invasive procedure is important advantage.
    Keywords Anemia and thalassemia syndromes ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Catholic University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: First Observation of Hemoglobin Kansas [β102(G4)Asn→Thr, AAC>ACC] in the Turkish Population

    Ibrahim Keser / Alev Öztaş / Türker Bilgen / Duran Canatan

    Turkish Journal of Hematology, Vol 32, Iss 4, Pp 374-

    2015  Volume 375

    Keywords Abnormal hemoglobins ; Hb Kansas ; Turkish population ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Burdur’da ilköğretim 8. sınıflarda β - talasemi taşıyıcılık sıklığı

    Binali Çatak / Sevinç Sütlü / Selçuk Kılınç / Okan Badıllıoğlu / Duran Canatan

    Cumhuriyet Medical Journal, Vol 35, Iss 2, Pp 193-

    2013  Volume 198

    Abstract: Amaç. Talasemi taşıyıcılığı ülkemizde önemli bir halk sağlığı sorunudur. Çalışmada Burdur’da ilköğretim 8. sınıflarda β talasemi taşıyıcılık sıklığı ve öğrencilerin talasemi konusunda bilgi düzeyini belirlemek amaçlanmıştır. Yöntem. Çalışmaya Burdur’da ... ...

    Abstract Amaç. Talasemi taşıyıcılığı ülkemizde önemli bir halk sağlığı sorunudur. Çalışmada Burdur’da ilköğretim 8. sınıflarda β talasemi taşıyıcılık sıklığı ve öğrencilerin talasemi konusunda bilgi düzeyini belirlemek amaçlanmıştır. Yöntem. Çalışmaya Burdur’da 2011 yılında ilköğretim 8. sınıfta eğitim ve öğrenim gören 3515 öğrenci katılmıştır. Çalışmada örnekleme için, Epi İnfo programında 739 öğrenci randomizasyonla belirlenmiştir. Öğrencilerden alınan kanlar, Burdur Talasemi Tanı Merkezi’nde Yüksek Performanslı Likid Kromatografi (HPLC) cihazı ile analiz edilmiştir. Veriler, SPSS 10,0 paket programında değerlendirilmiştir. Bulgular. Burdur’da 8. sınıf ilköğretim öğrencilerinde β talasemi taşıyıcılığı %5,2 , anormal hemoglobin ise %0,9 olarak bulunmuştur. Öğrencilerin ,9’u talasemi hastalığını bilmektedir. Talasemi hastalığını bilenlerin ,6’sı talaseminin kan hastalığı olduğunu, ,3’ü bulaşıcı bir hastalık olmadığını ve ,5’i ise doğum öncesi tanı konulabileceğini bilmektedir. Kan alınan öğrencilerin Burdur’da 34’ünde (%5,2) Hb A2 yüksekliği ile seyereden β -talasemi taşıyıcılığı ve 6 öğrencide (%0,9) anormal hemoglobin bulunmuştur. Sonuç. Burdur’da ilköğretim 8.sınıf öğrencilerinde talasemi taşıyıcılığı ülke genelinden yüksektir. Öğrencilerin talasemi konusundaki bilgi düzeyi yüksektir. Bu bağlamda talasemi taşıyıcılığı prevelansını azaltmak içen, periyodik okul giriş muayeneleri ile taşıyıcılar belirlenmeli ve gerek aileler, gerekse taşıyıcı çocuklar ayrıca eğitime tabi tutulmalıdır.
    Keywords β Talasemi taşıyıcılığı ; Öğrenci ; Bilgi düzeyi ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher Cumhuriyet University School of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Visceral Leishmaniasis of Childhood

    Duran Canatan / Elif Çomak / Ayça Esra Kuybulu

    Cocuk Enfeksiyon Dergisi, Vol 03, Iss 04, Pp 109-

    2009  Volume 111

    Abstract: Leishmaniasis is widespread in many countries, including Turkey. We present the clinical characteristics and the retrospective analysis of 22 children with visceral leishmaniasis, identified between 1995-2008.The mean age at presentation was 3.3±1.96 ... ...

    Abstract Leishmaniasis is widespread in many countries, including Turkey. We present the clinical characteristics and the retrospective analysis of 22 children with visceral leishmaniasis, identified between 1995-2008.The mean age at presentation was 3.3±1.96 years (range 0-8). All patients had splenomegaly. Fever was found in 19 (86.3%) cases. Anemia, thrombocytopenia, and leukopenia was observed in all, 19 (86.3%), and 13 (61%) cases respectively. Diagnosis of visceral leishmaniasis was made with the identification of amastigotes in giemsa-stained bone-marrow aspirate smears. Initial treatment consisted of meglumine antimoniate in 19 (86.3%) patients and liposomal amphotericin B in 3 (13.7%) patients. Three children who did not respond to meglumine antimoniate were cured with liposomal amphotericin B. The findings highlight liposomal amphotericin B as an effective therapy for visceral leishmaniasis in children. Early detection and appropriate management of complications may reduce morbidity and mortality in childhood visceral leishmaniasis.
    Keywords Visceral leishmaniasis ; childhood ; liposomal amphotericin B ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; DOAJ:Internal medicine
    Language Turkish
    Publishing date 2009-09-01T00:00:00Z
    Publisher Aves Yayincilik
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The effect of HBB:c.*+96T>C (3’UTR +1570 T>C) on the mild b-thalassemia intermedia phenotype

    Türker Bilgen / Duran Canatan / Yunus Arıkan / Akif Yeşilipek / İbrahim Keser

    Turkish Journal of Hematology, Vol 28, Iss 03, Pp 219-

    2011  Volume 222

    Abstract: Hemoglobin beta (HBB):c.*+96T>C substitution is very rare among β-globin gene mutations and its clinical significance remains to be clarified. The present study aimed to investigate the role of HBB:c.*+96T>C in the β-thalassemia intermedia phenotype in a ...

    Abstract Hemoglobin beta (HBB):c.*+96T>C substitution is very rare among β-globin gene mutations and its clinical significance remains to be clarified. The present study aimed to investigate the role of HBB:c.*+96T>C in the β-thalassemia intermedia phenotype in a Turkish family. The proband and parents were screened for β-globin gene mutations via direct sequencing. Hematological and physical examination results were recorded, and correlated according to genotype. The proband was compound heterozygous for Cod 8 (-AA) and HBB:c.*+96T>C, whereas his mother and father were heterozygous for Cod 8 (-AA) and HBB:c.*+96T>C, respectively. The father had almost normal hematological findings, whereas the mother had the typical β-thalassemia trait phenotype. The proband was diagnosed as mild β-thalassemia intermedia based on hepatosplenomegaly and hematological findings. To the best of our knowledge this is the first report of HBB:c.*+96T>C mutation in a Turkish family. HBB:c.* 96T>C substitution is a very rare, but clinically relevant β-globin gene mutation. Additionally, we think that if 1 spouse is a carrier for β-globin gene mutation the other should be screened for silent mutations, such as HBB:c.*+96T>C mutation of the β-globin gene, even if she/he does not have any clinical or hematological signs of the β-thalassemia trait phenotype.
    Keywords Mild β-thalassemia intermedia ; b-globin gene ; HBB:c.*+96T>C ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2011-09-01T00:00:00Z
    Publisher Aves Yayincilik
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: National Thalassemia Prevention Campaign

    Duran Canatan / Yeşim Aydınok / Yurdanur Kılınç / Zeynep Karakaş / İlgen Şaşmaz / Hilmi Apak / Nazan Sarper

    Turkish Journal of Hematology, Vol 30, Iss 1, Pp 91-

    The Talotır Project

    2013  Volume 92

    Keywords Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Language English
    Publishing date 2013-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A Novel Technique of Spectral Discrimination of Variants of Sickle Cell Anemia

    Vadivel Masilamani / Sandanasamy Devanesan / Fatma AlQathani / Mashael AlShebly / Hebatullah Hassan Daban / Duran Canatan / Karim Farhat / Mansour Jabry / Mohamad S. AlSalhi

    Disease Markers, Vol

    2018  Volume 2018

    Abstract: Sickle cell anemia (SCA) is an inherited blood disorder with worldwide incidence of 15%; out of this, it is found in up to 20% in countries like Kingdom of Saudi Arabia and Bahrain. The standard conventional method of detection is complete blood count ( ... ...

    Abstract Sickle cell anemia (SCA) is an inherited blood disorder with worldwide incidence of 15%; out of this, it is found in up to 20% in countries like Kingdom of Saudi Arabia and Bahrain. The standard conventional method of detection is complete blood count (CBC) followed by hemoglobin electrophoresis or high-performance liquid chromatography (HPLC) or both. In this context, spectral detection of variants of sickle cell anemia (SCA) is an innovative technique, which when made accurate and reliable could be an effective alternative, since the instrumentation is compact (5 kg) and hence portable. This makes mass screening even in remote villages possible. In this paper, we give the essential aspects of fluorescent spectral features of sickle cell trait (SCT), sickle cell disease (SCD), beta (β) thalassemia trait (BTT) + SCD, and beta (β) thalassemia disease (BTD) + SCD. All the above four major variants could be discriminated among themselves and also from the normal control blood sample. All these analyses could be carried out with 5 ml of blood, in a time period of 10 minutes. The results of this paper give strong support for an alternative method, a spectral technique, for molecular-level diagnosis of sickle cell anemia and other closely related blood disorders.
    Keywords Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey

    Ibrahim Aslan / Duran Canatan / Nihal Balta / Gulizar Kacar / Cengaver Dorak / Ahmet Ozsancak / Nurgul Oguz / Ruya Cosan

    International Journal of Endocrinology, Vol

    2012  Volume 2012

    Keywords Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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