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Article ; Online: How a discerning cytological examination can aid in the diagnosis of infectious diseases: case reports.

Faria, D K / Almeida Júnior, J N de / Faria, C S / Durante, B / Falasco, B F / Terreri Neto, E / Antonangelo, L

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2021 Volume 54, Issue 2, Page(s) e10462

Abstract: Infections caused by uncommon and resistant pathogens in unusual sites have been increasingly reported in medical literature. We describe four cases of rare cytological findings and clinical impact for patients. In the first case, Aspergillus sp and ... ...

Abstract	Infections caused by uncommon and resistant pathogens in unusual sites have been increasingly reported in medical literature. We describe four cases of rare cytological findings and clinical impact for patients. In the first case, Aspergillus sp and Pneumocystis jirovecii were observed in the bronchoalveolar lavage of a patient with severe systemic lupus. In the second and third cases, we describe the presence of Trichomonas sp and Strongyloides sp larvae in samples of pleural and peritoneal fluid, respectively. The fourth report is about a patient with a wrist subcutaneous nodule whose synovial aspiration and cytology revealed the presence of brown septate hyphae. The early identification of the infectious agent in the cytological examination was essential for the introduction and/or re-adaptation of therapy in the four cases described. Patients in this report were immunocompromised with severe comorbidities, conditions often associated with unfavorable clinical outcomes.
MeSH term(s)	Animals ; Ascitic Fluid/parasitology ; Aspergillus/isolation & purification ; Bronchoalveolar Lavage Fluid/microbiology ; Communicable Diseases/diagnosis ; Cytodiagnosis/methods ; Fatal Outcome ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion/parasitology ; Pneumocystis carinii/isolation & purification ; Strongyloides/isolation & purification ; Strongyloidiasis/diagnosis ; Trichomonas/isolation & purification ; Trichomonas Infections/diagnosis
Language	English
Publishing date	2021-01-08
Publishing country	Brazil
Document type	Case Reports ; Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X202010462
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Article ; Online: Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases.

Bleve, Augusto / Motta, Francesca / Durante, Barbara / Pandolfo, Chiara / Selmi, Carlo / Sica, Antonio

Clinical reviews in allergy & immunology

2022 Volume 64, Issue 2, Page(s) 123–144

Abstract: The immune system is the central regulator of tissue homeostasis, ensuring tissue regeneration and protection against both pathogens and the neoformation of cancer cells. Its proper functioning requires homeostatic properties, which are maintained by an ... ...

Abstract	The immune system is the central regulator of tissue homeostasis, ensuring tissue regeneration and protection against both pathogens and the neoformation of cancer cells. Its proper functioning requires homeostatic properties, which are maintained by an adequate balance of myeloid and lymphoid responses. Aging progressively undermines this ability and compromises the correct activation of immune responses, as well as the resolution of the inflammatory response. A subclinical syndrome of "homeostatic frailty" appears as a distinctive trait of the elderly, which predisposes to immune debilitation and chronic low-grade inflammation (inflammaging), causing the uncontrolled development of chronic and degenerative diseases. The innate immune compartment, in particular, undergoes to a sequela of age-dependent functional alterations, encompassing steps of myeloid progenitor differentiation and altered responses to endogenous and exogenous threats. Here, we will review the age-dependent evolution of myeloid populations, as well as their impact on frailty and diseases of the elderly.
MeSH term(s)	Humans ; Aged ; Immunosenescence/physiology ; Frailty ; Aging/physiology ; Inflammation ; Myeloid Cells
Language	English
Publishing date	2022-01-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/s12016-021-08909-7
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Article ; Online: Lipid Metabolism and Cancer Immunotherapy: Immunosuppressive Myeloid Cells at the Crossroad.

Bleve, Augusto / Durante, Barbara / Sica, Antonio / Consonni, Francesca Maria

International journal of molecular sciences

2020 Volume 21, Issue 16

Abstract: Cancer progression generates a chronic inflammatory state that dramatically influences hematopoiesis, originating different subsets of immune cells that can exert pro- or anti-tumor roles. Commitment towards one of these opposing phenotypes is driven by ... ...

Abstract	Cancer progression generates a chronic inflammatory state that dramatically influences hematopoiesis, originating different subsets of immune cells that can exert pro- or anti-tumor roles. Commitment towards one of these opposing phenotypes is driven by inflammatory and metabolic stimuli derived from the tumor-microenvironment (TME). Current immunotherapy protocols are based on the reprogramming of both specific and innate immune responses, in order to boost the intrinsic anti-tumoral activity of both compartments. Growing pre-clinical and clinical evidence highlights the key role of metabolism as a major influence on both immune and clinical responses of cancer patients. Indeed, nutrient competition (i.e., amino acids, glucose, fatty acids) between proliferating cancer cells and immune cells, together with inflammatory mediators, drastically affect the functionality of innate and adaptive immune cells, as well as their functional cross-talk. This review discusses new advances on the complex interplay between cancer-related inflammation, myeloid cell differentiation and lipid metabolism, highlighting the therapeutic potential of metabolic interventions as modulators of anticancer immune responses and catalysts of anticancer immunotherapy.
MeSH term(s)	Animals ; Cancer Vaccines/immunology ; Humans ; Immunosuppression ; Immunotherapy ; Lipid Metabolism ; Myeloid Cells/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy
Chemical Substances	Cancer Vaccines
Language	English
Publishing date	2020-08-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21165845
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Article ; Online: Immunometabolic interference between cancer and COVID-19.

Consonni, Francesca Maria / Durante, Barbara / Manfredi, Marcello / Bleve, Augusto / Pandolfo, Chiara / Garlatti, Valentina / Vanella, Virginia Vita / Marengo, Emilio / Barberis, Elettra / Bottazzi, Barbara / Bombace, Sara / My, Ilaria / Condorelli, Gianluigi / Torri, Valter / Sica, Antonio

Frontiers in immunology

2023 Volume 14, Page(s) 1168455

Abstract: Even though cancer patients are generally considered more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the mechanisms driving their predisposition to severe forms of coronavirus disease 2019 (COVID-19) have not ... ...

Abstract	Even though cancer patients are generally considered more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the mechanisms driving their predisposition to severe forms of coronavirus disease 2019 (COVID-19) have not yet been deciphered. Since metabolic disorders are associated with homeostatic frailty, which increases the risk of infection and cancer, we asked whether we could identify immunometabolic pathways intersecting with cancer and SARS-CoV-2 infection. Thanks to a combined flow cytometry and multiomics approach, here we show that the immunometabolic traits of COVID-19 cancer patients encompass alterations in the frequency and activation status of circulating myeloid and lymphoid subsets, and that these changes are associated with i) depletion of tryptophan and its related neuromediator tryptamine, ii) accumulation of immunosuppressive tryptophan metabolites (i.e., kynurenines), and iii) low nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Humans ; COVID-19/metabolism ; SARS-CoV-2 ; Leukocytes, Mononuclear ; NAD/metabolism ; Tryptophan/metabolism ; Neoplasms/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1168455
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Article ; Online: Evaluation of haptic devices and end-users: Novel performance metrics in tele-robotic microsurgery.

Hoshyarmanesh, Hamidreza / Zareinia, Kourosh / Lama, Sanju / Durante, Benjamin / Sutherland, Garnette R

The international journal of medical robotics + computer assisted surgery : MRCAS

2020 Volume 16, Issue 4, Page(s) e2101

Abstract: Background: Here, we present performance evaluation methodology that distinguishes the performance of a haptic device from end-user skill level in a tele-robotic system.: Methods: A pick-&-place experiment was designed and eight participants ... ...

Abstract	Background: Here, we present performance evaluation methodology that distinguishes the performance of a haptic device from end-user skill level in a tele-robotic system. Methods: A pick-&-place experiment was designed and eight participants micromanipulated cotton strips, similar to maneuvers performed during microsurgery. Using three nonredundant haptic devices: neuroArmPLUS Results: The participants showed variable skill level. For consistency, hand/gimbal agility and force characteristics, they performed significantly better when using neuroArmPLUS Conclusions: The integrated performance metrics allows independent evaluation of both the user and haptic device, thereby quantifying human-machine interactions.
MeSH term(s)	Benchmarking ; Equipment Design ; Hand ; Humans ; Microsurgery ; Robotic Surgical Procedures ; Robotics ; User-Computer Interface
Language	English
Publishing date	2020-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2101
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Zs.A 6382: Show issues

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Article ; Online: Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip.

Al-Shaghdali, Khalid / Durante, Barbara / Hayward, Christopher / Beal, Jane / Foey, Andrew

PloS one

2019 Volume 14, Issue 5, Page(s) e0214681

Abstract: Macrophages (Mϕs) play a central role in mucosal immunity by pathogen sensing and instruction of adaptive immune responses. Prior challenge to endotoxin can render Mφs refractory to secondary exposure, suppressing the inflammatory response. Previous ... ...

Abstract	Macrophages (Mϕs) play a central role in mucosal immunity by pathogen sensing and instruction of adaptive immune responses. Prior challenge to endotoxin can render Mφs refractory to secondary exposure, suppressing the inflammatory response. Previous studies demonstrated a differential subset-specific sensitivity to endotoxin tolerance (ET), mediated by LPS from the oral pathogen, Porphyromonas gingivalis (PG). The aim of this study was to investigate ET mechanisms associated with Mφ subsets responding to entropathogenic E. coli K12-LPS. M1- and M2-like Mφs were generated in vitro from the THP-1 cell line by differentiation with PMA and Vitamin D3, respectively. This study investigated ET mechanisms induced in M1 and M2 Mφ subsets, by measuring modulation of expression by RT-PCR, secretion of cytokines by sandwich ELISA, LPS receptor, TLR4, as well as endogenous TLR inhibitors, IRAK-M and Tollip by Western blotting. In contrast to PG-LPS tolerisation, E. coli K12-LPS induced ET failed to exhibit a subset-specific response with respect to the pro-inflammatory cytokine, TNFα, whereas exhibited a differential response for IL-10 and IL-6. TNFα expression and secretion was significantly suppressed in both M1- and M2-like Mφs. IL-10 and IL-6, on the other hand, were suppressed in M1s and refractory to suppression in M2s. ET suppressed TLR4 mRNA, but not TLR4 protein, yet induced differential augmentation of the negative regulatory molecules, Tollip in M1 and IRAK-M in M2 Mφs. In conclusion, E. coli K12-LPS differentially tolerises Mφ subsets at the level of anti-inflammatory cytokines, associated with a subset-specific divergence in negative regulators and independent of TLR4 down-regulation.
MeSH term(s)	Cell Differentiation ; Cell Line ; Cytokines/metabolism ; Down-Regulation/drug effects ; Escherichia coli/metabolism ; Humans ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Interleukin-10/analysis ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-6/analysis ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Intracellular Signaling Peptides and Proteins/drug effects ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipopolysaccharides/pharmacology ; Macrophage Activation ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Cytokines ; Interleukin-6 ; Intracellular Signaling Peptides and Proteins ; Lipopolysaccharides ; TLR4 protein, human ; TOLLIP protein, human ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; IRAK3 protein, human (EC 2.7.11.1) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2019-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0214681
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Article: Transient abnormal myelopoiesis with pericardial effusion in Down syndrome: Case report.

Falasco, Bianca Francisco / Durante, Brenda / Faria, Daniel Kanaan / Faria, Caroline Silvério / Rosolen, Débora Cristina Batista / Antonangelo, Leila

Clinical case reports

2019 Volume 7, Issue 7, Page(s) 1280–1284

Abstract: Pericardial effusion associated with transient abnormal myelopoiesis in Down's syndrome neonates needs to be diagnosed in a timely manner, and the comorbidities must be treated to prevent mortality. To our knowledge, the occurrence of basophilic/ ... ...

Abstract	Pericardial effusion associated with transient abnormal myelopoiesis in Down's syndrome neonates needs to be diagnosed in a timely manner, and the comorbidities must be treated to prevent mortality. To our knowledge, the occurrence of basophilic/eosinophilic pericardial effusion without an increase of these cells in the peripheral blood and with no evidence of associated hypothyroidism is rare.
Language	English
Publishing date	2019-05-17
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2184
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Article ; Online: Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation.

Al-Abady, Zainab N / Durante, Barbara / Moody, A John / Billington, Richard A

Biochemical and biophysical research communications

2013 Volume 442, Issue 1-2, Page(s) 51–55

Abstract: NAD is an important cofactor involved in multiple metabolic reactions and as a substrate for several NAD-dependent signalling enzymes. One such enzyme is CD38 which, alongside synthesising Ca(2+)-releasing second messengers and acting as a cell surface ... ...

Abstract	NAD is an important cofactor involved in multiple metabolic reactions and as a substrate for several NAD-dependent signalling enzymes. One such enzyme is CD38 which, alongside synthesising Ca(2+)-releasing second messengers and acting as a cell surface receptor, has also been suggested to play a key role in NAD(+) homeostasis. CD38 is well known as a negative prognostic marker in B-CLL but the role of its enzymatic activity has not been studied in depth to date. We have exploited the HL-60 cell line as a model of inducible CD38 expression, to investigate CD38-mediated regulation intracellular NAD(+) levels and the consequences of changes in NAD(+) levels on cell physiology. Intracellular NAD(+) levels fell with increasing CD38 expression and this was reversed with the CD38 inhibitor, kuromanin confirming the key role of CD38 in NAD(+) homeostasis. We also measured the consequences of CD38 expression during the differentiation on a number of functions linked to NAD(+) and we show that some but not all NAD(+)-dependent processes are significantly affected by the lowered NAD(+) levels. These data suggest that both functional roles of CD38 might be important in the pathogenesis of B-CLL.
MeSH term(s)	ADP-ribosyl Cyclase 1/biosynthesis ; ADP-ribosyl Cyclase 1/genetics ; Cell Differentiation ; HL-60 Cells ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; NAD/analysis ; NAD/metabolism ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics
Chemical Substances	RNA, Messenger ; NAD (0U46U6E8UK) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
Language	English
Publishing date	2013-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2013.10.170
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Article: Stabilizing the lateral crural flap in septorhinoplasty.

Durante, B J / Porubsky, E S

The Laryngoscope

1988 Volume 98, Issue 1, Page(s) 117–119

MeSH term(s)	Humans ; Nasal Septum/surgery ; Rhinoplasty/methods
Language	English
Publishing date	1988-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1288/00005537-198801000-00023
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Article: Reducing columella scarring in open septorhinoplasty.

Durante, B J / Porubsky, E S

The Laryngoscope

1986 Volume 96, Issue 7, Page(s) 810–811

MeSH term(s)	Cicatrix/prevention & control ; Humans ; Nasal Septum/surgery ; Rhinoplasty/methods
Language	English
Publishing date	1986-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1288/00005537-198607000-00017
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