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  1. Book ; Online ; E-Book: Thyroid cancer

    Grani, Giorgio / Cooper, David S. / Durante, Cosimo

    a case-based approach

    2021  

    Author's details Giorgio Grani, David S. Cooper, Cosimo Durante Editors
    Keywords Endocrinology  ; Oncology
    Subject code 616.4
    Language English
    Size 1 Online-Ressource (XVII, 403 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020697496
    ISBN 978-3-030-61919-0 ; 9783030619183 ; 9783030619206 ; 9783030619213 ; 3-030-61919-2 ; 3030619184 ; 3030619206 ; 3030619214
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Thyroid cancer

    Cooper, David S. / Durante, Cosimo

    a case-based approach

    2016  

    Keywords Thyroid cancer ; Thyroid nodules ; Medullary thyroid cancer ; Anaplastic thyroid cancer ; Differentiated thyroid cancer ; Papillary thyroid cancer ; Tyrosine kinase inhibitor treatment ; Nodular thyroid disease ; Thyroid lymphoma ; Thyroidectomy ; Radioactive iodine therapy ; Nodal metastases ; Follicular thyroid cancer ; C cell hyperplasia ; Hũrthle cell carcinoma
    Language English
    Size XVII, 430 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018824184
    ISBN 978-3-319-22400-8 ; 978-3-319-22401-5 ; 3-319-22400-X ; 3-319-22401-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 4067 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Head-to-head comparison of American, European, and Asian TIRADSs in thyroid nodule assessment: systematic review and meta-analysis.

    Piticchio, Tommaso / Russ, Gilles / Radzina, Maija / Frasca, Francesco / Durante, Cosimo / Trimboli, Pierpaolo

    European thyroid journal

    2024  Volume 13, Issue 2

    Abstract: Context: Ultrasound-based risk stratification systems (Thyroid Imaging Reporting and Data Systems (TIRADSs)) of thyroid nodules (TNs) have been implemented in clinical practice worldwide based on their high performance. However, it remains unexplored ... ...

    Abstract Context: Ultrasound-based risk stratification systems (Thyroid Imaging Reporting and Data Systems (TIRADSs)) of thyroid nodules (TNs) have been implemented in clinical practice worldwide based on their high performance. However, it remains unexplored whether different TIRADSs perform uniformly across a range of TNs in routine practice. This issue is highly relevant today, given the ongoing international effort to establish a unified TIRADS (i.e. I-TIRADS), supported by the leading societies specializing in TNs. The study aimed to conduct a direct comparison among ACR-, EU-, and K-TIRADS in the distribution of TNs: (1) across the TIRADS categories, and (2) based on their estimated cancer risk.
    Methods: A search was conducted on PubMed and Embase until June 2023. Original studies that sequentially assessed TNs using TIRADSs, regardless of FNAC indication, were selected. General study characteristics and data on the distribution of TNs across TIRADSs were extracted.
    Results: Seven studies, reporting a total of 41,332 TNs, were included in the analysis. The prevalence of ACR-TIRADS 1-2 was significantly higher than that of EU-TIRADS 2 and K-TIRADS 2, with no significant difference observed among intermediate- and high-risk categories of TIRADSs. According to malignancy risk estimation, K-TIRADS often classified TNs as having more severe risk, ACR-TIRADS as having moderate risk, and EU-TIRADS classified TNs as having lower risk.
    Conclusion: ACR-, EU-, and K-TIRADS assess TNs similarly across their categories, with slight differences in low-risk classifications. Despite this, focusing on cancer risk estimation, the three TIRADSs assess TNs differently. These findings should be considered as a prerequisite for developing the I-TIRADS.
    MeSH term(s) Humans ; United States/epidemiology ; Thyroid Nodule/diagnostic imaging ; Thyroid Neoplasms/diagnostic imaging ; Data Systems ; Retrospective Studies ; Tomography, X-Ray Computed ; Risk Assessment/methods
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2659767-6
    ISSN 2235-0802 ; 2235-0640
    ISSN (online) 2235-0802
    ISSN 2235-0640
    DOI 10.1530/ETJ-23-0242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New hope for patients with BRAF V600E-mutant anaplastic thyroid cancer: lights and shadows.

    Grani, Giorgio / Filetti, Sebastiano / Durante, Cosimo

    Annals of palliative medicine

    2022  Volume 11, Issue 8, Page(s) 2796–2801

    MeSH term(s) Humans ; Mutation/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Thyroid Carcinoma, Anaplastic/genetics ; Thyroid Neoplasms/genetics
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2022-07-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-22-603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Radiofrequency Ablation as an Alternative to Conventional Treatment.

    Pagano, Loredana / Durante, Cosimo / Tufano, Ralph Patrick

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 883809

    MeSH term(s) Catheter Ablation ; Humans ; Radiofrequency Ablation ; Thyroid Nodule/surgery
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.883809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ultrasound risk stratification systems for thyroid nodule: between lights and shadows, we are moving towards a new era.

    Trimboli, Pierpaolo / Durante, Cosimo

    Endocrine

    2020  Volume 69, Issue 1, Page(s) 1–4

    Abstract: Ultrasound (US) has long played a major role in the assessment of thyroid nodules and their risk of malignancy, and its importance has been further enhanced over the past decade by the development of a number of US-based risk stratification systems (US- ... ...

    Abstract Ultrasound (US) has long played a major role in the assessment of thyroid nodules and their risk of malignancy, and its importance has been further enhanced over the past decade by the development of a number of US-based risk stratification systems (US-RSSs), referred to in some cases as TIRADS (Thyroid Imaging Reporting And Data Systems). The high-risk categories of all currently available US-RSSs display strong associations to cytological diagnostic classes of "malignant/suspicious-for-malignancy" and the low-risk classes are clearly associated to "not neoplastic/benign" cytology. The introduction of these systems has elevated the diagnostic performance of US to a level approaching that of fine-needle aspiration (FNA) cytology. The time seems ripe to exploit this new level of accuracy to reduce the number of FNAs for nodules likely to be benign (i.e., sonographically classified as low-risk with no suspicious clinical features). In the near future, US-RSS could also become the main tool for diagnosing papillary thyroid cancers. The establishment of a new "international TIRADS"-currently in progress-will be critical to guide us towards a new era.
    MeSH term(s) Biopsy, Fine-Needle ; Humans ; Risk Assessment ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Nodule/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-020-02196-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Management of cytologically indeterminate thyroid nodules: primum non nocere.

    Durante, Cosimo / Pecce, Valeria / Grani, Giorgio

    Polish archives of internal medicine

    2021  Volume 131, Issue 12

    MeSH term(s) Biopsy, Fine-Needle ; Humans ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/surgery
    Language English
    Publishing date 2021-12-22
    Publishing country Poland
    Document type Editorial ; Comment
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
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  8. Article ; Online: A Reappraisal of Suspicious Sonographic Features of Thyroid Nodules: Shape Is Not an Independent Predictor of Malignancy.

    Grani, Giorgio / Del Gatto, Valeria / Cantisani, Vito / Mandel, Susan J / Durante, Cosimo

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 9, Page(s) e816–e822

    Abstract: Context: For the correct clinical application of the sonographic risk-stratification systems, the definition of independent risk features that are foundational to each system is crucial.: Objective: The aim of this study was to identify the gray- ... ...

    Abstract Context: For the correct clinical application of the sonographic risk-stratification systems, the definition of independent risk features that are foundational to each system is crucial.
    Objective: The aim of this study was to identify the gray-scale sonographic features independently associated with malignancy, and to compare different definitions.
    Methods: This prospective, diagnostic accuracy study took place in a single thyroid nodule referral center. All patients consecutively referred to our center for fine-needle aspiration cytology of a thyroid nodule between November 1, 2015 and March 30, 2020, were enrolled before cytology. Each nodule was examined by 2 experienced clinicians to record the sonographic features on a rating form. Histologic (when available) or cytologic diagnosis was used as the reference standard. For each single sonographic feature and definition, the sensitivity, specificity, positive and negative predictive values, and diagnostic odds ratios (DOR) were calculated. The significant predictors were then included in a multivariable regression model.
    Results: The final study cohort consisted of 903 nodules in 852 patients. A total of 76 nodules (8.4%) were malignant. Six features were independent predictors of malignancy: suspicious lymph node (DOR 16.23), extrathyroidal extension (DOR 6.60), irregular or infiltrative margins (DOR 7.13), marked hypoechogenicity (DOR 3.16), solid composition (DOR 3.61), and punctate hyperechoic foci (including microcalcifications and indeterminate foci; DOI 2.69). Taller-than-wide shape was not confirmed as an independent predictor.
    Conclusion: We identified the key suspicious features of thyroid nodules and provided a simplified definition of some debated ones. Malignancy rate increases with number of features.
    MeSH term(s) Humans ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Prospective Studies ; Ultrasonography ; Predictive Value of Tests ; Cytodiagnosis ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Sensitivity and Specificity
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.134: Show issues Location:
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  9. Article ; Online: Clinically Silent Thyroid Cancers: Drop Those Needles and Scalpels!

    Durante, Cosimo / Grani, Giorgio

    The Journal of clinical endocrinology and metabolism

    2019  Volume 105, Issue 3

    MeSH term(s) Carcinoma, Papillary ; Humans ; Needles ; Thyroid Neoplasms/epidemiology
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgz129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molecular analysis of fine-needle aspiration cytology in thyroid disease: where are we?

    Grani, Giorgio / Sponziello, Marialuisa / Filetti, Sebastiano / Durante, Cosimo

    Current opinion in otolaryngology & head and neck surgery

    2021  Volume 29, Issue 2, Page(s) 107–112

    Abstract: Purpose of review: The prevalence of thyroid nodules in the general population is high but only about 5% are malignant lesions. Cytology is usually appropriate to rule out malignancy in sonographically suspicious nodules but in many cases, reports are ... ...

    Abstract Purpose of review: The prevalence of thyroid nodules in the general population is high but only about 5% are malignant lesions. Cytology is usually appropriate to rule out malignancy in sonographically suspicious nodules but in many cases, reports are indeterminate. Molecular testing is a more recent approach to rule out malignancy and guide subsequent management.
    Recent findings: Although several different molecular testing approaches have proven useful in reducing unnecessary surgery, there are still several remaining issues, such as the possible occurrence of RAS mutations (which are difficult to interpret in clinical management) and the role of molecular analysis in specific histotypes, such as Hürthle cell carcinomas. Furthermore, conclusive evidence is lacking regarding the cost-effectiveness and appropriateness of surgical options following molecular tests.
    Summary: To be useful in clinical practice, molecular tests should be applied to appropriate candidates. In truly uncertain thyroid nodules in which diagnostic surgery may be considered, molecular testing may change the clinical approach and 'save' a number of thyroids.
    MeSH term(s) Biopsy, Fine-Needle ; Humans ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Nodule/diagnosis ; Thyroid Nodule/genetics
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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