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Article: Impact of Waiting Response Evaluation to First-Line Systemic Therapy before Considering Local Ablative Therapy in Metastatic Non-Small-Cell Lung Cancer.

Belaidi, Lahcene / Wang, Pascal / Quintin, Kevin / Durdux, Catherine / Giroux-Leprieur, Etienne / Giraud, Philippe

2023 Volume 15, Issue 21

Abstract: Stereotactic radiotherapy (SRT) is gaining increasing importance in metastatic non-small-cell lung cancer (mNSCLC) management. The optimal sequence of tumor irradiation relative to systemic treatment remains unclear. If waiting response evaluation to ... ...

Abstract	Stereotactic radiotherapy (SRT) is gaining increasing importance in metastatic non-small-cell lung cancer (mNSCLC) management. The optimal sequence of tumor irradiation relative to systemic treatment remains unclear. If waiting response evaluation to first-line systemic therapy (FLST) before considering local treatment may allow for the exclusion of poorer prognosis progressive tumors that may not benefit from SRT, performing irradiation near immune check point inhibitor (ICI) first administration seems to improve their synergic effect. Herein, we aimed to determine whether delaying SRT after response evaluation to FLST would result in better prognosis. We compared overall survival (OS), progression-free survival (PFS), and time to first subsequent therapy (TFST) for 50 patients locally treated before or within 90 days of initiating FLST (early SRT), with 49 patients treated at least 90 days after initiating FLST (late SRT). Patients treated with conventional chemotherapy alone exhibited significantly poorer median OS, PFS, and TFST in the early SRT arm: (in months) 16.5 [8.33-NR] vs. 58.3 [35.05-NR] (
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215127
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Article ; Online: Radiation Proctitis in Patients With Locally Advanced Cervical Cancer Treated by Chemoradiation: Analysis and Predictive Factors From a Retrospective Cohort.

Sauvage, Louis-Marie / Bentahila, Rita / Tran, Yohan / Guénégou-Arnoux, Armelle / Fabiano, Emmanuelle / Bats, Anne-Sophie / Borghese, Bruno / Durdux, Catherine

American journal of clinical oncology

2024

Abstract: Background: Radiation proctitis is a misunderstanding complication of chemoradiation in locally advanced cervical cancer. The objective of our study is to provide a detailed description and analysis of predictive factors associated with radiation ... ...

Abstract	Background: Radiation proctitis is a misunderstanding complication of chemoradiation in locally advanced cervical cancer. The objective of our study is to provide a detailed description and analysis of predictive factors associated with radiation proctitis in a retrospective cohort of patients treated by chemoradiation for locally advanced cervical cancer. Methods: All patients treated by exclusive chemoradiation or chemoradiation followed by brachytherapy for locally advanced cervical cancer from 2011 to 2017 were included in the study. A bivariate analysis was conducted to establish correlations between the occurrence of radiation proctitis and various clinical and technical variables. Results: A total of 128 patients were included in the study. The mean dose (SD) to the planning target volume was 47.1 Gy (6.2). Fifty-nine (46.1%) patients underwent brachytherapy. Sixteen patients (12.5%) developed radiation proctitis, grade 2 or higher in 12 patients (9.3%). In univariate analysis, anticoagulant or antiplatelet treatments (P=0.039), older age (P=0.049), rectal volume irradiated at 40 Gy (P=0.01) and 30 Gy (P=0.037) were significantly associated with the occurrence of a grade ≥2 radiation proctitis. The delivered dose to 2 cm3 of rectum (D2cm3) showed a potential association with the occurrence of radiation proctitis of all grades (P=0.064). Conclusion: This study highlights clinical and technical factors that should be considered in assessing the risk of radiation proctitis. These results contribute to a better understanding of this complication.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000001092
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Article: Le parcours du patient en radiothérapie.

Durdux, Catherine

La Revue du praticien

2011 Volume 61, Issue 1, Page(s) 73, 76–8

Abstract: Radiation therapy plays a key role in the treatment of cancer. About 60 to 70% of patients with cancer will be concerned by radiotherapy during the management of their disease. Radiation therapy often appears as a complex, unknown and disturbing ... ...

Title translation	Radiation therapy: the patient course.
Abstract	Radiation therapy plays a key role in the treatment of cancer. About 60 to 70% of patients with cancer will be concerned by radiotherapy during the management of their disease. Radiation therapy often appears as a complex, unknown and disturbing treatment for non oncologists as well as for patients. This paper describes the main steps required for carrying out an optimal radiation therapy treatment. These steps include consultations with radiotherapist, preparation and process of treatment, follow-up during and after treatment.
MeSH term(s)	Chemotherapy, Adjuvant ; Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Referral and Consultation
Language	French
Publishing date	2011-01
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Ethical Aspects of Artificial Intelligence in Radiation Oncology.

Lahmi, Lucien / Mamzer, Marie-France / Burgun, Anita / Durdux, Catherine / Bibault, Jean-Emmanuel

Seminars in radiation oncology

2022 Volume 32, Issue 4, Page(s) 442–448

Abstract: Radiation oncology is a field that heavily relies on new technology. Data science and artificial intelligence will have an important role in the entire radiotherapy workflow. A new paradigm of routine healthcare data reuse to automate treatments and ... ...

Abstract	Radiation oncology is a field that heavily relies on new technology. Data science and artificial intelligence will have an important role in the entire radiotherapy workflow. A new paradigm of routine healthcare data reuse to automate treatments and provide decision support is emerging. This review will discuss the ethical aspects of the use of artificial intelligence (AI) in radiation oncology. More specifically, the review will discuss the evolution of work through the ages, as well as the impact AI will have on it. We will then explain why AI opens a new technical era for the field and we will conclude on the challenges in the years to come.
MeSH term(s)	Artificial Intelligence ; Delivery of Health Care ; Humans ; Radiation Oncology ; Workflow
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1146999-7
ISSN	1532-9461 ; 1053-4296
ISSN (online)	1532-9461
ISSN	1053-4296
DOI	10.1016/j.semradonc.2022.06.013
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Article ; Online: Salvage stereotactic reirradiation for intraprostatic cancer recurrence: A large retrospective study.

Allali, Sofiane / Loap, Pierre / Bibault, Jean-Emmanuel / Krepps, Sarah / Deforge, Aurelien / Moreau, Damien / Durdux, Catherine / Giraud, Philippe

The Prostate

2023 Volume 83, Issue 8, Page(s) 743–750

Abstract: Introduction: Prostate cancer is the most common cancer in men. Thirty to forty-seven percent of patients treated with exclusive radiotherapy for prostate cancer will experience intraprostate recurrence. The use of radiotherapy in stereotactic ... ...

Abstract	Introduction: Prostate cancer is the most common cancer in men. Thirty to forty-seven percent of patients treated with exclusive radiotherapy for prostate cancer will experience intraprostate recurrence. The use of radiotherapy in stereotactic conditions allows millimetric accuracy in irradiation to the target zone that minimizes the dose to organs at risk. In this study, we evaluated the clinical outcome of prostatic reirradiation with stereotactic body radiation therapy (SBRT) in patients with intraprostatic recurrence initially treated by radiotherapy. Method: This single-center retrospective study included 41 patients diagnosed with exclusive local recurrence of prostate cancer after radiotherapy and treatedby stereotactic Cyberknife irradiation. The objective of this study was to assess the efficacy and the safety of stereotactic reirradiation for patients with intraprostatic recurrence initially treated with radiotherapy. Results: Median follow-up was 35 months. The 2-year biochemical relapse-free survival was 72.89%, the 2-year local recurrence free survival was 93.59%, the 2-year local regional recurrence-free survival was 85.24%, and the 2-year metastasis-free survival was to 91.49%. The analysis of toxicities showed a good tolerance of stereotactic irradiation. Urinary and gastro-intestinal adverse events was mostly of grades 1-2 (CTCAEv4). Grade 3 toxicity occurred in one to two patients. Conclusion: Stereotactic reirradiation appears effective and well-tolerated for local recurrence of prostate cancer and might allow to delay the introduction of hormonal therapy and its side effects.
MeSH term(s)	Male ; Humans ; Re-Irradiation/adverse effects ; Retrospective Studies ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/diagnosis ; Prostatic Neoplasms/drug therapy ; Prostate-Specific Antigen/therapeutic use ; Salvage Therapy/adverse effects
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.24511
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Article ; Online: Synchronous low grade endometrioid endometrial and ovarian cancer: Focus on therapeutic de-escalation proposed by the latest 2020 ESMO/ESTRO/ESP guidelines.

Dabreteau, Thomas / Koual, Meriem / Delanoy, Nicolas / Durdux, Catherine / Bentivegna, Enrica / Bats, Anne-Sophie / Azaïs, Henri

Journal of gynecology obstetrics and human reproduction

2022 Volume 51, Issue 7, Page(s) 102413

MeSH term(s)	Carcinoma, Endometrioid ; Carcinoma, Ovarian Epithelial ; Endometrial Neoplasms ; Female ; Humans ; Ovarian Neoplasms
Language	English
Publishing date	2022-05-26
Publishing country	France
Document type	Letter
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2022.102413
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Article ; Online: The impact of sarcopenia on survival and treatment tolerance in patients with head and neck cancer treated with chemoradiotherapy.

Bentahila, Rita / Giraud, Philippe / Decazes, Pierre / Kreps, Sarah / Nay, Paula / Chatain, Augustin / Fabiano, Emmanuelle / Durdux, Catherine

Cancer medicine

2022 Volume 12, Issue 4, Page(s) 4170–4183

Abstract: Background: Sarcopenia appears to be a negative prognostic factor for poor survival outcomes and worse treatment tolerance in patients with head-and-neck squamous cell carcinoma (HNSCC). We evaluated sarcopenia's impact on overall survival (OS), disease- ...

Abstract	Background: Sarcopenia appears to be a negative prognostic factor for poor survival outcomes and worse treatment tolerance in patients with head-and-neck squamous cell carcinoma (HNSCC). We evaluated sarcopenia's impact on overall survival (OS), disease-free survival (DFS) and chemo-radiation tolerance in patients with head-and-neck cancer (HNC) treated with chemoradiotherapy (CRT) from a monocentric observational study. Methods: We identified patients with HNC treated by CRT between 2009 and 2018 with pretreatment imaging using positron emission tomography-computed tomography scans (PET/CT). Sarcopenia was measured using the pretreatment PET/CT at the L3 vertebral body using previously published methods. Clinical variables were retrospectively retrieved. Results: Of 216 patients identified, 54 patients (25.47%) met the criteria for sarcopenia. These patients had a lower mean body mass index before treatment (21.92 vs. 25.65 cm/m Conclusion: Sarcopenia in HNSCC patients is an independent adverse prognostic factor for DFS after definitive chemoradiotherapy.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/therapy ; Sarcopenia/diagnostic imaging ; Sarcopenia/etiology ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/therapy ; Chemoradiotherapy/adverse effects ; Prognosis
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5278
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Article ; Online: Chimioradiothérapie concomitante des carcinomes de la vessie.

Durdux, Catherine

Bulletin du cancer

2005 Volume 92, Issue 12, Page(s) 1073–1077

Abstract: Bladder cancer is an urologic common tumor after prostate carcinoma. Radical treatment of localized invasive tumor is based on cystectomy. Surgical mutilation could be important when Bricker's urinary derivation is performed. Moreover, delated metastasis ...

Title translation	Chemoradiation in bladder cancer.
Abstract	Bladder cancer is an urologic common tumor after prostate carcinoma. Radical treatment of localized invasive tumor is based on cystectomy. Surgical mutilation could be important when Bricker's urinary derivation is performed. Moreover, delated metastasis appeared frequently in spite of radical surgery. So, for selected patients, chemoradiotherapy is a valid alternative treatment to cystectomy. Cisplatin or derivatives were administered concurrently to radiation therapy up to 60-65 Gy. Patients underwent control cystoscopy at midtime of treatment in order to select responders from non responders. This review summarizes the main published series of radiochemotherapy in invasive bladder cancer. Results for local control, survivals, bladder preservation rates and toxicity are presented.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Cystectomy ; Humans ; Pilot Projects ; Prognosis ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/surgery
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2005-12
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
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Article ; Online: Clinical outcomes of adapted hypofractionated radiotherapy for bladder cancer in elderly patients.

Mignot, Fabien / Fabiano, Emmanuelle / Xylinas, Evanguelos / Alati, Aurélia / Méjean, Arnaud / Masson-Lecomte, Alexandra / Hermieu, Jean-François / Desgrandchamps, François / Hennequin, Christophe / Durdux, Catherine / Quéro, Laurent

BJU international

2023 Volume 132, Issue 1, Page(s) 56–64

Abstract: Objective: To investigate the feasibility, efficacy, and safety of trimodal therapy (TMT) using a bifractionated split-course hypofractionated radiotherapy (RT) for non-metastatic muscle-invasive bladder cancer (MIBC) in elderly patients.: Patients ... ...

Abstract	Objective: To investigate the feasibility, efficacy, and safety of trimodal therapy (TMT) using a bifractionated split-course hypofractionated radiotherapy (RT) for non-metastatic muscle-invasive bladder cancer (MIBC) in elderly patients. Patients and methods: We retrospectively reviewed the characteristics and outcomes of patients aged >75 years with non-metastatic MIBC suitable or not for radical cystectomy (RC) and treated with transurethral resection of bladder tumour followed by concomitant radio-chemotherapy (platinum salt and 5-fluorouracil) at two institutions (Saint Louis Hospital, Paris, France and European Georges Pompidou Hospital, Paris, France) between 1990 and 2021. RT consisted of an adapted bifractionated split-course hypofractionated RT. Acute toxicities were reported according to Common Terminology Criteria for Adverse Events version 5.0 and late toxicities were reported according to the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer late radiation morbidity scoring schema. The primary end-point was overall survival (OS). Secondary end-points included other survivals outcomes and safety. Results: A total of 122 patients were identified, with a median (range) follow-up of 51.1 (0.5-210.8) months. In all, 83.5% of patients completed radio-chemotherapy. The OS rate was 61.7% at 3 years and 51.2% at 5 years. In multivariate analysis, the completion of RT and concomitant chemotherapy were significantly associated with better OS and cancer-specific survival. For patients fit for RC, a complete histological response was achieved for 77 patients (91.7%) with radio-chemotherapy and the bladder conservation rate was 90.5%. Acute and late Grade ≥3 toxicities were <5%. Conclusion: Bifractionated split-course hypofractionated RT with concomitant chemotherapy regimen appears to be well-tolerated and effective. Trimodal treatment seems to be a curative option for elderly patients unfit for radical surgery compared with palliative care and may contribute to improved survival in these patients.
MeSH term(s)	Aged ; Humans ; Retrospective Studies ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder/pathology ; Cystectomy ; Fluorouracil ; Neoplasm Invasiveness ; Treatment Outcome ; Combined Modality Therapy
Chemical Substances	Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15983
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Ui VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: RE: The Rise of Radiomics and Implications for Oncologic Management.

Foy, Jean-Philippe / Durdux, Catherine / Giraud, Philippe / Bibault, Jean-Emmanuel

Journal of the National Cancer Institute

2018 Volume 110, Issue 11, Page(s) 1275–1276

MeSH term(s)	Medical Oncology ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-02-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djy037
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