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Artikel ; Online: Therapeutic potential of mesenchymal stromal cells for the treatment of frostbite injury.

Volkova, Marina / Durymanov, Mikhail

Burns : journal of the International Society for Burn Injuries

2022 Band 48, Heft 5, Seite(n) 1277–1278

Mesh-Begriff(e)	Burns ; Frostbite/therapy ; Humans ; Mesenchymal Stem Cells
Sprache	Englisch
Erscheinungsdatum	2022-06-01
Erscheinungsland	Netherlands
Dokumenttyp	Letter
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2022.05.020
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis and biological activity of 11-Oxygenated and heterocyclic estrone analogs in pancreatic cancer monolayers and 3D spheroids.

Alseud, Khaled / Ostlund, Trevor / Durymanov, Mikhail / Reineke, Joshua / Halaweish, Fathi

Bioorganic & medicinal chemistry

2024 Band 103, Seite(n) 117678

Abstract: Pancreatic Ductal Adenocarcinoma (PDAC), representing over 90 % of pancreatic cancer diagnoses, is an aggressive disease with survivability among the worst of all cancers due to its difficulty in detection and its high metastatic properties. Current ... ...

Abstract	Pancreatic Ductal Adenocarcinoma (PDAC), representing over 90 % of pancreatic cancer diagnoses, is an aggressive disease with survivability among the worst of all cancers due to its difficulty in detection and its high metastatic properties. Current therapies for PDAC show limited success at extending life expectancies, primarily due to cancer resistance and lack of patient-specific targeted therapies. This work highlights the design and evaluation of estrone-derived analogs with both heterocyclic side-chain functionality and 11-oxygenated functionality for use in pancreatic cancer. First-round heterocyclic analogs show preliminary promise in AsPC-1 and Panc-1 cell lines, with IC
Mesh-Begriff(e)	Humans ; Estrone/pharmacology ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Gemcitabine ; Pancreas/metabolism ; Cell Line, Tumor ; Tumor Microenvironment
Chemische Substanzen	Estrone (2DI9HA706A) ; Gemcitabine
Sprache	Englisch
Erscheinungsdatum	2024-03-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2024.117678
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers.

Durymanov, Mikhail / Reineke, Joshua

Frontiers in pharmacology

2018 Band 9, Seite(n) 971

Abstract: Delivery of genes, including plasmid DNAs, short interfering RNAs (siRNAs), and messenger RNAs (mRNAs), using artificial non-viral nanotherapeutics is a promising approach in cancer gene therapy. However, multiple physiological barriers upon systemic ... ...

Abstract	Delivery of genes, including plasmid DNAs, short interfering RNAs (siRNAs), and messenger RNAs (mRNAs), using artificial non-viral nanotherapeutics is a promising approach in cancer gene therapy. However, multiple physiological barriers upon systemic administration remain a key challenge in clinical translation of anti-cancer gene therapeutics. Besides extracellular barriers including sequestration of gene delivery nanoparticles from the bloodstream by resident organ-specific macrophages, and their poor extravasation and tissue penetration in tumors, overcoming intracellular barriers is also necessary for successful delivery of nucleic acids. Whereas for RNA delivery the endosomal barrier holds a key importance, transfer of DNA cargo additionally requires translocation into the nucleus. Better understanding of crossing membrane barriers by nucleic acid nanoformulations is essential to the improvement of current non-viral carriers. This review aims to summarize relevant literature on intracellular trafficking of non-viral nanoparticles and determine key factors toward surmounting intracellular barriers. Moreover, recent data allowed us to propose new interpretations of current hypotheses of endosomal escape mechanisms of nucleic acid nanoformulations.
Sprache	Englisch
Erscheinungsdatum	2018-08-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00971
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Pre-treatment With PLGA/Silibinin Nanoparticles Mitigates Dacarbazine-Induced Hepatotoxicity.

Durymanov, Mikhail / Permyakova, Anastasia / Reineke, Joshua

Frontiers in bioengineering and biotechnology

2020 Band 8, Seite(n) 495

Abstract: Drug-induced hepatotoxicity is one of the major barriers limiting application of current pharmaceuticals as well as clinical translation of novel and perspective drugs. In this context, numerous hepatoprotective molecules have been proposed to prevent or ...

Abstract	Drug-induced hepatotoxicity is one of the major barriers limiting application of current pharmaceuticals as well as clinical translation of novel and perspective drugs. In this context, numerous hepatoprotective molecules have been proposed to prevent or mitigate drug-induced hepatotoxicity. To date, silibinin (SBN) is a one the most studied hepatoprotective plant-derived agents for prevention/alleviation of drug-induced liver injury. Hepatoprotective mechanisms of SBN include scavenging of free radicals, upregulation of detoxifying enzymes
Sprache	Englisch
Erscheinungsdatum	2020-06-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2020.00495
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Surface modification of fibroblasts with peroxiredoxin-1-loaded polymeric microparticles increases cell mobility, resistance to oxidative stress and collagen I production.

Shen, Ningfei / Qi, Xiaoli / Bagrov, Dmitry V / Krechetov, Sergey P / Sharapov, Mars G / Durymanov, Mikhail O

Colloids and surfaces. B, Biointerfaces

2022 Band 219, Seite(n) 112834

Abstract: Modification of the cell surface with artificial nano- and microparticles (also termed "cellular backpacks") containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some ... ...

Abstract	Modification of the cell surface with artificial nano- and microparticles (also termed "cellular backpacks") containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some cases, using cells as delivery vehicles leads to improved pharmacokinetics due to extended circulation time of cell-immobilized formulations. Another rationale for particle attachment to cells is augmentation of desirable cellular functions and cell proliferation in response to release of the particle contents. In this study, we conjugated poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with multifunctional antioxidant enzyme peroxiredoxin-1 (Prx1) to the surface of fibroblasts. The obtained microparticles were uniform in size and demonstrated sustained protein release. We found that the released Prx1 maintains its signaling activity resulting in macrophage activation, as indicated by TNFα upregulation and increase in ROS generation. Functionalization of fibroblasts with PLGA/Prx1 microparticles via EDC/sulfo-NHS coupling reaction did not affect cell viability but increased cell migratory properties and collagen I production. Moreover, PLGA/Prx1 backpacks increased resistance of fibroblasts to oxidative stress and attenuated cell senescence. In summary, we have developed a novel approach of fibroblast modification to augment their biological properties, which can be desirable for wound repair, cosmetic dermatology, and tissue engineering.
Mesh-Begriff(e)	Polylactic Acid-Polyglycolic Acid Copolymer/metabolism ; Polyglycolic Acid ; Lactic Acid/metabolism ; Fibroblasts/metabolism ; Collagen Type I/metabolism ; Oxidative Stress ; Particle Size
Chemische Substanzen	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Collagen Type I
Sprache	Englisch
Erscheinungsdatum	2022-09-10
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112834
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Acceleration of Electrospun PLA Degradation by Addition of Gelatin.

Bogdanova, Alexandra / Pavlova, Elizaveta / Polyanskaya, Anna / Volkova, Marina / Biryukova, Elena / Filkov, Gleb / Trofimenko, Alexander / Durymanov, Mikhail / Klinov, Dmitry / Bagrov, Dmitry

International journal of molecular sciences

2023 Band 24, Heft 4

Abstract: Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. ... ...

Abstract	Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. Usually, it improves hydrophilicity, enhances cell adhesion, and accelerates biodegradation. However, inclusion of proteins to a polyester-based material typically reduces its mechanical properties. Here, we describe the physicochemical properties of an electrospun polylactic acid (PLA)-gelatin blend with a 9:1 PLA:gelatin ratio. We found that a small content (10 wt%) of gelatin does not affect the extensibility and strength of wet electrospun PLA mats but significantly accelerates their in vitro and in vivo decomposition. After a month, the thickness of PLA-gelatin mats subcutaneously implanted in C57black mice decreased by 30%, while the thickness of the pure PLA mats remained almost unchanged. Thus, we suggest the inclusion of a small amount of gelatin as a simple tool to tune the biodegradation behavior of PLA mats.
Mesh-Begriff(e)	Mice ; Animals ; Gelatin/chemistry ; Polyesters/chemistry ; Tissue Scaffolds/chemistry ; Biocompatible Materials/chemistry ; Tissue Engineering/methods ; Acceleration ; Nanofibers/chemistry
Chemische Substanzen	poly(lactide) (459TN2L5F5) ; Gelatin (9000-70-8) ; Polyesters ; Biocompatible Materials
Sprache	Englisch
Erscheinungsdatum	2023-02-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043535
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Metal-Organic Framework-Based Nanomedicines for the Treatment of Intracellular Bacterial Infections.

Qi, Xiaoli / Shen, Ningfei / Al Othman, Aya / Mezentsev, Alexandre / Permyakova, Anastasia / Yu, Zhihao / Lepoitevin, Mathilde / Serre, Christian / Durymanov, Mikhail

Pharmaceutics

2023 Band 15, Heft 5

Abstract: Metal-organic frameworks (MOFs) are a highly versatile class of ordered porous materials, which hold great promise for different biomedical applications, including antibacterial therapy. In light of the antibacterial effects, these nanomaterials can be ... ...

Abstract	Metal-organic frameworks (MOFs) are a highly versatile class of ordered porous materials, which hold great promise for different biomedical applications, including antibacterial therapy. In light of the antibacterial effects, these nanomaterials can be attractive for several reasons. First, MOFs exhibit a high loading capacity for numerous antibacterial drugs, including antibiotics, photosensitizers, and/or photothermal molecules. The inherent micro- or meso-porosity of MOF structures enables their use as nanocarriers for simultaneous encapsulation of multiple drugs resulting in a combined therapeutic effect. In addition to being encapsulated into an MOF's pores, antibacterial agents can sometimes be directly incorporated into an MOF skeleton as organic linkers. Next, MOFs contain coordinated metal ions in their structure. Incorporation of Fe
Sprache	Englisch
Erscheinungsdatum	2023-05-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15051521
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Mathematical Modeling of Non-Small-Cell Lung Cancer Biology through the Experimental Data on Cell Composition and Growth of Patient-Derived Organoids.

Sulimanov, Rushan / Koshelev, Konstantin / Makarov, Vladimir / Mezentsev, Alexandre / Durymanov, Mikhail / Ismail, Lilian / Zahid, Komal / Rumyantsev, Yegor / Laskov, Ilya

Life (Basel, Switzerland)

2023 Band 13, Heft 11

Abstract: Mathematical models of non-small-cell lung cancer are powerful tools that use clinical and experimental data to describe various aspects of tumorigenesis. The developed algorithms capture phenotypic changes in the tumor and predict changes in tumor ... ...

Abstract	Mathematical models of non-small-cell lung cancer are powerful tools that use clinical and experimental data to describe various aspects of tumorigenesis. The developed algorithms capture phenotypic changes in the tumor and predict changes in tumor behavior, drug resistance, and clinical outcomes of anti-cancer therapy. The aim of this study was to propose a mathematical model that predicts the changes in the cellular composition of patient-derived tumor organoids over time with a perspective of translation of these results to the parental tumor, and therefore to possible clinical course and outcomes for the patient. Using the data on specific biomarkers of cancer cells (PD-L1), tumor-associated macrophages (CD206), natural killer cells (CD8), and fibroblasts (αSMA) as input, we proposed a model that accurately predicts the cellular composition of patient-derived tumor organoids at a desired time point. Combining the obtained results with "omics" approaches will improve our understanding of the nature of non-small-cell lung cancer. Moreover, their implementation into clinical practice will facilitate a decision-making process on treatment strategy and develop a new personalized approach in anti-cancer therapy.
Sprache	Englisch
Erscheinungsdatum	2023-11-20
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13112228
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DTPA(DOTA)-Nimotuzumab Radiolabeling with Generator-produced Thorium for Radioimmunotherapy of EGFR-overexpressing Carcinomas.

Bravo, Magdiel G / Egorova, Bayirta V / Vasiliev, Aleksandr N / Lapshina, Elena V / Ermolaev, Stanislav V / Durymanov, Mikhail O

Current radiopharmaceuticals

2023 Band 16, Heft 3, Seite(n) 233–242

Abstract: Introduction: The feasibility of preparing the "in-house" generators and the Th- DTPA(DOTA)-Nimotuzumab radioimmunoconjugate was evaluated. : Methods: TEVA extraction chromatographic resin and anion exchange resin AG 1x8 were used as sorbents for : ...

Abstract	Introduction: The feasibility of preparing the "in-house" generators and the Th- DTPA(DOTA)-Nimotuzumab radioimmunoconjugate was evaluated. Methods: TEVA extraction chromatographic resin and anion exchange resin AG 1x8 were used as sorbents for Results: The generator on the base of TEVA resin has shown higher volume activity of the product compared to the AG 1x8. The Conclusion: Thorium-234 incorporation into both radioimmunoconjugates reached 45-50%. It has been shown that Th-DTPA-Nimotuzumab radioimmunoconjugate specifically bound with EGFR overexpressing epidermoid carcinoma A431 cells.
Mesh-Begriff(e)	Humans ; Radioimmunotherapy/methods ; Thorium ; Radiopharmaceuticals ; Radioisotopes ; Immunoconjugates/chemistry ; Carcinoma ; Pentetic Acid ; ErbB Receptors/metabolism ; Cell Line, Tumor
Chemische Substanzen	nimotuzumab (6NS400BXKH) ; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Thorium (60YU5MIG9W) ; Radiopharmaceuticals ; Radioisotopes ; Immunoconjugates ; Pentetic Acid (7A314HQM0I) ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
Sprache	Englisch
Erscheinungsdatum	2023-02-17
Erscheinungsland	United Arab Emirates
Dokumenttyp	Journal Article
ISSN	1874-4729
ISSN (online)	1874-4729
DOI	10.2174/1874471016666230221102518
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Retrovirus-like gag protein Arc/Arg3.1 is involved in extracellular-vesicle-mediated mRNA transfer between glioma cells.

Al Othman, Aya / Bagrov, Dmitry / Rozenberg, Julian M / Glazova, Olga / Skryabin, Gleb / Tchevkina, Elena / Mezentsev, Alexandre / Durymanov, Mikhail

Biochimica et biophysica acta. General subjects

2023 Band 1868, Heft 1, Seite(n) 130522

Abstract: Background: Activity-regulated cytoskeleton-associated (Arc) protein is predominantly expressed in excitatory glutamatergic neurons of vertebrates, where it plays a pivotal role in regulation of synaptic plasticity. Arc protein forms capsid-like ... ...

Abstract	Background: Activity-regulated cytoskeleton-associated (Arc) protein is predominantly expressed in excitatory glutamatergic neurons of vertebrates, where it plays a pivotal role in regulation of synaptic plasticity. Arc protein forms capsid-like particles, which can encapsulate and transfer mRNA in extracellular vesicles (EVs) between hippocampal neurons. Once glioma cell networks actively interact with neurons via paracrine signaling and formation of neurogliomal glutamatergic synapses, we predicted the involvement of Arc in a process of EV-mediated mRNA transfer between glioma cells. Materials and methods: Arc expression in three human glioma cell lines was evaluated by WB and immunocytochemistry. The properties of Arc protein/mRNA-containing EVs produced by glioma cells were analyzed by RT-PCR, TEM, and WB. Flow cytometry, RT-PCR, and fluorescent microscopy were used to show the involvement of Arc in EV-mediated mRNA transfer between glioma cells. Results: It was found that human glioma cells can produce EVs containing Arc/Arg3.1 protein and Arc mRNA (or "Arc EVs"). Arc EVs from U87 glioma cells internalize and deliver Arc mRNA to recipient U87 cells, where it is translated into a protein. Arc overexpression significantly increases EV production, alters EV morphology, and enhances intercellular transfer of highly expressed mRNA in glioma cell culture. Conclusion: These findings indicate involvement of Arc EVs into mRNA transfer between glioma cells that could contribute to tumor progression and affect synaptic plasticity in cancer patients.
Mesh-Begriff(e)	Animals ; Humans ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Gene Products, gag/chemistry ; Gene Products, gag/genetics ; Extracellular Vesicles/metabolism ; Glioma/genetics
Chemische Substanzen	Cytoskeletal Proteins ; RNA, Messenger ; Gene Products, gag
Sprache	Englisch
Erscheinungsdatum	2023-11-22
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2023.130522
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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