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  1. Article: Clinical frailty score as an independent predictor of outcome in COVID-19 hospitalised patients.

    Koduri, Gouri / Gokaraju, Sriya / Darda, Maria / Warrier, Vinod / Duta, Irina / Hayes, Fiona / Sayed, Iman El / Noeman-Ahmed, Yasser

    European geriatric medicine

    2021  Volume 12, Issue 5, Page(s) 1065–1073

    Abstract: Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.: Methods: Retrospective study collecting demographic and ... ...

    Abstract Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.
    Methods: Retrospective study collecting demographic and clinical characteristics of patients admitted at Southend University Hospital from 20th February to 7th May 2020.
    Results: The mean age of the cohort admitted to hospital with Covid-19 was 69.4 and 58% were over 70. Comorbidities were more frequently observed in non-survivors, whose mean Clinical Frailty Scale was significantly higher (5 vs 3) than survivors, p < 0.001. In addition, mean C-reactive protein was significantly higher.
    Conclusion: Older and frailer patients with high inflammatory markers were at risk of poor outcomes. Integrated frailty and age-based risk stratification is essential, in addition to monitoring saturation /FiO2 ratio (SFR) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes. A frailty-based risk-stratification approach, rather than age may prove more valuable when considering interventions in patients with multiple comorbidities.
    MeSH term(s) COVID-19 ; Comorbidity ; Frailty/diagnosis ; Humans ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-021-00508-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Screening for Gestational Diabetes during the COVID-19 Pandemic-Current Recommendations and Their Consequences.

    Panaitescu, Anca Maria / Ciobanu, Anca Marina / Popa, Maria / Duta, Irina / Gica, Nicolae / Peltecu, Gheorghe / Veduta, Alina

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 4

    Abstract: Gestational diabetes mellitus (GDM) is recognized as one of the most common medical complications of pregnancy that can lead to significant short-term and long-term risks for the mother and the fetus if not detected early and treated appropriately. ... ...

    Abstract Gestational diabetes mellitus (GDM) is recognized as one of the most common medical complications of pregnancy that can lead to significant short-term and long-term risks for the mother and the fetus if not detected early and treated appropriately. Current evidence suggests that, with the use of appropriate screening programs for GDM, those women diagnosed and treated have reduced perinatal morbidity. It has been implied that, when screening for GDM, there should be uniformity in the testing used and in further management. This paper summarizes and compares current screening strategies proposed by international bodies and discusses application in the context of the COVID-19 pandemic.
    MeSH term(s) COVID-19 ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Female ; Humans ; Mass Screening ; Pandemics ; Pregnancy ; SARS-CoV-2
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57040381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Association between Insulin Resistance and Proliferative Retinopathy in Type 1 Diabetes.

    Duţă, Irina / Fica, Simona / Ion, Daniela Adriana

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2015  Volume 53, Issue 3, Page(s) 261–266

    Abstract: Introduction: Little is known about the relationship between insulin resistance and proliferative diabetic retinopathy in type 1 diabetes. The aim of this article is to explore the relationship between sight-threatening proliferative diabetic ... ...

    Abstract Introduction: Little is known about the relationship between insulin resistance and proliferative diabetic retinopathy in type 1 diabetes. The aim of this article is to explore the relationship between sight-threatening proliferative diabetic retinopathy and insulin resistance.
    Methods: This was a cross-sectional study that included 167 type 1 diabetes patients. Insulin resistance was assessed using eGDR (estimated glucose disposal rate) formula. Diabetic retinopathy was assessed by ophthalmoscopy using Early Treatment Diabetic Retinopathy classification. The association between eGDR and proliferative diabetic retinopathy was assessed in uni- and multivariate models using stepwise logistic regression of covariates. The contribution of individual predictors in the final regresion model was examined using Wald statistic.
    Results: Significantly lower eGDR's values were observed in patients with proliferative diabetic retinopathy: 5.5 vs. 7 (p = 0.002). The results remained significant (p < 0.001) after adjusting for multiple covariates (sex, diabetes duration, body mass index, HDL cholesterol, LDL cholesterol, triglycerides, smoking). eGDR variable was retained in the final model of stepwise logistic regression (p < 0.001) and showed the strongest association with proliferative diabetic retinopathy (Wald= 12.73).
    Conclusions: In type 1 diabetes patients insulin resistance was the most important independent risk factor associated with diabetic proliferative retinopathy.
    MeSH term(s) Adult ; Body Mass Index ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetic Retinopathy/complications ; Female ; Humans ; Insulin Resistance ; Logistic Models ; Male ; Middle Aged ; Risk Factors ; Sex Factors
    Language English
    Publishing date 2015-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015966-3
    ISSN 1220-4749 ; 0035-3973 ; 1582-3296
    ISSN 1220-4749 ; 0035-3973 ; 1582-3296
    DOI 10.1515/rjim-2015-0034
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: The Association Between Insulin Resistance And Advanced Renal Disease In Type 1 Diabetes

    Duţă Irina / Rusu Emilia / Costache Adrian / Radulian Gabriela / Ion Daniela Adriana

    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Vol 22, Iss 2, Pp 167-

    2015  Volume 173

    Abstract: Background and Aims. Insulin resistance is documented in type 1 diabetes and it has been associated with chronic complications. Diabetic nephropathy is a major cause of morbidity and mortality. The purpose of this article is to quantify insulin ... ...

    Abstract Background and Aims. Insulin resistance is documented in type 1 diabetes and it has been associated with chronic complications. Diabetic nephropathy is a major cause of morbidity and mortality. The purpose of this article is to quantify insulin resistance in type 1 diabetes subjects according to the presence or absence of advanced renal disease. A secondary objective was to study the possible association between insulin resistance and advanced renal disease.
    Keywords type 1 diabetes ; insulin resistance ; estimated glucose disposal rate ; diabetic renal disease ; Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Clinical characteristics and Outcomes of 500 patients with COVID Pneumonia : Results from a Single center (Southend University Hospital)

    Koduri, Gouri / Gokaraju, Sriya / Darda, Maria / Warrier, Vinod / Duta, Irina / Hayes, Fiona / El Sayed, Iman / Ahmed, Yasser Noeman

    medRxiv

    Abstract: Objectives To characterise the clinical features of hospitalised COVID 19 patients in a single centre during the first epidemic wave and explore potential predictive variables associated with outcomes such as mortality and the need for mechanical ... ...

    Abstract Objectives To characterise the clinical features of hospitalised COVID 19 patients in a single centre during the first epidemic wave and explore potential predictive variables associated with outcomes such as mortality and the need for mechanical ventilation, using baseline clinical parameters. Methodology We conducted a retrospective review of electronic records for demographic, clinical and laboratory data, imaging and outcomes for 500 hospitalised patients between February 20th and May 7th 2020 from Southend University Hospital, Essex, UK. Multivariate logistic regression models were used to identify risk factors relevant to outcome. Results The mean age of the cohort admitted to hospital with Covid-19, was 69.4 and 290 (58%) were over 70. The majority were Caucasians, 437 (87%) with less than 2 co-morbidities 280(56%). Most common were hypertension 186(37 %), Cardiovascular disease 178(36 %) and Diabetes 128 (26 %), represented in a larger proportion on the mortality group. Mean CFS was 4 with Non Survivors had significantly higher CFS 5 vs 3 in survivors, p<0.001. In addition, Mean CRP was significantly higher 150 vs 90, p<0.001 in Non Survivors. We observed the baseline predictors for mortality were age, CFS and CRP. Conclusions In this single centre study, older and frailer patients with more comorbidities and a higher baseline CRP and creatinine were risk factors for worse outcomes. Integrated frailty and age based risk stratification are essential, in addition to monitoring SFR (Sp02/Fi02) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.08.13.20163030
    Database COVID19

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  6. Article: Precursor and interstitial Cajal cells in the human embryo liver.

    Rusu, Mugurel Constantin / Dută, Irina / Didilescu, Andreea Cristiana / Vrapciu, Alexandra Diana / Hostiuc, Sorin / Anton, Emil

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2012  Volume 55, Issue 2, Page(s) 291–296

    Abstract: Interstitial Cajal Cells (ICCs) were only proven in human adult hepatic tissue. The immune phenotypes of various cell types in the human embryonic liver (HEL) are scarcely described. It was hypothesized that in HEL ICCs are present and distinctive to the ...

    Abstract Interstitial Cajal Cells (ICCs) were only proven in human adult hepatic tissue. The immune phenotypes of various cell types in the human embryonic liver (HEL) are scarcely described. It was hypothesized that in HEL ICCs are present and distinctive to the precursor/progenitor cells populations. It was aimed and performed a qualitative study of HEL by use of antibodies against CD117/c-kit, CD31, CD34, CD90, CD105, DOG1, Ki67, and adiponectin. Five human embryos of 23-29 mm were used. Blasts and hematopoietic cells were comprising the two major cell populations in late stage embryos. The general population of blasts in the HEL was CD34-/CD105, although scarce CD117/c-kit+ and CD90+ such cells were found. Hematopoietic precursors were Ki67+. Adiponectin-positive plasmalemmas were found mostly in blasts. Endothelia were CD31+/CD34+. Interstitial cells with moniliform prolongations were found; such cells were scarcely CD117/c-kit+ but consistently DOG1+. They were diagnosed as ICCs but based on the morphology of their prolongations they can be equally viewed as being telocytes (TCs). Further studies should better correlate the precursor cell-types and immune phenotypes during human liver organogenesis. Liver ICCs and/or TCs should be also investigated in the human fetal liver.
    MeSH term(s) Adiponectin/metabolism ; Antigens, CD/metabolism ; Antigens, CD34/metabolism ; Embryo, Mammalian ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Endoglin ; Gestational Age ; Humans ; Interstitial Cells of Cajal/cytology ; Interstitial Cells of Cajal/metabolism ; Liver/cytology ; Liver/embryology ; Liver/metabolism ; Organogenesis ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, Cell Surface/metabolism
    Chemical Substances ADIPOQ protein, human ; Adiponectin ; Antigens, CD ; Antigens, CD34 ; ENG protein, human ; Endoglin ; Platelet Endothelial Cell Adhesion Molecule-1 ; Receptors, Cell Surface ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2012-11-16
    Publishing country Romania
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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