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  1. Article ; Online: A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine.

    Shah, Nitin / Ghosh, Apurba / Kumar, Kishore / Dutta, Trayambak / Mahajan, Manish

    Human vaccines & immunotherapeutics

    2024  Volume 20, Issue 1, Page(s) 2302685

    Abstract: Measles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable ... ...

    Abstract Measles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable responses for anti-mumps antibodies. Most common strains for MMR vaccines, currently available in India, are the Edmonston-Zagreb measles strain, Leningrad Zagreb (L-Z) mumps strain, and the RA 27/3 rubella strain. L-Z strain of mumps virus has been found to be associated with aseptic meningitis by different studies from different parts of the world including India. Recently, a novel freeze-dried MMR vaccine developed by Zydus Lifesciences (Zyvac MMR) contains Edmonston Zagreb measles strain, Hoshino mumps strain, and RA 27/3 rubella strain. The Hoshino strain is WHO approved and was found to induce interferon gamma production. This review article aims to provide a comprehensive appraisal of the data available on the safety and immunogenicity of the novel MMR vaccine.
    MeSH term(s) Child ; Humans ; Infant ; Child, Preschool ; Mumps/prevention & control ; Rubella Vaccine ; Measles-Mumps-Rubella Vaccine/adverse effects ; Measles/prevention & control ; Rubella/prevention & control ; Mumps virus ; Antibodies, Viral ; Measles Vaccine
    Chemical Substances Rubella Vaccine ; Measles-Mumps-Rubella Vaccine ; Antibodies, Viral ; Measles Vaccine
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2024.2302685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Real-World Safety of TwinRab, the World's First Novel Cocktail of Rabies Monoclonal Antibodies, in a Clinical Setting.

    Manna, Asis / Kundu, Asis Kumar / Sharma Sarkar, Biswanath / Maji, Baisakhi / Dutta, Trayambak / Mahajan, Manish

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52163

    Abstract: Objectives: Every year, 18,000-20,000 people die from rabies in India, with children younger than the age of 15 accounting for 30%-60% of all cases. Wound cleaning, vaccination, and rabies immunoglobulin : Methods: This open-label observational study ...

    Abstract Objectives: Every year, 18,000-20,000 people die from rabies in India, with children younger than the age of 15 accounting for 30%-60% of all cases. Wound cleaning, vaccination, and rabies immunoglobulin
    Methods: This open-label observational study was conducted in patients with WHO category-III animal bites by suspected rabid animals. All participants were screened, enrolled, and were administered the TwinRab
    Result: The study enrolled 401 participants, 55.61% (n = 223) male, whose median age was 34 years. Adults made up 69.83% (n = 280) of the participants. The most exposed sites were the lower parts of the body (60.6%, n = 243); 99.75% (n = 400) of the population showed normal cardiovascular, gastrointestinal, and central nervous systems. After seven days of the last postexposure prophylaxis (PEP) dose, 9.98% of the total study population experienced 80 mild local solicited AEs and were assessed and treated.
    Conclusion: The study concluded that TwinRab
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-Marketing Surveillance of the World's First Novel Cocktail of Rabies Monoclonal Antibodies: TwinRab™ in Real \-World Setting.

    Tambe, Muralidhar P / Parande, Malangori A / Nanaware, Mangesh B / Salunke, Nandkumar M / Dutta, Trayambak / Mahajan, Manish

    Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

    2024  Volume 49, Issue 2, Page(s) 443–447

    Abstract: Rabies presents with a high fatality rate, which imposes a significant global public health challenge, and therefore the use of post-exposure prophylaxis (PEP) is crucial for prevention. Monoclonal antibodies (mAbs) have emerged as a promising substitute ...

    Abstract Rabies presents with a high fatality rate, which imposes a significant global public health challenge, and therefore the use of post-exposure prophylaxis (PEP) is crucial for prevention. Monoclonal antibodies (mAbs) have emerged as a promising substitute for rabies immunoglobulins (RIGs) due to their high efficacy and standardized manufacturing process. A prospective, open-label, post-marketing surveillance study (PMS) was conducted at Byramjee Jeejeebhoy Medical College (BJMC), Pune. The study included patients aged more than 2 years who had recently sustained Category III-suspected rabid animal bite exposures. These patients were administered TwinRabTM at a dosage of 40 IU/kg in and around the wound as intralesional transfer, along with the anti-rabies vaccine (ARV). Adverse events (AEs) grading was performed with reference to the Food and Drug Administration (FDA) toxicity grading. In this study, 215 subjects received the TwinRabTM mAb with a 100% completion rate. Out of 215 patients, three (1.3%) patients in the range of 18 to 65 years of age showed solicited local AEs, which were resolved after the appropriate treatment intervention, but causality assessment was non-assessable. The overall tolerability assessment showed positive ratings from doctors (91.63%) and patients (67.91%) for the mAb cocktail. The PMS demonstrated the safety of TwinRabTM in patients who experienced Category III-suspected rabid animal bites, thereby supporting its potential as an alternative option for post-exposure prophylaxis in the management of animal bites for the prevention of rabies.
    Language English
    Publishing date 2024-03-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2085330-0
    ISSN 1998-3581 ; 0970-0218
    ISSN (online) 1998-3581
    ISSN 0970-0218
    DOI 10.4103/ijcm.ijcm_562_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Typhoid Conjugate Vaccine: A Boon for Endemic Regions.

    Agarwal, Nitesh / Gupta, Naveen / Nishant / H S, Surendra / Dutta, Trayambak / Mahajan, Manish

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56454

    Abstract: Typhoid fever has the highest disease burden in countries in low- and middle-income countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such as the live attenuated typhoid (Ty21a) vaccine and Vi (virulence) capsular ... ...

    Abstract Typhoid fever has the highest disease burden in countries in low- and middle-income countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such as the live attenuated typhoid (Ty21a) vaccine and Vi (virulence) capsular polysaccharide vaccine had the limitation that they could not be administered with other standard childhood immunizations and were ineffective in children under two years of age. To address these shortcomings of the previous vaccines, typhoid conjugate vaccines (TCVs) were developed and prequalified by the World Health Organization. Cross-reacting material and tetanus toxoid are widely used as carrier proteins in TCVs. According to various studies, TCV has higher efficacy, has a more extended protection period, and is safe and immunogenic in infants as young as six months. This review article aims to comprehensively appraise the data available on TCVs' efficacy, duration of protection, safety, and immunogenicity in endemic regions.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Supportive therapy for dysmenorrhea

    Nachimuthu Gomathy / Karukkupalayam Ramasamy Dhanasekar / Dutta Trayambak / Rajasekar Amirtha

    Journal of Family Medicine and Primary Care, Vol 8, Iss 11, Pp 3487-

    Time to look beyond mefenamic acid in primary care

    2019  Volume 3491

    Abstract: Dysmenorrhea is a recurrent and chronic primary health care issue. Mefenamic acid and NSAID based therapy regimens have unwanted side effects on its long-term usage. NSAIDs reduce pain, albeit they do not address the enhanced pain sensitivity and other ... ...

    Abstract Dysmenorrhea is a recurrent and chronic primary health care issue. Mefenamic acid and NSAID based therapy regimens have unwanted side effects on its long-term usage. NSAIDs reduce pain, albeit they do not address the enhanced pain sensitivity and other neuronal symptoms of dysmenorrhea. Hence, there is a need for supportive therapy which can target both pelvic pain and the neuronal symptoms. Historically, European medicinal plants and their extracts such as, valeriana officinalis, humulus lupulus, and passiflora incarnata have been used in menstrual disorders for centuries. The current review is focused on the available evidence for its use as monotherapy or as supportive therapy in combination with other conventional medications.
    Keywords dysmenorrhea ; humulus ; mefenamic acid ; passiflora ; primary care ; valerian ; Medicine ; R
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Amino acids in post-stroke rehabilitation.

    Ramasamy, Dhanasekar Karukkupalayam / Dutta, Trayambak / Kannan, Vellaichamy / Chandramouleeswaran, Venkatraman

    Nutritional neuroscience

    2019  Volume 24, Issue 6, Page(s) 426–431

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Amino Acids/therapeutic use ; Animals ; Dietary Supplements ; Humans ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Stroke Rehabilitation
    Chemical Substances Amino Acids
    Language English
    Publishing date 2019-07-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1447449-9
    ISSN 1476-8305 ; 1028-415X
    ISSN (online) 1476-8305
    ISSN 1028-415X
    DOI 10.1080/1028415X.2019.1641295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7024: Show issues

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  7. Article: A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis.

    Murugesan, Gangadevi / Sudha, Kulur Mukhyaprana / Subaramoniam, Malathi Krishnamurthy / Dutta, Trayambak / Dhanasekar, Karukkupalayam Ramasamy

    Journal of Indian Society of Periodontology

    2018  Volume 22, Issue 5, Page(s) 438–441

    Abstract: Context: The role of synbiotic in the management of aggressive periodontitis (AP) is not well established.: Aim: We designed this study to evaluate the efficacy and safety of synbiotic as an add-on therapy in the management of AP.: Settings and ... ...

    Abstract Context: The role of synbiotic in the management of aggressive periodontitis (AP) is not well established.
    Aim: We designed this study to evaluate the efficacy and safety of synbiotic as an add-on therapy in the management of AP.
    Settings and design: This was a randomized, double-blind, placebo-controlled study.
    Materials and methods: Sixty patients with AP were randomized to two groups of 30 each. Study group received standard treatment, i.e., scaling and root planing along with doxycycline 100 mg twice daily for the 1
    Statistical analysis used: Pearson's Chi-square test and one-way analysis of variance were used to analyze distribution of sex and age, respectively. Differences within the groups were analyzed by Student's paired
    Results: On comparison at 12 weeks, there was a statistically significant reduction (
    Conclusion: Co-administration of synbiotic lozenge along with standard therapy is highly efficacious in improving periodontal health in patients with AP.
    Language English
    Publishing date 2018-09-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2545458-4
    ISSN 0975-1580 ; 0972-124X
    ISSN (online) 0975-1580
    ISSN 0972-124X
    DOI 10.4103/jisp.jisp_155_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A study of promotional advertisements of drugs in a medical journal: an ethics perspective.

    Nath, Sarmila / Bhowmick, Subhrojyoti / Dutta, Trayambak / Chowrasia, V R / Bhattacharya, Shipra / Chatterjee, R N / Sarkar, Manjula / Ram, A K / Mukherjee, P K

    Indian journal of medical ethics

    2014  Volume 11, Issue 4, Page(s) 237–241

    Abstract: The study assessed 54 advertisements of 145 different drugs, published over one year (from December 2011 to November 2012) in an Indian medical journal, circulated widely mainly among general practitioners (GPs). The ethical guidelines of the World ... ...

    Abstract The study assessed 54 advertisements of 145 different drugs, published over one year (from December 2011 to November 2012) in an Indian medical journal, circulated widely mainly among general practitioners (GPs). The ethical guidelines of the World Health Organization (WHO) and Organisation of Pharmaceutical Producers of India (OPPI) for medicinal drug promotion were applied. The brand name was mentioned in all advertisements (100% compliance both with the WHO and OPPI criteria) and the names of the active ingredients were also mentioned in 128 (90.14%) advertisements. However, major adverse drug reactions were mentioned in only two advertisements (1.37%); precautions, contraindications and warnings in only two (1.37%); and major interactions in only one (0.68%). Only three advertisements (2.06%) were well substantiated with references. To ensure the ethical promotionof drugs among GPs, journals must introduce compulsory review and appraisal of promotional advertisements by a dedicated review board, including at least one member trained in pharmacology and one representative from the medical division of a pharmaceutical company.
    MeSH term(s) Advertising as Topic/ethics ; Drug Industry/ethics ; Ethical Review ; Ethics, Business ; General Practice ; Guideline Adherence ; Humans ; India ; Periodicals as Topic/ethics ; Pharmaceutical Preparations ; Publishing
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2014-10
    Publishing country India
    Document type Journal Article
    ISSN 0975-5691
    ISSN (online) 0975-5691
    DOI 10.20529/IJME.2014.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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