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Article: Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences.

Clemmons, Elizabeth A / Alfson, Kendra J / Dutton, John W

Animals : an open access journal from MDPI

2021 Volume 11, Issue 7

Abstract: Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly ... ...

Abstract	Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11072039
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Clemmons, Elizabeth A. / Alfson, Kendra J. / Dutton, John W.

Animals. 2021 July 08, v. 11, no. 7

2021

Abstract	Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.
Keywords	diagnostic techniques ; food supply chain ; humans ; morbidity ; mortality ; pathogenesis ; public health ; trade
Language	English
Dates of publication	2021-0708
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11072039
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Article ; Online: Comparison of oral, nebulized and combination antibiotic treatment of Bordetella bronchiseptica in baboons (Papio spp.).

Clemmons, Elizabeth A / Chavez, Deborah / Condel, Laura / Dutton, John W / Price, Sharon / Lanford, Robert

Journal of veterinary pharmacology and therapeutics

2021 Volume 44, Issue 5, Page(s) 836–841

Abstract: Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis ...

Abstract	Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research-related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty-five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long-term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non-infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Bordetella bronchiseptica ; Bordetella pertussis ; Papio
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.12975
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Article: Assessment of Pain Associated with the Injection of Sodium Pentobarbital in Laboratory Mice (

Dutton, John W / Artwohl, James E / Huang, Xichen / Fortman, Jeffrey D

Journal of the American Association for Laboratory Animal Science : JAALAS

2019 Volume 58, Issue 3, Page(s) 373–379

Abstract: ... ...

Abstract	The
MeSH term(s)	Animals ; Euthanasia, Animal/methods ; Female ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Injections, Intraperitoneal/adverse effects ; Injections, Intraperitoneal/veterinary ; Laboratory Animal Science ; Male ; Mice ; Pain/chemically induced ; Pain/veterinary ; Pain Measurement ; Pentobarbital/administration & dosage ; Pentobarbital/adverse effects
Chemical Substances	Hypnotics and Sedatives ; Pentobarbital (I4744080IR)
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1559-6109
ISSN	1559-6109
DOI	10.30802/AALAS-JAALAS-18-000094
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Article: Comparison of oral, nebulized and combination antibiotic treatment of Bordetella bronchiseptica in baboons (Papio spp.)

Clemmons, Elizabeth A. / Chavez, Deborah / Condel, Laura / Dutton, John W., III / Price, Sharon / Lanford, Robert

Journal of veterinary pharmacology and therapeutics. 2021 Sept., v. 44, no. 5

2021

Abstract	Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research‐related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty‐five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long‐term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non‐infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.
Keywords	Bordetella bronchiseptica ; Bordetella pertussis ; Papio ; atomization ; cough ; etiological agents ; gentamicin ; humans ; juveniles ; models ; pharmacology ; sulfamethoxazole ; trimethoprim ; vaccination
Language	English
Dates of publication	2021-09
Size	p. 836-841.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.12975
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gingival histoplasmosis: An atypical presentation of African histoplasmosis in three baboons (Papio spp).

Johannigman, Taylor A / Gonzalez, Olga / Dutton, John W / Kumar, Shyamesh / Dick, Edward J

Journal of medical primatology

2019 Volume 49, Issue 1, Page(s) 47–51

Abstract: Gingival lesions as the sole manifestation of African histoplasmosis (Histoplasma capsulatum var. duboisii) have never been reported in baboons. Grossly, lesions can be indistinguishable from bacterial ulcerative gingivitis or gingival hyperplasia. ... ...

Abstract	Gingival lesions as the sole manifestation of African histoplasmosis (Histoplasma capsulatum var. duboisii) have never been reported in baboons. Grossly, lesions can be indistinguishable from bacterial ulcerative gingivitis or gingival hyperplasia. Clinical outcomes of primary gingival histoplasmosis in baboons are unknown and may complicate colony management decisions.
MeSH term(s)	Animals ; Diagnosis, Differential ; Gingival Diseases/diagnosis ; Gingival Diseases/parasitology ; Gingival Diseases/veterinary ; Histoplasma/isolation & purification ; Histoplasmosis/diagnosis ; Histoplasmosis/parasitology ; Histoplasmosis/veterinary ; Male ; Monkey Diseases/diagnosis ; Monkey Diseases/parasitology ; Papio
Language	English
Publishing date	2019-10-08
Publishing country	Denmark
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/jmp.12443
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Article ; Online: Indices of muscle and liver dysfunction after surviving hemorrhage and prolonged hypotension.

Hinojosa-Laborde, Carmen / Shade, Robert E / Frost, Patrice A / Dutton, John W / Muniz, Gary W / Hudson, Ian L / Carter, Robert / Ryan, Kathy L

The journal of trauma and acute care surgery

2019 Volume 87, Issue 1S Suppl 1, Page(s) S101–S109

Abstract: Background: This study determined the long-term effects of prolonged hypotension (PH) on liver, muscle, and kidney dysfunction. The hypothesis was that longer duration of PH after hemorrhage will result in greater organ dysfunction.: Methods: Baboons ...

Abstract	Background: This study determined the long-term effects of prolonged hypotension (PH) on liver, muscle, and kidney dysfunction. The hypothesis was that longer duration of PH after hemorrhage will result in greater organ dysfunction. Methods: Baboons were sedated and hemorrhaged (30% blood volume). Systolic blood pressure greater than 80 mm Hg was maintained for 1 hour (1 hr-PH; n = 5), 2 hours (2 hr-PH; n = 5), or 3 hours (3 hr-PH; n = 5). After PH, hemorrhage volume was replaced. Animals were recovered and monitored for 21 days. Control animals were hemorrhaged and immediately resuscitated (0 hr-PH, n = 3). Data are Mean ± Standard Deviation, and analyzed by 2-way repeated measures ANOVA and Holm-Sidak test. Results: Hemorrhage resulted in mild hypotension. Minimal resuscitation was required during the hypotensive phase, and survival rate was 100%. Significant increases (p < 0.001) in alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, and lactate dehydrogenase occurred on Day 1 after PH, and were significantly greater (p < 0.001) in the 2 hr- and 3 hr-PH groups than the 0 hr-PH group. Maximum alanine aminotransferase levels (U/L) were 140 ± 56 (0 hr-PH), 170 ± 130 (1 hr-PH), 322 ± 241 (2 hr-PH), and 387 ± 167 (3 hr-PH). Maximum aspartate aminotransferase levels (U/L) were 218 ± 44 (0 hr-PH), 354 ± 219 (1 hr-PH), 515 ± 424 (2 hr-PH), and 711 ± 278 (3 hr-PH). Maximum creatine phosphokinase values (U/L) were 7834 ± 3681 (0 hr-PH), 24336 ± 22268 (1 hr-PH), 50494 ± 67653 (2 hr-PH), and 59857 ± 32408 (3 hr-PH). Maximum lactic acid dehydrogenase values (U/L) were 890 ± 396 (0 hr-PH), 2055 ± 1520 (1 hr-PH), 3992 ± 4895 (2 hr-PH), and 4771 ± 1884 (3 hr-PH). Plasma creatinine and blood urea nitrogen were unaffected by PH (p > 0.10). Conclusion: These results indicate that PH up to 3 hours in duration results in transient liver and muscle dysfunction that was most severe after 2 hr-PH and 3 hr-PH. Prolonged hypotension produced minimal effects on the kidney. Level of evidence: Basic science research, Level of evidence not required for basic science research.
MeSH term(s)	Animals ; Hemorrhage/complications ; Hypotension/etiology ; Hypotension/physiopathology ; Kidney/physiopathology ; Liver/physiopathology ; Male ; Muscles/physiopathology ; Papio ; Time Factors
Language	English
Publishing date	2019-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000002311
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Article ; Online: Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area.

Dutton, John W / Chen, Hu / You, Chang / Brodie, Mark S / Lasek, Amy W

Addiction biology

2017 Volume 22, Issue 3, Page(s) 665–678

Abstract: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol dependence in humans and behavioral responses to ethanol in mice. To characterize the ability of ALK to control ethanol consumption, we treated mice with the ALK ... ...

Abstract	Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol dependence in humans and behavioral responses to ethanol in mice. To characterize the ability of ALK to control ethanol consumption, we treated mice with the ALK inhibitors TAE684 or alectinib before testing them for binge-like drinking using the drinking in the dark protocol. Mice treated with ALK inhibitors drank less ethanol than controls. In addition, TAE684 treatment abolished ethanol conditioned place preference, indicating that ALK regulates the rewarding properties of ethanol. Because the ventral tegmental area (VTA) is a key brain region involved in the rewarding effects of ethanol, we determined if Alk expression in the VTA is important for binge-like ethanol consumption. Mice expressing a short hairpin ribonucleic acid targeting Alk in the VTA drank less ethanol compared with controls. ALK is expressed on dopamine (DA) neurons in the VTA, suggesting that ALK might regulate their firing properties. Extracellular recordings of putative DA neurons in VTA slices demonstrated that ALK inhibition did not affect the ability of ethanol to stimulate, or DA to inhibit, the firing of DA neurons. However, inhibiting ALK attenuated the time-dependent reversal of inhibition produced by moderate concentrations of DA, suggesting that ALK affects DA D2 autoreceptor (D2R) desensitization. Altered desensitization of the D2R changes the firing of DA neurons and is predicted to affect DA levels and alcohol drinking. These data support the possibility that ALK might be a novel target of pharmacotherapy for reducing excessive alcohol consumption.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Binge Drinking/genetics ; Binge Drinking/metabolism ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Dopamine/metabolism ; Ventral Tegmental Area/metabolism
Chemical Substances	Receptors, Dopamine ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; anaplastic lymphoma kinase (EC 2.7.10.1)
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.12358
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Article ; Online: The impact of housing on birth outcomes in breeding macaque groups across multiple research centers.

American journal of primatology

2023 Volume 85, Issue 11, Page(s) e23554

Abstract: Demand for nonhuman primates in research has increased over the past several years, while nonhuman primate supply remains a challenge in the United States. Global nonhuman primate supply issues make it increasingly important to maximize domestic colony ... ...

Abstract	Demand for nonhuman primates in research has increased over the past several years, while nonhuman primate supply remains a challenge in the United States. Global nonhuman primate supply issues make it increasingly important to maximize domestic colony production. To explore how housing conditions across primate breeding colonies impact infant survival and animal production more broadly, we collected medical records from 7959 rhesus macaques (Macaca mulatta) and 492 pigtail macaques (Macaca nemestrina) across seven breeding facilities and used generalized mixed-effect modeling to determine prenatal and infant survival odds by housing type and group size. Infant survival odds for each housing type and group size varied for prenatal, neonatal, early infant, and late infant age groups. Odds of prenatal survival were lowest in paired indoor housing and small and medium outdoor groups. No housing type performed better than large outdoor groups for neonatal survival. Odds of early infant survival was greatest in indoor and mixed indoor/outdoor housing compared to large outdoor enclosures. Large outdoor housing was associated with higher survival odds for late infant survival compared to small and medium outdoor housing. These results may influence housing choices at macaque breeding facilities hoping to maximize infant success, although there are relative care costs, the promotion of species-typical behaviors, and infrastructure factors to also consider. Our study used an interinstitutional collaboration that allowed for the analysis of more infant macaque medical records than ever before and used the broad variations across the seven national primate research centers to make the results applicable to many other facilities housing macaques.
MeSH term(s)	Humans ; Pregnancy ; Female ; Animals ; Macaca mulatta ; Macaca nemestrina ; Housing, Animal ; Breeding
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1495834-X
ISSN	1098-2345 ; 0275-2565
ISSN (online)	1098-2345
ISSN	0275-2565
DOI	10.1002/ajp.23554
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Article: Single-Shot ChAd3-MARV Vaccine in Modified Formulation Buffer Shows 100% Protection of NHPs.

Finch, Courtney L / King, Thomas H / Alfson, Kendra J / Albanese, Katie A / Smith, Julianne N P / Smock, Paul / Jakubik, Jocelyn / Goez-Gazi, Yenny / Gazi, Michal / Dutton, John W / Clemmons, Elizabeth A / Mattix, Marc E / Carrion, Ricardo / Rudge, Thomas / Ridenour, Alex / Woodin, Sovann F / Hunegnaw, Ruth / Sullivan, Nancy J / Xu, Rong

Vaccines

2022 Volume 10, Issue 11

Abstract: Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24-88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no candidate ... ...

Abstract	Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24-88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no candidate has yet reached regulatory approval. Here, we evaluate a replication-defective chimpanzee adenovirus type 3 (ChAd3)-vectored MARV Angola glycoprotein (GP)-expressing vaccine against lethal MARV challenge in macaques. The ChAd3 platform has previously been reported to protect against the MARV-related viruses, Ebola virus (EBOV) and Sudan virus (SUDV), and MARV itself in macaques, with immunogenicity demonstrated in macaques and humans. In this study, we present data showing 100% protection against MARV Angola challenge (versus 0% control survival) and associated production of GP-specific IgGs generated by the ChAd3-MARV vaccine following a single dose of 1 × 10
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10111935
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