LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Book ; Online: An Epigraphical Approach to the Representer Theorem

Duval, Vincent

2019

Abstract: Describing the solutions of inverse problems arising in signal or image processing is an important issue both for theoretical and numerical purposes. We propose a principle which describes the solutions to convex variational problems involving a finite ... ...

Abstract	Describing the solutions of inverse problems arising in signal or image processing is an important issue both for theoretical and numerical purposes. We propose a principle which describes the solutions to convex variational problems involving a finite number of measurements. We discuss its optimality on various problems concerning the recovery of Radon measures.
Keywords	Mathematics - Optimization and Control ; Electrical Engineering and Systems Science - Signal Processing
Publishing date	2019-12-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Exact recovery of the support of piecewise constant images via total variation regularization

De Castro, Yohann / Duval, Vincent / Petit, Romain

2023

Abstract: This work is concerned with the recovery of piecewise constant images from noisy linear measurements. We study the noise robustness of a variational reconstruction method, which is based on total (gradient) variation regularization. We show that, if the ... ...

Abstract	This work is concerned with the recovery of piecewise constant images from noisy linear measurements. We study the noise robustness of a variational reconstruction method, which is based on total (gradient) variation regularization. We show that, if the unknown image is the superposition of a few simple shapes, and if a non-degenerate source condition holds, then, in the low noise regime, the reconstructed images have the same structure: they are the superposition of the same number of shapes, each a smooth deformation of one of the unknown shapes. Moreover, the reconstructed shapes and the associated intensities converge to the unknown ones as the noise goes to zero.
Keywords	Mathematics - Numerical Analysis ; Electrical Engineering and Systems Science - Signal Processing ; Mathematics - Optimization and Control
Publishing date	2023-07-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases.

Duval, Vincent / Alayrac, Paul / Silvestre, Jean-Sébastien / Levoye, Angélique

Frontiers in endocrinology

2022 Volume 13, Page(s) 906586

Abstract: Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors. The discovery that chemokines can also bind to atypical ... ...

Abstract	Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors. The discovery that chemokines can also bind to atypical chemokine receptors (ACKRs) and initiate alternative signaling pathways has changed the paradigm regarding chemokine-related functions. Among these ACKRs, several studies have highlighted the exclusive role of ACKR3, previously known as C-X-C chemokine receptor type 7 (CXCR7), in CVD. Indeed, ACKR3 exert atheroprotective, cardioprotective and anti-thrombotic effects through a wide range of cells including endothelial cells, platelets, inflammatory cells, fibroblasts, vascular smooth muscle cells and cardiomyocytes. ACKR3 functions as a scavenger receptor notably for the pleiotropic chemokine CXCL12, but also as a activator of different pathways such as β-arrestin-mediated signaling or modulator of CXCR4 signaling through the formation of ACKR3-CXCR4 heterodimers. Hence, a better understanding of the precise roles of ACKR3 may pave the way towards the development of novel and improved therapeutic strategies for CVD. Here, we summarize the structural determinant characteristic of ACKR3, the molecules targeting this receptor and signaling pathways modulated by ACKR3. Finally, we present and discuss recent findings regarding the role of ACKR3 in CVD.
MeSH term(s)	Cardiovascular Diseases/genetics ; Chemokine CXCL12 ; Endothelial Cells/metabolism ; Humans ; Receptors, CXCR/metabolism ; Signal Transduction/physiology
Chemical Substances	ACKR3 protein, human ; Chemokine CXCL12 ; Receptors, CXCR
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.906586
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Rôle délétère des lymphocytes B de la zone marginale de la rate dans le remodelage ventriculaire après un infarctus du myocarde.

Duval, Vincent / Alayrac, Paul / Mallat, Ziad / Silvestre, Jean-Sébastien

Medecine sciences : M/S

2022 Volume 38, Issue 10, Page(s) 766–768

Title translation	Deleterious role of spleen marginal zone B lymphocytes in ventricular remodeling after myocardial infarction.
MeSH term(s)	B-Lymphocytes ; Humans ; Myocardial Infarction ; Spleen ; Ventricular Remodeling
Language	French
Publishing date	2022-10-11
Publishing country	France
Document type	News
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2022119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Pharmacokinetics-Time to Alleviation of Symptoms Model to Support Extrapolation of Baloxavir Marboxil Clinical Efficacy in Different Ethnic Groups with Influenza A or B.

Retout, Sylvie / De Buck, Stefan / Jolivet, Sébastien / Duval, Vincent / Cosson, Valérie

Clinical pharmacology and therapeutics

2022 Volume 112, Issue 2, Page(s) 372–381

Abstract: Baloxavir marboxil, the prodrug of baloxavir acid, is an anti-influenza antiviral. Here, a pharmacokinetics-time to alleviation of symptoms (PK-TTAS) model was developed and used to (I) characterize the PK-TTAS relationship, (II) quantify the impact of ... ...

Abstract	Baloxavir marboxil, the prodrug of baloxavir acid, is an anti-influenza antiviral. Here, a pharmacokinetics-time to alleviation of symptoms (PK-TTAS) model was developed and used to (I) characterize the PK-TTAS relationship, (II) quantify the impact of covariates, and (III) predict TTAS in different ethnic groups. Data from 1781 otherwise-healthy (OwH) or high-risk (HR) patients included in phase II (JapicCTI-153090) and III studies (NCT02954354 and NCT02949011) were used; patients received either placebo or oral baloxavir marboxil. The natural distribution of TTAS in placebo-treated patients was modeled, then TTAS data from the baloxavir marboxil arms were added to model the impact of baloxavir acid concentration on TTAS. PK parameters estimated by a population PK model and informed by phase I data (NCT03959332 and KCT0003535) were included to simulate TTAS in Chinese and South Korean patients. Composite symptom score at baseline (TSS0), ethnicity, sex, and patient type (OwH or HR) significantly impacted the natural TTAS distribution. TTAS reduced with increasing baloxavir acid concentrations. Compared with placebo, high and low baloxavir acid exposures (AUC
MeSH term(s)	Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Clinical Studies as Topic ; Dibenzothiepins/pharmacokinetics ; Dibenzothiepins/therapeutic use ; Ethnicity ; Humans ; Influenza A virus ; Influenza B virus ; Influenza, Human/drug therapy ; Influenza, Human/ethnology ; Morpholines/pharmacokinetics ; Morpholines/therapeutic use ; Pyridones/pharmacokinetics ; Pyridones/therapeutic use ; Treatment Outcome ; Triazines/pharmacokinetics ; Triazines/therapeutic use
Chemical Substances	Antiviral Agents ; Dibenzothiepins ; Morpholines ; Pyridones ; Triazines ; baloxavir (4G86Y4JT3F)
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2648
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 20: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Towards Off-the-grid Algorithms for Total Variation Regularized Inverse Problems

de Castro, Yohann / Duval, Vincent / Petit, Romain

2021

Abstract: We introduce an algorithm to solve linear inverse problems regularized with the total (gradient) variation in a gridless manner. Contrary to most existing methods, that produce an approximate solution which is piecewise constant on a fixed mesh, our ... ...

Abstract	We introduce an algorithm to solve linear inverse problems regularized with the total (gradient) variation in a gridless manner. Contrary to most existing methods, that produce an approximate solution which is piecewise constant on a fixed mesh, our approach exploits the structure of the solutions and consists in iteratively constructing a linear combination of indicator functions of simple polygons. Comment: For the short conference version see arXiv:2104.06706v2. For the long journal version see arXiv:2104.06706v5
Keywords	Electrical Engineering and Systems Science - Signal Processing ; Mathematics - Numerical Analysis ; Mathematics - Optimization and Control
Publishing date	2021-04-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Cardiomyocytes and Macrophages Discourse on the Method to Govern Cardiac Repair.

Gomez, Ingrid / Duval, Vincent / Silvestre, Jean-Sébastien

Frontiers in cardiovascular medicine

2018 Volume 5, Page(s) 134

Abstract: In response to pathophysiological stress, the cardiac tissue undergoes profound remodeling process that incorporates the elimination of dying resident cells, compensatory hypertrophy of functional cardiomyocytes, growth and remodeling of the vascular ... ...

Abstract	In response to pathophysiological stress, the cardiac tissue undergoes profound remodeling process that incorporates the elimination of dying resident cells, compensatory hypertrophy of functional cardiomyocytes, growth and remodeling of the vascular compartment and formation of a fibrotic scar. Accumulating evidences indicate that cardiac remodeling is, at least in part, controlled by a complex crosstalk between cardiomyocytes and macrophages. The strategic location of abundant macrophages to the proximity of cardiomyocytes suggest that they could regulate the fate of cardiomyocytes in the injured heart. As such, macrophages appear as critical support cells for cardiomyocytes and play central roles in cardiac hypertrophy, fibrosis and remodeling. Notably, the cardiac tissue expands heterogeneous population of cardiac macrophages through local proliferation of resident macrophage as well as recruitment and differentiation of blood-derived monocytes. It has also been suggested that cardiac-resident macrophages display distinct functional properties from that of monocyte-derived macrophages in cardiac tissue. Furthermore, macrophages are an overflowing source of biological entities with non-canonical roles on cardiac conduction or cardiomyocyte proliferation by regulating action potential diffusion or cardiac cell cycle reentry. Alternatively, stressed cardiomyocytes can trigger the release of a broad repertoire of instructive signals that can regulate macrophage number, skew their phenotype and therefore direct their beneficial or deleterious actions. In this review, we highlight recent discoveries describing how the intricate dialogue between cardiomyocytes and macrophages can shape the deleterious or healing signaling mechanisms in the injured cardiac tissue.
Language	English
Publishing date	2018-10-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2018.00134
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Pharmacokinetics, safety, and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals.

Liu, Yanmei / Retout, Sylvie / Duval, Vincent / Jia, Jingying / Zou, Yang / Wang, Yijun / Cosson, Valérie / Jolivet, Sébastien / De Buck, Stefan

Clinical and translational science

2022 Volume 15, Issue 5, Page(s) 1196–1203

Abstract: Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist for Chinese patients in global studies. This randomized, open-label, phase I study evaluated the pharmacokinetics (PK) and ... ...

Abstract	Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist for Chinese patients in global studies. This randomized, open-label, phase I study evaluated the pharmacokinetics (PK) and safety of baloxavir marboxil in healthy Chinese volunteers and was used to anticipate efficacy in Chinese patients. Patients received a single oral dose of baloxavir marboxil (40 or 80 mg [1:1]). Serial blood samples were collected predose and at various timepoints up to 14 days postdose. Baloxavir marboxil and acid plasma concentrations were determined by liquid chromatography tandem mass spectrometry. PK parameters of baloxavir acid were estimated by noncompartmental analysis. Adverse events (AEs) were recorded. Time to alleviation of symptoms (TTAS) was simulated for otherwise healthy (OwH) and high-risk (HR) Chinese and Asian patients. Thirty-two male patients received baloxavir marboxil. Baloxavir acid plasma concentration peaked 4 h postdose. Mean maximum concentration (C
MeSH term(s)	Antiviral Agents ; China ; Dibenzothiepins/adverse effects ; Humans ; Influenza, Human/drug therapy ; Male ; Morpholines ; Pyridones/adverse effects ; Triazines
Chemical Substances	Antiviral Agents ; Dibenzothiepins ; Morpholines ; Pyridones ; Triazines ; baloxavir (4G86Y4JT3F)
Language	English
Publishing date	2022-02-19
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13237
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Selection of Nemolizumab Clinical Dosage for Atopic Dermatitis.

Wagner, Nathalie / Loprete, Luca / Duval, Vincent / Jauslin, Petra / Benkali, Khaled / Silverberg, Jonathan I / Wollenberg, Andreas / Saito, Tomohisa / Ahmad, Faiz / Graeber, Michael / Winkelman, Warren / Piketty, Christophe

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 10, Page(s) 1017–1020

Abstract: Nemolizumab is a monoclonal antibody directed against the interleukin-31 receptor A subunit, which is involved in the pathogenesis of pruritus and inflammation in atopic dermatitis (AD). Clinical trial results were combined with population PK (popPK) and ...

Abstract	Nemolizumab is a monoclonal antibody directed against the interleukin-31 receptor A subunit, which is involved in the pathogenesis of pruritus and inflammation in atopic dermatitis (AD). Clinical trial results were combined with population PK (popPK) and pharmacokinetic/ pharmacodynamic (PK/PD) models to optimize nemolizumab dosing. Phase 1 and 2a clinical studies indicated that weight-based nemolizumab dosing reduced pruritus in patients with moderate-to-severe AD with good safety and tolerability even at the highest dose (3 mg/kg single dose and 2 mg/kg multiple doses). Nemolizumab PK profile was characterized by a slow absorption with peak serum concentrations reached 4.5-9.2 days post-dose, and a long terminal half-life ranging from 12.6 to 16.5 days. A change from weight-based dosing to flat dose was supported by an additional phase 2b study sponsored by Galderma. Flat dosing provides several practical advantages, including ease of preparation for self- or auto-injection and reduced chance of dosing errors. Doses of 10, 30, and 90 mg were selected based on popPK and PK/PD simulations to result in nemolizumab serum concentrations sufficient to achieve efficacy. Loading doses were administrated at the 2 lower doses in order to achieve target systemic concentrations from the first injection. The efficacy of Nemolizumab in improving cutaneous signs of inflammation and pruritus in AD and its safety profile, combined with popPK and PK/PD analyses, supported selection of the flat-dose regimen of 30 mg (with a 60 mg loading dose) given every 4 weeks subcutaneously for 16 weeks in the phase 3 ARCADIA studies sponsored by Galderma. J Drugs Dermatol. 2023;22(10):1017-1020 doi:10.36849/JDD.7437R1.
MeSH term(s)	Humans ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/complications ; Pruritus/drug therapy ; Pruritus/etiology ; Antibodies, Monoclonal, Humanized ; Inflammation
Chemical Substances	nemolizumab (GN465U8B72) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7437R1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5931: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Population Pharmacokinetics and Exposure-Response Analysis for the CTLA-4 Inhibitor Tremelimumab in Metastatic NSCLC Patients in the Phase III POSEIDON Study.

He, Jimmy Zhijian / Duval, Vincent / Jauslin, Petra / Gonçalves, Antonio / Abegesah, Aburough / Fan, Chunling / Lim, KyoungSoo / Song, Xuyang / Chen, Cecil / Shi, Xiaojin / Mann, Helen / Krug, Lee / Ren, Song / Phipps, Alex / Gibbs, Megan / Zhou, Diansong

Clinical pharmacology and therapeutics

2023 Volume 114, Issue 6, Page(s) 1375–1386

Abstract: Blockade of CTLA-4 by tremelimumab combined with anti-PD-L1 durvalumab and chemotherapy provided increased antitumor activity and long-term survival benefits in first-line metastatic non-small cell lung cancer (mNSCLC) in the phase III POSEIDON study. We ...

Abstract	Blockade of CTLA-4 by tremelimumab combined with anti-PD-L1 durvalumab and chemotherapy provided increased antitumor activity and long-term survival benefits in first-line metastatic non-small cell lung cancer (mNSCLC) in the phase III POSEIDON study. We performed population pharmacokinetic modeling for tremelimumab using data from 1,605 patients across 6 studies (including POSEIDON) in multiple tumors (lung cancer, bladder cancer, malignant mesothelioma, and other solid tumors), and identified a 2-compartment model with linear and time-varying clearance for tremelimumab. Cox proportional hazard regression models were applied to 326 patients with mNSCLC from POSEIDON to evaluate the association between exposure metrics and efficacy end points, adjusting for baseline prognostic covariates. Improved progression-free survival (PFS) and overall survival (OS) in the tremelimumab arm (in combination with durvalumab and chemotherapy) was associated with higher tremelimumab exposure (e.g., minimum concentration at 5th dose (C
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms ; Immune Checkpoint Inhibitors/therapeutic use ; Treatment Outcome ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antibodies, Monoclonal, Humanized
Chemical Substances	tremelimumab (QEN1X95CIX) ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3063
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 20: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito