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Article ; Online: Labor Economics and Career Development in the Context of Globalized World

Dvorakova Zuzana

SHS Web of Conferences, Vol 92, p

2021 Volume 07019

Abstract: Research background: The paper uses labor economics and career theory to design an integrative approach to career research focusing on new occupations and career development. Purpose of the article: The purpose of this paper is to call for an integrative ...

Abstract	Research background: The paper uses labor economics and career theory to design an integrative approach to career research focusing on new occupations and career development. Purpose of the article: The purpose of this paper is to call for an integrative approach to career research aiming to characterize labor market trends and discuss perspectives on careers using highly skilled migrants from Central and Eastern Europe as a case. The paper discusses the specificity of career development in the context of the Industry 4.0. and an integrative approach vs. other approaches. Methods: The methodology insists on several ways that enable a triangular analysis. The research combines in-depth-analysis of bibliographic data in the Web of Science database, unstructured interviews with top managers/co-owners of multinational companies in August and September 2020 as a base for writing two narrative cases. Findings & Value added: Findings show the tendency of career theory to provide a narrow view of a career. They highlight the trends in considering the wide variety of career situations, which results from the fact that careers locate in time and space. The paper provides examples to explore career differences better and seek for alternative explanations to career experiences. Because career dynamics are influenced by individual characteristics and career development practices, a more integrative approach to career research must address the complexity of labor markets. The added value is to encourage discussions about career theory focusing on a wide range of issues.
Keywords	labor economics ; occupations ; career ; career development ; Social Sciences ; H
Subject code	300
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Sustainable human resource management in a time of global uncertainty

Dvorakova Zuzana

SHS Web of Conferences, Vol 83, p

2020 Volume 01012

Abstract: The paper characterizes the state-of-the-art knowledge of sustainable human resource management (HRM) based on on-the-desk analysis of articles in the Web of Science database published in the last two years in journals in Q1 and Q2. In the literature, ... ...

Abstract	The paper characterizes the state-of-the-art knowledge of sustainable human resource management (HRM) based on on-the-desk analysis of articles in the Web of Science database published in the last two years in journals in Q1 and Q2. In the literature, sustainable HRM is considered an extension of strategic HRM with a focus on long-term human resource development, regeneration, and renewal. The current focus has been on economic, environmental aspects in HR processes, and it turns out that social sustainability remains on the edge of HR managers´ interests. The situation in the Czech environment illustrates two narrative cases from March and April 2020. It becomes a challenge for all actors in education to change their view of ways of education and to accept as a necessity to apply distance education on a mass scale.
Keywords	Social Sciences ; H
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Optimization of the capital structure of an agricultural company in the Czech Republic

Vrbka Jaromír / Kalinová Eva / Dvořáková Zuzana

SHS Web of Conferences, Vol 132, p

2022 Volume 01008

Abstract: The topic of optimizing capital structure is very important for a company to work efficiently and reliably. It is important for every company to optimize everything so that they have the highest possible efficiency. Entrepreneurs also try to make this ... ...

Abstract	The topic of optimizing capital structure is very important for a company to work efficiently and reliably. It is important for every company to optimize everything so that they have the highest possible efficiency. Entrepreneurs also try to make this optimization last them as long as possible. Therefore, the aim of this paper is to determine the optimal capital structure of an agricultural company operating in the Czech Republic. The base source of data is the closing data of individual agricultural companies from the Albertina database of Bisnode. More than 9,000 agricultural enterprises operating in the given sector of the national economy in the Czech Republic are recorded in this data set. The calculation of the WACC method and the level of debt of individual agricultural companies are used. Subsequently, the equation for calculating the cost of capital is determined using power regression. Here we also obtain the value of reliability, which in this particular case is not ideal, but still reasonable. A line chart is used to determine the optimal interval for the agricultural company. The optimal debt interval comes out to 20 to 25%, at which the cost of capital is declared to be from 22 to 24%. If agricultural companies had higher or lower debt ratios, it would be inefficient for the enterprise.
Keywords	optimal capital structure ; debt ; power regression ; cost of capital ; agriculture ; optimization ; Social Sciences ; H
Subject code	338
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Localization and classification of scattered nonlinear ultrasonic signatures in bio-mechanical media using time reversal approach.

Dvořáková, Zuzana / Dos Santos, Serge / Kůs, Václav / Převorovský, Zdeněk

The Journal of the Acoustical Society of America

2023 Volume 154, Issue 3, Page(s) 1684–1695

Abstract: This paper deals with the time reversal approach along with signal classification using ϕ-divergences in biomedical applications for localization and statistical classification of ultrasonic nonlinearities. The time reversal (TR) approach in combination ... ...

Abstract	This paper deals with the time reversal approach along with signal classification using ϕ-divergences in biomedical applications for localization and statistical classification of ultrasonic nonlinearities. The time reversal (TR) approach in combination with nonlinear elastic wave spectroscopy (NEWS) is used to obtain the nonlinear signature of air bubbles with different sizes and ultrasound contrast agents in a liquid. An optimized chirp-coded signal in the range of 0.6-3 MHz is used as a compression coding. The signal classification is performed using the fuzzy classification method and the divergence decision tree algorithm using specific ϕ-divergence spectral measures extracted from the received ultrasonic response containing acoustic nonlinearities. The classification results prove that different types of nonlinearities extracted with classical "pulse inversion" based coding methods can be identified. Simultaneously, the different positions of scattered sources are distinguished by ϕ-divergence methods. The potential of time reversal nonlinear elastic wave spectroscopy methods for understanding of ultrasonic wave propagation in complex media is clearly exhibited.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0020658
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Article ; Online: Monitoring changes at work

Fedorova Alena / Dvorakova Zuzana / Kacane Ilze / Atas Huseyin / Badambayeva Valeriya

SHS Web of Conferences, Vol 129, p

cross-cultural difference in employees’ evaluation

2021 Volume 08006

Abstract: Research background: Globalization and digitalization of society are leading to fundamental alterations in the labour sphere. Global trends and turbulent times are changing the work environment, stipulating the emergence of new forms of labour relations ... ...

Abstract	Research background: Globalization and digitalization of society are leading to fundamental alterations in the labour sphere. Global trends and turbulent times are changing the work environment, stipulating the emergence of new forms of labour relations and employment models. Thinking on the on-going transformation processes requires a monitoring study of new phenomena, as well as the creation of a knowledge system about the directions and prospects of human resources management and labour relations development. Purpose of the article: The article presents the interim results of the current monitoring changes in labour relations conducted by the international research team members. The empirical data obtained are considered in the context of the social and cultural features of respondents from different countries that contributes to a deeper understanding of the phenomena under study. Methods: In 2020, the authors carried out a sociological survey involving employees of enterprises operating in various sectors of the economy in the Russian Federation, the Czech Republic, Latvia, Turkey and Kazakhstan. The total number of respondents formed by random sampling is amounted to 1138 people. For the purpose of a comprehensive typology of the surveyed workers from different countries, a cluster analysis of the collected data was carried out. Findings & Value added: A comparative analysis of the sociological survey results reflects the trends in work transformation and labour relations that have developed under the Covid-19 pandemic. Cross-cultural analysis reveals the impact of social and cultural factors on respondents’ assessment and companies’ human resource management practices.
Keywords	cross-country study ; labour relations ; human resource management practices ; comparative analysis ; cluster analysis ; Social Sciences ; H
Subject code	650 ; 300
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article: Determination of capsaicin in hot peppers (Capsicum spp.) by direct analysis in real time (DART) method

Tobolka, Adam / Škorpilová, Tereza / Dvořáková, Zuzana / Cusimamani, Eloy Fernández / Rajchl, Aleš

Journal of food composition and analysis. 2021 Oct., v. 103

2021

Abstract: In this study, 46 different cultivars of chilli peppers and their seeds were analysed. Capsaicin, the alkaloid responsible for the pungency of chilli peppers, was first analysed with the optimised direct analysis in real time (DART) and time of flight ... ...

Abstract	In this study, 46 different cultivars of chilli peppers and their seeds were analysed. Capsaicin, the alkaloid responsible for the pungency of chilli peppers, was first analysed with the optimised direct analysis in real time (DART) and time of flight mass spectrometry (TOF-MS) method, and the capsaicin content values obtained were compared with those obtained from the high-performance liquid chromatography with diode array detection (HPLC–DAD) method. The correlation coefficient values for the DART–TOF-MS method with the HPLC–DAD method were R² = 0.845 for the pulp of chilli peppers and R² = 0.776 for the chilli pepper seeds. The optimised DART–TOF-MS method was evaluated as a suitable tool for rapidly distinguishing between chilli peppers and their seeds based on pungency and capsaicin content. The obtained mass spectral data were statistically evaluated by principal component analysis (PCA), and the individual types of chilli peppers were distinguished by their varying pungency, based on choosing selected specific m/z values for the capsaicin compound.
Keywords	Capsicum ; capsaicin ; cultivars ; diodes ; food composition ; high performance liquid chromatography ; hot peppers ; mass spectrometry ; principal component analysis ; pulp ; spectral analysis
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	743572-1
ISSN	0889-1575 ; 1096-0481
ISSN	0889-1575 ; 1096-0481
DOI	10.1016/j.jfca.2021.104074
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Article: Socioeconomic and gender inequalities in smoking. Findings from the Czech National Tobacco Surveys 2012-2015.

Csémy, Ladislav / Sovinová, Hana / Dvořáková, Zuzana

Central European journal of public health

2018 Volume 26, Issue 1, Page(s) 28–33

Abstract: Objective: Smoking significantly affects morbidity and mortality of the population. The incidence of smoking is determined by gender and socioeconomic status (SES) of an individual. The aim of this study is to analyse the relationship between gender and ...

Abstract	Objective: Smoking significantly affects morbidity and mortality of the population. The incidence of smoking is determined by gender and socioeconomic status (SES) of an individual. The aim of this study is to analyse the relationship between gender and SES indicators and smoking. Methods: The analysis is based on data from the Czech National Tobacco Surveys from 2012 to 2015 (N∼1,800 per year). The prevalence of smoking, average daily consumption of cigarettes, initiation ratio and quit ratio were monitored. Smoking habits of the respondents were surveyed using the Czech version of the standard Tobacco Questions for Surveys (TQS) questionnaire. SES was measured by a composite index comprising three variables (level of education, income and job prestige); it had four categories: low, lower-middle, upper-middle, and high. Results: In comparison with women, men had a higher smoking prevalence (OR=1.41, 95% CI=1.09-1.84), higher consumption of cigarettes (B=4.11, 95% CI=1.97-6.26), and higher rate of smoking initiation (OR=1.38, 95% CI=1.10-1.74), but they did not differ in the quit rate (OR=0.85, 95% CI=0.60-1.21). Persons in the low SES category had higher prevalence of smoking and higher initiation ratio compared with those in the high SES category (OR=2.59, 95% CI=1.36-4.97; OR=2.23, 95% CI=1.26-3.95). Cigarette consumption and quit ratio did not differ according to SES. The prevalence of smoking in the years 2012-2014 did not differ; in 2015, it was lower compared to the previous three years. Conclusions: Inequalities in socioeconomic status affect smoking, which significantly contributes to morbidity and mortality. Measures aimed at reducing inequalities in health must take into account both smoking as a risk factor and socioeconomic status, which affects its occurrence. Programmes to reduce tobacco use should reflect the different needs of individuals with different SES levels. It is especially necessary to seek effective approaches for smokers with low socioeconomic status.
MeSH term(s)	Adult ; Czech Republic/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Sex Factors ; Smoking/epidemiology ; Social Class ; Surveys and Questionnaires
Language	English
Publishing date	2018-04-23
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1176053-9
ISSN	1803-1048 ; 1210-7778 ; 0022-1732
ISSN (online)	1803-1048
ISSN	1210-7778 ; 0022-1732
DOI	10.21101/cejph.a4923
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Article: Spectroscopic insights into quadruplexes of five-repeat telomere DNA sequences upon G-block damage.

Dvořáková, Zuzana / Vorlíčková, Michaela / Renčiuk, Daniel

Biochimica et biophysica acta. General subjects

2017 Volume 1861, Issue 11 Pt A, Page(s) 2750–2757

Abstract: Background: The DNA lesions, resulting from oxidative damage, were shown to destabilize human telomere four-repeat quadruplex and to alter its structure. Long telomere DNA, as a repetitive sequence, offers, however, other mechanisms of dealing with the ... ...

Abstract	Background: The DNA lesions, resulting from oxidative damage, were shown to destabilize human telomere four-repeat quadruplex and to alter its structure. Long telomere DNA, as a repetitive sequence, offers, however, other mechanisms of dealing with the lesion: extrusion of the damaged repeat into loop or shifting the quadruplex position by one repeat. Methods: Using circular dichroism and UV absorption spectroscopy and polyacrylamide electrophoresis, we studied consequences of lesions at different positions of the model five-repeat human telomere DNA sequences on the structure and stability of their quadruplexes in sodium and in potassium. Results: The repeats affected by lesion are preferentially positioned as terminal overhangs of the core quadruplex structurally similar to the four-repeat one. Forced affecting of the inner repeats leads to presence of variety of more parallel folds in potassium. In sodium the designed models form mixture of two dominant antiparallel quadruplexes whose population varies with the position of the affected repeat. The shapes of quadruplex CD spectra, namely the height of dominant peaks, significantly correlate with melting temperatures. Conclusion: Lesion in one guanine tract of a more than four repeats long human telomere DNA sequence may cause re-positioning of its quadruplex arrangement associated with a shift of the structure to less common quadruplex conformations. The type of the quadruplex depends on the loop position and external conditions. General significance: The telomere DNA quadruplexes are quite resistant to the effect of point mutations due to the telomere DNA repetitive nature, although their structure and, consequently, function might be altered.
MeSH term(s)	Circular Dichroism ; G-Quadruplexes/drug effects ; Guanine/chemistry ; Humans ; Nucleic Acid Conformation/drug effects ; Oxidative Stress/genetics ; Point Mutation ; Repetitive Sequences, Nucleic Acid/genetics ; Sodium/toxicity ; Spectroscopy, Near-Infrared ; Telomere/chemistry ; Telomere/drug effects ; Telomere/genetics
Chemical Substances	Guanine (5Z93L87A1R) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2017-07-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0304-4165 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0304-4165 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2017.07.019
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Article: Spectroscopic insights into quadruplexes of five-repeat telomere DNA sequences upon G-block damage

Dvořáková, Zuzana / Daniel Renčiuk / Michaela Vorlíčková

Biochimica et biophysica acta. 2017 Nov., v. 1861, no. 11

2017

Abstract: The DNA lesions, resulting from oxidative damage, were shown to destabilize human telomere four-repeat quadruplex and to alter its structure. Long telomere DNA, as a repetitive sequence, offers, however, other mechanisms of dealing with the lesion: ... ...

Abstract	The DNA lesions, resulting from oxidative damage, were shown to destabilize human telomere four-repeat quadruplex and to alter its structure. Long telomere DNA, as a repetitive sequence, offers, however, other mechanisms of dealing with the lesion: extrusion of the damaged repeat into loop or shifting the quadruplex position by one repeat.Using circular dichroism and UV absorption spectroscopy and polyacrylamide electrophoresis, we studied consequences of lesions at different positions of the model five-repeat human telomere DNA sequences on the structure and stability of their quadruplexes in sodium and in potassium.The repeats affected by lesion are preferentially positioned as terminal overhangs of the core quadruplex structurally similar to the four-repeat one. Forced affecting of the inner repeats leads to presence of variety of more parallel folds in potassium. In sodium the designed models form mixture of two dominant antiparallel quadruplexes whose population varies with the position of the affected repeat. The shapes of quadruplex CD spectra, namely the height of dominant peaks, significantly correlate with melting temperatures.Lesion in one guanine tract of a more than four repeats long human telomere DNA sequence may cause re-positioning of its quadruplex arrangement associated with a shift of the structure to less common quadruplex conformations. The type of the quadruplex depends on the loop position and external conditions.The telomere DNA quadruplexes are quite resistant to the effect of point mutations due to the telomere DNA repetitive nature, although their structure and, consequently, function might be altered.
Keywords	circular dichroism spectroscopy ; DNA ; DNA damage ; electrophoresis ; extrusion ; guanine ; humans ; melting ; models ; nucleotide sequences ; point mutation ; polyacrylamide ; potassium ; sodium ; telomeres ; ultraviolet-visible spectroscopy
Language	English
Dates of publication	2017-11
Size	p. 2750-2757.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	840755-1
ISSN	0304-4165
ISSN	0304-4165
DOI	10.1016/j.bbagen.2017.07.019
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Article ; Online: Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology.

Holoubek, Jiří / Bednářová, Klára / Haviernik, Jan / Huvarová, Ivana / Dvořáková, Zuzana / Černý, Jiří / Outlá, Martina / Salát, Jiří / Konkol'ová, Eva / Boura, Evzen / Růžek, Daniel / Vorlíčková, Michaela / Eyer, Luděk / Renčiuk, Daniel

Nucleic acids research

2022 Volume 50, Issue 8, Page(s) 4574–4600

Abstract: We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human infections and numerous deaths every year. The formation of G4s was confirmed by biophysical ... ...

Abstract	We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human infections and numerous deaths every year. The formation of G4s was confirmed by biophysical methods on synthetic oligonucleotides derived from the predicted TBEV sequences. TBEV-5, located at the NS4b/NS5 boundary and conserved among all known flaviviruses, was tested along with its mutated variants for interactions with a panel of known G4 ligands, for the ability to affect RNA synthesis by the flaviviral RNA-dependent RNA polymerase (RdRp) and for effects on TBEV replication fitness in cells. G4-stabilizing TBEV-5 mutations strongly inhibited RdRp RNA synthesis and exhibited substantially reduced replication fitness, different plaque morphology and increased sensitivity to G4-binding ligands in cell-based systems. In contrast, strongly destabilizing TBEV-5 G4 mutations caused rapid reversion to the wild-type genotype. Our results suggest that there is a threshold of stability for G4 sequences in the TBEV genome, with any deviation resulting in either dramatic changes in viral phenotype or a rapid return to this optimal level of G4 stability. The data indicate that G4s are critical elements for efficient TBEV replication and are suitable targets to tackle TBEV infection.
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Encephalitis Viruses, Tick-Borne/drug effects ; Encephalitis Viruses, Tick-Borne/genetics ; Encephalitis, Tick-Borne/drug therapy ; Encephalitis, Tick-Borne/genetics ; G-Quadruplexes ; Humans ; Ligands ; RNA, Viral/genetics ; RNA-Dependent RNA Polymerase/genetics
Chemical Substances	Antiviral Agents ; Ligands ; RNA, Viral ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkac225
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