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  1. Book ; Online: Marine Compounds and Cancer 2020

    Honecker, Friedemann / Dyshlovoy, Sergey A.

    2021  

    Keywords Medicine ; apoptosis ; fucoidan ; hepatocellular carcinoma ; reactive oxygen species ; 3-alkylpyridinium polymers ; nicotine ; nicotinic acetylcholine receptor ; non-small cell lung carcinoma ; melanoma ; sinulariolide ; proteomic ; mitochondria ; caspase cascade ; marine fungus ; sediment ; anthranilic acid ; Penicillium paneum ; cytotoxicity ; dibromotyrosine ; mitochondrial dysfunction ; oxidative stress ; topoisomerase ; epigonal organ ; bonnethead shark ; Jurkat ; tumor cell line ; hippuristanol ; PEL ; AP-1 ; STAT3 ; Akt ; colorectal cancer ; marine mollusc ; brominated indoles ; shrimp ; chemoprevention ; fatty acids ; carotenoids ; cancer ; nanoparticle ; osteosarcoma ; lung metastasis ; elisidepsin ; lipid rafts ; hydroxylated lipids ; fatty acid 2-hydroxylase ; cooperative binding ; membrane permeabilization ; marine organisms ; polysaccharides ; anticancer ; anticarcinogenic ; mechanisms of action ; fumigaclavine C ; anti-proliferation ; mitochondrial pathway ; anti-cancer ; anti-proliferative ; carotenoid ; cell cycle arrest ; fucoxanthin ; azoxymethane ; bioactive natural product ; isatin ; in vivo model ; Marthasterias glacialis L. ; palmitic acid ; ER-stress ; CHOP ; Antibody Drug Conjugates (ADCs) ; marine antitumor agents ; clinical trials ; approved antitumor agents ; AD0157 ; angiogenesis ; marine drug ; pyrrolidinedione ; secondary metabolites ; cancer preventive ; chemopreventive ; trabectedin ; plitidepsin ; tumor-associated macrophages ; tumor microenvironment ; preclinical ; anticancer immunity ; antiangiogenesis ; fascaplysin ; cyclin-dependent kinase ; small cell lung cancer ; camptothecin ; poly(ADP-ribose)-polymerase inhibitor ; breast cancer ; seaweed ; therapeutic compounds ; autophagy ; marine drugs ; autophagy inhibitors ; autophagy inducers ; macrolide ; programmed cell death ; energy stress ; araguspongine C ; c-Met ; HER2 ; gemcitabine ; pazopanib ; phase I ; safety ; soft tissue sarcoma ; pachastrissamine ; jaspine B ; carbocyclic analogue ; sphingosine kinase inhibitor ; molecular modeling ; ET-743 ; DNA minor groove binder ; chemotherapy ; bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) ; anti-metastatic activity ; cell adhesion ; β1-integrin ; FAK ; BEL-7402 cell ; triterpene glycosides ; sea cucumbers ; antitumor activities ; arrest of cell cycle ; antibacterial ; marangucyclines ; deep-sea ; Streptomyces sp. SCSIO 11594 ; LS-1 ; SNU-C5/5-FU ; TGF-β signaling ; carcinoembryonic antigen ; kalkitoxin ; Moorea producens ; mitochondria toxin ; VEGF ; angiogenesis inhibitor ; hypoxia-inducible factor-1 ; HIF-1 ; Lyngbya majuscula ; marine metabolites ; SZ-685C ; nonfunctioning pituitary adenomas ; Ecklonia cava ; phlorotannins ; dieckol ; migration ; sipholenol A ; ABC transporter ; multidrug resistance ; P-gp/ABCB1 ; BCRP/ABCG2 ; MRP1/ABCC1 ; marine natural products ; glioblastoma ; xyloketal B ; proliferation ; TRPM7 ; marine compound ; ribosomal protein genes ; snoRNA ; FAU ; RPS30 ; SNORA62 ; evolution ; Porifera ; n/a ; Penicillium brevicompactum ; Brevianamide ; Mycochromenic acid derivative ; antifouling ; Caribbean sponge ; plakortide ; endoperoxide ; leukemia ; multi-drug resistant leukemia ; Sarcophyton ehrenbergi ; soft coral ; terpenes ; cembranoids ; cytotoxic activity ; molecular docking ; uveal melanoma ; virtual screening ; Topo I inhibitor ; low toxic ; natural product ; Ulva fasciata ; selenium-containing polysaccharide-protein complex ; pseudopterosin ; NF-κB ; p65 ; inflammation ; cytokine release ; IL-6 ; TNFα ; MCP-1 ; glucocorticoid receptor ; paulomycins ; Micromonospora ; antitumor ; Cantabrian Sea-derived actinobacteria ; puupehenones ; sponges ; antiangiogenic ; antitumoral ; porifera/sponge ; cancer genes ; molecular oncology ; bromophenol ; molecular mechanisms ; cell cycle ; PI3K/Akt ; p38/ERK ; ROS ; human lung cancer ; glycosaminoglycans ; antiproliferative ; heparan sulphate ; gliotoxin ; NSCLC ; adriamycin resistance ; Sepia ink polysaccharides ; antitumour ; chemosensitization ; anticoagulation ; sea anemone ; drug discovery ; endothelial cells ; RGD motif ; kunitz type inhibitor ; prostate cancer ; antioxidant ; natural marine compounds ; marine biotechnology ; microalgae ; marine sponges ; Aeroplysinin ; Isofistularin ; pheochromocytoma and paraganglioma ; metastasis ; cancer progression ; cell adhesion molecules ; integrin β1 ; hypoxia ; phycocyanin ; non-small cell lung cancer ; NF-κB signaling ; marine-derived drugs ; bioanalysis ; chromatography ; manzamine A ; epithelial-mesenchymal transition ; lung cancer ; circulating tumor cells ; signal transduction ; cisplatin ; Lampetra morii ; buccal gland ; cystatin F ; anti-angiogenesis ; cystatin superfamily ; Antimicrobial peptide (AMP) ; Tilapia piscidin 4 (TP4) ; non-small cell lung cancer (NSCLC) ; itampolin A ; FBDD ; p38α ; novel inhibitor ; tetracenomycin X ; cyclin D1 ; proteasomal degradation ; p38 ; c-JUN ; λ-carrageenan ; heparanase ; anticoagulant ; depolymerisation ; cell migration ; Aspergillus ; naphthopyrones ; endophytic fungus ; Leathesia nana ; mangrove-derived actinomycete ; ansamycins ; divergolides ; apoptosis-inducing activity ; actinomycin ; EMT ; invasion ; low molecular weight fucoidan extract ; N-Ras ; neuroblastoma-rat sarcoma ; Cancer ; programmed cell death-ligand 1 ; programmed cell death-ligand 2 ; human sarcoma cell line (HT1080 cells) ; human normal diploid fibroblast (TIG-1 cells) ; chimera ; chemical conjugation ; anticancer agent ; hybridization ; α9-nicotinic acetylcholine receptors (nAChRs) ; breast cancer cells ; αO-conotoxin GeXIVA ; targeted therapy ; gorgonian ; Leptogorgia ; humulane sesquiterpenoids ; anticancer activity ; 12-deacetyl-12-epi-scalaradial ; HeLa cells ; Nur77 ; MAPK/ERK pathway ; Mycalin A ; C15 acetogenins ; synthetic analogues ; antiproliferative activity ; A375 and HeLa cell lines ; polyoxygenated steroids ; sponge ; Haliclona gracilis ; Thalassia testudinum ; thalassiolin B ; polyphenols ; CYP1A1 ; benzo[a]pyrene ; JNK1/2 ; natural products ; synergism ; A549 cells ; cytoskeleton ; P2X7 receptor ; pollution ; anti-angiogenic ; gene expression ; HSP90 ; inhibitor
    Size 1 electronic resource (480 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290047
    ISBN 9783036506319 ; 3036506314
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Marine Compounds and Cancer

    Honecker, Friedemann / Dyshlovoy, Sergey A.

    2018  

    Abstract: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called "targeted agents", there is still an urgent need for new drugs in oncology. Hope comes from the marine ... ...

    Abstract In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called "targeted agents", there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity.Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between "targeted" and "untargeted" therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future.This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development
    Keywords Medicine (General)
    Size 1 electronic resource (VI, 112 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020098765
    ISBN 9783038427650 ; 9783038427667 ; 3038427659 ; 3038427667
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Recent Updates on Marine Cancer-Preventive Compounds.

    Dyshlovoy, Sergey A

    Marine drugs

    2021  Volume 19, Issue 10

    Abstract: The natural compounds derived from marine organisms often exhibit unique chemical structures and potent biological activities. Cancer-preventive activity is one of the rather new activities that has emerged and been extensively studied over the last ... ...

    Abstract The natural compounds derived from marine organisms often exhibit unique chemical structures and potent biological activities. Cancer-preventive activity is one of the rather new activities that has emerged and been extensively studied over the last decades. This review summarizes the recent updates on the marine chemopreventive compounds covering the relevant literature published in 2013-2021 and following the previous comprehensive review by Stonik and Fedorov (
    MeSH term(s) Animals ; Antineoplastic Agents ; Aquatic Organisms ; Biological Products ; Chemoprevention
    Chemical Substances Antineoplastic Agents ; Biological Products
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19100558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Blue-Print Autophagy in 2020: A Critical Review.

    Dyshlovoy, Sergey A

    Marine drugs

    2020  Volume 18, Issue 9

    Abstract: Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a ... ...

    Abstract Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a number of pathological conditions, including cancer and neurodegenerative disorders. At the same time, due to the relatively young age of the field, there are still some pitfalls in the autophagy monitoring assays and interpretation of the experimental data. This critical review provides an overview of the marine natural compounds, which have been reported to affect autophagy. The time period from the beginning of 2016 to the middle of 2020 is covered. Additionally, the published data and conclusions based on the experimental results are re-analyzed with regard to the guidelines developed by Klionsky and colleagues (Autophagy. 2016; 12(1): 1-222), which are widely accepted by the autophagy research community. Remarkably and surprisingly, more than half of the compounds reported to be autophagy activators or inhibitors could not ultimately be assigned to either category. The experimental data reported for those substances could indicate both autophagy activation and inhibition, requiring further investigation. Thus, the reviewed molecules were divided into two groups: having validated and non-validated autophagy modulatory effects. This review gives an analysis of the recent updates in the field and raises an important problem of standardization in the experimental design and data interpretation.
    MeSH term(s) Animals ; Aquatic Organisms/metabolism ; Autophagy/drug effects ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18090482
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Marine Compounds and Cancer: Updates 2022.

    Dyshlovoy, Sergey A / Honecker, Friedemann

    Marine drugs

    2022  Volume 20, Issue 12

    Abstract: The field of marine bioactive compounds (marine drugs) has evolved significantly in recent years [ ... ]. ...

    Abstract The field of marine bioactive compounds (marine drugs) has evolved significantly in recent years [...].
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20120759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Recent Updates on Marine Cancer-Preventive Compounds

    Dyshlovoy, Sergey A.

    Marine drugs. 2021 Sept. 29, v. 19, no. 10

    2021  

    Abstract: The natural compounds derived from marine organisms often exhibit unique chemical structures and potent biological activities. Cancer-preventive activity is one of the rather new activities that has emerged and been extensively studied over the last ... ...

    Abstract The natural compounds derived from marine organisms often exhibit unique chemical structures and potent biological activities. Cancer-preventive activity is one of the rather new activities that has emerged and been extensively studied over the last decades. This review summarizes the recent updates on the marine chemopreventive compounds covering the relevant literature published in 2013–2021 and following the previous comprehensive review by Stonik and Fedorov (Marine Drugs 2014, 12, 636–671). In the current article, only the molecules having an effect on malignant transformation (or related pathway and molecules), cancer stem cells, or carcinogen-induced in vivo tumor development were considered to be “true” cancer-preventive compounds and were, therefore, reviewed. Additionally, particular attention has been given to the molecular mechanisms of chemoprevention, executed by the reported marine compounds.
    Keywords aquatic organisms ; bioactive properties ; chemical structure ; chemoprevention ; drugs ; exhibitions ; neoplasm cells ; neoplasms ; stem cells
    Language English
    Dates of publication 2021-0929
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19100558
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Marine Compounds and Cancer: Updates 2022

    Dyshlovoy, Sergey A. / Honecker, Friedemann

    Mar Drugs. 2022 Dec. 01, v. 20, no. 12

    2022  

    Abstract: The field of marine bioactive compounds (marine drugs) has evolved significantly in recent years [ ... ] ...

    Abstract The field of marine bioactive compounds (marine drugs) has evolved significantly in recent years [...]
    Keywords bioactive compounds ; drugs ; fields ; neoplasms
    Language English
    Dates of publication 2022-1201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20120759
    Database NAL-Catalogue (AGRICOLA)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Blue-Print Autophagy in 2020: A Critical Review

    Dyshlovoy, Sergey A

    Marine drugs. 2020 Sept. 21, v. 18, no. 9

    2020  

    Abstract: Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a ... ...

    Abstract Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a number of pathological conditions, including cancer and neurodegenerative disorders. At the same time, due to the relatively young age of the field, there are still some pitfalls in the autophagy monitoring assays and interpretation of the experimental data. This critical review provides an overview of the marine natural compounds, which have been reported to affect autophagy. The time period from the beginning of 2016 to the middle of 2020 is covered. Additionally, the published data and conclusions based on the experimental results are re-analyzed with regard to the guidelines developed by Klionsky and colleagues (Autophagy. 2016; 12(1): 1–222), which are widely accepted by the autophagy research community. Remarkably and surprisingly, more than half of the compounds reported to be autophagy activators or inhibitors could not ultimately be assigned to either category. The experimental data reported for those substances could indicate both autophagy activation and inhibition, requiring further investigation. Thus, the reviewed molecules were divided into two groups: having validated and non-validated autophagy modulatory effects. This review gives an analysis of the recent updates in the field and raises an important problem of standardization in the experimental design and data interpretation.
    Keywords age ; assays ; autophagy ; drugs ; experimental design ; guidelines ; monitoring ; neurodegenerative diseases ; research ; standardization ; therapeutics
    Language English
    Dates of publication 2020-0921
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18090482
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Marine Compounds and Cancer: Updates 2020.

    Dyshlovoy, Sergey A / Honecker, Friedemann

    Marine drugs

    2020  Volume 18, Issue 12

    Abstract: By the end of the year 2020, there are nine marine-derived anticancer drugs available on the market, and the field is currently growing exponentially [ ... ]. ...

    Abstract By the end of the year 2020, there are nine marine-derived anticancer drugs available on the market, and the field is currently growing exponentially [...].
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biological Products ; Humans ; Marine Biology ; Marine Toxins/pharmacology ; Marine Toxins/therapeutic use ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents ; Biological Products ; Marine Toxins
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18120643
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article ; Online: Marine Drugs Acting as Autophagy Modulators.

    Dyshlovoy, Sergey A / Honecker, Friedemann

    Marine drugs

    2020  Volume 18, Issue 1

    Abstract: Autophagy (Ancient Greek αὐτόφαγος [ ...

    Abstract Autophagy (Ancient Greek αὐτόφαγος [
    MeSH term(s) Autophagy/drug effects ; Biological Products/therapeutic use ; Humans ; Pharmaceutical Preparations/administration & dosage
    Chemical Substances Biological Products ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-01-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18010053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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