Article ; Online: Sex-Linked Discrepancies in C57BL6/J Mouse Osteoarthritis are Associated With the Gut Microbiome and are Transferrable by Microbiome Transplantation.
Arthritis & rheumatology (Hoboken, N.J.)
2023 Volume 76, Issue 2, Page(s) 231–237
Abstract: Objective: Females have reduced osteoarthritis (OA) in surgical models. The objective of the current study was to evaluate a sex-linked gut microbiome in the pathogenesis of OA.: Methods: We induced OA via destabilization of the medial meniscus ... ...
| Abstract | Objective: Females have reduced osteoarthritis (OA) in surgical models. The objective of the current study was to evaluate a sex-linked gut microbiome in the pathogenesis of OA. Methods: We induced OA via destabilization of the medial meniscus surgery in adult male and female C57BL6/J mice with and without opposite-sex microbiome transplantation. Eight weeks later, animals were euthanized, and OA severity, synovitis, and osteophyte scores were determined. Serum lipopolysaccharide was measured chromogenically, and serum cytokines were quantified via multiplex immunoassay. Cecal microbiome profiles were generated using 16S deep sequencing. Results: Males had worse OA histology (3.5x, P = 6 × 10 Conclusion: Sex-linked differences in the mouse gut microbiome are associated with OA outcomes, are reversible by opposite-sex microbiome transplantation, and are associated with serum cytokine changes. |
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| MeSH term(s) | Male ; Female ; Mice ; Animals ; Gastrointestinal Microbiome ; Osteophyte/etiology ; Osteoarthritis/pathology ; Mice, Inbred C57BL ; Synovitis/pathology ; Cytokines ; Cartilage, Articular/pathology | |||||
| Chemical Substances | Cytokines | |||||
| Language | English | |||||
| Publishing date | 2023-12-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural | |||||
| ZDB-ID | 2756371-6 | |||||
| ISSN | 2326-5205 ; 2326-5191 | |||||
| ISSN (online) | 2326-5205 | |||||
| ISSN | 2326-5191 | |||||
| DOI | 10.1002/art.42687 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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