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Article ; Online: Challenges of the Immunotherapy: Perspectives and Limitations of the Immune Checkpoint Inhibitor Treatment.

Dobosz, Paula / Stępień, Maria / Golke, Anna / Dzieciątkowski, Tomasz

International journal of molecular sciences

2022 Volume 23, Issue 5

Abstract: Immunotherapy is a quickly developing type of treatment and the future of therapy in oncology. This paper is a review of recent findings in the field of immunotherapy with an emphasis on immune checkpoint inhibitors. The challenges that immunotherapy ... ...

Abstract	Immunotherapy is a quickly developing type of treatment and the future of therapy in oncology. This paper is a review of recent findings in the field of immunotherapy with an emphasis on immune checkpoint inhibitors. The challenges that immunotherapy might face in near future, such as primary and acquired resistance and the irAEs, are described in this article, as well as the perspectives such as identification of environmental modifiers of immunity and development of anti-cancer vaccines and combined therapies. There are multiple factors that may be responsible for immunoresistance, such as genomic factors, factors related to the immune system cells or to the cancer microenvironment, factors emerging from the host cells, as well as other factors such as advanced age, biological sex, diet, many hormones, existing comorbidities, and the gut microbiome.
MeSH term(s)	Cancer Vaccines/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunologic Factors/therapeutic use ; Immunotherapy ; Neoplasms/drug therapy ; Tumor Microenvironment
Chemical Substances	Cancer Vaccines ; Immune Checkpoint Inhibitors ; Immunologic Factors
Language	English
Publishing date	2022-03-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23052847
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Intriguing History of Cancer Immunotherapy.

Dobosz, Paula / Dzieciątkowski, Tomasz

Frontiers in immunology

2019 Volume 10, Page(s) 2965

Abstract: Immunotherapy is often perceived as a relatively recent advance. In reality, however, one should be looking for the beginnings of cancer immunotherapy under different names as far as in the Antiquity. The first scientific attempts to modulate patients' ... ...

Abstract	Immunotherapy is often perceived as a relatively recent advance. In reality, however, one should be looking for the beginnings of cancer immunotherapy under different names as far as in the Antiquity. The first scientific attempts to modulate patients' immune systems to cure cancer can be attributed to two German physicians, Fehleisen and Busch, who independently noticed significant tumor regression after erysipelas infection. The next significant advances came from William Bradley Coley who is known today as the Father of Immunotherapy. It was Coley who first attempted to harness the immune system for treating bone cancer in 1891. His achievements were largely unnoticed for over fifty years, and several seminal discoveries in the field of Immunology, such as the existence of T cells and their crucial role in immunity in 1967, stepped up the research toward cancer immunotherapy known today. The following paper tracks cancer immunotherapy from its known beginnings up until recent events, including the 2018 Nobel Prize award to James Allison and Tasuku Honjo for their meticulous work on checkpoint molecules as potential therapeutic targets. That work has led to the successful development of new checkpoint inhibitors, CAR T-cells and oncolytic viruses and the pace of such advances brings the highest hope for the future of cancer treatment.
MeSH term(s)	Bone Neoplasms/history ; Bone Neoplasms/immunology ; Bone Neoplasms/therapy ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Immunotherapy/history
Language	English
Publishing date	2019-12-17
Publishing country	Switzerland
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02965
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Article ; Online: mRNA vaccines: The future of prevention of viral infections?

Rzymski, Piotr / Szuster-Ciesielska, Agnieszka / Dzieciątkowski, Tomasz / Gwenzi, Willis / Fal, Andrzej

Journal of medical virology

2023 Volume 95, Issue 2, Page(s) e28572

Abstract: Messenger RNA (mRNA) vaccines against COVID-19 are the first authorized biological preparations developed using this platform. During the pandemic, their administration has been proven to be a life-saving intervention. Here, we review the main advantages ...

Abstract	Messenger RNA (mRNA) vaccines against COVID-19 are the first authorized biological preparations developed using this platform. During the pandemic, their administration has been proven to be a life-saving intervention. Here, we review the main advantages of using mRNA vaccines, identify further technological challenges to be met during the development of the mRNA platform, and provide an update on the clinical progress on leading mRNA vaccine candidates against different viruses that include influenza viruses, human immunodeficiency virus 1, respiratory syncytial virus, Nipah virus, Zika virus, human cytomegalovirus, and Epstein-Barr virus. The prospects and challenges of manufacturing mRNA vaccines in low-income countries are also discussed. The ongoing interest and research in mRNA technology are likely to overcome some existing challenges for this technology (e.g., related to storage conditions and immunogenicity of some components of lipid nanoparticles) and enhance the portfolio of vaccines against diseases for which classical formulations are already authorized. It may also open novel pathways of protection against infections and their consequences for which no safe and efficient immunization methods are currently available.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Epstein-Barr Virus Infections ; COVID-19 ; Herpesvirus 4, Human/genetics ; Virus Diseases ; Respiratory Syncytial Virus, Human/genetics ; RNA, Messenger ; Zika Virus/genetics ; Zika Virus Infection ; Viral Vaccines ; Influenza Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; Viral Vaccines ; Influenza Vaccines
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28572
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Article: Coronaviruses - a new old menace.

Golke, Anna / Piekarska, Karolina / Dzieciątkowski, Tomasz

Postepy biochemii

2021 Volume 66, Issue 4, Page(s) 303–308

Abstract: The current pandemic caused by novel coronavirus SARS-CoV-2 pandemic has been described as a global health emergency. The outbreak of this virus has raised a number of questions: what exactly is SARS-CoV-2? How transmissible the novel coronavirus is? How ...

Abstract	The current pandemic caused by novel coronavirus SARS-CoV-2 pandemic has been described as a global health emergency. The outbreak of this virus has raised a number of questions: what exactly is SARS-CoV-2? How transmissible the novel coronavirus is? How severely affected are patients infected with SARS-CoV-2? What are the risk factors for COVID-19? What are the differences between this novel coronavirus and other coronaviruses? To answer these questions, a comparative study of three pathogenic coronaviruses that primarily invade the human respiratory system and may cause death, namely, severe acute respiratory syndrome (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Middle East respiratory syndrome coronavirus (MERS-CoV). This review describes the source of origin, transmission, and pathogenicity of these viruses. Prevention of SARS-CoV-2 spreading entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The novel coronavirus spreads faster than its two predecessors - the SARS-CoV-1 and MERS-CoV - but has lower fatality rate. The global impact of this new pandemic is still uncertain, but it is a challenge to healthcare systems around the world.
MeSH term(s)	COVID-19 ; Humans ; Middle East Respiratory Syndrome Coronavirus ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-01-05
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
DOI	10.18388/pb.2020_357
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Article: Infections with hantavirus, with particular emphasis on the European population and their clinical picture against other hemorrhagic fevers

Stopnicka, Kamila Julia / De Walthoffen, Szymon Walter / Dzieciątkowski, Tomasz

Postepy biochemii

2021 Volume 66, Issue 4, Page(s) 379–384

Title translation	Zakażenia hantawirusami ze szczególnym uwzględnieniem populacji europejskiej i ich obraz kliniczny na tle innych gorączek krwotocznych.
MeSH term(s)	Fever ; Hantavirus ; Hantavirus Infections/diagnosis ; Hantavirus Infections/epidemiology ; Hemorrhagic Fevers, Viral ; Humans
Language	Polish
Publishing date	2021-01-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
DOI	10.18388/pb.2020_356
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Article ; Online: Self-testing with antigen tests as a method for reduction SARS-CoV-2.

Peacock, Frank W / Dzieciatkowski, Tomasz / Chirico, Francesco / Szarpak, Lukasz

The American journal of emergency medicine

2021 Volume 53, Page(s) 274–275

MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Testing/instrumentation ; COVID-19 Testing/standards ; COVID-19 Testing/statistics & numerical data ; Humans ; Immunoassay/instrumentation ; Immunoassay/standards ; Immunoassay/statistics & numerical data ; Mass Screening/methods ; Mass Screening/standards ; Mass Screening/statistics & numerical data ; Self-Testing ; Sensitivity and Specificity
Language	English
Publishing date	2021-05-06
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2021.05.010
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Article ; Online: Metagenomic search of viral coinfections in herpes simplex encephalitis patients.

Perlejewski, Karol / Radkowski, Marek / Rydzanicz, Małgorzata / Dzieciątkowski, Tomasz / Silling, Steffi / Wieczorek, Magdalena / Makowiecki, Michał / Horban, Andrzej / Laskus, Tomasz

Journal of neurovirology

2023 Volume 29, Issue 5, Page(s) 588–597

Abstract: Little is known about concomitant central nervous system (CNS) infections by more than one virus. Current diagnostics are based on molecular tests for particular pathogens making it difficult to identify multi-viral infections. In the present study, we ... ...

Abstract	Little is known about concomitant central nervous system (CNS) infections by more than one virus. Current diagnostics are based on molecular tests for particular pathogens making it difficult to identify multi-viral infections. In the present study, we applied DNA- and RNA-based next-generation sequencing metagenomics (mNGS) to detect viruses in cerebrospinal fluids from 20 patients with herpes simplex encephalitis. Coinfection was detected in one patient: sequences in cerebrospinal fluids matched enterovirus A (2.660 reads; 4% of recovered genome) and enterovirus B (1.571 reads; 13% of recovered genome). Subsequent PCR combined with serotyping allowed to identify human echovirus 6, a representative of enterovirus B. Several other mNGS hits (human pegivirus, Merkel cell polyomavirus, human papillomavirus type 5) were not considered to represent a genuine signal as they could not be confirmed by specific RT-PCR/PCR. HSV DNA, while being detectable by PCR in every patient, was detected by mNGS in only one. In conclusion, contaminations and false signals may complicate mNGS interpretation; however, the method can be useful in diagnostics of viral coinfections in CNS, particularly in the case of rare pathogens.
MeSH term(s)	Humans ; Coinfection ; Encephalitis, Herpes Simplex/diagnosis ; Virus Diseases ; Polymerase Chain Reaction/methods ; Enterovirus B, Human ; Central Nervous System Infections ; DNA ; High-Throughput Nucleotide Sequencing/methods
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283265-0
ISSN	1538-2443 ; 1355-0284
ISSN (online)	1538-2443
ISSN	1355-0284
DOI	10.1007/s13365-023-01157-9
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Zs.A 4426: Show issues

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Article: Upper Respiratory Tract Disease in a Dog Infected by a Highly Pathogenic Avian A/H5N1 Virus.

Szaluś-Jordanow, Olga / Golke, Anna / Dzieciątkowski, Tomasz / Czopowicz, Michał / Kardas, Michał / Mickiewicz, Marcin / Moroz-Fik, Agata / Łobaczewski, Andrzej / Markowska-Daniel, Iwona / Frymus, Tadeusz

Microorganisms

2024 Volume 12, Issue 4

Abstract: In summer 2023, during an outbreak of highly pathogenic avian influenza (HPAI) in cats in Poland, a 16-year-old dog was presented to the veterinary clinic with persistent, debilitating, dry cough, submandibular lymphadenomegaly, mild serous nasal ... ...

Abstract	In summer 2023, during an outbreak of highly pathogenic avian influenza (HPAI) in cats in Poland, a 16-year-old dog was presented to the veterinary clinic with persistent, debilitating, dry cough, submandibular lymphadenomegaly, mild serous nasal discharge, and left apical heart murmur. A preliminary diagnosis of kennel cough was made and the treatment with amoxicillin/clavulanic acid and dexamethasone was initiated. Due to the lack of improvement within 2 days, a blood check-up, thoracic radiography and ultrasonography, and echocardiography were performed. Moreover, a rapid test for orthomyxovirus type A antigen in a throat swab was carried out and proved positive. The result was verified using RT-qPCR, which yielded a positive result for A/H5N1 influenza virus and negative results for A/H1N1, A/H3N2, type B influenza, and SARS-CoV-2. This case indicates that HPAI should be considered as a differential diagnosis not only in cats, but also in dogs with upper respiratory tract disease, particularly in regions experiencing A/H5N1 avian influenza outbreaks.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12040689
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Article ; Online: Should emergency medical service stuff use respirators with filtered valve in COVID-19 pandemic?

Barycka, Katarzyna / Dzieciątkowski, Tomasz / Drozd, Anna / Szarpak, Łukasz / Jaguszewski, Miłosz J / Filipiak, Krzysztof J

Advances in respiratory medicine

2021 Volume 88, Issue 6, Page(s) 638–639

Abstract: Performing medical procedures with the use of personal protective equipment may reduce the efficiency of medical procedures performed, for example, as with the current use of respiratory protection devices, including N95 or surgical masks. Healthcare ... ...

Abstract	Performing medical procedures with the use of personal protective equipment may reduce the efficiency of medical procedures performed, for example, as with the current use of respiratory protection devices, including N95 or surgical masks. Healthcare workers (HCWs) using N95 respirators or medical masks may experience discomfort associated with wearing a mask when performing medical procedures, in particular those associated with increased physical activity, causing increased respiratory effort.
MeSH term(s)	COVID-19/prevention & control ; Emergency Medical Services ; Humans ; Infection Control/methods ; Masks/standards ; N95 Respirators/standards ; Occupational Exposure/prevention & control
Language	English
Publishing date	2021-01-13
Publishing country	Poland
Document type	Letter
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.5603/ARM.a2020.0167
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Article: Nanoparticles: a breakthrough in COVID-19 prevention, diagnosis and treatment.

Skwarek, Aleksandra / Gąsecka, Aleksandra / Jaguszewski, Miłosz J / Szarpak, Łukasz / Dzieciątkowski, Tomasz / Filipiak, Krzysztof J

Archives of medical science : AMS

2021 Volume 19, Issue 5, Page(s) 1410–1420

Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), declared a global pandemic by the World Health Organization (WHO). The three key principles in management of the COVID-19 ...

Abstract	Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), declared a global pandemic by the World Health Organization (WHO). The three key principles in management of the COVID-19 pandemic are prevention, early detection and targeted treatment. Vaccine-based prevention together with early detection has already proven its efficacy in controlling the pandemic. Early detection of infected patients could substantially accelerate the implementation of treatment, but also help to identify infection hotspots, whereas targeted treatment might destroy the virus and minimize damage to healthy tissue. Nanoparticles hold great promise with respect to these aspects. They may also be the solution to emerging clinical problems such as reinfection, pregnancy-related COVID-19 and coinfection. Here, we aim to discuss the potential applications of nanoparticles to combat the COVID-19 pandemic.
Language	English
Publishing date	2021-10-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/142103
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