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  1. Article: Isolation of phytoconstituents and evaluation of anticancer and Antioxidant potential of Launaea mucronata (Forssk.) Muschl. subsp.

    Elsharkawy, Eman R

    Pakistan journal of pharmaceutical sciences

    2017  Volume 30, Issue 2, Page(s) 399–405

    Abstract: Traditional Medicine is widely used in clinical research due to its low toxicity, low number of side effects, and low cost. Many components of common fruits and vegetables play well-documented roles as chemo preventive or chemotherapeutic agents that ... ...

    Abstract Traditional Medicine is widely used in clinical research due to its low toxicity, low number of side effects, and low cost. Many components of common fruits and vegetables play well-documented roles as chemo preventive or chemotherapeutic agents that suppress tumor genesis. The present study was aimed to identify the DPPH (2, 2-diphenyl-1-picrylhydrazyl) free-radical scavenging constituents from methanol extract of Launaea mucronata using bioassay-guided fractionation. The methanolic extract revealed a strong antioxidant activity, the IC50 values (the concentration with scavenging activity of 50%) was 25.94 mg/ml. The fractionation of the active methanol extract by silica gel column chromatography revealed compounds with strong antioxidant activity. The isolated bioactive compound was determined as, apigenin, quercetin, rutin, isorhamnetin-3-O-β-glucoside, quercetin-3-O-β-glucoside, apigenin-7-O- β-diglucoside, kaempferol-3-o-rutinoside), by comparing spectral data (UV, IR,
    MeSH term(s) Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Asteraceae/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Inhibitory Concentration 50 ; Neoplasms/pathology ; Phytochemicals/isolation & purification ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Antioxidants ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2017-06-22
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
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  2. Article: UPLC/ESI-MS Phytochemical Screening of

    Alhumaydhi, Fahad A / Aljohani, Abdullah S M / Elsharkawy, Eman R

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 4718854

    Abstract: Herbal plants represent a new source of hypoglycemic antidiabetic drugs; haematological and histopathological studies of methanol extract ... ...

    Abstract Herbal plants represent a new source of hypoglycemic antidiabetic drugs; haematological and histopathological studies of methanol extract of
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/4718854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  3. Article: Effect of habitat variations on the chemical composition, antioxidant, and antimicrobial activities of

    Elsharkawy, Eman R / Alghanem, Suliman M / Elmorsy, Ekramy

    Biotechnology reports (Amsterdam, Netherlands)

    2020  Volume 29, Page(s) e00581

    Abstract: ... Achilea ... ...

    Abstract Achilea fragmentisma
    Language English
    Publishing date 2020-12-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2801018-8
    ISSN 2215-017X
    ISSN 2215-017X
    DOI 10.1016/j.btre.2020.e00581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DFT calculations and POM analyses of cytotoxicity of some flavonoids from aerial parts of Cupressus sempervirens: Docking and identification of pharmacophore sites.

    Elsharkawy, Eman R / Almalki, Faisal / Ben Hadda, Taibi / Rastija, Vesna / Lafridi, Hind / Zgou, Hsaine

    Bioorganic chemistry

    2020  Volume 100, Page(s) 103850

    Abstract: Two known polyphenols named apigenin 7-O-β-d-glucopyranoside (S1) and querctine-3-O-glucoside (S2), along with another two new compounds apigenin 4'-geranyl-8-glucopyranosyl-7-O-α-glucopyranoside (S3) and apigenin 4'-pernyl-8-glucopyranosyl -7-O-α- ... ...

    Abstract Two known polyphenols named apigenin 7-O-β-d-glucopyranoside (S1) and querctine-3-O-glucoside (S2), along with another two new compounds apigenin 4'-geranyl-8-glucopyranosyl-7-O-α-glucopyranoside (S3) and apigenin 4'-pernyl-8-glucopyranosyl -7-O-α-glucopyranoside (S4), were isolated from the leaves of Cupressus sempervirens. Structure elucidation of the isolated polyphenols was established on the basis of detailed spectroscopic analysis like 1D and 2D NMR analyses including
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cupressus/chemistry ; Density Functional Theory ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Plant Leaves/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Flavonoids
    Language English
    Publishing date 2020-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.103850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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  5. Article ; Online: Trillium govanianum Wall. Ex. Royle rhizomes extract-medicated silver nanoparticles and their antimicrobial activity

    Uz-Zaman Khaleeq / Bakht Jehan / Malikovna Bates Kudaibergenova / Elsharkawy Eman R. / Khalil Anees Ahmed / Bawazeer Saud / Rauf Abdur

    Green Processing and Synthesis, Vol 9, Iss 1, Pp 503-

    2020  Volume 514

    Abstract: Synthesis of nanoparticles is a fast-growing area of interest in the current development in science and technology. Nanoparticles are also used in biomedical applications. Green synthesis of nanoparticles is an environmental friendly and cost-effective ... ...

    Abstract Synthesis of nanoparticles is a fast-growing area of interest in the current development in science and technology. Nanoparticles are also used in biomedical applications. Green synthesis of nanoparticles is an environmental friendly and cost-effective technique. Trillium govanianum Wall. Ex. Royle crude extract was used for the eco-friendly genesis of silver nanoparticles (AgNPs). Aromatic amines were the functional groups involved in the bio-fabrication and synthesis of the AgNPs. The production of AgNPs was established by the appearance of brown color. The manufactured AgNPs were characterized by UV-Vis spectrophotometer, X-ray diffractometer, and FTIR spectrophotometer. AgNPs were face-centered cubic in nature with an average size of 9.99 nm. The produced AgNPs (18 µL disc−1) showed substantial antibacterial (53.74, 52.75, 51.61, 43.00, 36.84, and 36.84%) and antifungal (54.05, 42.11, 41.10, 40.85, 30.55, and 29.73%) potential against the tested bacterial (X. campestris, P. aeruginosa, S. aureus, E. coli, B. subtilis, and K. pneumoniae) and fungal (A. alternaria, Paecilomyces, C. albicans, Curvularia, A. niger, and Rhizopus) strains, respectively.
    Keywords trillium govanianum ; agnps ; uv ; ft-ir ; x-ray diffractometer ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Determination of Volatile Compounds of

    Hamad Al-Mijalli, Samiah / ELsharkawy, Eman R / Abdallah, Emad M / Hamed, Munerah / El Omari, Nasreddine / Mahmud, Shafi / Alshahrani, Mohammed Merae / Mrabti, Hanae Naceiri / Bouyahya, Abdelhakim

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9306251

    Abstract: ... Mentha ... ...

    Abstract Mentha piperita
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9306251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  7. Article ; Online: Medicinal Applications of Cannabinoids Extracted from Cannabis sativa (L.): A New Route in the Fight Against COVID-19?

    Khalid, Shah / Almalki, Faisal A / Hadda, Taibi Ben / Bader, Ammar / Abu-Izneid, Tareq / Berredjem, Malika / Elsharkawy, Eman R / Alqahtani, Ali M

    Current pharmaceutical design

    2020  Volume 27, Issue 13, Page(s) 1564–1578

    Abstract: Cannabis sativa is a well-known plant that has been recognized for its benefits since ancient times by several medicinal systems, including those of China, India, Greece, and Egypt. Although C. sativa is one of the most investigated medicinal plants in ... ...

    Abstract Cannabis sativa is a well-known plant that has been recognized for its benefits since ancient times by several medicinal systems, including those of China, India, Greece, and Egypt. Although C. sativa is one of the most investigated medicinal plants in the world, it faces some of the greatest controversies surrounding its legalization and use as a medication. C. sativa contains several hundred phytoconstituents, including the infamous "cannabinoids". It is necessary to properly understand the medicinal importance of these phytochemicals and spread awareness among the countries where cannabis is still facing legal obstacles. The current review focuses on the most recent literature pertaining to various applications of cannabinoids, with a special focus on the medicinal aspect of these phytochemicals. Peer-reviewed articles focusing on the importance of cannabis and cannabinoids are the target of this review. Articles were selected based on the relevance to the general scope of the work, i.e., application of cannabinoids. Cannabinoids can truly be regarded as wonder drugs, considering their immense diversity of usage. Unfortunately, however, many of the mares have never been researched biologically or pharmacologically due to their low yield in the plant. However, the approval of some cannabinoids by the FDA (along with other recognized national medical health systems) has opened the horizon for the use of these natural drugs in medicines such as Epidiolex® (cannabidiol, used for the treatment of severe forms of epilepsy) and Sativex®(Δ
    MeSH term(s) Animals ; COVID-19 ; Cannabidiol ; Cannabinoids ; Cannabis ; China ; Dronabinol ; Female ; Greece ; Horses ; Humans ; SARS-CoV-2
    Chemical Substances Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-12-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666201202125807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
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