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  1. Article ; Online: Tracking and tracing the tobacco industry: potential tobacco industry influence over the EU's system for tobacco traceability and security features.

    Gallagher, Allen William Andrew / Gilmore, Anna B / Eads, Michael

    Tobacco control

    2019  Volume 29, Issue e1, Page(s) e56–e62

    Abstract: Background: Subsequent to the transnational tobacco companies' (TTC) history of involvement in tobacco smuggling, the Illicit Trade Protocol (ITP) requires that tobacco tracking and tracing (T&T) systems be established independent of the industry. In ... ...

    Abstract Background: Subsequent to the transnational tobacco companies' (TTC) history of involvement in tobacco smuggling, the Illicit Trade Protocol (ITP) requires that tobacco tracking and tracing (T&T) systems be established independent of the industry. In response, TTCs developed a T&T system, originally called Codentify, promoting it via an elaborate set of front groups to create a false impression of independence. The European Union (EU) is one of the first and largest jurisdictions to operationalise T&T. We explore how industry efforts to influence T&T have evolved.
    Methods: Analysis of tobacco industry documents, policy documents, submissions to a relevant consultation and relationships between the tobacco industry and organisations proposed by it and approved by the European Commission to provide a data repository function within the EU's T&T system.
    Findings: 17 months after TTCs sold Codentify to Inexto and Philip Morris International claimed Inexto was independent, leaked documents suggest TTCs and Inexto continued to have a financial and operational relationship. Inexto's meetings with TTCs, engagement with EU Member States and promotion of industry-favoured technical standards suggest TTCs influenced Inexto's activities, using the company to undermine EU T&T. The EU's T&T system appears to be inconsistent with the ITP due to its 'mixed' governance and seven of eight organisations approved as data repository providers having pre-existing industry business links.
    Conclusions: TTC's efforts to maximise their control and minimise external scrutiny of T&T systems seriously limit attempts to address tobacco smuggling. Countries implementing T&T should be alert to such efforts and should not replicate the EU system.
    MeSH term(s) Commerce ; European Union ; Humans ; Nicotiana ; Tobacco Industry ; Tobacco Products
    Language English
    Publishing date 2019-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tobaccocontrol-2019-055094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Virtual office visits: a reachable and reimbursable innovation.

    Eads, Michelle

    Family practice management

    2007  Volume 14, Issue 9, Page(s) 20–22

    MeSH term(s) Communication ; Family Practice/economics ; Family Practice/organization & administration ; Humans ; Insurance, Physician Services ; Physician-Patient Relations ; Practice Management, Medical/economics ; Practice Management, Medical/organization & administration ; Remote Consultation/economics ; User-Computer Interface
    Language English
    Publishing date 2007-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226804-5
    ISSN 1069-5648
    ISSN 1069-5648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Why governments cannot afford Codentify to support their track and trace solutions.

    Ross, Hana / Eads, Michael / Yates, Michael

    Tobacco control

    2018  Volume 27, Issue 6, Page(s) 706–708

    Abstract: Background: In anticipation of the Protocol to Eliminate Illicit Trade in Tobacco Products (ITP) entering into force in 2018, there is a growing demand for information on track and trace (T&T) solutions for tobacco products. This article contrasts the ... ...

    Abstract Background: In anticipation of the Protocol to Eliminate Illicit Trade in Tobacco Products (ITP) entering into force in 2018, there is a growing demand for information on track and trace (T&T) solutions for tobacco products. This article contrasts the efficacy of Codentify from the perspective of authentication with that of material-based multilayered security technologies.
    Method: To calculate the probability of detecting one fraudulent pack under Codentify, we relied on a modified Bernoulli trial experiment with independent repeated sampling without replenishment. The probability is calculated using a multinomial distribution formula adjusted for the fact that both legitimate and non-legitimate packs may be sold in the market.
    Results: In a relatively small market, a law enforcement authority would have to inspect over 27 000 (almost 31 000) packs per week to have a 90% (95%) certainty that it did not miss a fraudulent pack under the Codentify system. A material based T&T solution would require only 45 (59) pack inspections a week to have the same level of confidence.
    Conclusions: This study demonstrates the inefficiency of Codentify compared to other solutions that incorporate material-based security features. Signatories to the ITP should reject Codentify due to both its low efficacy and its clear violation of the ITP's requirement that T&T shall not be performed by or delegated to the tobacco industry or its front groups.
    MeSH term(s) Humans ; Law Enforcement ; Security Measures/statistics & numerical data ; Tobacco Industry/methods ; Tobacco Products/legislation & jurisprudence
    Language English
    Publishing date 2018-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tobaccocontrol-2017-053970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quadriceps Strength and Kinesiophobia Predict Long-Term Function After ACL Reconstruction: A Cross-Sectional Pilot Study.

    Van Wyngaarden, Joshua J / Jacobs, Cale / Thompson, Katherine / Eads, Molly / Johnson, Darren / Ireland, Mary Lloyd / Noehren, Brian

    Sports health

    2020  Volume 13, Issue 3, Page(s) 251–257

    Abstract: Background: Many patients live with long-term deficits in knee function after an anterior cruciate ligament reconstruction (ACLR). However, research is inconclusive as to which physical performance measure is most strongly related to long-term patient- ... ...

    Abstract Background: Many patients live with long-term deficits in knee function after an anterior cruciate ligament reconstruction (ACLR). However, research is inconclusive as to which physical performance measure is most strongly related to long-term patient-reported outcomes after ACLR.
    Hypothesis: Quadriceps strength would be most strongly associated with patient-reported long-term outcomes after ACLR.
    Study design: Cross-sectional study.
    Level of evidence: Level 3.
    Methods: A total of 40 patients (29 female) consented and participated an average of 10.9 years post-ACLR (range, 5-20 years). Patients completed the Lower Extremity Functional Scale (LEFS), the International Knee Documentation Committee (IKDC) Scale, Knee injury and Osteoarthritis Outcome Score Quality of Life (KOOS QoL) and Sport (KOOS Sport) subscales, and the Tampa Scale of Kinesiophobia (TSK-17). Each patient subsequently performed maximal isometric quadriceps contraction, a 60-second single-leg step-down test, and the single-leg single hop and triple hop for distance tests. Multivariate linear and logistic regression models determined how performance testing was associated with each patient-reported outcome when controlling for time since surgery, age, and TSK-17.
    Results: When controlling for time since surgery, age at the time of consent, and TSK-17 score, maximal isometric quadriceps strength normalized to body weight was the sole physical performance measure associated with IKDC (
    Conclusion: Isometric quadriceps strength and kinesiophobia are significantly associated with long-term patient-reported outcomes after ACLR.
    Clinical relevance: These results suggest that training to improve quadriceps strength and addressing kinesiophobia in the late stages of recovery from ACLR may improve long-term self-reported function.
    MeSH term(s) Adult ; Age Factors ; Anterior Cruciate Ligament Injuries/physiopathology ; Anterior Cruciate Ligament Injuries/psychology ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/rehabilitation ; Body Weight ; Cross-Sectional Studies ; Exercise Test ; Fear ; Female ; Follow-Up Studies ; Humans ; Male ; Muscle Strength ; Patient Reported Outcome Measures ; Pilot Projects ; Quadriceps Muscle/physiopathology ; Self Report ; Time Factors
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2508802-6
    ISSN 1941-0921 ; 1941-7381
    ISSN (online) 1941-0921
    ISSN 1941-7381
    DOI 10.1177/1941738120946323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Synergistic interactions of endogenous opioids and cannabinoid systems.

    Welch, S P / Eads, M

    Brain research

    1999  Volume 848, Issue 1-2, Page(s) 183–190

    Abstract: Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The ... ...

    Abstract Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The endocannabinoid, anandamide (AEA), fails to release dynorphin A. The synthetic cannabinoid, CP55,940, releases dynorphin B. Neither AEA nor CP55,940 enhances morphine analgesia. The CB1 antagonist, SR141716A, differentially blocks Delta(9)-THC versus AEA. Tolerance to Delta(9)-THC, but not AEA, involves a decrease in the release of dynorphin A. Our preclinical studies indicate that Delta(9)-THC and morphine can be useful in low dose combination as an analgesic. Such is not observed with AEA or CP55,940. We hypothesize the existence of a new CB receptor differentially linked to endogenous opioid systems based upon data showing the stereoselectivity of endogenous opioid release. Such a receptor, due to the release of endogenous opioids, may have significant impact upon the clinical development of cannabinoid/opioid combinations for the treatment of a variety of types of pain in humans.
    MeSH term(s) Animals ; Cannabinoid Receptor Modulators ; Cannabinoids/metabolism ; Cannabinoids/pharmacology ; Male ; Opioid Peptides/drug effects ; Opioid Peptides/metabolism ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Cannabinoid Receptor Modulators ; Cannabinoids ; Opioid Peptides
    Language English
    Publishing date 1999-11-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/s0006-8993(99)01908-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Global pathways to men's caregiving: mixed methods findings from the International Men and Gender Equality Survey and the Men Who Care study.

    Kato-Wallace, Jane / Barker, Gary / Eads, Marci / Levtov, Ruti

    Global public health

    2014  Volume 9, Issue 6, Page(s) 706–722

    Abstract: Promoting men's participation in unpaid care work is part of the Programme of Action for the International Conference on Population and Development. However, men's involvement in care work does not mirror the advances women have made in paid work outside ...

    Abstract Promoting men's participation in unpaid care work is part of the Programme of Action for the International Conference on Population and Development. However, men's involvement in care work does not mirror the advances women have made in paid work outside the home. This mixed method study explores which men are more involved in caregiving, and what childhood and adulthood factors influence their level of involvement. Quantitative research presents findings from 1169 men across six countries with children aged 0-4, and a qualitative study presents findings from in-depth interviews with 83 men engaged in atypical caregiving practices. Survey research finds that being taught to care for children, witnessing one's father take care of one's siblings, respondents' present attitudes about gender equality and having outside help (or none, in some cases) were all also associated with men's higher level of involvement. Qualitative research reveals that men's experiences of violence, the normalisation of domestic work as children and life circumstances rather than greater-than-average beliefs in gender equality all propelled them into care work. Findings suggest that engaging more men into care work implies changes to policies and structural realities in the workplace coupled with changing gender attitudes. These insights inform policy and practice aimed at promoting greater involvement in care work by men.
    MeSH term(s) Adolescent ; Adult ; Attitude ; Caregivers ; Child, Preschool ; Father-Child Relations ; Humans ; Infant ; Infant, Newborn ; Internationality ; Male ; Masculinity ; Middle Aged ; Qualitative Research ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1692
    ISSN (online) 1744-1706
    ISSN 1744-1692
    DOI 10.1080/17441692.2014.921829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide.

    Houser, S J / Eads, M / Embrey, J P / Welch, S P

    Brain research

    2000  Volume 857, Issue 1-2, Page(s) 337–342

    Abstract: The endogenous opioid dynorphin B was evaluated for its role in cannabinoid-induced antinociception. Previous work in our laboratory has shown that the synthetic, bicyclic cannabinoid, CP55,940, induces the release of dynorphin B whilst the naturally ... ...

    Abstract The endogenous opioid dynorphin B was evaluated for its role in cannabinoid-induced antinociception. Previous work in our laboratory has shown that the synthetic, bicyclic cannabinoid, CP55,940, induces the release of dynorphin B whilst the naturally occurring cannabinoid, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), releases dynorphin A. The dynorphins contribute in part to the antinociceptive effects of both cannabinoids at the level of the spinal cord. The present study compares dynorphin B released from perfused rat spinal cord in response to acute administration of anandamide (AEA), Delta(9)-THC and CP55,940 at two time points, 10 min and 30 min post administration, and attempts to correlate such release with antinociceptive effects of the drugs. Dynorphin B was collected from spinal perfusates of rats pretreated with Delta(9)-THC, CP55,940 or AEA. The supernatant was lyophilized and the concentrations of dynorphin B were measured via radioimmunoassay. At a peak time of antinociception (10 min), CP55,940 and Delta(9)-THC induced significant two-fold increases in the release of dynorphin B. AEA did not significantly release dynorphin B. Upon a 30-min pretreatment with the drugs, no significant dynorphin B release was observed, although antinociceptive effects persisted for CP55,940 and Delta(9)-THC. Previous work indicates that Delta(9)-THC releases dynorphin A while AEA releases no dynorphin A. This study confirms that although all three test drugs produced significant antinociception at 10 min, the endocannabinoid, AEA, does not induce antinociception via dynorphin release. Thus, our data indicate a distinct mechanism which underlies AEA-induced antinociception.
    MeSH term(s) Analgesia ; Analgesics/pharmacology ; Analgesics, Non-Narcotic/pharmacology ; Animals ; Arachidonic Acids/pharmacology ; Calcium Channel Blockers/pharmacology ; Cannabinoid Receptor Modulators ; Cannabinoids/pharmacology ; Cyclohexanols/pharmacology ; Dronabinol/pharmacology ; Dynorphins/analysis ; Dynorphins/drug effects ; Endocannabinoids ; Endorphins/analysis ; Endorphins/drug effects ; Male ; Pain/drug therapy ; Pain/physiopathology ; Polyunsaturated Alkamides ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/cytology ; Spinal Cord/drug effects ; Spinal Cord/metabolism
    Chemical Substances Analgesics ; Analgesics, Non-Narcotic ; Arachidonic Acids ; Calcium Channel Blockers ; Cannabinoid Receptor Modulators ; Cannabinoids ; Cyclohexanols ; Endocannabinoids ; Endorphins ; Polyunsaturated Alkamides ; Dynorphins (74913-18-1) ; Dronabinol (7J8897W37S) ; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol (83003-12-7) ; rimorphin (83335-41-5) ; anandamide (UR5G69TJKH)
    Language English
    Publishing date 2000-02-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/s0006-8993(00)01981-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm.

    Aguillard, D P / Albahri, T / Allspach, D / Anisenkov, A / Badgley, K / Baeßler, S / Bailey, I / Bailey, L / Baranov, V A / Barlas-Yucel, E / Barrett, T / Barzi, E / Bedeschi, F / Berz, M / Bhattacharya, M / Binney, H P / Bloom, P / Bono, J / Bottalico, E /
    Bowcock, T / Braun, S / Bressler, M / Cantatore, G / Carey, R M / Casey, B C K / Cauz, D / Chakraborty, R / Chapelain, A / Chappa, S / Charity, S / Chen, C / Cheng, M / Chislett, R / Chu, Z / Chupp, T E / Claessens, C / Convery, M E / Corrodi, S / Cotrozzi, L / Crnkovic, J D / Dabagov, S / Debevec, P T / Di Falco, S / Di Sciascio, G / Drendel, B / Driutti, A / Duginov, V N / Eads, M / Edmonds, A / Esquivel, J / Farooq, M / Fatemi, R / Ferrari, C / Fertl, M / Fienberg, A T / Fioretti, A / Flay, D / Foster, S B / Friedsam, H / Froemming, N S / Gabbanini, C / Gaines, I / Galati, M D / Ganguly, S / Garcia, A / George, J / Gibbons, L K / Gioiosa, A / Giovanetti, K L / Girotti, P / Gohn, W / Goodenough, L / Gorringe, T / Grange, J / Grant, S / Gray, F / Haciomeroglu, S / Halewood-Leagas, T / Hampai, D / Han, F / Hempstead, J / Hertzog, D W / Hesketh, G / Hess, E / Hibbert, A / Hodge, Z / Hong, K W / Hong, R / Hu, T / Hu, Y / Iacovacci, M / Incagli, M / Kammel, P / Kargiantoulakis, M / Karuza, M / Kaspar, J / Kawall, D / Kelton, L / Keshavarzi, A / Kessler, D S / Khaw, K S / Khechadoorian, Z / Khomutov, N V / Kiburg, B / Kiburg, M / Kim, O / Kinnaird, N / Kraegeloh, E / Krylov, V A / Kuchinskiy, N A / Labe, K R / LaBounty, J / Lancaster, M / Lee, S / Li, B / Li, D / Li, L / Logashenko, I / Lorente Campos, A / Lu, Z / Lucà, A / Lukicov, G / Lusiani, A / Lyon, A L / MacCoy, B / Madrak, R / Makino, K / Mastroianni, S / Miller, J P / Miozzi, S / Mitra, B / Morgan, J P / Morse, W M / Mott, J / Nath, A / Ng, J K / Nguyen, H / Oksuzian, Y / Omarov, Z / Osofsky, R / Park, S / Pauletta, G / Piacentino, G M / Pilato, R N / Pitts, K T / Plaster, B / Počanić, D / Pohlman, N / Polly, C C / Price, J / Quinn, B / Qureshi, M U H / Ramachandran, S / Ramberg, E / Reimann, R / Roberts, B L / Rubin, D L / Santi, L / Schlesier, C / Schreckenberger, A / Semertzidis, Y K / Shemyakin, D / Sorbara, M / Stöckinger, D / Stapleton, J / Still, D / Stoughton, C / Stratakis, D / Swanson, H E / Sweetmore, G / Sweigart, D A / Syphers, M J / Tarazona, D A / Teubner, T / Tewsley-Booth, A E / Tishchenko, V / Tran, N H / Turner, W / Valetov, E / Vasilkova, D / Venanzoni, G / Volnykh, V P / Walton, T / Weisskopf, A / Welty-Rieger, L / Winter, P / Wu, Y / Yu, B / Yucel, M / Zeng, Y / Zhang, C

    Physical review letters

    2023  Volume 131, Issue 16, Page(s) 161802

    Abstract: We present a new measurement of the positive muon magnetic anomaly, a_{μ}≡(g_{μ}-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our ... ...

    Abstract We present a new measurement of the positive muon magnetic anomaly, a_{μ}≡(g_{μ}-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, ω[over ˜]_{p}^{'}, and of the anomalous precession frequency corrected for beam dynamics effects, ω_{a}. From the ratio ω_{a}/ω[over ˜]_{p}^{'}, together with precisely determined external parameters, we determine a_{μ}=116 592 057(25)×10^{-11} (0.21 ppm). Combining this result with our previous result from the 2018 data, we obtain a_{μ}(FNAL)=116 592 055(24)×10^{-11} (0.20 ppm). The new experimental world average is a_{μ}(exp)=116 592 059(22)×10^{-11} (0.19 ppm), which represents a factor of 2 improvement in precision.
    Language English
    Publishing date 2023-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.161802
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  9. Article: Microbial growth patterns in a total parenteral nutrition formulation containing lipid emulsion.

    Gilbert, M / Gallagher, S C / Eads, M / Elmore, M F

    JPEN. Journal of parenteral and enteral nutrition

    1986  Volume 10, Issue 5, Page(s) 494–497

    Abstract: Microbial growth of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans was evaluated in a standard amino acid-dextrose-based total parenteral nutrition (TPN) solution, 10% lipid emulsion, and a combined TPN formulation ... ...

    Abstract Microbial growth of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans was evaluated in a standard amino acid-dextrose-based total parenteral nutrition (TPN) solution, 10% lipid emulsion, and a combined TPN formulation containing amino acids, dextrose, and lipid emulsion. At an initial inoculum of 10(4) CFU/ml, all three bacterial organisms grew well in 10% lipid emulsion, died in the standard solution and grew only minimally or died in the combined formulation. C. albicans grew in all three formulations at an initial inoculum of 10(4) CFU/ml; however, at an initial inoculum of 10(2) CFU/ml, which approximates touch contamination, growth of Candida in the standard and combined formulations was less than 1 log at 24 hr in contrast to the 10% lipid emulsion which showed significant growth greater than 2 log at 24 hr. It is concluded that a 24-hr infusion time is safe for the combined TPN formulation used in this study. This should result in significant cost savings compared to the previously recommended 12-hr infusion time.
    MeSH term(s) Bacteria/growth & development ; Candida albicans/growth & development ; Escherichia coli/growth & development ; Fat Emulsions, Intravenous ; Humans ; Hydrogen-Ion Concentration ; Parenteral Nutrition, Total ; Staphylococcus aureus/growth & development
    Chemical Substances Fat Emulsions, Intravenous
    Language English
    Publishing date 1986-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1177/0148607186010005494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Umbilical blood waveforms in fetal surveillance of twins.

    Saldana, L R / Eads, M C / Schaefer, T R

    American journal of obstetrics and gynecology

    1987  Volume 157, Issue 3, Page(s) 712–715

    Abstract: Umbilical arterial velocity waveforms were recorded in 69 pairs of twins by means of continuous-wave Doppler analysis and an Angioscan spectrum analyzer. A systolic/diastolic ratio was measured for each twin. The sum of the systolic/diastolic ratio was ... ...

    Abstract Umbilical arterial velocity waveforms were recorded in 69 pairs of twins by means of continuous-wave Doppler analysis and an Angioscan spectrum analyzer. A systolic/diastolic ratio was measured for each twin. The sum of the systolic/diastolic ratio was calculated and the difference between each twin was expressed as the delta systolic/diastolic ratio. Significant differences in delta systolic/diastolic and neonatal weight were previously set at 0.4 and 350 gm, respectively. Sonography was used for fetal age confirmation and diagnosis of fetal growth retardation. All neonates were weighed; at birth gestational age was assigned by Dubowitz criteria and categorized as adequate-, small-, or large-for-gestational age. The sensitivity, specificity, and predictive value of the delta systolic/diastolic ratio were determined. The perinatal implications of this test in the management of twin pregnancy are discussed.
    MeSH term(s) Blood Flow Velocity ; Embryonic and Fetal Development ; Female ; Fetal Blood/physiology ; Fetal Monitoring ; Gestational Age ; Humans ; Pregnancy ; Pregnancy, Multiple ; Rheology ; Twins
    Language English
    Publishing date 1987-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/s0002-9378(87)80035-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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