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  1. Article: Editorial: Gilles de la Tourette Syndrome: Cross-Cultural Perspectives With a Focus on the Asia-Pacific Region.

    Eapen, Valsamma

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 678089

    Language English
    Publishing date 2021-04-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.678089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Autism : A Neurodevelopmental Journey from Genes to Behaviour

    Eapen, Valsamma

    2011  

    Keywords Neurosciences
    Size 1 electronic resource (500 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021045729
    ISBN 9789535164487 ; 9535164481
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: New insights into the link between childhood adversity and epigenetic changes.

    Lin, Ping-I / Eapen, Valsamma

    The Lancet. Child & adolescent health

    2023  Volume 7, Issue 8, Page(s) 520–521

    MeSH term(s) Humans ; Adverse Childhood Experiences ; Stress, Psychological ; Epigenesis, Genetic
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(23)00106-2
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  4. Article: Editorial: Equity, diversity and inclusion in child and adolescent mental health - equality of opportunities should be every child's right and every society's obligation.

    Ani, Cornelius / Ola, Bolanle / Hodes, Matthew / Eapen, Valsamma

    Child and adolescent mental health

    2024  Volume 29, Issue 2, Page(s) 123–125

    Abstract: Socio-ecological factors are major determinants of poor mental health across the life span. These factors can lead to health inequalities, which refer to differences in the health of individuals or groups (Kirkbride et al., 2024). Health inequity "is a ... ...

    Abstract Socio-ecological factors are major determinants of poor mental health across the life span. These factors can lead to health inequalities, which refer to differences in the health of individuals or groups (Kirkbride et al., 2024). Health inequity "is a specific type of health inequality that denotes an unjust, avoidable, systematic and unnecessary difference in health" (Arcaya, Arcaya, & Subramanian, 2015). Among several intersecting social adversities, inequity is one of the most pervasive contributors to poor mental health across all regions (Venkatapuram & Marmot, 2023). Structural inequity creates institutional power structures that marginalise large sections of the population and concentrate resources in the hands of a small minority (Shim, Kho, & Murray-García, 2018). The world is now more prosperous than it has ever been, yet the world is witnessing more within country inequality with the vast majority of the world's resources in the hands of a small minority of individuals or regions (United Nations, 2020).
    MeSH term(s) Child ; Humans ; Adolescent ; Mental Health ; Health Status Disparities ; Diversity, Equity, Inclusion ; Adolescent Health ; Health Inequities
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2073663-0
    ISSN 1475-3588 ; 1475-357X
    ISSN (online) 1475-3588
    ISSN 1475-357X
    DOI 10.1111/camh.12698
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  5. Article ; Online: The relationship between mental health reforms and general population suicide rates in Australia over the past three and a half decades: 1987-2021.

    Wang, Samantha Sijing / Eapen, Valsamma / Lin, Ping-I

    Psychiatry research

    2024  Volume 335, Page(s) 115884

    Abstract: Nearly 3,000 Australians tragically end their lives by suicide each year, underscoring a major national public health challenge with substantial socio-economic ramifications. Australia's National Mental Health Plans (NMHPs) aim to improve mental health ... ...

    Abstract Nearly 3,000 Australians tragically end their lives by suicide each year, underscoring a major national public health challenge with substantial socio-economic ramifications. Australia's National Mental Health Plans (NMHPs) aim to improve mental health and reduce suicide rates. This study investigates their effectiveness by analyzing how age-standardized suicide rates across Australian jurisdictions have fluctuated alongside the implementation of five NMHPs from 1987 to 2021. Findings reveal mixed impacts, with some plans linked to decreases and others associated with increases in suicide rates across different periods and regions. Notably, the recent decline in 2020 requires careful consideration amidst COVID-19 pandemic influences. These insights not only provide valuable evidence for shaping future mental health policies and initiatives but also for future health services research.
    MeSH term(s) Humans ; Mental Health ; Australia/epidemiology ; Health Care Reform ; Pandemics ; Suicide ; Australasian People
    Language English
    Publishing date 2024-03-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115884
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Assessing tics in children.

    Eapen, Valsamma / Usherwood, Tim

    BMJ (Clinical research ed.)

    2022  Volume 376, Page(s) e069346

    MeSH term(s) Child ; Diagnosis, Differential ; Female ; Humans ; Male ; Tic Disorders/diagnosis ; Tics/diagnosis ; Tourette Syndrome/diagnosis
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2021-069346
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  7. Article ; Online: Combined Effect of Maternal Separation and Early-Life Immune Activation on Brain and Behaviour of Rat Offspring.

    Biswas, Bharti / Eapen, Valsamma / Morris, Margaret J / Jones, Nicole M

    Biomolecules

    2024  Volume 14, Issue 2

    Abstract: Adversity during early life, a critical period for brain development, increases vulnerability and can have a lasting impact on the brain and behaviour of a child. However, the long-term effects of cumulative early-life stressors on brain and behaviour ... ...

    Abstract Adversity during early life, a critical period for brain development, increases vulnerability and can have a lasting impact on the brain and behaviour of a child. However, the long-term effects of cumulative early-life stressors on brain and behaviour are not well known. We studied a 2-hit rat model of early-life adversity using maternal separation (MS) and immune activation (lipopolysaccharide (LPS)). Rat pups underwent MS for 15 (control) or 180 (MS) minutes per day from postnatal day (P)2-14 and were administered saline or LPS (intraperitoneal) on P3. Open-field (OFT) and object-place recognition tests were performed on rat offspring at P33-35 and P42-50, respectively. The pre-frontal cortex (PFC) and hippocampus were removed at the experimental endpoint (P52-55) for mRNA expression. MS induced anxiety-like behaviour in OFT in male and reduced locomotor activity in both male and female offspring. LPS induced a subtle decline in memory in the object-place recognition test in male offspring. MS increased glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor expression in PFC and ionised calcium-binding adapter molecule-1 expression in male hippocampus. MS and LPS resulted in distinct behavioural phenotypes in a sex-specific manner. The combination of MS and LPS had a synergistic effect on the anxiety-like behaviour, locomotor activity, and
    MeSH term(s) Humans ; Child ; Rats ; Animals ; Male ; Female ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Maternal Deprivation ; Brain/metabolism ; Hippocampus/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Lipopolysaccharides ; RNA, Messenger
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14020197
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  8. Article ; Online: Using visual attention estimation on videos for automated prediction of autism spectrum disorder and symptom severity in preschool children.

    de Belen, Ryan Anthony J / Eapen, Valsamma / Bednarz, Tomasz / Sowmya, Arcot

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0282818

    Abstract: Atypical visual attention in individuals with autism spectrum disorders (ASD) has been utilised as a unique diagnosis criterion in previous research. This paper presents a novel approach to the automatic and quantitative screening of ASD as well as ... ...

    Abstract Atypical visual attention in individuals with autism spectrum disorders (ASD) has been utilised as a unique diagnosis criterion in previous research. This paper presents a novel approach to the automatic and quantitative screening of ASD as well as symptom severity prediction in preschool children. We develop a novel computational pipeline that extracts learned features from a dynamic visual stimulus to classify ASD children and predict the level of ASD-related symptoms. Experimental results demonstrate promising performance that is superior to using handcrafted features and machine learning algorithms, in terms of evaluation metrics used in diagnostic tests. Using a leave-one-out cross-validation approach, we obtained an accuracy of 94.59%, a sensitivity of 100%, a specificity of 76.47% and an area under the receiver operating characteristic curve (AUC) of 96% for ASD classification. In addition, we obtained an accuracy of 94.74%, a sensitivity of 87.50%, a specificity of 100% and an AUC of 99% for ASD symptom severity prediction.
    MeSH term(s) Humans ; Child, Preschool ; Autism Spectrum Disorder/diagnosis ; ROC Curve ; Machine Learning ; Videotape Recording ; Algorithms
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282818
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  9. Article: Integrated cognitive behavioral intervention for functional tics (I-CBiT): case reports and treatment formulation.

    Maxwell, Amanda / Zouki, Jade-Jocelyne / Eapen, Valsamma

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1265123

    Abstract: Introduction: The onset of the COVID-19 pandemic saw a global surge in functional tic-like behaviors (FTLBs). FTLBs are unique from primary tic disorders. They are thought to manifest through a complex interplay between environmental and personal ... ...

    Abstract Introduction: The onset of the COVID-19 pandemic saw a global surge in functional tic-like behaviors (FTLBs). FTLBs are unique from primary tic disorders. They are thought to manifest through a complex interplay between environmental and personal factors, including the stress-arousal system, and are characterized by their sudden and explosive onset. Accordingly, common interventions for tic disorders show limited efficacy in this population. We present an Integrated Cognitive Behavioral Intervention for Functional Tics (I-CBiT) that uses an urge acceptance model to manage tics and related stress and anxiety.
    Methods: We describe the treatment outcomes of eight young people presenting with new and sudden onset FTLBs who underwent I-CBiT, which integrates traditional behavioral tic interventions with third-wave cognitive behavioral therapies. All cases completed the three-phase intervention involving core components of psychoeducation, exposure and response prevention with urge acceptance, sensory grounding strategies, and cognitive behavioral intervention targeting the stress-arousal system. Tic severity and impairment were assessed prior to treatment and at completion.
    Results: All cases showed a significant reduction in tic severity post I-CBiT and an improvement in overall daily living function. These cases highlight the role of urge acceptance in managing both tic urges and the underlying stress-arousal system to bring about long-term change.
    Conclusion: We demonstrated the efficacy of I-CBiT for managing FTLBs. Our findings illustrate the importance of treating underlying stress and anxiety in this population and, therefore, a need for greater interaction between multidisciplinary services in managing FTLBs to comprehensively cover the varied symptom presentations linked to thoughts, emotions, bodily sensations, and stress responses.
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1265123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Implementing a National Navigation Service for Perinatal and Infant Mental Health: Early Learnings from the ForWhen Model.

    Harris, Sophia A / Eapen, Valsamma / Kohlhoff, Jane

    Community mental health journal

    2023  Volume 60, Issue 3, Page(s) 581–588

    Abstract: ForWhen is an Australia-based national navigation service aimed at helping parents and carers navigate the perinatal mental health service landscape and connect them with appropriate support and clinical services. The current study forms part of a mixed- ... ...

    Abstract ForWhen is an Australia-based national navigation service aimed at helping parents and carers navigate the perinatal mental health service landscape and connect them with appropriate support and clinical services. The current study forms part of a mixed-methods evaluation of the ForWhen program. Semi-structured interviews were conducted with ForWhen navigators during the early design and implementation phases of the service. Results were used to characterise the ForWhen navigator activities and responsibilities, identify navigator core competencies, and examine facilitators and barriers to successful implementation of a large-scale navigation program for perinatal and infant mental health. Further research will be crucial for evidencing the utility and potential of navigation models in addressing identified issues with access to treatment for perinatal and infant mental health issues.
    MeSH term(s) Female ; Pregnancy ; Infant ; Humans ; Mental Health ; Delivery of Health Care ; Mental Health Services ; Australia ; Parents ; Patient Navigation/methods
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215855-3
    ISSN 1573-2789 ; 0010-3853
    ISSN (online) 1573-2789
    ISSN 0010-3853
    DOI 10.1007/s10597-023-01211-0
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