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  1. Article ; Online: The role of catheter ablation in the management of atrial fibrillation.

    Ang, Richard / Earley, Mark J

    Clinical medicine (London, England)

    2016  Volume 16, Issue 3, Page(s) 267–271

    Abstract: Atrial fibrillation is driven by spontaneous electrical activation emerging from the pulmonary veins. Catheter ablation using either radiofrequency or cryothermal energy electrically isolates these veins from the left atrium, both reducing the burden of ... ...

    Abstract Atrial fibrillation is driven by spontaneous electrical activation emerging from the pulmonary veins. Catheter ablation using either radiofrequency or cryothermal energy electrically isolates these veins from the left atrium, both reducing the burden of atrial fibrillation episodes and improving the patient's symptoms. Catheter ablation is superior to antiarryhthmic drugs when patients are carefully selected. Underlying medical problems - including obesity, hypertension and obstructive sleep apnoea - should be optimally treated before considering ablation. Although this treatment has the potential to cure patients of their symptoms, they should be aware of the important associated procedural complications.
    MeSH term(s) Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Humans ; Postoperative Complications
    Language English
    Publishing date 2016-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.16-3-267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Remote Clinics and Investigations in Arrhythmia Services: What Have We Learnt During Coronavirus Disease 2019?

    Honarbakhsh, Shohreh / Sporton, Simon / Monkhouse, Christopher / Lowe, Martin / Earley, Mark J / Hunter, Ross J

    Arrhythmia & electrophysiology review

    2021  Volume 10, Issue 2, Page(s) 120–124

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has had a dramatic impact on the way that medical care is delivered. To minimise hospital attendance by both patients and staff, remote clinics, meetings and investigations have been used. Technologies ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has had a dramatic impact on the way that medical care is delivered. To minimise hospital attendance by both patients and staff, remote clinics, meetings and investigations have been used. Technologies including hand-held ECG monitoring using smartphones, patch ECG monitoring and sending out conventional Holter monitors have aided remote investigations. Platforms such as Google Meet and Zoom have allowed remote multidisciplinary meetings to be delivered effectively. The use of phone consultations has allowed outpatient care to continue despite the pandemic. The COVID-19 pandemic has resulted in a radical, and probably permanent, change in the way that outpatient care is delivered. Previous experience in remote review and the available technologies for monitoring have allowed the majority of outpatient care to be conducted without obviously compromising quality or safety.
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2813970-7
    ISSN 2050-3377 ; 2050-3369
    ISSN (online) 2050-3377
    ISSN 2050-3369
    DOI 10.15420/aer.2020.37
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: EHRA certification: a 15-year journey of attesting excellence in arrhythmia healthcare.

    Tzeis, Stylianos / Theuns, Dominic A / Earley, Mark / Merino, Jose Luis / Leclercq, Christophe

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2021  Volume 24, Issue 2, Page(s) 175–178

    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/therapy ; Certification ; Delivery of Health Care ; Humans
    Language English
    Publishing date 2021-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euab181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How to perform a transseptal puncture.

    Earley, Mark J

    Heart (British Cardiac Society)

    2009  Volume 95, Issue 1, Page(s) 85–92

    MeSH term(s) Angioplasty, Balloon, Coronary/instrumentation ; Angioplasty, Balloon, Coronary/methods ; Anticoagulants/therapeutic use ; Atrial Fibrillation/therapy ; Cardiac Catheterization ; Catheter Ablation ; Equipment Design ; Heart Defects, Congenital/therapy ; Humans ; Punctures/methods ; Ultrasonography, Interventional
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/hrt.2007.135939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Non-Physician, Outpatient Implantable Loop Recorder Explant Service Is Safe And Cost Effective. The OLÉ Audit.

    Monkhouse, Christopher / Fazil, Sufna / Binoy, Jincymol / Harvie, Helen / Granville, Hollie / Proctor, William / Maclean, Edward / Schilling, Richard / Chow, Anthony / Finlay, Malcolm / Honarbakhsh, Shohreh / Hunter, Ross / Lambiase, Pier D / Providencia, Rui / Ahsan, Syed / Earley, Mark

    Heart rhythm

    2024  

    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.04.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Catheter ablation of atrial fibrillation with a multi-electrode radiofrequency balloon; first and early two centre experience in Europe.

    Kanthasamy, Vijayabharathy / Breitenstein, Alexander / Schilling, Richard / Hofer, Daniel / Tiongco, Benny / Ang, Richard / Hunter, Ross / Earley, Mark / Ahsan, Syed / Mangiafico, Valentina / Honarbakhsh, Shohreh / Ahluwalia, Nikhil / Maclean, Edd / Creta, Antonio / Finlay, Malcolm

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 6, Page(s) 1350–1359

    Abstract: Introduction: The Heliostar™ ablation system is a novel RF balloon ablation technology with an integrated three-dimensional mapping system. Here, we describe our early experience and procedural outcomes using this technology for atrial fibrillation ... ...

    Abstract Introduction: The Heliostar™ ablation system is a novel RF balloon ablation technology with an integrated three-dimensional mapping system. Here, we describe our early experience and procedural outcomes using this technology for atrial fibrillation catheter ablation.
    Methods: We sought to comprehensively assess the first 60 consecutive patients undergoing pulmonary vein isolation using the novel HELISOTAR™ RF balloon technology including procedural outcomes. A comparison of the workflow between two different anaesthetic modalities (conscious sedation [CS] vs. general anaesthesia [GA]) was made. Procedural data were collected prospectively from two high-volume centers (Barts Heart Centre, UK and University Hospital of Zurich, Zurich). A standardized approach for catheter ablation was employed.
    Results: A total of 35 patients had the procedure under CS and the remaining under GA. Mean procedural and fluoroscopy times were 84 ± 33 min and 1.1 min. The median duration of RF energy application was 7 (5-9.8) mins per patient. All veins were successfully isolated, and the median isolation time was 10 (7-15) seconds. Our cohort's rate of procedural complications was low, with no mortality within 30 days postprocedure.
    Conclusion: Our early experience shows that catheter ablation using the Heliostar™ technology can be performed efficiently and safely; however, long-term data is yet to be established. Low fluoroscopy requirements, short learning curves and use of this technology with CS is possible, including the use of an oesophageal temperature probe.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Treatment Outcome ; Europe ; Electrodes ; Pulmonary Veins/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: ECGI targeted ablation for persistent AF not responding to pulmonary vein isolation: Results of a two-staged strategy (TARGET AF2).

    Dhillon, Gurpreet / Honarbakhsh, Shohreh / Abbas, Hakam / Waddingham, Peter / Dennis, Adam S / Ahluwalia, Nikhil / Finlay, Malcolm / Sohaib, Afzal / Welch, Sophie / Daw, Holly / Sporton, Simon / Chow, Anthony / Earley, Mark J / Lambiase, Pier D / Hunter, Ross J

    Heart rhythm O2

    2023  Volume 4, Issue 10, Page(s) 609–617

    Abstract: Background: Mechanisms sustaining persistent atrial fibrillation (AF) remain unclear.: Objectives: The study sought to evaluate both the clinical outcomes and response to ablation of potential drivers in patients with recurrent persistent AF ... ...

    Abstract Background: Mechanisms sustaining persistent atrial fibrillation (AF) remain unclear.
    Objectives: The study sought to evaluate both the clinical outcomes and response to ablation of potential drivers in patients with recurrent persistent AF recurrence following pulmonary vein isolation (PVI).
    Methods: A total of 100 patients with persistent AF of <2 years' duration underwent cryoballoon PVI (ECGI phenotyping of persistent AF based on driver burden and distribution to predict response to pulmonary vein isolation). Patients with documented recurrence of atrial arrhythmia within 12 months were recruited and underwent repeat PVI (if needed) followed by ablation of potential drivers (PDs) identified by electrocardiographic imaging (ECGI). PDs were defined as rotational activity >1.5 revolutions or focal activations. Cycle lengths were measured pre- and postablation. The primary outcome was freedom from atrial arrhythmia off antiarrhythmic drugs at 1 year as per guidelines.
    Results: Of 37 patients recruited, 26 had recurrent AF and underwent ECGI-guided ablation of PDs. An average of 6.4 ± 2.7 PDs were targeted per patient. The mean ablation time targeting PDs was 15.5 ± 6.9 minutes. An ablation response occurred in 20 patients (AF termination in 6, cycle length prolongation ≥10% in 14). At 1 year, 14 (54%) of 26 patients were free from arrhythmia, and 12 (46%) of 26 were off antiarrhythmic drugs. Considering the 96 patients who completed follow-up out of the original cohort of 100 patients undergoing cryoablation in this staged strategy, freedom from arrhythmia at 1 year following the last procedure was 72 (75%) of 96, or 70 (73%) of 96 off antiarrhythmic drugs.
    Conclusions: In patients with recurrent AF despite PVI, ECGI-guided ablation caused an acute response in a majority with reasonable long-term outcomes.
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2023.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Feasibility of double-blinded, placebo-controlled interventional study for assessing catheter ablation efficacy in persistent atrial fibrillation: Insights from the ORBITA AF feasibility study.

    Kanthasamy, Vijayabharathy / Schilling, Richard / Zongo, Olivier / Khan, Kamran / Earley, Mark / Monk, Vivienne / Hunter, Ross / Mangiafico, Valentina / Ang, Richard / Creta, Antonio / Aluwhalia, Nikhil / Honarbakhsh, Shohreh / Dhinoja, Mehul / Gupta, Dhiraj / Finlay, Malcolm

    American heart journal

    2023  Volume 269, Page(s) 56–71

    Abstract: Background: To date, there are no randomized, double-blinded clinical trials comparing catheter ablation to DC cardioversion (DCCV) with medical therapy in patients with persistent atrial fibrillation (PersAF). Conducting a large-scale trial to address ... ...

    Abstract Background: To date, there are no randomized, double-blinded clinical trials comparing catheter ablation to DC cardioversion (DCCV) with medical therapy in patients with persistent atrial fibrillation (PersAF). Conducting a large-scale trial to address this question presents considerable challenges, including recruitment, blinding, and implementation. We conducted a pilot study to evaluate the feasibility of conducting a definitive placebo-controlled trial.
    Methods: This prospective trial was carried out at Barts Heart Centre, United Kingdom, employing a randomized, double-blinded, placebo-controlled design. Twenty patients with PersAF (duration <2 years) were recruited, representing 10% of the proposed larger trial as determined by a power calculation. The patients were randomized in a 1:1 ratio to receive either PVI ± DCCV (PVI group) or DCCV + Placebo (DCCV group). The primary endpoint of this feasibility study was to evaluate patient blinding. Patients remained unaware of their treatment allocation until end of study.
    Results: During the study, 35% of patients experienced recurrence of PersAF prior to completion of 12 months follow-up. Blinding was successfully maintained amongst both patients and medical staff. The DCCV group had a trend to higher recurrence and repeat procedure rate compared to the PVI group (recurrence of PersAF 60% vs 30%; p = .07 and repeat procedure 70% vs 40%; p = .4). The quality of life experienced by individuals in the PVI group showed improvement, as evidenced by enhanced scores on the AF specific questionnaire (AF PROMS) (3 [±4] vs 21 [±8]) and SF-12 mental-component raw score (51.4 [±7] vs 43.24 [±15]) in patients who maintained sinus rhythm at 12 months.
    Conclusion: This feasibility study establishes the potential for conducting a blinded, placebo-controlled trial to evaluate the efficacy of PVI versus DCCV in patients with PersAF.
    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Atrial Fibrillation/drug therapy ; Feasibility Studies ; Quality of Life ; Prospective Studies ; Angina, Stable/surgery ; Pilot Projects ; Pulmonary Veins/surgery ; Percutaneous Coronary Intervention ; Catheter Ablation/methods ; Treatment Outcome ; Recurrence
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2023.12.007
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  9. Article ; Online: The utility of implantable loop recorders in patient management: an age- and indication-stratified study in the outpatient-implant era.

    Sanghvi, Mihir M / Jones, Daniel M / Kalindjian, Jeremy / Monkhouse, Christopher / Providencia, Rui / Schilling, Richard J / Ahluwalia, Nikhil / Earley, Mark J / Finlay, Malcolm

    European heart journal. Quality of care & clinical outcomes

    2021  Volume 8, Issue 7, Page(s) 770–777

    Abstract: Aim: Implantable loop recorders (ILRs) are now routinely implanted for long-term cardiac monitoring in the clinical setting. The aim of this study was to examine the real-world performance of these devices focusing on the management changes made in ... ...

    Abstract Aim: Implantable loop recorders (ILRs) are now routinely implanted for long-term cardiac monitoring in the clinical setting. The aim of this study was to examine the real-world performance of these devices focusing on the management changes made in response to ILR-recorded data.
    Methods and results: This was a single-centre, prospective observational study of consecutive patients undergoing ILR implantation. All patients who underwent implantation of a Medtronic Reveal LINQ device from September 2017 to June 2019 at Barts Heart Centre were included. Five hundred and one patients were included. Three hundred and two (60%) patients underwent ILR implantation for an indication of pre-syncope/syncope, 96 (19%) for palpitations, 72 (14%) for atrial fibrillation (AF) detection with a history of cryptogenic stroke, and 31 (6%) for high risk of serious cardiac arrhythmia. The primary outcome of this study was that an ILR-derived diagnosis altered management in 110 patients (22%). Secondary outcomes concerned subgroup analyses by indication: in patients who presented with syncope/pre-syncope, a change in management resulting from ILR data was positively associated with age [hazard ratio (HR) 1.04, 95% confidence interval 1.02-1.06; P < 0.001] and negatively associated with a normal electrocardiogram at baseline (HR 0.54 [0.31-0.93]; P = 0.03). Few patients (1/57, 2%) aged <40 years in this group underwent device implantation, compared to 19/62 patients (31%) aged 75 years and over (P = 0.0024). Out of 183 (12%) patients, 22 in the 40-74 age range had a device implanted. Among patients who underwent ILR insertion following cryptogenic stroke, 13/72 (18%) had AF detected, leading to a decision to commence anticoagulation.
    Conclusion: These results inform the utility of ILR in the clinical setting. Diagnoses provided by ILR that lead to changes in management are rare in patients under age 40, particularly following syncope, pre-syncope, or palpitations. In older patients, new diagnoses are frequently made and trigger important changes in treatment.
    MeSH term(s) Humans ; Aged ; Electrocardiography, Ambulatory/methods ; Outpatients ; Syncope/diagnosis ; Syncope/epidemiology ; Syncope/etiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Anticoagulants ; Ischemic Stroke
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcab071
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  10. Article ; Online: First experience of POLARx™ versus Arctic Front Advance™: An early technology comparison.

    Creta, Antonio / Kanthasamy, Viijayabharathy / Schilling, Richard J / Rosengarten, James / Khan, Fakhar / Honarbakhsh, Shohreh / Earley, Mark J / Hunter, Ross J / Finlay, Malcom

    Journal of cardiovascular electrophysiology

    2021  Volume 32, Issue 4, Page(s) 925–930

    Abstract: Introduction: Cryoballoon ablation is an established technique to achieve pulmonary vein isolation in patients with atrial fibrillation (AF). Recently, a new manufacturer of cryoballoon achieved regulatory CE marking (POLARx™; Boston Scientific). We ... ...

    Abstract Introduction: Cryoballoon ablation is an established technique to achieve pulmonary vein isolation in patients with atrial fibrillation (AF). Recently, a new manufacturer of cryoballoon achieved regulatory CE marking (POLARx™; Boston Scientific). We describe our early experience of using this new market entrant of the technology and describe procedural aspects in comparison to the incumbent Medtronic Arctic Front Advance™.
    Methods: We assessed the first 40 AF ablations performed with the POLARx catheter at the Barts Heart Centre. These patients were compared with a contemporaneous series of patients undergoing ablation by the same operators using the Arctic Front Advance. Procedural metrics were prospectively recorded.
    Results: A total of four operators undertook 40 cases using the POLARx catheter, compared with 40 cases using the Arctic Front Advance. Procedure times (60.0 vs. 60.0 min) were similar between the two technologies, however left atrial dwell time (35.0 vs 39.0 min) and fluoroscopy times (3.3 vs. 5.2 min) were higher with the POLARx. Measured nadir and isolation balloon temperatures were significantly lower with POLARx. Almost all veins were isolated with a median freezing time of 16.0 (POLARx) versus 15.0 (Arctic Front Advance) min. The rate of procedural complications was low in both groups.
    Conclusion: The POLARx cryoballoon is effective for pulmonary vein isolation. Measured isolation and nadir temperatures are lower compared with the predicate Arctic Front Advance catheter. The technology appears similar in acute efficacy and has a short learning curve, but formal dosing studies may be required to prove equivalence of efficacy.
    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation ; Cryosurgery/adverse effects ; Fluoroscopy ; Humans ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Technology ; Treatment Outcome
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.14951
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