Article ; Online: Shear wave elastography and Afirma™ gene expression classifier in thyroid nodules with indeterminate cytology: a comparison study.
2018 Volume 59, Issue 3, Page(s) 573–584
Abstract: Purpose: To compare shear wave elastography (SWE) and Afirma™ gene expression classifier (GEC) for diagnosis of malignancy in thyroid nodules (TNs) with Bethesda Classification (BC) III or IV indeterminate cytology.: Methods: This preliminary single- ... ...
Abstract | Purpose: To compare shear wave elastography (SWE) and Afirma™ gene expression classifier (GEC) for diagnosis of malignancy in thyroid nodules (TNs) with Bethesda Classification (BC) III or IV indeterminate cytology. Methods: This preliminary single-center prospective study was approved by the Institutional Review Board. We evaluated 151 consented patients with 151 indeterminate TNs (123 BC III, 28 BC IV) on fine-needle aspiration biopsy (FNAB). B-mode ultrasound, vascularity, and SWE were performed prior to FNAB. TN stiffness was measured as shear wave velocity (SWV) in meters per second (m/s). The stiffest area of the TN was selected for SWV measurement. GEC testing was performed with a second FNAB. Surgery was recommended for GEC-suspicious TNs, or GEC-benign TNs with two or more worrisome B-mode US features. Results: Surgical pathology confirmed 31 malignant TNs. Among the GEC-suspicious group, 28 of 59 TNs were malignant. The SWV value of ≥3.59 m/s was the best cut-off for malignancy risk based on the receiver operating curve (ROC). Twenty-six malignant TNs had SWV ≥ 3.59 m/s. The sensitivity and specificity for SWV ≥ 3.59 m/s were 83.9 and 79.2%, respectively. Positive predictive value (PPV) was 51.0% and negative predictive value (NPV) was 95.0%. For the GEC-suspicious group, sensitivity, specificity, PPV, and NPV were 90.3, 74.2, 47.5, and 96.7%, respectively. In multivariate analysis, SWV and GEC-suspicious were significant predictors of malignancy, but B-mode features and vascularity were not. Conclusion: This preliminary study indicates that SWE and GEC are independent predictors of malignancy in TNs with BC III or IV. |
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MeSH term(s) | Adult ; Aged ; Biopsy, Fine-Needle ; Elasticity Imaging Techniques/methods ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/genetics ; Thyroid Nodule/pathology |
Language | English |
Publishing date | 2018-01-19 |
Publishing country | United States |
Document type | Comparative Study ; Journal Article |
ZDB-ID | 1194484-5 |
ISSN | 1559-0100 ; 1355-008X ; 0969-711X |
ISSN (online) | 1559-0100 |
ISSN | 1355-008X ; 0969-711X |
DOI | 10.1007/s12020-017-1509-9 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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