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  1. Article ; Online: Non-pharmaceutical primary care interventions to improve mental health in deprived populations: a systematic review.

    Tanner, Louise M / Wildman, Josephine M / Stoniute, Akvile / Still, Madeleine / Bernard, Kate / Green, Rhiannon / Eastaugh, Claire H / Thomson, Katie H / Sowden, Sarah

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2023  Volume 73, Issue 729, Page(s) e242–e248

    Abstract: Background: Common mental health disorders are especially prevalent among people from socioeconomically disadvantaged backgrounds. Non-pharmaceutical primary care interventions, such as social prescribing and collaborative care, provide alternatives to ... ...

    Abstract Background: Common mental health disorders are especially prevalent among people from socioeconomically disadvantaged backgrounds. Non-pharmaceutical primary care interventions, such as social prescribing and collaborative care, provide alternatives to pharmaceutical treatments for common mental health disorders, but little is known about the impact of these interventions for patients who are socioeconomically disadvantaged.
    Aim: To synthesise evidence for the effects of non-pharmaceutical primary care interventions on common mental health disorders and associated socioeconomic inequalities.
    Design and setting: Systematic review of quantitative primary studies published in English and undertaken in high-income countries.
    Method: Six bibliographic databases were searched and additional grey literature sources screened. Data were extracted onto a standardised proforma and quality assessed using the Effective Public Health Practice Project tool. Data were synthesised narratively and effect direction plots were produced for each outcome.
    Results: Thirteen studies were included. Social-prescribing interventions were evaluated in 10 studies, collaborative care in two studies, and a new model of care in one study. Positive results (based on effect direction) were reported for the impact of the interventions on wellbeing in groups that were socioeconomically deprived. Inconsistent (mainly positive) results were reported for anxiety and depression. One study reported that people from the group with least deprivation, compared with the group with greatest deprivation, benefitted most from these interventions. Overall, study quality was weak.
    Conclusion: Targeting non-pharmaceutical primary care interventions at areas of socioeconomic deprivation may help to reduce inequalities in mental health outcomes. However, only tentative conclusions can be drawn from the evidence in this review and more-robust research is required.
    MeSH term(s) Humans ; Mental Health ; Anxiety/therapy ; Income ; Anxiety Disorders ; Primary Health Care
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/BJGP.2022.0343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Promoting sexual health in older adults: Findings from two rapid reviews.

    Stowell, Melanie / Hall, Alex / Warwick, Stephanie / Richmond, Catherine / Eastaugh, Claire H / Hanratty, Barbara / McDermott, Jane / Craig, Dawn / Spiers, Gemma Frances

    Maturitas

    2023  Volume 177, Page(s) 107795

    Abstract: Background: Sexual health throughout the life course is increasingly recognised as important to maintaining one's overall health, wellbeing, and relationships. We aimed to provide an overview of the evidence on sexual health needs and sexual health ... ...

    Abstract Background: Sexual health throughout the life course is increasingly recognised as important to maintaining one's overall health, wellbeing, and relationships. We aimed to provide an overview of the evidence on sexual health needs and sexual health promotion in later life.
    Methods: We undertook two rapid reviews, drawing on systematic review evidence. Searches were conducted in Epistemonikos. Studies were eligible if they reported evidence about the sexual health needs of, or sexual health promotion interventions for, people aged 50+ years. Evidence was quality assessed and summarised in a narrative synthesis.
    Results: Fifteen systematic reviews were included in Review 1 (sexual health needs) and 12 in Review 2 (interventions). Key concerns and needs of older adults included the impacts of cultural stigma/misperceptions, barriers to sexual expression, and a need for tailored support in a welcoming environment. Key concerns and needs of health and social care professionals included mixed attitudes towards and knowledge of later-life sexuality and a need for more training and education. Approaches to promoting sexual health in later life included training and workshops for care home professionals, education for older people at risk of/living with HIV, and interventions to address sexual health-related symptoms of menopause. Gaps in the evidence from current reviews and methodological issues in primary studies were identified.
    Conclusion: Older people have specific needs relating to their sexual health. Health and social care professionals working with older people may benefit from education/training around sexuality in later life. Evidence on effective interventions and strategies is limited.
    MeSH term(s) Female ; Humans ; Aged ; Sexual Health ; Health Promotion ; Social Support
    Language English
    Publishing date 2023-07-05
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2023.107795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predictive accuracy of risk prediction models for recurrence, metastasis and survival for early-stage cutaneous melanoma: a systematic review.

    Kunonga, Tafadzwa Patience / Kenny, R P W / Astin, Margaret / Bryant, Andrew / Kontogiannis, Vasileios / Coughlan, Diarmuid / Richmond, Catherine / Eastaugh, Claire H / Beyer, Fiona R / Pearson, Fiona / Craig, Dawn / Lovat, Penny / Vale, Luke / Ellis, Robert

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e073306

    Abstract: Objectives: To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.: ... ...

    Abstract Objectives: To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.
    Design: Systematic review and narrative synthesis.
    Data sources: Searched MEDLINE, Embase, CINAHL, Cochrane Library, Science Citation Index and grey literature sources including cancer and guideline websites from 2000 to September 2021.
    Eligibility criteria: Included studies on risk prediction models for stage I and II melanoma in adults ≥18 years. Outcomes included OS, recurrence, metastases and model performance. No language or country of publication restrictions were applied.
    Data extraction and synthesis: Two pairs of reviewers independently screened studies, extracted data and assessed the risk of bias using the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies checklist and the Prediction study Risk of Bias Assessment Tool. Heterogeneous predictors prevented statistical synthesis.
    Results: From 28 967 records, 15 studies reporting 20 models were included; 8 (stage I), 2 (stage II), 7 (stages I-II) and 7 (stages not reported), but were clearly applicable to early stages. Clinicopathological predictors per model ranged from 3-10. The most common were: ulceration, Breslow thickness/depth, sociodemographic status and site. Where reported, discriminatory values were ≥0.7. Calibration measures showed good matches between predicted and observed rates. None of the studies assessed clinical usefulness of the models. Risk of bias was high in eight models, unclear in nine and low in three. Seven models were internally and externally cross-validated, six models were externally validated and eight models were internally validated.
    Conclusions: All models are effective in their predictive performance, however the low quality of the evidence raises concern as to whether current follow-up recommendations following surgical treatment is adequate. Future models should incorporate biomarkers for improved accuracy.
    Prospero registration number: CRD42018086784.
    MeSH term(s) Adult ; Humans ; Melanoma ; Prognosis ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Considerations for the Cure Assumption in an NICE Single Technology Appraisal of Nivolumab with Chemotherapy for Neoadjuvant Treatment of Resectable Non-Small Cell Lung Cancer: Evidence Assessment Group Perspective.

    Orozco-Leal, Giovany / Johnson, Eugenie Evelynne / Hosseinijebeli, Sedighe / Robinson, Tomos / Homer, Tara / Eastaugh, Claire H / Richmond, Catherine / Tanner, Louise / Meader, Nick / Kenny, Ryan / Wallace, Sheila A / Rice, Stephen

    PharmacoEconomics

    2023  Volume 42, Issue 2, Page(s) 133–136

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Nivolumab/therapeutic use ; Neoadjuvant Therapy ; Lung Neoplasms/drug therapy ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Nivolumab (31YO63LBSN) ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2023-11-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-023-01328-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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