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  1. AU="Ebina-Shibuya, Risa"
  2. AU="Vogel, Ida"
  3. AU="Facchiano, Angelo"
  4. AU="Tara Rava Zolnikov"
  5. AU="Akther, Tahmina"
  6. AU=Chung Eugene S
  7. AU=Josephson M E

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  1. Artikel ; Online: Reply to letter to the editor "antibody responses to second doses of COVID-19 vaccination in lung cancer patients: Comment".

    Narita, Daisuke / Ebina-Shibuya, Risa

    Respiratory investigation

    2023  Band 61, Heft 3, Seite(n) 347–348

    Mesh-Begriff(e) Humans ; COVID-19 Vaccines ; Antibody Formation ; COVID-19/prevention & control ; Lung Neoplasms ; Vaccination
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-03-07
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2023.02.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: TSLP-targeting therapy: Beyond allergy?

    Ebina-Shibuya, Risa / Leonard, Warren J

    Clinical and translational medicine

    2023  Band 13, Heft 5, Seite(n) e1241

    Mesh-Begriff(e) Humans ; Hypersensitivity/drug therapy ; Cytokines
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2023-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1241
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Role of thymic stromal lymphopoietin in allergy and beyond.

    Ebina-Shibuya, Risa / Leonard, Warren J

    Nature reviews. Immunology

    2022  Band 23, Heft 1, Seite(n) 24–37

    Abstract: Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and ... ...

    Abstract Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and recruitment. It is best known for its role in promoting type 2 immune responses such as in allergic diseases and, in 2021, a monoclonal antibody targeting TSLP was approved for the treatment of severe asthma. However, it is now clear that TSLP has many other important roles in a variety of settings. Indeed, several genetic variants for TSLP are linked to disease severity, and chromosomal alterations in TSLP are common in certain cancers, indicating important roles of TSLP in disease. In this Review, we discuss recent advances in TSLP biology, highlighting how it regulates the tissue environment not only in allergic disease but also in infectious diseases, inflammatory diseases and cancer. Encouragingly, therapies targeting the TSLP pathway are being actively pursued for several diseases.
    Mesh-Begriff(e) Humans ; Thymic Stromal Lymphopoietin ; Immunity, Innate ; Lymphocytes/metabolism ; Cytokines ; Hypersensitivity ; Neoplasms
    Chemische Substanzen Thymic Stromal Lymphopoietin (GT0IL38SP4) ; Cytokines
    Sprache Englisch
    Erscheinungsdatum 2022-06-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00735-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC.

    Kimura, Nozomu / Tsukita, Yoko / Ebina-Shibuya, Risa / Miyauchi, Eisaku / Yamada, Mitsuhiro / Narita, Daisuke / Saito, Ryota / Inoue, Chihiro / Fujino, Naoya / Ichikawa, Tomohiro / Tamada, Tsutomu / Sugiura, Hisatoshi

    Cancer biomarkers : section A of Disease markers

    2024  

    Abstract: Background: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination of immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable.: Objective: This study aims to seek predictors of ... ...

    Abstract Background: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination of immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable.
    Objective: This study aims to seek predictors of combination of ICI/chemotherapy response in NSCLC patients using peripheral blood samples.
    Methods: Patients diagnosed with advanced NSCLC between July 2019 and May 2021 receiving combination of ICI/chemotherapy were included and assessed for partial responses (PR), stable disease (SD) or progressive disease (PD). We measured circulating immune cells, plasma cytokines and chemokines.
    Results: Nineteen patients were enrolled. The proportions of circulating natural killer (NK) cells within CD45 + cells, programmed death 1 (PD-1) + Tim-3 + T cells within CD4 + cells, and the amount of chemokine C-X-C ligand (CXCL10) in the plasma were significantly elevated in PR relative to SD/PD patients (median 8.1%-vs-2.1%, P= 0.0032; median 1.2%-vs-0.3%, P= 0.0050; and median 122.6 pg/ml-vs-76.0 pg/ml, P= 0.0125, respectively). Patients with 2 or 3 elevated factors had longer progression-free survival than patients with 0 or only one (not reached-vs-5.6 months, P= 0.0002).
    Conclusions: We conclude that NK cells, CD4 + PD-1 + Tim-3 + T cells, and CXCL10 levels in pre-treatment peripheral blood may predict the efficacy of combination of ICI/chemotherapy in NSCLC.
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-230301
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Current national policies for infant universal bacille Calmette-Guérin vaccination were associated with lower mortality from coronavirus disease 2019.

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Clinical and experimental vaccine research

    2020  Band 9, Heft 2, Seite(n) 179–182

    Abstract: An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCG-vaccinated people are less suffered from the virus because BCG vaccination is ... ...

    Abstract An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCG-vaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17-52) decrease of COVID-19 mortality per population compared to countries without the policy.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-31
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2684652-4
    ISSN 2287-366X ; 2287-3651
    ISSN (online) 2287-366X
    ISSN 2287-3651
    DOI 10.7774/cevr.2020.9.2.179
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19.

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology (Carlton, Vic.)

    2020  Band 25, Heft 8, Seite(n) 898–899

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-18
    Erscheinungsland Australia
    Dokumenttyp Letter ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13885
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  7. Artikel ; Online: Antibody responses to second doses of COVID-19 vaccination in lung cancer patients undergoing treatment.

    Narita, Daisuke / Ebina-Shibuya, Risa / Miyauchi, Eisaku / Tsukita, Yoko / Saito, Ryota / Murakami, Koji / Kimura, Nozomu / Sugiura, Hisatoshi

    Respiratory investigation

    2022  Band 61, Heft 2, Seite(n) 247–253

    Abstract: Background: Several reports have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection tends to have more severe outcomes in cancer patients. Although vaccination reduces the risk of severe disease, data on antibody titers ...

    Abstract Background: Several reports have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection tends to have more severe outcomes in cancer patients. Although vaccination reduces the risk of severe disease, data on antibody titers achieved by vaccination is scarce in cancer patients.
    Methods: We collected 79 blood samples (69 lung cancer patients and 10 control individuals) and conducted an anti-SARS-CoV-2 antibody assay to compare the antibody titer achieved with current treatment. Sixty-eight patients (86%) received the BNT162 mRNA vaccine and 11 (14%) received the mRNA-1273 vaccine. They were categorized according to the current treatment: control individuals without cancer (cohort A), lung cancer patients who were treated with cytotoxic chemotherapy (cohort B), immunotherapy (cohort C), combination of cytotoxic chemotherapy and immunotherapy (cohort D), tyrosine kinase inhibitors (cohort E), and radiation therapy (cohort F).
    Results: Among 69 lung cancer patients (cohort B-F), 57 (83%) had adenocarcinoma, and 66 (96%) had advanced-stage cancer. In the anti-SARS-CoV-2 antibody assay, the antibody titer was significantly lower in lung cancer patients than in control individuals (p = 0.01). The median antibody titers were 161 AU/ml in control individuals and 59.9 AU/ml in lung cancer patients.
    Conclusions: Antibody titers after the second vaccination were lower in cancer patients than those in healthy individuals. Our findings provide essential information for understanding the benefits and necessity of additional vaccination to prevent SARS-CoV-2 infection in lung cancer patients.
    Mesh-Begriff(e) Humans ; COVID-19 Vaccines ; Antibody Formation ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19 ; SARS-CoV-2 ; Lung Neoplasms ; Vaccination ; BNT162 Vaccine
    Chemische Substanzen COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine
    Sprache Englisch
    Erscheinungsdatum 2022-12-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2022.11.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Current national policies for infant universal bacille calmetteguérin vaccination were associated with lower mortality from coronavirus disease 2019

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Clin. Exp. Vaccine Res.

    Abstract: An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCGvaccinated people are less suffered from the virus because BCG vaccination is ... ...

    Abstract An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCGvaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17–52) decrease of COVID-19 mortality per population compared to countries without the policy.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #736870
    Datenquelle COVID19

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  9. Artikel: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19

    Ebina-Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #603888
    Datenquelle COVID19

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  10. Artikel ; Online: National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID ‐19

    Ebina‐Shibuya, Risa / Horita, Nobuyuki / Namkoong, Ho / Kaneko, Takeshi

    Respirology

    2020  Band 25, Heft 8, Seite(n) 898–899

    Schlagwörter Pulmonary and Respiratory Medicine ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13885
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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